Ornistop indications
Intravenous
Prophylaxis of postoperative anaerobic bacterial infections
Adult: 1 g by IV about 30 minutes before surgery.
Intravenous
Anaerobic bacterial infections
Adult: Initially, 0.5-1 g followed by 1 g daily as a single dose or in 2 divided doses for 5-10 days. Doses to be given via infusion. Substitute with 500 mg every 12 hr orally as soon as possible.
Child: 10 mg/kg every 12 hr for 5-10 days.
Intravenous
Severe amoebic dysentery, Amoebic liver abscess
Adult: Initially, 0.5-1 g infusion followed by 0.5 g every 12 hrs for 3-6 days.
Child: 20-30 mg/kg body wt daily.
Oral
Amoebic dysentery
Adult: 1.5 g as a single daily dose for 3 days. Alternatively for patients >60 kg: 1 g bid for 3 days.
Child: 40 mg/kg daily.
Oral
Trichomoniasis
Adult: 1.5 g as a single daily dose or 0.5 g bid for 5 days. Treat sexual partners concomitantly.
Child: 25 mg/kg as a single dose.
Oral
Amoebiasis
Adult: 0.5 g bid for 5-10 days.
Child: 25 mg/kg as a single daily dose for 5-10 days.
Oral
Giardiasis
Adult: 1-1.5 g as a single daily dose for 1-2 days.
Child: 30-40 mg/kg daily.
Uses of Ornistop in details
Ornistop is used in the treatment of infections of vagina, urinary tract, intestine and other parts of the body caused by anaerobic bacteria (bacteria that do not use oxygen) or protozoa (amoeba or single-celled parasites). It is also used to prevent these infections during surgical procedures.
Ornistop description
Ornistop blocks the release of noradrenaline from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibrillation. The primary mode of action for bretylium is thought to be inhibition of voltage-gated K(+) channels. Recent evidence has shown that bretylium may also inhibit the Na,K-ATPase by binding to the extracellular K-site.
Ornistop dosage
Oral
Amoebiasis
Adult: 0.5 g bid for 5-10 days.
Child: 25 mg/kg as a single daily dose for 5-10 days.
Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.
Hepatic impairment: Severe: Double the interval between doses.
Oral
Amoebic dysentery
Adult: 1.5 g as a single daily dose for 3 days. Alternatively for patients >60 kg: 1 g bid for 3 days.
Child: 40 mg/kg daily.
Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.
Hepatic impairment: Severe: Double the interval between doses.
Oral
Giardiasis
Adult: 1-1.5 g as a single daily dose for 1-2 days.
Child: 30-40 mg/kg daily.
Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.
Hepatic impairment: Severe: Double the interval between doses.
Oral
Trichomoniasis
Adult: 1.5 g as a single daily dose or 0.5 g bid for 5 days. Treat sexual partners concomitantly.
Child: 25 mg/kg as a single dose.
Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.
Hepatic impairment: Severe: Double the interval between doses.
Intravenous
Severe amoebic dysentery; Amoebic liver abscess
Adult: Initially, 0.5-1 g infusion followed by 0.5 g every 12 hrs for 3-6 days.
Child: 20-30 mg/kg body wt daily.
Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.
Hepatic impairment: Severe: Double the interval between doses.
Reconstitution: Dilute to a concentration of ≤5 mg/ml.
Intravenous
Anaerobic bacterial infections
Adult: Initially, 0.5-1 g followed by 1 g daily as a single dose or in 2 divided doses for 5-10 days. Doses to be given via infusion. Substitute with 500 mg every 12 hr orally as soon as possible.
Child: 10 mg/kg every 12 hr for 5-10 days.
Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.
Hepatic impairment: Severe: Double the interval between doses.
Reconstitution: Dilute to a concentration of ≤5 mg/ml.
Intravenous
Prophylaxis of postoperative anaerobic bacterial infections
Adult: 1 g by IV about 30 minutes before surgery.
Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.
Hepatic impairment: Severe: Double the interval between doses.
Reconstitution: Dilute to a concentration of ≤5 mg/ml.
Ornistop interactions
Digitalis toxicity may be aggravated by the initial release of norepinephrine caused by Ornistop Tosylate Injection.
The pressor effects of catecholamines such as dopamine or norepinephrine are enhanced by Ornistop Tosylate. When catecholamines are administered, dilute solutions should be used and blood pressure should be monitored closely.
Although there is little published information on concomitant administration of lidocaine and Ornistop Tosylate, these drugs are often administered concurrently without any evidence of interactions resulting in adverse effects or diminished efficacy.
Ornistop side effects
Somnolence, headache, nausea, vomiting, dizziness, tremor, rigidity, poor coordination, seizures, tiredness, vertigo, temporary loss of consciousness and signs of sensory or mixed peripheral neuropathy, taste disturbances, abnormal LFTs, skin reactions.
Ornistop contraindications
Hypersensitivity to Ornistop or to other nitroimidazole derivatives.
