Ornidazole Uses

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Ornidazole indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Oral

Amoebiasis

Adult: 0.5 g bid for 5-10 days.

Child: 25 mg/kg as a single daily dose for 5-10 days.

Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.

Hepatic impairment: Severe: Double the interval between doses.

Oral

Amoebic dysentery

Adult: 1.5 g as a single daily dose for 3 days. Alternatively for patients >60 kg: 1 g bid for 3 days.

Child: 40 mg/kg daily.

Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.

Hepatic impairment: Severe: Double the interval between doses.

Oral

Giardiasis

Adult: 1-1.5 g as a single daily dose for 1-2 days.

Child: 30-40 mg/kg daily.

Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.

Hepatic impairment: Severe: Double the interval between doses.

Oral

Trichomoniasis

Adult: 1.5 g as a single daily dose or 0.5 g bid for 5 days. Treat sexual partners concomitantly.

Child: 25 mg/kg as a single dose.

Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.

Hepatic impairment: Severe: Double the interval between doses.

Intravenous

Severe amoebic dysentery; Amoebic liver abscess

Adult: Initially, 0.5-1 g infusion followed by 0.5 g every 12 hrs for 3-6 days.

Child: 20-30 mg/kg body wt daily.

Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.

Hepatic impairment: Severe: Double the interval between doses.

Reconstitution: Dilute to a concentration of ≤5 mg/ml.

Intravenous

Anaerobic bacterial infections

Adult: Initially, 0.5-1 g followed by 1 g daily as a single dose or in 2 divided doses for 5-10 days. Doses to be given via infusion. Substitute with 500 mg every 12 hr orally as soon as possible.

Child: 10 mg/kg every 12 hr for 5-10 days.

Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.

Hepatic impairment: Severe: Double the interval between doses.

Reconstitution: Dilute to a concentration of ≤5 mg/ml.

Intravenous

Prophylaxis of postoperative anaerobic bacterial infections

Adult: 1 g by IV about 30 minutes before surgery.

Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.

Hepatic impairment: Severe: Double the interval between doses.

Reconstitution: Dilute to a concentration of ≤5 mg/ml.

Uses of Ornidazole in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Ornidazole is used in the treatment of infections of vagina, urinary tract, intestine and other parts of the body caused by anaerobic bacteria (bacteria that do not use oxygen) or protozoa (amoeba or single-celled parasites). It is also used to prevent these infections during surgical procedures.

Ornidazole description

Ornidazole blocks the release of noradrenaline from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibrillation. The primary mode of action for bretylium is thought to be inhibition of voltage-gated K(+) channels. Recent evidence has shown that bretylium may also inhibit the Na,K-ATPase by binding to the extracellular K-site.

Ornidazole dosage

Oral

Amoebiasis

Adult: 0.5 g bid for 5-10 days.

Child: 25 mg/kg as a single daily dose for 5-10 days.

Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.

Hepatic impairment: Severe: Double the interval between doses.

Oral

Amoebic dysentery

Adult: 1.5 g as a single daily dose for 3 days. Alternatively for patients >60 kg: 1 g bid for 3 days.

Child: 40 mg/kg daily.

Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.

Hepatic impairment: Severe: Double the interval between doses.

Oral

Giardiasis

Adult: 1-1.5 g as a single daily dose for 1-2 days.

Child: 30-40 mg/kg daily.

Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.

Hepatic impairment: Severe: Double the interval between doses.

Oral

Trichomoniasis

Adult: 1.5 g as a single daily dose or 0.5 g bid for 5 days. Treat sexual partners concomitantly.

Child: 25 mg/kg as a single dose.

Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.

Hepatic impairment: Severe: Double the interval between doses.

Intravenous

Severe amoebic dysentery; Amoebic liver abscess

Adult: Initially, 0.5-1 g infusion followed by 0.5 g every 12 hrs for 3-6 days.

Child: 20-30 mg/kg body wt daily.

Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.

Hepatic impairment: Severe: Double the interval between doses.

Reconstitution: Dilute to a concentration of ≤5 mg/ml.

Intravenous

Anaerobic bacterial infections

Adult: Initially, 0.5-1 g followed by 1 g daily as a single dose or in 2 divided doses for 5-10 days. Doses to be given via infusion. Substitute with 500 mg every 12 hr orally as soon as possible.

Child: 10 mg/kg every 12 hr for 5-10 days.

Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.

Hepatic impairment: Severe: Double the interval between doses.

Reconstitution: Dilute to a concentration of ≤5 mg/ml.

Intravenous

Prophylaxis of postoperative anaerobic bacterial infections

Adult: 1 g by IV about 30 minutes before surgery.

Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.

Hepatic impairment: Severe: Double the interval between doses.

Reconstitution: Dilute to a concentration of ≤5 mg/ml.

Ornidazole interactions

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Digitalis toxicity may be aggravated by the initial release of norepinephrine caused by Ornidazole Tosylate Injection.

The pressor effects of catecholamines such as dopamine or norepinephrine are enhanced by Ornidazole Tosylate. When catecholamines are administered, dilute solutions should be used and blood pressure should be monitored closely.

Although there is little published information on concomitant administration of lidocaine and Ornidazole Tosylate, these drugs are often administered concurrently without any evidence of interactions resulting in adverse effects or diminished efficacy.

Ornidazole side effects

Somnolence, headache, nausea, vomiting, dizziness, tremor, rigidity, poor coordination, seizures, tiredness, vertigo, temporary loss of consciousness and signs of sensory or mixed peripheral neuropathy, taste disturbances, abnormal LFTs, skin reactions.

Ornidazole contraindications

Hypersensitivity to Ornidazole or to other nitroimidazole derivatives.

Active ingredient matches for Ornidazole:

Ornidazole


Unit description / dosage (Manufacturer)Price, USD
Injectable; Injection; Ornidazole 5 mg / ml
Injectable; Injection; Ornidazole 200 mg / ml

List of Ornidazole substitutes (brand and generic names):

ORNIDAZOLE 500MG TABLET 1 strip / 10 tablets each (Jan Aushadhi)$ 0.25
ORNIDEN INFUSION 1 bottle / 100 ML infusion each (Denis Chem Lab Ltd)$ 0.61
ORNIGYL IV 500MG INFUSION 1 bottle / 100 ML infusion each (JB Chemicals)$ 0.56
Ornikem 500 mg Tablet (Swisskem Healthcare)$ 0.07
Ornilet 500mg TAB / 10x10 (Avyukt)$ 7.60
ORNILET tab 500 mg x 10's (Avyukt)$ 0.76
500 mg x 10's (Obsurge Biotech Limited)$ 0.82
Ornimax 500 mg Tablet (Obsurge Biotech Limited)$ 0.08
Ornimax 500mg FC-TAB / 10 (Obsurge Biotech Limited)$ 0.82
ORNIMAX 500MG TABLET 1 strip / 10 tablets each (Obsurge Biotech Limited)$ 0.89
ORNIMAX film-coated tab 500 mg x 10's (Obsurge Biotech Limited)$ 0.82
Ornimax 500mg FC-TAB / 10 (Obsurge Biotech Limited)$ 0.82
Ornimax 500mg Tablet (Obsurge Biotech Limited)$ 0.09
Tablet, Film-Coated; Oral; Ornidazole 500 mg
Tablet; Vaginal; Ornidazole 500 mg
ORNIPIDI INFUSION 1 bottle / 100 ML infusion each (Parenteral Drugs India Ltd)$ 0.49
Tablet, Film-Coated; Oral; Ornidazole 250 mg (Abdi)
Tablet, Film-Coated; Oral; Ornidazole 500 mg (Abdi)
Tablet; Vaginal; Ornidazole 500 mg (Abdi)
ORNISTOP SUSPENSION 1 bottle / 50 ML suspension each (Delvin Formulations Pvt Ltd)$ 1.19
500 mg x 100's (East African (I) Remedies Pvt Ltd)$ 7.94
Ornivir 500 mg Tablet (East African (I) Remedies Pvt Ltd)$ 0.08
Ornivir 500mg TAB / 100 (East African (I) Remedies Pvt Ltd)$ 7.94
ORNIVIR tab 500 mg x 10's (East African (I) Remedies Pvt Ltd)$ 0.79
Ornivir 500mg TAB / 100 (East African (I) Remedies Pvt Ltd)$ 7.94
Orniz 500 mg Tablet (Udik Pharmaceuticals Pvt. Ltd.)$ 0.07

References

  1. PubChem. "Ornidazole". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  2. DrugBank. "Ornidazole". http://www.drugbank.ca/drugs/DB13026 (accessed September 17, 2018).
  3. DTP/NCI. "Ornidazole: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Ornidazole are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Ornidazole. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported useful

No survey data has been collected yet


Consumer reported price estimates

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1 consumer reported time for results

To what extent do I have to use Ornidazole before I begin to see changes in my health conditions?
As part of the reports released by ndrugs.com website users, it takes 1 day and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Ornidazole. To get the time effectiveness of using Ornidazole drug by other patients, please click here.
Users%
1 day1
100.0%


1 consumer reported age

Users%
1-51
100.0%


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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