|
||
Ornilet Uses |
||
Amoebiasis
Adult: 0.5 g bid for 5-10 days.
Child: 25 mg/kg as a single daily dose for 5-10 days.
Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.
Hepatic impairment: Severe: Double the interval between doses.
Amoebic dysentery
Adult: 1.5 g as a single daily dose for 3 days. Alternatively for patients >60 kg: 1 g bid for 3 days.
Child: 40 mg/kg daily.
Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.
Hepatic impairment: Severe: Double the interval between doses.
Giardiasis
Adult: 1-1.5 g as a single daily dose for 1-2 days.
Child: 30-40 mg/kg daily.
Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.
Hepatic impairment: Severe: Double the interval between doses.
Trichomoniasis
Adult: 1.5 g as a single daily dose or 0.5 g bid for 5 days. Treat sexual partners concomitantly.
Child: 25 mg/kg as a single dose.
Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.
Hepatic impairment: Severe: Double the interval between doses.
Severe amoebic dysentery; Amoebic liver abscess
Adult: Initially, 0.5-1 g infusion followed by 0.5 g every 12 hrs for 3-6 days.
Child: 20-30 mg/kg body wt daily.
Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.
Hepatic impairment: Severe: Double the interval between doses.
Reconstitution: Dilute to a concentration of ≤5 mg/ml.
Anaerobic bacterial infections
Adult: Initially, 0.5-1 g followed by 1 g daily as a single dose or in 2 divided doses for 5-10 days. Doses to be given via infusion. Substitute with 500 mg every 12 hr orally as soon as possible.
Child: 10 mg/kg every 12 hr for 5-10 days.
Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.
Hepatic impairment: Severe: Double the interval between doses.
Reconstitution: Dilute to a concentration of ≤5 mg/ml.
Prophylaxis of postoperative anaerobic bacterial infections
Adult: 1 g by IV about 30 minutes before surgery.
Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.
Hepatic impairment: Severe: Double the interval between doses.
Reconstitution: Dilute to a concentration of ≤5 mg/ml.
Ornilet is used in the treatment of infections of vagina, urinary tract, intestine and other parts of the body caused by anaerobic bacteria (bacteria that do not use oxygen) or protozoa (amoeba or single-celled parasites). It is also used to prevent these infections during surgical procedures.
Ornilet blocks the release of noradrenaline from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibrillation. The primary mode of action for bretylium is thought to be inhibition of voltage-gated K(+) channels. Recent evidence has shown that bretylium may also inhibit the Na,K-ATPase by binding to the extracellular K-site.
Amoebiasis
Adult: 0.5 g bid for 5-10 days.
Child: 25 mg/kg as a single daily dose for 5-10 days.
Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.
Hepatic impairment: Severe: Double the interval between doses.
Amoebic dysentery
Adult: 1.5 g as a single daily dose for 3 days. Alternatively for patients >60 kg: 1 g bid for 3 days.
Child: 40 mg/kg daily.
Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.
Hepatic impairment: Severe: Double the interval between doses.
Giardiasis
Adult: 1-1.5 g as a single daily dose for 1-2 days.
Child: 30-40 mg/kg daily.
Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.
Hepatic impairment: Severe: Double the interval between doses.
Trichomoniasis
Adult: 1.5 g as a single daily dose or 0.5 g bid for 5 days. Treat sexual partners concomitantly.
Child: 25 mg/kg as a single dose.
Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.
Hepatic impairment: Severe: Double the interval between doses.
Severe amoebic dysentery; Amoebic liver abscess
Adult: Initially, 0.5-1 g infusion followed by 0.5 g every 12 hrs for 3-6 days.
Child: 20-30 mg/kg body wt daily.
Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.
Hepatic impairment: Severe: Double the interval between doses.
Reconstitution: Dilute to a concentration of ≤5 mg/ml.
Anaerobic bacterial infections
Adult: Initially, 0.5-1 g followed by 1 g daily as a single dose or in 2 divided doses for 5-10 days. Doses to be given via infusion. Substitute with 500 mg every 12 hr orally as soon as possible.
Child: 10 mg/kg every 12 hr for 5-10 days.
Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.
Hepatic impairment: Severe: Double the interval between doses.
Reconstitution: Dilute to a concentration of ≤5 mg/ml.
Prophylaxis of postoperative anaerobic bacterial infections
Adult: 1 g by IV about 30 minutes before surgery.
Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.
Hepatic impairment: Severe: Double the interval between doses.
Reconstitution: Dilute to a concentration of ≤5 mg/ml.
Digitalis toxicity may be aggravated by the initial release of norepinephrine caused by Ornilet Tosylate Injection.
The pressor effects of catecholamines such as dopamine or norepinephrine are enhanced by Ornilet Tosylate. When catecholamines are administered, dilute solutions should be used and blood pressure should be monitored closely.
Although there is little published information on concomitant administration of lidocaine and Ornilet Tosylate, these drugs are often administered concurrently without any evidence of interactions resulting in adverse effects or diminished efficacy.
