Palovir Overdose

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Overdose of Palovir in details

When a dose is taken in higher dose than the recommended doses, it is called Overdose. Overdose always needs a clinical supervision. Any medicine or drug when consumed in Overdose produces untoward side effects on one or various organs in the body. A medicine is excreted in the kidney or metabolized in the liver most of the times. This process goes without any hurdles when taken in normal dose, but when taken in an overdose, the body is not able to metabolize it or send it out properly which causes the effects of anoverdose.
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Since there is no specific antidote, treatment of adverse effects and/or overdosage should be symptomatic and supportive with possible utilization of the following: Adequate hydration to prevent precipitation of Palovir into the renal tubules.

Hemodialysis to aid in the removal of Palovir from the blood, especially in patients with acute renal failure and anuria.

Palovir warnings

Warnings are a mix of Precautions. Contraindications and interactions and serious harmful effects associated with the medicine intake. A diabetic or Hypertensive patient need to be warned about few drug interactions. A known hypersensitivity patient needs to be careful about the reactions or anaphylactic shock. A pregnant woman or a breastfeeding woman should be warned of certain medications. A Hepatitis [liver disease] patient or a cardiac patient should avoid few drugs.

dosage adjustment is recommended when administering Palovir to patients with renal impairment. Caution should also be exercised when administering Palovir to patients receiving potentially nephrotoxic agents since this may increase the risk of renal dysfunction and/or the risk of reversible central nervous system symptoms such as those that have been reported in patients treated with intravenous Palovir.

Information for Patients: patients are instructed to consult with their physician if they experience severe or troublesome adverse reactions, they become pregnant or intend to become pregnant, they intend to breastfeed while taking orally administered Palovir or they have any other questions.

Herpes zoster: there are no data on treatment initiated more than 72 hours after onset of the zoster rash.

Genital herpes infections: patients should be informed that Palovir is not a cure for genital herpes.

Chickenpox: adolescents and adults tend to have more severe disease. Treatment was initiated within 24 hours of the typical chickenpox rash.

Pregnancy: Pregnancy Category B.

Nursing Mothers: Palovir should be administered to a nursing mother with caution and only when indicated.

Pediatric Use: safety and effectiveness of oral formulations of Palovir in pediatric patients less than 2 years of age have not been established.

Geriatric Use: elderly patients are more likely to have reduced renal function and require dose reduction. Elderly patients are also more likely to have renal or CNS adverse events.

Palovir precautions

Certain people who are very sick or very old or who are sensitive show an exacerbation of side effect of the drug which can turn dangerous at times. So, it is very important to remember the precautions while taking the medicine. Pregnancy and Breastfeeding are also special categories wherein extra care or precaution is needed when taking a drug. Few patients may have a hypersensitivity reaction to few medications, and that can be life-threatening rarely. Penicillin hypersensitivity is one example. Diarrhea, rashes are few other symptoms which need a watch. A patient with other co-existing diseases like liver disease, heart disease, kidney disease should take special precautions.
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Dehydration or Renal Function Impairment:

Intravenous Palovir may increase the potential for nephrotoxicity; it is recommended that Palovir be administered in a reduced dosage to patients with impaired renal function.

Neurological Abnormalities or Prior Neurologic Reactions to Cytotoxic Medications:

Intravenous Palovir may increase the potential for neurologic side effects.

Palovir should be used with caution for patients with renal impairment and doses should be adjusted according to creatinine clearance.

Women with herpes genitalis may have an increased risk of developing cervical cancer; annual Pap tests may be required. Check with physician if no improvement within a few days.

Use of Palovir has not been shown to prevent the transmission of herpes simplex virus to sexual partners.

Use in Pregnancy & Lactation: Palovir crosses placenta. No adverse fetal effects have been reported. FDA pregnancy category C.

Palovir passes into breast milk. No toxicity is observed in infants.


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References

  1. DailyMed. "ACYCLOVIR: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. DrugBank. "acyclovir". http://www.drugbank.ca/drugs/DB00787 (accessed September 17, 2018).
  3. MeSH. "Antiviral Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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