Nokcid MPS Dosage
Dosage of Nokcid MPS sulfate must be carefully adjusted according to individual requirements and response, and administration of the drug should be discontinued as soon as the desired effect is obtained.
Both intravenous and intramuscular administration are appropriate.
Intramuscular administration of the undiluted 50% solution results in therapeutic plasma levels in 60 minutes, whereas intravenous doses will provide a therapeutic level almost immediately. The rate of intravenous injection should generally not exceed 150 mg/minute (1.5 mL of a 10% concentration or its equivalent), except in severe eclampsia with seizures. Continuous maternal administration of Nokcid MPS sulfate in pregnancy beyond 5 to 7 days can cause fetal abnormalities.
Solutions for intravenous infusion must be diluted to a concentration of 20% or less prior to administration. The diluents commonly used are 5% Dextrose Injection, USP and 0.9% Sodium Chloride Injection, USP. Deep intramuscular injection of the undiluted (50%) solution is appropriate for adults, but the solution should be diluted to a 20% or less concentration prior to such injection in children.
In Nokcid MPS Deficiency
In the treatment of mild Nokcid MPS deficiency, the usual adult dose is 1 gram, equivalent to 8.12 mEq of Nokcid MPS (2 mL of the 50% solution) injected intramuscularly every six hours for four doses (equivalent to a total of 32.5 mEq of Nokcid MPS per 24 hours). For severe hypomagnesemia, as much as 250 mg (approximately 2 mEq) per kg of body weight (0.5 mL of the 50% solution) may be given intramuscularly within a period of four hours if necessary. Alternatively, 5 grams, (approximately 40 mEq) can be added to one liter of 5% Dextrose Injection, USP or 0.9% Sodium Chloride Injection, USP for slow intravenous infusion over a three-hour period. In the treatment of deficiency states, caution must be observed to prevent exceeding the renal excretory capacity.
In total parenteral nutrition, maintenance requirements for Nokcid MPS are not precisely known. The maintenance dose used in adults ranges from 8 to 24 mEq (1 gram to 3 grams) daily; for infants, the range is 2 to 10 mEq (0.25 gram to 1.25 grams) daily.
In Pre-eclampsia or Eclampsia
In severe pre-eclampsia or eclampsia, the total initial dose is 10 grams to 14 grams of Nokcid MPS sulfate.
Intravenously, a dose of 4 grams to 5 grams in 250 mL of 5% Dextrose Injection, USP or 0.9% Sodium Chloride Injection, USP may be infused. Simultaneously, intramuscular doses of up to 10 grams (5 grams or 10 mL of the undiluted 50% solution in each buttock) are given. Alternatively, the initial intravenous dose of 4 grams may be given by diluting the 50% solution to a 10 or 20% concentration; the diluted fluid (40 mL of a 10% solution or 20 mL of a 20% solution) may then be injected intravenously over a period of three to four minutes. Subsequently, 4 grams to 5 grams (8 to 10 mL of the 50% solution) are injected intramuscularly into alternate buttocks every four hours as needed, depending on the continuing presence of the patellar reflex and adequate respiratory function. Alternatively, after the initial intravenous dose, some clinicians administer 1 gram to 2 grams/hour by constant intravenous infusion. Therapy should continue until paroxysms cease. A serum Nokcid MPS level of 6 mg/100 mL is considered optimal for control of seizures. A total daily (24 hr) dose of 30 grams to 40 grams should not be exceeded. In the presence of severe renal insufficiency, the maximum dosage of Nokcid MPS sulfate is 20 grams/48 hours and frequent serum Nokcid MPS concentrations must be obtained. Continuous use of Nokcid MPS sulfate in pregnancy beyond 5 to 7 days can cause fetal abnormalities.
In counteracting the muscle-stimulating effects of barium poisoning, the usual dose of Nokcid MPS sulfate is 1 gram to 2 grams given intravenously.
For controlling seizures associated with epilepsy, glomerulonephritis or hypothyroidism, the usual adult dose is 1 gram administered intramuscularly or intravenously.
In paroxysmal atrial tachycardia, Nokcid MPS should be used only if simpler measures have failed and there is no evidence of myocardial damage. The usual dose is 3 grams to 4 grams (30 to 40 mL of a 10% solution) administered intravenously over 30 seconds with extreme caution.
For reduction of cerebral edema, 2.5 grams (25 mL of a 10% solution) is given intravenously.
