Ostine Uses


Ostine indications

infoAn indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

this antacid is useful for the temporary relief of occasional indigestion and heartburn. Frequent, daily or nightly symptoms usually mean a more serious problem. Antacids by themselves do not correct these problems. The medications that are now available to treat acid problems are generally superior to antacids.

The second and more important use of Calcium Carbonate (Ostine) is as a source of calcium, necessary for bones and teeth and to prevent osteoporosis. A quart of milk contains about 1500 mg of calcium which is about what you need. Otherwise this or a similar calcium preparation can be taken.

Uses of Ostine in details

infoThere are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

This combination medication is used to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets. It may be used to treat conditions caused by low calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany). It may also be used in certain patients to make sure they are getting enough calcium (e.g., women who are pregnant, nursing, or postmenopausal, people taking certain medications such as phenytoin, phenobarbital, or prednisone).

Calcium plays a very important role in the body. It is necessary for normal functioning of nerves, cells, muscle, and bone. If there is not enough calcium in the blood, then the body will take calcium from bones, thereby weakening bones. Vitamin D helps your body absorb calcium and phosphorus. Having the right amounts of vitamin D, calcium, and phosphorus is important for building and keeping strong bones.

How to use Calcium 600 + D(3)

Take this medication by mouth with food. If your product contains calcium citrate, then it may be taken with or without food. Follow all directions on the product package, or take as directed by your doctor. For best absorption, if your total daily dose is more than 600 milligrams, then divide your dose and space it throughout the day. If you are uncertain about any of the information, consult your doctor or pharmacist.

If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

If you are taking the chewable form of this medication, chew thoroughly before swallowing. If you are taking capsules, swallow each capsule whole.

Do not crush or chew extended-release tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.

If your doctor has recommended that you follow a special diet, it is very important to follow the diet to get the most benefit from this medication and to prevent serious side effects. Do not take other supplements/vitamins unless ordered by your doctor.

Calcium supplements come in different forms that contain different amounts of calcium/vitamin D. Ask your doctor or pharmacist to help select the best product for you.

If you think you may have a serious medical problem, seek immediate medical attention.

Ostine description


Each chewable tablet contains Calcium Carbonate (Ostine) 1500 mg (equivalent to elemental calcium 600 mg) and cholecalciferol concentrate 4 mg (equivalent to vitamin D3 400 IU).

Ostine dosage

Adult and the

Elderly: 1 tab twice daily [eg, 1 tab in the morning and in the evening (equivalent to calcium 1200 mg & vitamin D3 800 IU)]. Reduction of intake should be considered necessary following the monitoring of calcium levels.

Pregnant Women: 1 tab daily. No dose adjustment is required in cases of hepatic insufficiency.

The tablets are chewed and then swallowed with some liquid. In exceptional cases (eg, disabled patients), the tablets can, after consulting a doctor, be sucked.

Ostine should be taken by adults only.

Ostine interactions

Thiazide diuretics reduce calcium excretion in the urine. Because of the increased risk of hypercalcaemia, calcium monitoring is recommended in cases when thiazide diuretics are given simultaneously.

Systemic corticosteroids reduce calcium absorption. In the case of concomitant administration of corticosteroids, it might be necessary to increase the dose of Ostine.

Orlistat, combined ion-exchange resin treatment eg, cholestyramine or laxatives eg, paraffin oil can reduce the gastrointestinal absorption of vitamin D3. An interval of at least 2 hrs should be observed between ingestion of ion-exchange resins (eg, cholestyramine) or laxatives and Ostine as otherwise the absorption of vitamin D3 is reduced.

Calcium Carbonate (Ostine) can alter tetracycline absorption when given simultaneously. It is recommended that taking tetracycline be staggered by at least 2 hrs before or 4-6 hrs after taking calcium by mouth.

Hypercalcaemia can increase the toxicity of cardiac glycosides in the case of simultaneous administration with calcium and vitamin D. Consequently patients must be monitored regularly (ECG check and calcaemia).

Rifampicin, phenytoin or barbiturates may reduce the activity of vitamin D3, since they increase the rate of its metabolism.

Calcium salts may decrease the absorption of iron, zinc or strontium. Consequently, the iron, zinc or strontium preparation should be taken at a distance of 2 hrs from the calcium preparation.

Calcium salts may reduce the absorption of the estramustin or thyroid hormones. It is recommended that taking Ostine be spaced at least 2 hrs from these medicines.

In the case of concomitant bisphosphonate, sodium fluoride or fluoroquinolone administration, it is recommended that taking Ostine be spaced by at least 3 hrs, as their absorption during digestion may be reduced.

Oxalic acid (found in spinach and rhubarb) and phytic acid (found in wholegrain cereals) can inhibit calcium absorption by forming insoluble compound with calcium ions. Patients must not take calcium containing-products in the 2 hrs after the consumption of foods rich in oxalic acid and phytic acid.

Ostine side effects


Rare cases of hepatitis.

Teratogenic risk.

Confusion, or seizure: a case of stupor has been described during therapy with valproic acid, were isolated or associated with an increased incidence of seizures during therapy and regressed upon discontinuation of treatment or the decrease in dose.

