Pregnancy of Noretisterona [Inn-Spanish] in details
Several reports have suggested the risk of hypospadias in the general population, approximately 5 to 8 per 1000 male births, may double with progestin exposure within the first four months of pregnancy. Although there are insufficient data to quantify the risk to exposed female fetuses, progestin use within the first trimester has been associated with mild virilization of the external genitalia.
Noretisterona [Inn-Spanish] has been assigned to pregnancy category X by the FDA. Animal studies have not been reported. Postmarketing human pregnancy data have revealed a possible association between first trimester progestin use and genitourinary anomalies in male and female fetuses. Noretisterona [Inn-Spanish] use is considered contraindicated during pregnancy.
See references
Noretisterona [Inn-Spanish] breastfeeding
Progestin excretion into human milk results in steroid levels in infant plasma of 1% to 6% of the levels of maternal plasma. Long-term follow-up studies have failed to document adverse developmental effects due to exposure to progestins in breast milk.
Progestins are excreted into human milk in small amounts. The effects in the nursing infant are unknown. Progestins, such as progesterone, are considered compatible with breast-feeding by the American Academy of Pediatrics.
See references
References for pregnancy information
- "Product Information. Aygestin (Noretisterona [Inn-Spanish])." ESI Lederle Generics, Philadelphia, PA.
- "Product Information. Micronor (Noretisterona [Inn-Spanish])" Ortho McNeil Pharmaceutical, Raritan, NJ.
- "Product Information. Nor-QD (Noretisterona [Inn-Spanish])" Watson Laboratories Inc, Corona, CA.
References for breastfeeding information
- "Product Information. Micronor (Noretisterona [Inn-Spanish])" Ortho McNeil Pharmaceutical, Raritan, NJ.
- "Product Information. Aygestin (Noretisterona [Inn-Spanish])." ESI Lederle Generics, Philadelphia, PA.
- "Product Information. Nor-QD (Noretisterona [Inn-Spanish])" Watson Laboratories Inc, Corona, CA.
References
- DailyMed. "NORETHINDRONE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubMed Health. "Errin: This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
- Human Metabolome Database (HMDB). "Norethindrone: The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.". http://www.hmdb.ca/metabolites/HMDB0... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
