Oliet Uses

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What is Oliet?

Oliet blocks some of the fat that you eat, keeping it from being absorbed by your body.

Oliet is used together with a reduced-calorie diet and weight maintenance to treat obesity in people with certain risk factors (such as diabetes, high blood pressure, and high cholesterol or triglycerides).

Oliet may also be used for purposes not listed in this medication guide.

It is dangerous to purchase Oliet on the Internet or from vendors outside of the United States. Medications distributed from Internet sales may contain dangerous ingredients, or may not be distributed by a licensed pharmacy. Samples of "alli" purchased on the Internet have been found to contain sibutramine (Meridia), a prescription weight loss medication that can have dangerous side effects in certain people. For more information, contact the U.S. Food and Drug Administration (FDA) or visit www.fda.gov/buyonlineguide.

Oliet indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Oliet is indicated for obesity management including weight loss and weight maintenance when used in conjunction with a reduced-calorie diet. Oliet is also indicated to reduce the risk for weight regain after prior weight loss. Oliet is indicated for obese patients with an initial body mass index (BMI) ≥30 kg/m2 or ≥27 kg/m2 in the presence of other risk factors (eg, hypertension, diabetes, dyslipidemia).

Table 1 illustrates body mass index (BMI) according to a variety of weights and heights. The BMI is calculated by dividing weight in kilograms by height in meters squared. For example, a person who weighs 180 lbs and is 5'5" would have a BMI of 30.

Table 1 Body Mass Index (BMI), kg/m2*
*
Conversion Factors:

Weight in lbs ÷ 2.2 = weight in kilograms (kg)

Height in inches × 0.0254 = height in meters (m)

1 foot = 12 inches

How should I use Oliet?

Use Oliet as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Oliet.

Uses of Oliet in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Use: Labeled Indications

Obesity management:

OTC: Weight loss in overweight adults when used along with a reduced-calorie and low-fat diet.

Rx: Obesity management, including weight loss and weight maintenance, when used in conjunction with a reduced-calorie diet; to reduce the risk for weight regain after prior weight loss.

Limitations of use: Oliet is indicated for obese patients with an initial body mass index of ≥30 kg/m in the presence of other risk factors (eg, hypertension, diabetes, dyslipidemia).

Oliet description

Oliet is a drug designed to treat obesity. Its primary function is preventing the absorption of fats from the human diet, thereby reducing caloric intake. Oliet works by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine. Without this enzyme, triglycerides from the diet are prevented from being hydrolyzed into absorbable free fatty acids and are excreted undigested.

Oliet dosage

Oliet Dosage

Generic name: Oliet 120mg

Dosage form: capsule

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Recommended Dosing

The recommended dose of Oliet is one 120-mg capsule three times a day with each main meal containing fat (during or up to 1 hour after the meal).

The patient should be on a nutritionally balanced, reduced-calorie diet that contains approximately 30% of calories from fat. The daily intake of fat, carbohydrate, and protein should be distributed over three main meals. If a meal is occasionally missed or contains no fat, the dose of Oliet can be omitted.

Because Oliet has been shown to reduce the absorption of some fat-soluble vitamins and beta-carotene, patients should be counseled to take a multivitamin containing fat-soluble vitamins to ensure adequate nutrition. The vitamin supplement should be taken at least 2 hours before or after the administration of Oliet, such as at bedtime.

For patients receiving both Oliet and cyclosporine therapy, administer cyclosporine 3 hours after Oliet.

For patients receiving both Oliet and levothyroxine therapy, administer levothyroxine and Oliet at least 4 hours apart. Patients treated concomitantly with Oliet and levothyroxine should be monitored for changes in thyroid function.

Doses above 120 mg three times a day have not been shown to provide additional benefit.

Based on fecal fat measurements, the effect of Oliet is seen as soon as 24 to 48 hours after dosing. Upon discontinuation of therapy, fecal fat content usually returns to pretreatment levels within 48 to 72 hours.

More about Oliet (Oliet)

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Related treatment guides

Oliet interactions

See also:
What other drugs will affect Oliet?

