Obesin Dosage

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Dosage of Obesin in details

infoThe dose of a drug and dosage of the drug are two different terminologies. Dose is defined as the quantity or amount of medicine given by the doctor or taken by the patient at a given period. Dosage is the regimen prescribed by the doctor about how many days and how many times per day the drug is to be taken in specified dose by the patient. The dose is expressed in mg for tablets or gm, micro gm sometimes, ml for syrups or drops for kids syrups. The dose is not fixed for a drug for all conditions, and it changes according to the condition or a disease. It also changes on the age of the patient.
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2.1 Important Information Prior to Initiating Treatment

Prior to treating children, adolescents, and adults with CNS stimulants, including Obesin, assess for the presence of cardiac disease (i.e., perform a careful history, family history of sudden death or ventricular arrhythmia, and physical exam).

Assess the risk of abuse prior to prescribing, and monitor for signs of abuse and dependence while on therapy. Maintain careful prescription records, educate patients about abuse, monitor for signs of abuse and overdose, and periodically re-evaluate the need for Obesin use.

2.2 General Dosing Information

Obesin should be orally administered once daily in the morning with or without food. The dose should be individualized according to the needs and responses of the patient. Before administering the dose, shake the bottle of Obesin.

In children 6 years of age and older, start with 2.5 mg or 5 mg once daily in the morning. The dose may be increased in increments of 2.5 mg to 10 mg per day every 4 to 7 days up to a maximum dose of 20 mg per day.

Pharmacological treatment of ADHD may be needed for extended periods. Healthcare providers should periodically re-evaluate the long-term use of Obesin, and adjust dosage as needed.

2.3 Switching from other Obesin Products

If switching from other Obesin products, discontinue that treatment, and titrate with Obesin using the above titration schedule.

Do not substitute for other Obesin products on a milligram-per-milligram basis, because of different Obesin base compositions and differing pharmacokinetic profiles.

2.4 Dosage Modifications due to Drug Interactions

Agents that alter urinary pH can impact urinary excretion and alter blood levels of Obesin. Acidifying agents (e.g., ascorbic acid) decrease blood levels, while alkalinizing agents (e.g., sodium bicarbonate) increase blood levels. Adjust Obesin dosage accordingly.

What other drugs will affect Obesin?

Do not take Obesin if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), or phenelzine (Nardil) in the last 14 days.

Before taking Obesin, tell your doctor if you are taking any of the following medicines:

  • insulin or another medicine to treat diabetes;

  • guanethidine (Ismelin) or reserpine (Diutensin-R);

  • doxazosin (Cardura), terazosin (Hytrin), prazosin (Minipress), or guanadrel(Hylorel);

  • a tricyclic antidepressant such as amitriptyline (Elavil), amoxapine (Asendin), doxepin (Sinequan), nortriptyline (Pamelor), imipramine (Tofranil), clomipramine (Anafranil), protriptyline (Vivactil), or desipramine (Norpramin)

  • a phenothiazine such as chlorpromazine (Thorazine);

  • lithium (Lithobid, Lithonate, Eskalith, others); or

  • haloperidol (Haldol).

You may not be able to take Obesin, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with Obesin. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