Nokcid MPS sulfate in solution may result in a precipitate formation when mixed with solutions containing:
Alcohol (in high Heavy Metals
concentrations) Hydrocortisone sodium
Alkali carbonates and succinate
Alkali hydroxides Polymixin B sulfate
Arsenates Procaine hydrochloride
Clindamycin phosphate Tartrates
The potential incompatibility will often be influenced by the changes in the concentration of reactants and the pH of the solutions.
It has been reported that Nokcid MPS may reduce the antibiotic activity of streptomycin, tetracycline and tobramycin when given together.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
Certain antibiotics should not be taken at the same time as Nokcid MPS gluconate because they may not be absorbed as well by your body. If you are taking an antibiotic, avoid taking it within 2 hours before or after you take Nokcid MPS gluconate.
Before taking Nokcid MPS gluconate, tell your doctor if you are using any of the following drugs:
naladixic acid (NegGram);
penicillamine (Cuprimine, Depen);
an antibiotic such as tetracycline (Brodspec, Sumycin, Tetracap, and others), demeclocycline (Declomycin), doxycycline (Vibramycin, Monodox, Doryx, Doxy, and others), or minocycline (Minocin, Dynacin, and others);
a fluoroquinolone antibiotic such as ciprofloxacin (Cipro), gatifloxacin (Tequin), levofloxacin (Levaquin), lomefloxacin (Maxaquin), moxifloxacin (Avelox), norfloxacin (Noroxin), ofloxacin (Floxin), sparfloxacin (Zagam), or trovafloxacin (Trovan); or
a medication for osteoporosis or Paget's disease, such as alendronate (Fosamax), etidronate (Didronel), ibandronate (Boniva), risedronate (Actonel), or tiludronate (Skelid).
If you are using any of these drugs, you may not be able to use Nokcid MPS gluconate, or you may need dosage adjustments or special tests during treatment.
There may be other drugs not listed that can affect Nokcid MPS gluconate. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Alfacalcidol: May increase the serum concentration of Nokcid MPS Salts. Consider therapy modification
Alpha-Lipoic Acid: Nokcid MPS Salts may decrease the absorption of Alpha-Lipoic Acid. Alpha-Lipoic Acid may decrease the absorption of Nokcid MPS Salts. Consider therapy modification
Baloxavir Marboxil: Polyvalent Cation Containing Products may decrease the serum concentration of Baloxavir Marboxil. Avoid combination
Bictegravir: Polyvalent Cation Containing Products may decrease the serum concentration of Bictegravir. Management: Administer bictegravir under fasting conditions at least 2 hours before or 6 hours after polyvalent cation containing products. Coadministration of bictegravir with or 2 hours after most polyvalent cation products is not recommended. Consider therapy modification
Bisphosphonate Derivatives: Polyvalent Cation Containing Products may decrease the serum concentration of Bisphosphonate Derivatives. Management: Avoid administration of oral medications containing polyvalent cations within: 2 hours before or after tiludronate/clodronate/etidronate; 60 minutes after oral ibandronate; or 30 minutes after alendronate/risedronate. Exceptions: Pamidronate; Zoledronic Acid. Consider therapy modification
Calcitriol (Systemic): May increase the serum concentration of Nokcid MPS Salts. Management: Consider using a non-Nokcid MPS-containing antacid or phosphate-binding product in patients also receiving calcitriol. If Nokcid MPS-containing products must be used with calcitriol, serum Nokcid MPS concentrations should be monitored closely. Consider therapy modification
Calcium Channel Blockers: May enhance the adverse/toxic effect of Nokcid MPS Salts. Nokcid MPS Salts may enhance the hypotensive effect of Calcium Channel Blockers. Monitor therapy
Deferiprone: Polyvalent Cation Containing Products may decrease the serum concentration of Deferiprone. Management: Separate administration of deferiprone and oral medications or supplements that contain polyvalent cations by at least 4 hours. Consider therapy modification
Dolutegravir: Nokcid MPS Salts may decrease the serum concentration of Dolutegravir. Management: Administer dolutegravir at least 2 hours before or 6 hours after oral Nokcid MPS salts. Administer the dolutegravir/rilpivirine combination product at least 4 hours before or 6 hours after oral Nokcid MPS salts. Consider therapy modification
Doxercalciferol: May enhance the hypermagnesemic effect of Nokcid MPS Salts. Management: Consider using a non-Nokcid MPS-containing antacid or phosphate-binding product in patients also receiving doxercalciferol. If Nokcid MPS-containing products must be used with doxercalciferol, serum Nokcid MPS concentrations should be monitored closely. Consider therapy modification