Somnolence, headache, nausea, vomiting, dizziness, tremor, rigidity, poor coordination, seizures, tiredness, vertigo, temporary loss of consciousness and signs of sensory or mixed peripheral neuropathy, taste disturbances, abnormal LFTs, skin reactions.
Hypersensitivity to Ornilet or to other nitroimidazole derivatives.
Ornidazole in India.
Unit description / dosage (Manufacturer) | Price, USD |
Ornilet 500mg TAB / 10x10 | $ 7.60 |
ORNILET tab 500 mg x 10's (Avyukt) | $ 0.76 |
List of Ornilet substitutes (brand and generic names): | |
Ornil (Bangladesh, Georgia) | |
ORNIMAX (India) | |
500 mg x 10's (Obsurge Biotech Limited) | $ 0.82 |
Ornimax 500 mg Tablet (Obsurge Biotech Limited) | $ 0.08 |
Ornimax 500mg FC-TAB / 10 (Obsurge Biotech Limited) | $ 0.82 |
ORNIMAX 500MG TABLET 1 strip / 10 tablets each (Obsurge Biotech Limited) | $ 0.89 |
ORNIMAX film-coated tab 500 mg x 10's (Obsurge Biotech Limited) | $ 0.82 |
Ornimax 500mg FC-TAB / 10 (Obsurge Biotech Limited) | $ 0.82 |
Ornimax 500mg Tablet (Obsurge Biotech Limited) | $ 0.09 |
Ornimed (Georgia) | |
Orniona | |
Tablet, Film-Coated; Oral; Ornidazole 500 mg | |
Tablet; Vaginal; Ornidazole 500 mg | |
ORNIPIDI | |
ORNIPIDI INFUSION 1 bottle / 100 ML infusion each (Parenteral Drugs India Ltd) | $ 0.49 |
Ornisid (Georgia, Russian Federation, Turkey) | |
Tablet, Film-Coated; Oral; Ornidazole 250 mg (Abdi) | |
Tablet, Film-Coated; Oral; Ornidazole 500 mg (Abdi) | |
Tablet; Vaginal; Ornidazole 500 mg (Abdi) | |
Ornisid Fort (Turkey) | |
Ornisid Forte (Russian Federation) | |
ORNISTOP | |
ORNISTOP SUSPENSION 1 bottle / 50 ML suspension each (Delvin Formulations Pvt Ltd) | $ 1.19 |
Ornitop (Turkey) | |
ORNİTOP | |
ORNIVIR (India) | |
500 mg x 100's (East African (I) Remedies Pvt Ltd) | $ 7.94 |
Ornivir 500 mg Tablet (East African (I) Remedies Pvt Ltd) | $ 0.08 |
Ornivir 500mg TAB / 100 (East African (I) Remedies Pvt Ltd) | $ 7.94 |
ORNIVIR tab 500 mg x 10's (East African (I) Remedies Pvt Ltd) | $ 0.79 |
Ornivir 500mg TAB / 100 (East African (I) Remedies Pvt Ltd) | $ 7.94 |
Orniz | |
Orniz 500 mg Tablet (Udik Pharmaceuticals Pvt. Ltd.) | $ 0.07 |
ORNIZEN (India) | |
ORNIZEN Capsule/ Tablet / 500mg / 10 units (Sun Pharmaceutical Industries Ltd.) | $ 0.72 |
Ornizen 500mg TAB / 10 (Sun Pharmaceutical Industries Ltd.) | $ 0.72 |
500 mg x 10's (Sun Pharmaceutical Industries Ltd.) | $ 0.72 |
Ornizen 500 mg Tablet (Sun Pharmaceutical Industries Ltd.) | $ 0.07 |
ORNIZEN 500MG TABLET 1 strip / 10 tablets each (Sun Pharmaceutical Industries Ltd.) | $ 0.77 |
ORNIZEN tab 500 mg x 10's (Sun Pharmaceutical Industries Ltd.) | $ 0.72 |
Ornizen 500mg TAB / 10 (Sun Pharmaceutical Industries Ltd.) | $ 0.72 |
Ornizen 500mg Tablet (Sun Pharmaceutical Industries Ltd.) | $ 0.08 |
ORNIZOLE | |
ORNIZOLE 500 MG TABLET 1 strip / 10 tablets each (Intas Pharmaceuticals Ltd) | $ 0.55 |
Ornizole 500mg Tablet (Intas Pharmaceuticals Ltd) | $ 0.06 |
Ornol (India) | |
Ornol 500 mg Tablet (Olcare Laboratories) | $ 0.07 |
ORNOL 500MG TABLET 1 strip / 10 tablets each (Olcare Laboratories) | $ 0.76 |
ORNOL tab 500 mg x 10's (Olcare Laboratories) | $ 0.78 |
Ornol 500mg Tablet (Olcare Laboratories) | $ 0.08 |
Ornosol (Georgia) | |
See 442 substitutes for Ornilet |
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
|