Ornicétil Actions

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Actions of Ornicétil in details

The action of the drug on the human body is called Pharmacodynamics in Medical terminology. To produce its effect and to change the pathological process that is happening the body and to reduce the symptom or cure the disease, the medicine has to function in a specific way. The changes it does to the body at cellular level gives the desired result of treating a disease. Drugs act by stimulating or inhibiting a receptor or an enzyme or a protein most of the times. Medications are produced in such a way that the ingredients target the specific site and bring about chemical changes in the body that can stop or reverse the chemical reaction which is causing the disease.
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Pharmacology: Pharmacodynamics: Mechanism of Action: In vivo, L-Ornicétil L-aspartate acts on 2-key ammoniac detoxification pathways: Urea synthesis and glutamine synthesis, via the amino acids Ornicétil and aspartate.

Urea synthesis takes place in the periportal hepatocytes, in which Ornicétil serves both as an activator of the 2 enzymes Ornicétil carbamoyl transferase and carbamoyl phosphate synthetase and as a substrate for urea synthesis.

Glutamine synthesis is localized in the perivenous hepatocytes. Under pathological conditions in particular, aspartate and other dicarboxylates, including metabolic products of Ornicétil, are taken up into the cells where they are used in form of glutamine to bind ammonia.

Both physiologically and pathophysiologically, glutamine serves as an ammonia-binding amino acid, which not only provide a nontoxic form for excretion of ammonia but also activates the important urea cycles (intercellular glutamine exchange).

Under physiological conditions, Ornicétil and aspartate are not limiting for urea synthesis.

Experimental studies in animals point to increased glutamine synthesis as a mechanism of the ammonia-lowering effect. Some clinical studies have shown an improvement in the ratio of branched chain to aromatic amino acids.

Pharmacokinetics: Ornicétil and aspartate have a short elimination half-life (t½) of 0.3-0.4 hrs. Some of the aspartate is excreted unchanged in the urine.


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References

  1. NCIt. "Ornithine: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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