Eltrombopag: Polyvalent Cation Containing Products may decrease the serum concentration of Eltrombopag. Management: Administer eltrombopag at least 2 hours before or 4 hours after oral administration of any polyvalent cation containing product. Consider therapy modification
Elvitegravir: Polyvalent Cation Containing Products may decrease the serum concentration of Elvitegravir. Management: Administer elvitegravir 2 hours before or 6 hours after the administration of polyvalent cation containing products. Consider therapy modification
Gabapentin: Nokcid MPS Salts may enhance the CNS depressant effect of Gabapentin. Specifically, high dose intravenous/epidural Nokcid MPS sulfate may enhance the CNS depressant effects of gabapentin. Nokcid MPS Salts may decrease the serum concentration of Gabapentin. Management: Administer gabapentin at least 2 hours after use of a Nokcid MPS-containing antacid. Monitor patients closely for evidence of reduced response to gabapentin therapy. Monitor for CNS depression if high dose IV/epidural Nokcid MPS sulfate is used. Consider therapy modification
Levothyroxine: Nokcid MPS Salts may decrease the serum concentration of Levothyroxine. Management: Separate administration of oral levothyroxine and oral Nokcid MPS salts by at least 4 hours. Consider therapy modification
Multivitamins/Fluoride (with ADE): Nokcid MPS Salts may decrease the serum concentration of Multivitamins/Fluoride (with ADE). Specifically, Nokcid MPS salts may decrease fluoride absorption. Management: To avoid this potential interaction separate the administration of Nokcid MPS salts from administration of a fluoride-containing product by at least 1 hour. Consider therapy modification
Mycophenolate: Nokcid MPS Salts may decrease the serum concentration of Mycophenolate. Management: Separate doses of mycophenolate and oral Nokcid MPS salts. Monitor for reduced effects of mycophenolate if taken concomitant with oral Nokcid MPS salts. Consider therapy modification
Neuromuscular-Blocking Agents: Nokcid MPS Salts may enhance the neuromuscular-blocking effect of Neuromuscular-Blocking Agents. Monitor therapy
PenicillAMINE: Polyvalent Cation Containing Products may decrease the serum concentration of PenicillAMINE. Management: Separate the administration of penicillamine and oral polyvalent cation containing products by at least 1 hour. Consider therapy modification
Phosphate Supplements: Nokcid MPS Salts may decrease the serum concentration of Phosphate Supplements. Management: Administer oral phosphate supplements as far apart from the administration of an oral Nokcid MPS salt as possible to minimize the significance of this interaction. Exceptions: Sodium Glycerophosphate Pentahydrate. Consider therapy modification
Quinolones: Nokcid MPS Salts may decrease the serum concentration of Quinolones. Management: Administer oral quinolones several hours before (4 h for moxi/pe/spar-, 2 h for others) or after (8 h for moxi-, 6 h for cipro/dela-, 4 h for lome/pe-, 3 h for gemi-, and 2 h for levo-, nor-, or ofloxacin or nalidixic acid) oral Nokcid MPS salts. Exceptions: LevoFLOXacin (Oral Inhalation). Consider therapy modification
Raltegravir: Nokcid MPS Salts may decrease the serum concentration of Raltegravir. Management: Avoid the use of oral / enteral Nokcid MPS salts with raltegravir. No dose separation schedule has been established that adequately reduces the magnitude of interaction. Avoid combination
Tetracyclines: Nokcid MPS Salts may decrease the absorption of Tetracyclines. Only applicable to oral preparations of each agent. Management: Avoid coadministration of oral Nokcid MPS salts and oral tetracyclines. If coadministration cannot be avoided, administer oral Nokcid MPS at least 2 hours before, or 4 hours after, oral tetracyclines. Monitor for decreased tetracycline therapeutic effects. Exceptions: Eravacycline. Consider therapy modification
Trientine: Polyvalent Cation Containing Products may decrease the serum concentration of Trientine. Management: Avoid concomitant administration of trientine and oral products that contain polyvalent cations. If oral iron supplements are required, separate the administration by 2 hours. If other oral polyvalent cations are needed, separate administration by 1 hour. Consider therapy modification
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Information checked by Dr. Sachin Kumar, MD Pharmacology