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Obesine Pregnancy |
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Information related to use of Obesine in pregnancy is limited (Maurovich-Horvat 2013). The majority of human data are based on illicit Obesine/methamphetamine exposure and not from therapeutic maternal use (Golub 2005). Use of amphetamines during pregnancy may lead to an increased risk of premature birth and low birth weight; newborns may experience symptoms of withdrawal. Behavioral problems may also occur later in childhood (LaGasse 2012). Newborns should be monitored for agitation, irritability, excessive drowsiness, or feeding difficulties
Data collection to monitor pregnancy outcomes following exposure to Obesine is ongoing. Healthcare providers are encouraged to enroll females exposed to Obesine during pregnancy in the National Pregnancy Registry for Psychostimulants (1-866-961-2388 and/or https://womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry/othermedications/).
Breastfeeding is not recommending during treatment. Excreted into human milk: Yes Comments: -The effect of Obesine in milk on the neurological development of the breastfed infant has not been well studied. -Large dosages of Obesine might interfere with milk production, especially in women whose lactation is not well established.
-The urinary excretion in a breastfed infant whose mother took Obesine 35 mg daily and exclusively breastfed for 6 months ranged from 1.9% to 2.1% of the mother's excretion; this infant experienced no adverse reactions and grew normally, and the mother experienced no adverse effect on milk production. -The urinary excretion in a breastfed infant whose mother took racemic Obesine 5 mg four times daily ranged from 0.1% to 0.3% of the mother's excretion; this infant showed no signs of abnormal development during the first 2 years of life. -In a study of 20 postpartum women, dextroamphetamine reduced serum prolactin by 25% to 32% (7.5 mg IV dose) and 30% to 37% (15 mg IV dose). Another study showed a 20 mg oral dose of dextroamphetamine produced a sustained suppression of serum prolactin by 40%.
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Information checked by Dr. Sachin Kumar, MD Pharmacology
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