Active ingredient matches for Ornistop:
| Unit description / dosage (Manufacturer) | Price, USD |
| ORNISTOP SUSPENSION 1 bottle / 50 ML suspension each (Delvin Formulations Pvt Ltd) | $ 0.90 |
List of Ornistop substitutes (brand and generic names): | |
| Ornisid Forte (Russian Federation) | |
| Ornitop (Turkey) | |
| ORNİTOP | |
| ORNIVIR (India) | |
| 500 mg x 100's (East African (I) Remedies Pvt Ltd) | $ 6.02 |
| Ornivir 500 mg Tablet (East African (I) Remedies Pvt Ltd) | $ 0.06 |
| Ornivir 500mg TAB / 100 (East African (I) Remedies Pvt Ltd) | $ 6.02 |
| ORNIVIR tab 500 mg x 10's (East African (I) Remedies Pvt Ltd) | $ 0.60 |
| Ornivir 500mg TAB / 100 (East African (I) Remedies Pvt Ltd) | $ 6.02 |
| Orniz | |
| Orniz 500 mg Tablet (Udik Pharmaceuticals Pvt. Ltd.) | $ 0.05 |
| ORNIZEN (India) | |
| ORNIZEN Capsule/ Tablet / 500mg / 10 units (Sun Pharmaceutical Industries Ltd.) | $ 0.54 |
| Ornizen 500mg TAB / 10 (Sun Pharmaceutical Industries Ltd.) | $ 0.54 |
| 500 mg x 10's (Sun Pharmaceutical Industries Ltd.) | $ 0.54 |
| Ornizen 500 mg Tablet (Sun Pharmaceutical Industries Ltd.) | $ 0.05 |
| ORNIZEN 500MG TABLET 1 strip / 10 tablets each (Sun Pharmaceutical Industries Ltd.) | $ 0.59 |
| ORNIZEN tab 500 mg x 10's (Sun Pharmaceutical Industries Ltd.) | $ 0.54 |
| Ornizen 500mg TAB / 10 (Sun Pharmaceutical Industries Ltd.) | $ 0.54 |
| Ornizen 500mg Tablet (Sun Pharmaceutical Industries Ltd.) | $ 0.06 |
| ORNIZOLE | |
| ORNIZOLE 500 MG TABLET 1 strip / 10 tablets each (Intas Pharmaceuticals Ltd) | $ 0.42 |
| Ornizole 500mg Tablet (Intas Pharmaceuticals Ltd) | $ 0.04 |
| Ornol (India) | |
| Ornol 500 mg Tablet (Olcare Laboratories) | $ 0.05 |
| ORNOL 500MG TABLET 1 strip / 10 tablets each (Olcare Laboratories) | $ 0.58 |
| ORNOL tab 500 mg x 10's (Olcare Laboratories) | $ 0.59 |
| Ornol 500mg Tablet (Olcare Laboratories) | $ 0.06 |
| Ornosol (Georgia) | |
| Orocyp | |
| Orocyp 500 mg Tablet (Cyper Pharma) | $ 0.05 |
| ORTINI | |
| ORTINI 500MG TABLET 1 strip / 10 tablets each (Merck Ltd) | $ 0.53 |
| ORTINI 500MG TABLET 1 strip / 20 tablets each (Merck Ltd) | $ 1.06 |
| Otic OL | |
| Otic OL 200+500+LB Tablet (Haledew Remedies) | $ 0.09 |
| Ovax OZ | |
| Ovax OZ 200+500 Tablet (Lanark Laboratories Pvt Ltd) | $ 0.09 |
| Ovax OZ 30 ml Suspension (Lanark Laboratories Pvt Ltd) | $ 0.07 |
| Oxcin ORD | |
| Oxcin ORD 200+500 Tablet (Uniroyal Biotech) | $ 0.07 |
| Oxdiflox OZ | |
| Oxdiflox OZ 200+500 Tablet (Diya Healthcare Pvt Ltd) | $ 0.09 |
| Oxin OZ | |
| Oxin OZ 200+500 Tablet (Eugenics Medicare Pvt. Ltd) | $ 0.08 |
| Oxl OZ | |
| Oxl OZ 200+500 Tablet (Prism Pharma) | $ 0.11 |
| OZ (MARC PHARMA) | |
| OZ 500MG TABLET 1 strip / 10 tablets each (Marc Laboratories Pvt Ltd) | $ 0.54 |
| Ozio | |
| Ozio 200+500 Tablet (Magna Formulations) | $ 0.08 |
| Pusili (China) | |
| Qi Ke (China) | |
| RAMORD | |
| RAMORD 500MG TABLET 1 strip / 10 tablets each (Ramose Laboratories Pvt Ltd) | $ 0.60 |
| Robic (Bangladesh) | |
| Rui Shen (China) | |
See 443 substitutes for Ornistop | |
References
- PubChem. "Ornidazole". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "Ornidazole". http://www.drugbank.ca/drugs/DB13026 (accessed September 17, 2018).
- DTP/NCI. "Ornidazole: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Ornistop are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Ornistop. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
