Oradine Plus Uses

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What is Oradine Plus?

Oradine Plus is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Oradine Plus is used to treat sneezing, runny nose, watery eyes, hives, skin rash, itching, and other cold or allergy symptoms.

Oradine Plus is also used to treat skin hives and itching in people with chronic skin reactions.

Oradine Plus may also be used for purposes not listed in this medication guide.

Oradine Plus indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Treatment of seasonal allergic rhinitis, perennial rhinitis, urticaria, allergic dermatologic disorders, angioedema and conjunctivitis. Oradine Plus is generally considered to be ineffective in asthma.

Acute anaphylaxis should be treated with adrenaline; Oradine Plus and corticosteroids are given to prevent relapse.

Oradine Plus is also used to control the pruritus associated with skin disorders eg, atopic eczema.

How should I use Oradine Plus?

Use Oradine Plus orally disintegrating tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Oradine Plus orally disintegrating tablets.

Uses of Oradine Plus in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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This medication is an antihistamine that treats symptoms such as itching, runny nose, watery eyes, and sneezing from "hay fever" and other allergies. It is also used to relieve itching from hives.

Oradine Plus does not prevent hives or prevent/treat a serious allergic reaction (e.g., anaphylaxis). Therefore, if your doctor has prescribed epinephrine to treat allergic reactions, always carry your epinephrine injector with you. Do not use Oradine Plus in place of your epinephrine.

If you are self-treating with this medication, it is important to read the manufacturer's package instructions carefully so you know when to consult your doctor or pharmacist.

Do not use this medication in children younger than 6 years unless directed by the doctor.

How to use Oradine Plus

If you are using the over-the-counter product to self-treat, read all the directions on the product package before taking this medication. If your doctor has prescribed this medication, follow your doctor's directions and the instructions on your prescription label. If you have any questions, consult your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor or the product package, usually once or twice a day. Remove the tablet from its foil pack immediately before taking and place the tablet on the tongue. It will dissolve quickly. You may swallow the dissolved medication with or without water. Dosage is based on your age, condition, and response to treatment. Do not increase your dose or take this drug more often than directed. Do not take more of this medication than recommended for your age.

Tell your doctor if your allergy symptoms do not improve after 3 days of treatment or if your hives last more than 6 weeks. Seek immediate medical attention if your condition worsens or you think you have a serious medical problem (e.g., very serious allergic reaction/anaphylaxis).

Oradine Plus description

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Oradine Plus competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. In addition to the usual allergic symptoms, the drug also treats irritant cough and nausea, vomiting, and vertigo associated with motion sickness. Oradine Plus's anticholinergic action appears to be due to a central antimuscarinic effect, which also may be responsible for its antiemetic effects, although the exact mechanism is unknown. It also is used commonly to treat drug-induced extrapyramidal symptoms as well as to treat mild cases of Parkinson's disease.

Oradine Plus dosage

Oradine Plus Dosage

Applies to the following strength(s): 10 mg; 5 mg/5 mL; 5 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Allergic Rhinitis

10 mg orally once a day

Usual Adult Dose for Urticaria

10 mg orally once a day

Usual Pediatric Dose for Allergic Rhinitis

2 to 5 years: 5 mg orally once a day (syrup)

6 years or older: 10 mg orally once a day (tablets, capsule, and disintegrating tablets)

Usual Pediatric Dose for Urticaria

2 to 5 years: 5 mg orally once a day (syrup)

6 years or older: 10 mg orally once a day (tablets, capsule, and disintegrating tablets)

Renal Dose Adjustments

CrCl less than 30 mL/min: administer dosage every other day initially

Liver Dose Adjustments

Liver failure: administer dosage every other day initially

Dialysis

Oradine Plus is not significantly removed by hemodialysis, thus supplementary dosing is not required following hemodialysis.

More about Oradine Plus

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Oradine Plus interactions

See also:
What other drugs will affect Oradine Plus?