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Amiodarone: Oliet may decrease the serum concentration of Amiodarone. Monitor therapy

Anticonvulsants: Oliet may decrease the serum concentration of Anticonvulsants. Exceptions: Fosphenytoin; PENTobarbital; Thiopental. Monitor therapy

Antiretroviral Agents: Oliet may decrease the serum concentration of Antiretroviral Agents. Monitor therapy

CycloSPORINE (Systemic): Oliet may decrease the serum concentration of CycloSPORINE (Systemic). Management: Administer Oliet at least 3 hours before or after oral cyclosporine. Monitor for decreased serum concentrations of oral cyclosporine, even with the recommended dose separation. Consider therapy modification

Levothyroxine: Oliet may decrease the serum concentration of Levothyroxine. Management: Separate administration of oral levothyroxine and Oliet by a least 4 hours. Monitor patients closely for signs and symptoms of hypothyroidism. Consider therapy modification

Multivitamins/Fluoride (with ADE): Oliet may decrease the serum concentration of Multivitamins/Fluoride (with ADE). Specifically, Oliet may impair absorption of fat-solube vitamins. Management: Administer oral fat soluble vitamins (such as vitamins A, D, E, and/or K that are contained in many multivitamin products) at least 2 hours before or after the administration of Oliet. Consider therapy modification

Multivitamins/Minerals (with ADEK, Folate, Iron): Oliet may decrease the serum concentration of Multivitamins/Minerals (with ADEK, Folate, Iron). Specifically, Oliet may impair the absorption of fat-soluble vitamins. Management: Administer oral fat soluble vitamins (such as vitamins A, D, E, and/or K that are contained in many multivitamin products) at least 2 hours before or after the administration of Oliet. Consider therapy modification

Multivitamins/Minerals (with AE, No Iron): Oliet may decrease the serum concentration of Multivitamins/Minerals (with AE, No Iron). Specifically, Oliet may impair absorption of fat-solube vitamins. Management: Administer oral fat soluble vitamins (such as vitamins A, D, E, and/or K that are contained in many multivitamin products) at least 2 hours before or after the administration of Oliet. Consider therapy modification

Paricalcitol: Oliet may decrease the serum concentration of Paricalcitol. Management: Monitor clinical response to paricalcitol closely when used with Oliet. When this combination must be used, consider administering paricalcitol at least 1 hour before or 4 to 6 hours after the administration of Oliet Consider therapy modification

Propafenone: Oliet may decrease the serum concentration of Propafenone. Monitor therapy

Sincalide: Drugs that Affect Gallbladder Function may diminish the therapeutic effect of Sincalide. Management: Consider discontinuing drugs that may affect gallbladder motility prior to the use of sincalide to stimulate gallbladder contraction. Consider therapy modification

Vitamin D Analogs: Oliet may decrease the serum concentration of Vitamin D Analogs. More specifically, Oliet may impair absorption of Vitamin D Analogs. Management: Monitor clinical response (including serum calcium) to oral vitamin D analogs closely if used with Oliet. If this combination must be used, consider giving the vitamin D analog at least 2 hrs before or after Oliet. Exceptions: Calcipotriene; Calcitriol (Topical); Tacalcitol. Consider therapy modification

Vitamin K Antagonists (eg, warfarin): Oliet may enhance the anticoagulant effect of Vitamin K Antagonists. Monitor therapy

Vitamins (Fat Soluble): Oliet may decrease the serum concentration of Vitamins (Fat Soluble). Management: Administer oral fat soluble vitamins at least 2 hours before or after the administration of Oliet. Similar precautions do not apply to parenterally administered fat soluble vitamins. Exceptions: Calcipotriene. Consider therapy modification

Oliet side effects

See also:
What are the possible side effects of Oliet?

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Clinical Trials

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in patients.

Commonly Observed (based on first year and second year data)

Gastrointestinal (GI) symptoms were the most commonly observed treatment-emergent adverse events associated with the use of Oliet in the seven double-blind, placebo-controlled clinical trials and are primarily a manifestation of the mechanism of action. (Commonly observed is defined as an incidence of ≥ 5% and an incidence in the Oliet 120 mg group that is at least twice that of placebo.)

Table 2 : Commonly Observed Adverse Events

Adverse Event Year 1 Year 2
Oliet* % Patients

(N=1913)

Placebo* % Patients

(N=1466)

Oliet* % Patients

(N=613)

Placebo* % Patients

(N=524)

Oily Spotting† 26.6 1.3 4.4 0.2
Flatus with Discharge 23.9 1.4 2.1 0.2
Fecal Urgency 22.1 6.7 2.8 1.7
Fatty/Oily Stool† 20.0 2.9 5.5 0.6
Oily Evacuation† 11.9 0.8 2.3 0.2
Increased Defecation 10.8 4.1 2.6 0.8
Fecal Incontinence 7.7 0.9 1.8 0.2
*Treatment designates Oliet three times a day plus diet or placebo plus diet

†Oily discharge may be clear or have a coloration such as orange or brown.

In general, the first occurrence of these events was within 3 months of starting therapy. Overall, approximately 50% of all episodes of GI adverse events associated with Oliet treatment lasted for less than 1 week, and a majority lasted for no more than 4 weeks. However, GI adverse events may occur in some individuals over a period of 6 months or longer.

