Treating solar lentigines (darkened lesions on skin that has been exposed to sunlight over a long period of time). P-Guaiacol/Tretinoin is used with a total skin care and sunlight avoidance program. It may also be used for other conditions as determined by your doctor.
P-Guaiacol/Tretinoin is a combination depigmentation agent and retinoid. Exactly how it works is unknown.
P-Guaiacol is the monobenzyl ether of hydroquinone used medically for depigmentation. P-Guaiacol occurs as a white, almost tasteless crystalline powder, soluble in alcohol and practically insoluble in waterhe topical application of monobenzone in animals increases the excretion of melanin from the melanocytes. The same action is thought to be responsible for the depigmenting effect of the drug in humans. P-Guaiacol may cause destruction of melanocytes and permanent depigmentation.
Some MEDICINES MAY INTERACT with P-Guaiacol/Tretinoin. Tell your health care provider if you are taking any other medicines, especially any of the following:
Fluoroquinolones (eg, levofloxacin), phenothiazines (eg, chlorpromazine), sulfonamides (eg, glipizide, sulfamethoxazole), tetracyclines (eg, doxycycline), or thiazide diuretics (eg, hydrochlorothiazide) because the risk of sunburn may be increased
This may not be a complete list of all interactions that may occur. Ask your health care provider if P-Guaiacol/Tretinoin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Burning, dry skin, itching, peeling, redness, stinging, tingling, or warmth at application site; unusual sensitivity to wind and cold.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blistering, crusting, swelling, or excessive redness of the skin; changes in skin color; lightening of the skin surrounding the treatment area.
Do NOT use P-Guaiacol/Tretinoin if:
you are allergic to any ingredient in P-Guaiacol/Tretinoin
you are taking a fluoroquinolone (eg, levofloxacin), a phenothiazine (eg, chlorpromazine), a sulfonamide (eg, glipizide, sulfamethoxazole), a tetracycline (eg, doxycycline), a thiazide diuretic (eg, hydrochlorothiazide), or other medicines that may increase your skin’s sensitivity to the sun. Ask your doctor or pharmacist if you have questions about whether any of your medicines increase your skin’s sun sensitivity.
you are pregnant or may become pregnant
Contact your doctor or health care provider right away if any of these apply to you.
List of P-Guaiacol substitutes (brand and generic names)
|Sort by popularity|
|Unit description / dosage (Manufacturer)||Price, USD|
|Ointment; Topical; Mequinol 8% (Homme de fer)|
|Any 8% (France)|
|Ointment; Topical; Mequinol 5% (Bcs)|
|Ointment; Topical; Mequinol 10% (Bcs)|
|Clairodermyl 10% (France)|
|Clairodermyl 5% (France)|
|Creme 3 Fleurs d' Orient|
|Ointment; Topical; Mequinol 10%|
|Creme des 3 Fleurs d'Orient Ointment|
|Ointment; Topical; Mequinol|
|Crème des 3 fleurs d`orient (France)|
|Leucobasal Forte (Peru)|
|Leucodinine B (Algeria, Benin, Burkina Faso, Cameroon, Central African Republic, Congo, Cote D'ivoire, France, Gabon, Guinea, Mauritania, Niger, Senegal, Togo, Tunisia, Zaire)|
|Ointment; Topical; Mequinol 10% (Db)|
|Leucodinine B 10 % x 30 g x 1 tube (Db)|
|Leucodinine B 10% (France)|
|Mequinol 30 Packs|
|Mequinol (Congo, France, Tunisia, Vietnam)|
|Mequinol 30 Packs|
|Mequinol 30 Packs|
|Novo Dermoquinona (Spain)|
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Information checked by Dr. Sachin Kumar, MD Pharmacology