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Oradine Plus (10 mg once daily) has been coadministered with therapeutic doses of erythromycin, cimetidine, and ketoconazole in controlled clinical pharmacology studies in adult volunteers. Although increased plasma concentrations (AUC 0-24 hrs) of Oradine Plus and/or descarboethoxyloratadine were observed following coadministration of Oradine Plus with each of these drugs in normal volunteers (n = 24 in each study), there were no clinically relevant changes in the safety profile of Oradine Plus, as assessed by electrocardiographic parameters, clinical laboratory tests, vital signs, and adverse events. There were no significant effects on QTc intervals, and no reports of sedation or syncope. No effects on plasma concentrations of cimetidine or ketoconazole were observed. Plasma concentrations (AUC 0-24 hrs) of erythromycin decreased 15% with coadministration of Oradine Plus relative to that observed with erythromycin alone. The clinical relevance of this difference is unknown. These above findings are summarized in TABLE 1.

TABLE 1 Effects on Plasma Concentrations (AUC 0-24 hrs) of Oradine Plus and Descarboethoxyloratadine After 10 Days of Coadministration (Oradine Plus 10 mg) in Normal Volunteers
Oradine Plus Descarboethoxyloratadine
Erythromycin (500 mg q8h) + 40% +46%
Cimetidine (300 mg qid) +103% + 6%
Ketoconazole (200 mg q12h) +307% +73%

Oradine Plus side effects

See also:
What are the possible side effects of Oradine Plus?

Applies to Oradine Plus: oral fixed-combination tablets, oral orally disintegrating tablets, oral solution, oral tablets

Side effects include:

Children 2–5 years of age receiving oral solution: Diarrhea, epistaxis, pharyngitis, flu-like symptoms, fatigue, stomatitis, tooth disorder, earache, viral infection, rash.

Children 6–12 years of age receiving oral solution: Nervousness, wheezing, fatigue, hyperkinesia, abdominal pain, conjunctivitis, dysphonia, upper respiratory tract infection.

Adults and children ≥12 years of age receiving conventional or orally disintegrating tablets: Headache, somnolence, fatigue, dry mouth.

Fixed combination Oradine Plus (the active ingredient contained in Oradine Plus Reditab) pseudoephedrine sulfate preparations: Insomnia, dry mouth, headache, somnolence, nervousness, dizziness, fatigue.

Oradine Plus contraindications

See also:
What is the most important information I should know about Oradine Plus?

Do NOT use Oradine Plus if:

you are allergic to any ingredient in Oradine Plus

Contact your doctor or health care provider right away if any of these apply to you.



Active ingredient matches for Oradine Plus:

Loratadine in Bangladesh.


List of Oradine Plus substitutes (brand and generic names)

Sort by popularity
Unit description / dosage (Manufacturer)Price, USD
Oziatidin 10 mg x 10 Blister x 10 Tablet
Pharmaniaga Loratadine 10 mg x 10 x 10's (Pharmaniaga Manufacturing Berhad)
Pharmaniaga Loratadine 10 mg x 10 x 10's (Pharmaniaga Manufacturing Berhad)
Pharmaniaga Loratadine 1 mg/1 mL x 1 L (Pharmaniaga Manufacturing Berhad)
Pharmaniaga Loratadine 10 mg x 10 Blister x 10 Tablet (Pharmaniaga Manufacturing Berhad)
Pharmaniaga Loratadine 1 mg/1 mL x 1 Bottle 100 mL (Pharmaniaga Manufacturing Berhad)
Pharmaniaga Loratadine syr 1 mg/mL 1 L x 1's (Pharmaniaga Manufacturing Berhad)
Pharmaniaga Loratadine tab 10 mg 10 x 10's (Pharmaniaga Manufacturing Berhad)
Philmidin 10 mg x 1 Blister x 10 Tablet
pms-Loratadin 10 mg x 2 Blister x 10 Tablet
Tablet; Oral; Fenfluramine Hydrochloride 20 mg
Prevahist 10 mg x 10's
Pylor 10 mg x 50's (Pyridam)$ 21.08
Pylor 5 mg/5 mL x 60 mL (Pyridam)$ 1.80
Rahistin 10 mg x 10 x 10's (Kimia)$ 27.01
Ratalin tab 10 mg 50's (Medic+Aid)$ 0.37
10 mg x 100's (Sanify (Star Biomed))$ 6.33
Ratlo-10 10mg TAB / 100 (Sanify (Star Biomed))$ 6.33

References

  1. DailyMed. "LORATADINE; PSEUDOEPHEDRINE SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "loratadine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "loratadine". http://www.drugbank.ca/drugs/DB00455 (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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