Discontinuation Of Treatment

In controlled clinical trials, 8.8% of patients treated with Oliet discontinued treatment due to adverse events, compared with 5.0% of placebo-treated patients. For Oliet, the most common adverse events resulting in discontinuation of treatment were gastrointestinal.

Other Adverse Clinical Events

The following table lists other treatment-emergent adverse events from seven multicenter, double-blind, placebo-controlled clinical trials that occurred at a frequency of ≥ 2% among patients treated with Oliet 120 mg three times a day and with an incidence that was greater than placebo during year 1 and year 2, regardless of relationship to study medication.

Table 3 : Other Treatment-Emergent Adverse Events From Seven Placebo-Controlled Clinical Trials

Body System/

Adverse Event

Year 1 Year 2
Oliet* % Patients

(N=1913)

Placebo* % Patients

(N=1466)

Oliet* % Patients

(N=613)

Placebo* % Patients

(N=524)

Gastrointestinal System
Abdominal Pain/Discomfort 25.5 21.4 - -
Nausea 8.1 7.3 3.6 2.7
Infectious Diarrhea 5.3 4.4 -
Rectal Pain/Discomfort 5.2 4.0 3.3 1.9
Tooth Disorder 4.3 3.1 2.9 2.3
Gingival Disorder 4.1 2.9 2.0 1.5
Vomiting 3.8 3.5
Respiratory System
Influenza 39.7 36.2 -
Upper Respiratory Infection 38.1 32.8 26.1 25.8
Lower Respiratory Infection 7.8 6.6
Ear, Nose & Throat Symptoms 2.0 1.6
Musculoskeletal System
Back Pain 13.9 12.1
Pain Lower Extremities - - 10.8 10.3
Arthritis 5.4 4.8
Myalgia 4.2 3.3
Joint Disorder 2.3 2.2
Tendonitis 2.0 1.9
Central Nervous System
Headache 30.6 27.6
Dizziness 5.2 5.0
Body as a Whole
Fatigue 7.2 6.4 3.1 1.7
Sleep Disorder 3.9 3.3
Skin & Appendages
Rash 4.3 4.0
Dry Skin 2.1 1.4
Reproductive, Female
Menstrual Irregularity 9.8 7.5
Vaginitis 3.8 3.6 2.6 1.9
Urinary System
Urinary T ract Infection 7.5 7.3 5.9 4.8
Psychiatric Disorder
Psychiatric Anxiety 4.7 2.9 2.8 2.1
Depression 3.4 2.5
Hearing & Vestibular Disorders
Otitis 4.3 3.4 2.9 2.5
Cardiovascular Disorders
Pedal Edema 2.8 1.9
- None reported at a frequency ≥ 2% and greater than placebo

* Treatment designates Oliet 120 mg three times a day plus diet or placebo plus diet

Table 4 illustrates the percentage of adult patients on Oliet and placebo who developed a low vitamin level on two or more consecutive visits during 1 and 2 years of therapy in studies in which patients were not previously receiving vitamin supplementation.

Table 4 : Incidence of Low Vitamin Values on Two or More Consecutive Visits (Nonsupplemented Adult Patients With Normal Baseline Values - Firs t and Second Year)

Placebo* Oliet*
Vitamin A 1.0% 2.2%
Vitamin D 6.6% 12.0%
Vitamin E 1.0% 5.8%
Beta-carotene 1.7% 6.1%
* Treatment designates placebo plus diet or Oliet plus diet

Table 5 illustrates the percentage of adolescent patients on Oliet and placebo who developed a low vitamin level on two or more consecutive visits during the 1-year study.

Table 5 : Incidence of Low Vitamin Values on Two or More Consecutive Vis its (Pediatric Patients With Normal Baseline Values*)

Placebo† Oliet†
Vitamin A 0.0% 0.0%
Vitamin D 0.7% 1.4%
Vitamin E 0.0% 0.0%
Beta-carotene 0.8% 1.5%
*All patients were treated with vitamin supplementation throughout the course of the study

†Treatment designates placebo plus diet or Oliet plus diet

In the 4-year XENDOS study, the general pattern of adverse events was similar to that reported for the 1- and 2-year studies with the total incidence of gastrointestinal-related adverse events occurring in year 1 decreasing each year over the 4-year period.

In clinical trials in obese diabetic patients, hypoglycemia and abdominal distension were also observed.

Pediatric Patients

In clinical trials with Oliet in adolescent patients ages 12 to 16 years, the profile of adverse reactions was generally similar to that observed in adults.

Postmarketing Experience

The following adverse reactions have been identified during postapproval use of Oliet. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to Oliet exposure.

Oliet contraindications

See also:
What is the most important information I should know about Oliet?

Do not take Oliet if you are pregnant. Weight loss is not recommended during pregnancy, even if you are overweight or obese.

