Nobfen Uses

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Nobfen indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Nobfen has anti-inflammatory and analgesic effects on the following diseases and symptoms: Chronic articular rheumatism, osteoarthritis, lumbago, periarthritis of the shoulder and shoulder-arm-neck syndrome.

Nobfen relieves pain and inflammation after operation, trauma and tooth extraction.

Nobfen description

Nobfen (INN) is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group, which also includes Nobfen and naproxen among others. It is marketed in Brazil, Mexico and Japan by Sankyo as its sodium salt, Nobfen sodium, under the trade name Loxonin, Argentina as Oxeno and in India as Loxomac. It is available in these countries for oral administration, and a transdermal preparation was approved for sale in Japan on January 2006.

Nobfen dosage

For general use, 60 mg of Nobfen sodium (as anhydrous) is orally administered to adults 3 times a day.

For a single administration, 60-120 mg is orally given.

The dosages should be adjusted according to age and symptoms.

Nobfen interactions

Coumarin-Type Anticoagulants: Several short-term controlled studies failed to wshow that Nobfen significantly affected prothrombin times or a variety of other clotting factors when administered to individuals on coumarin-type anticoagulants. However, because bleeding has been reported when Nobfen and other nonsteroidal anti-inflammatory agents have been administered to patients on coumarin-type anticoagulants, the physician should be cautious when administering Nobfen to patients on anticoagulants.

Aspirin: Animal studies wshow that aspirin given with nonsteroidal anti-inflammatory agents, including Nobfen, yields a net decrease in anti-inflammatory activity with lowered blood levels of the non-aspirin drug. Single dose bioavailability studies in normal volunteers have failed to wshow an effect of aspirin on Nobfen blood levels. Correlative clinical studies have not been performed.

Methotrexate: Nobfen, as well as other nonsteroidal anti-inflammatory drugs, probably reduces the tubular secretion of methotrexate based on in vitro studies in rabbit kidney slices. This may indicate that Nobfen could enhance the toxicity of methotrexate. Caution should be used if Nobfen is administered concomitantly with methotrexate.

H-2 Antagonists: In studies with human volunteers, co-administration of cimetidine or ranitidine with Nobfen had no substantive effect on Nobfen serum concentrations.

Furosemide: Clinical studies, as well as random observations, have shown that Nobfen can reduce the natriuretic effect of furosemide and thiazides in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis. During concomitant therapy with Nobfen, the patient should be observed closely for signs of renal failure, as well as to assure diuretic efficacy.

Lithium: Nobfen produced an elevation of plasma lithium levels and a reduction in renal lithium clearance in a study of eleven normal volunteers. The mean minimum lithium concentration increased 15% and the renal clearance of lithium was decreased by 19% during this period of concomitant drug administration.

This effect has been attributed to inhibition of renal prostaglandin synthesis by Nobfen. Thus, when Nobfen and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity. (Read circulars for lithium preparation before use of such concurrent therapy).

Nobfen side effects


Adverse GI effects, anorexia, vomiting, diarrhoea, constipation. Anaemia, leucopenia, thrombocytopenia.

Nobfen contraindications

Nobfen tablets or Nobfen childrens suspension should not be used in patients who have previously exhibited hypersensitivity to the drug, or in individuals with the syndrome of nasal polyps, angioedema, and bronchospastic reactivity to aspirin or other nonsteroidal anti-inflammatory agents. Anaphylactoid reactions have occurred in such patients.

Active ingredient matches for Nobfen:

Loxoprofen in Japan.


List of Nobfen substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
400 mg x 10's (Cadila Healthcare (Zydus Cadila Healthcare Ltd))$ 0.10
Norswel 400 mg Tablet (Cadila Healthcare (Zydus Cadila Healthcare Ltd))$ 0.01
NORSWEL tab 400 mg x 10's (Cadila Healthcare (Zydus Cadila Healthcare Ltd))$ 0.10
Norswel 400mg Tablet (Cadila Healthcare (Zydus Cadila Healthcare Ltd))$ 0.01
Norswell 400mg TAB / 10$ 0.10
Novidol 500 mg x 2 Blister x 10 Tablet (Synpharma)
Tablet; Oral; Ibuprofen 200 mg (Novopharm)
Tablet; Oral; Ibuprofen 300 mg (Novopharm)
Tablet; Oral; Ibuprofen 400 mg (Novopharm)
Tablet; Oral; Ibuprofen 600 mg (Novopharm)
Tablets; Oral; Ibuprofen 200 mg (Novopharm)
Tablets; Oral; Ibuprofen 300 mg (Novopharm)
Tablets; Oral; Ibuprofen 400 mg (Novopharm)
Tablets; Oral; Ibuprofen 600 mg (Novopharm)
Novo-profen tablet 600 mg (Novopharm)
Novo-profen tablet 400 mg (Novopharm)
Novo-profen tablet 200 mg (Novopharm)
Novo-profen tablet 300 mg (Novopharm)
Capsule, Retard; Oral; Ibuprofen (Temmler)
Capsules, Retard; Oral; Ibuprofen (Temmler)
Tablet; Oral; Ibuprofen 200 mg


  1. DailyMed. "IBUPROFEN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". (accessed September 17, 2018).
  2. PubChem. "Loxoprofen". (accessed September 17, 2018).
  3. PubChem. "ibuprofen". (accessed September 17, 2018).


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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