Obesin interactions

infoInteractions are the effects that happen when the drug is taken along with the food or when taken with other medications. Suppose if you are taking a drug Obesin, it may have interactions with specific foods and specific medications. It will not interact with all foods and medications. The interactions vary from drug to drug. You need to be aware of interactions of the medicine you take. Most medications may interact with alcohol, tobacco, so be cautious.
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Acidifying agents - Gastrointestinal acidifying agents (guanethidine,reserpine, glutamic acid HCl,ascorbic acid, fruit juices, etc.) lower absorption of amphetamines Urinary acidifying agents -(ammonium chloride, sodium acid phosphate, etc.) Increase the concentration of the ionized species of the Obesin Primary excretion - Both Groups of agents lower blood levels and efficacy of amphetamines Adrenergic blockers - Adrenergic blockers are inhibited by amphetamines Alkalinizing agents -Gastrointestinal alkalinizing agents (sodium bicarbonate, etc.)increase absorption of amphetamines. Urinary alkalinizing agents (acetazolamide, some thiazides) increase the concentration of the non-ionized species of the Obesin molecule, thereby decreasing urinary excretion. Both groups of agents increase blood levels and therefore potentate the actions of amphetamines Antidepressants, tricyclic - Adipans may enhance the activity of tricyclic or sympathomimetic agents; d-amphetamine with desipramine or protriptyline and possibly other tricyclics cause striking and sustained increases in the concentration of d-amphetamine in the brain; cardiovascular effects can be potentiated MAO inhibitors - MAO antidepressants, as well as a metabolite of furazolidone, slow Obesin metabolism. This slowing potentiates amphetamines, increasing their effect on the release of norepinephrine and other monoamines from adrenergic nerve endings, this can cause headaches and other signs of hypertensive crisis. A variety of neurological toxic effects and malignant hyperpyrexia can occur, sometimes with fatal results Antihistamines - Adipans may counteract the sedative effect of antihistamines Antihypertensives - Adipans may antagonize the hypotensive effects of antihypertensives Chlorpromazine - Chlorpromazine blocks dopamine and norepinephrine receptors, thus inhibiting the central stimulant effects of amphetamines, and can be used to treat Obesin poisoning Ethosuximide - Adipans may delay intestinal absorption of ethosuximide Haloperidol - Haloperidol blocks dopamine receptors, thus inhibiting the central stimulant effects of amphetamines Lithium carbonate - The anorectic and stimulatory effects of amphetamines may be inhibited by lithium carbonate Meperidine - Adipans pone the analgesic effect of meperidine Methenamine therapy - Urinary excretion of amphetamines is increased, and efficacy is reduced, by acidifying agents used in methenamine therapy Norepinephrine - Adipans enhance the adrenergic effect of norepinephrine Phenobarbital - Adipans may delay intestinal absorption of phenobarbital; co-administration of phenobarbital may produce a synergistic anticonvulsant action Phenytoin - Adipans may delay intestinal absorption of phenytoin; co-administration of phenytoin may produce a synergistic anticonvulsant action Propoxyphene - In cases of propoxyphene overdose, Obesin CNS stimulation is potentiated and fatal convulsions can occur Veratrum alkaloids - Adipans inhibit the hypotensive effect of veratrum alkaloids Drug/Laboratory Test Interaction Adipans can cause a significant elevation in plasma corticosteroid levels. This increase is greatest in the evening Adipans may interfere with urinary steroid determinations.


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References

  1. DailyMed. "AMPHETAMINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. Wikipedia. "propylhexedrine: Link to the compound information in Wikipedia.". https://en.wikipedia.org/wiki/Propyl... (accessed September 17, 2018).
  3. Wikipedia. "amphetamine: Link to the compound information in Wikipedia.". https://en.wikipedia.org/wiki/Amphet... (accessed September 17, 2018).
  4. MeSH. "Dopamine Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
  5. MeSH. "MeSH Tree: MeSH (Medical Subject Headings) is the NLM controlled vocabulary thesaurus used for indexing articles for PubMed.". http://www.nlm.nih.gov/mesh/meshhome... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Obesin are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Obesin. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

5 consumers reported doses

What doses of Obesin drug you have used?
The drug can be in various doses. Most anti-diabetic, anti-hypertensive drugs, pain killers, or antibiotics are in different low and high doses and prescribed by the doctors depending on the severity and demand of the condition suffered by the patient. In our reports, ndrugs.com website users used these doses of Obesin drug in following percentages. Very few drugs come in a fixed dose or a single dose. Common conditions, like fever, have almost the same doses, e.g., [acetaminophen, 500mg] of drug used by the patient, even though it is available in various doses.
Users%
501mg-1g3
60.0%
11-50mg1
20.0%
201-500mg1
20.0%

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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