You should not take this medication if you are allergic to Oliet, if you are pregnant, or if you have gallbladder problems or chronic malabsorption syndrome (an inability to absorb food and nutrients properly).

Before taking Oliet, tell your doctor if you have an underactive thyroid, a history of gallstones or pancreatitis, type 1 or type 2 diabetes, an eating disorder, liver or kidney disease, or if you take other weight-loss medications (prescription or over-the-counter).

Do not give over-the-counter Oliet (alli) to a child younger than 18 years old. Prescription Oliet should not be used by anyone age 12 to 18 without the advice of a doctor.

Oliet should be used only by the person for whom it was prescribed. Never share Oliet with another person, especially someone who has a history of eating disorder. Keep the medication in a place where others cannot get to it.

Oliet is only part of a complete program of treatment that also includes diet, exercise, and weight control. Your daily intake of fat, protein, and carbohydrates should be evenly divided over all of your daily meals. Follow your diet, medication, and exercise routines very closely.

Avoid a diet that is high in fat. High-fat meals taken in combination with Oliet can increase your risk of unpleasant side effects on your stomach or intestines.



Active ingredient matches for Oliet:

Orlistat in South Korea.


List of Oliet substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
Olisat 60mg CAP / 10 (Biocon Limited)$ 3.97
Olisat 120mg CAP / 10 (Biocon Limited)$ 6.03
60 mg x 10's (Biocon Limited)$ 3.97
120 mg x 10's (Biocon Limited)$ 6.03
Olisat 120 mg Capsule (Biocon Limited)$ 0.60
Olisat 60 mg Capsule (Biocon Limited)$ 0.40
OLISAT 120 MG CAPSULE 1 strip / 10 capsules each (Biocon Limited)$ 6.03
OLISAT 60 MG CAPSULE 1 strip / 10 capsules each (Biocon Limited)$ 3.97
OLISAT cap 60 mg x 10's (Biocon Limited)$ 3.97
OLISAT cap 120 mg x 10's (Biocon Limited)$ 6.03
Olisat 120mg Capsule (Biocon Limited)$ 0.60
Olisat 60mg Capsule (Biocon Limited)$ 0.40
ORLAK cap 120 mg x 10's (Corazon)$ 6.19
120 mg x 10's (Emcure)$ 6.03
Orle 120mg CAP / 10 (Emcure)$ 6.03
Orle 60mg CAP / 10 (Emcure)$ 3.10
ORLE 120 MG CAPSULE 1 strip / 10 capsules each (Emcure)$ 7.30
ORLE 60 MG TABLET 1 strip / 10 tablets each (Emcure)$ 3.74
ORLE cap 60 mg x 10's (Emcure)$ 3.10
ORLE cap 120 mg x 10's (Emcure)$ 6.03
Orle 120mg CAP / 10 (Emcure)$ 6.03
Orle 60mg CAP / 10 (Emcure)$ 3.10
Orlean 120mg CAP / 10 (Eris (Enzo Biopharma))$ 6.27
Orlean 60 mg Capsule (Eris (Enzo Biopharma))$ 0.35
Orlean 120 mg Capsule (Eris (Enzo Biopharma))$ 0.63
ORLEAN 120 MG CAPSULE 1 strip / 10 capsules each (Eris (Enzo Biopharma))$ 6.58
ORLEAN 60 MG CAPSULE 1 strip / 10 capsules each (Eris (Enzo Biopharma))$ 3.49
ORLEAN cap 120 mg x 10's (Eris (Enzo Biopharma))$ 6.27
Orlean 120mg Capsule (Eris (Enzo Biopharma))$ 0.72
Orlean 60mg Capsule (Eris (Enzo Biopharma))$ 0.38
Orlica 120mg CAP / 10 (Azuca (Torrent Pharmaceuticals Ltd.))$ 3.03
120 mg x 10's (Azuca (Torrent Pharmaceuticals Ltd.))$ 6.03
Orlica 60 mg Capsule (Azuca (Torrent Pharmaceuticals Ltd.))$ 0.30
Orlica 120 mg Capsule (Azuca (Torrent Pharmaceuticals Ltd.))$ 0.63
ORLICA 120 MG CAPSULE 1 strip / 10 capsules each (Azuca (Torrent Pharmaceuticals Ltd.))$ 7.32
ORLICA 60 MG CAPSULE 1 strip / 10 capsules each (Azuca (Torrent Pharmaceuticals Ltd.))$ 4.17
ORLICA cap 60 mg x 10's (Azuca (Torrent Pharmaceuticals Ltd.))$ 3.03

References

  1. DailyMed. "ORLISTAT: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "orlistat". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "orlistat". http://www.drugbank.ca/drugs/DB01083 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Oliet are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Oliet. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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