These cases have been reported, particularly during combination therapy (especially with phenobarbital) or after a sharp increase in doses of valproate.

Digestive disorders (nausea, stomach pain) occur frequently in some patients early in treatment but usually disappear after a few days without interrupting the treatment.

Frequently reported side effects were transient and / or dose-related: hair loss, fine postural tremor.

Have been isolated reports of reduction of fibrinogen or lengthening of bleeding time, usually without associated clinical signs and particularly with high doses (valproate has an inhibitory effect on the second phase of platelet aggregation).

Frequent occurrence of: thrombocytopenia, rare cases of anemia, leucopenia or pancytopenia.

There have been occasional reports of pancreatitis, sometimes lethal.

It ’was reported the appearance of vasculitis.

May occur frequently isolated moderate hyperammonemia without alteration of liver function tests and this should not cause treatment discontinuation.

However, in the course of monotherapy or polytherapy (phenobarbital, carbamazepine, phenytoin, topiramate) may have a syndrome of acute hyperammonemic encephalopathy with normal liver function and absence of cytolysis.

Syndrome encephalopathy hyperammonemia induced by valproate is manifested in an acute form and is characterized by loss of consciousness, and focal neurological signs and with the general increase in the frequency of epileptic seizures.

May appear after several days or several weeks of therapy and regresses after discontinuation of valproate.

The encephalopathy is not dose-related, and changes are characterized by the appearance of EEG slow waves and increase in epileptic discharges.

There may be weight gain, have also been reported amenorrhea and irregular menstruation.

It has been rare reports of hearing loss, both reversible irreversible, however, is not an established cause-effect relationship.

Rash, irritability (occasionally aggression, behavioral problems and hyperactivity), hypoplastic glubuli red reduction of fibrinogen.

Also been reported cases of Stevens-Johnson syndrome and toxic epidermal necrolysis.

Ostine contraindications


Hypersensitivity to the Calcium Carbonate (Ostine) or cholecalciferol, or to any of the excipients of Ostine. Renal failure; hypercalciuria and hypercalcaemia and diseases and/or conditions, which lead to hypercalcaemia and/or hypercalciuria (eg, myeloma, bone metastases, primary hyperparathyroidism); kidney stones (nephrolitiasis, nephrocalcinosis); hypervitaminosis D.

Active ingredient matches for Ostine:

Calcium Carbonate/Colecalciferol in Spain.

Chondroitin sulphate/Glucosamine HCl/manganese/Mg/vit C/Zn in Indonesia.

Unit description / dosage (Manufacturer)Price, USD
Ostine 6 x 10's$ 25.45

List of Ostine substitutes (brand and generic names):

Tablet, Effervescent; Oral; Calcium / Calcium Carbonate; Vitamin D3 / Cholecalciferol (Sudmedica)
Oyst-O-Cal Vit D3 125iu, Ca 250mg FC-TAB / 10 (Cadila (Vibra))$ 0.19
10's (Cadila (Vibra))$ 0.19
OYST-O-CAL film-coated tab 10's (Cadila (Vibra))$ 0.19
Prima-Cal 1250 mg x 30's (Nupharma)
Prima-Cal 1250 mg x 60's (Nupharma)
Prima-Cal 1250 mg x 500's (Nupharma)
Prima-Cal Plus Vit D 30's (Nupharma)
Prima-Cal Plus Vit D 60's (Nupharma)
Prima-Cal Plus Vit D 500's (Nupharma)
Risbone Calcium carbonate 500 mg, vitamin D3 250 IU. TAB / 10 (Auris)$ 0.62
RISBONE tab 10's (Auris)$ 0.62
Rndcal Ca Carbonate 1250mg, Vit D3250iu TAB / 10 (RND Lab)$ 0.38
10's (RND Lab)$ 0.38
RNDCAL tab 10's (RND Lab)$ 0.58
20's (Novartis India Ltd)$ 1.11
Sandochew Ca 500mg, Cholecalciferol 250iu CHW-TAB / 20 (Novartis India Ltd)$ 1.11
Sandochew Calcium 500 mg, Cholecalciferol 250 IU. CHW-TAB / 20 (Novartis India Ltd)$ 1.11
Sandochew Ca 500mg, Cholecalciferol250IU CHW-TAB / 20 (Novartis India Ltd)$ 1.11
Sandochew 1250 mg+250 iu Tablet (Novartis India Ltd)$ 0.06
SANDOCHEW chewable tab 10's (Novartis India Ltd)$ 0.56
Sandochew Ca 500mg, Cholecalciferol250IU CHW-TAB / 20 (Novartis India Ltd)$ 1.11
Sandochew Ca 500mg, Cholecalciferol 250iu CHW-TAB / 20 (Novartis India Ltd)$ 1.11
Sandochew Calcium 500 mg, Cholecalciferol 250 IU. CHW-TAB / 20 (Novartis India Ltd)$ 1.11


  1. DailyMed. "CALCIUM CARBONATE; FAMOTIDINE; MAGNESIUM HYDROXIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. DailyMed. "CALCIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  3. PubChem. "Calcium". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  4. PubChem. "Manganese". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  5. PubChem. "CALCIUM CARBONATE". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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