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Palovir Side effects |
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Herpes simplex:
Short term administration: the most frequent adverse events reported with Palovir 200 mg administered orally 5 times daily every 4 hours for 10 days were nausea and/or vomiting.
Long term administration: the most frequent adverse events reported in a clinical trial for the prevention of recurrences with continuous administration of 400 mg 2 times daily for 1 year were nausea (4.8%) and diarrhea (2.4%).
Herpes zoster: the most frequent adverse event reported with 800 mg of oral Palovir 5 times daily for 7 to 10 days in 323 patients was malaise (11.5%).
Chickenpox: the most frequent adverse event reported with oral Palovir at doses of 10 to 20 mg/kg 4 times daily for 5 to 7 days was diarrhea (3.2%).
Observed during clinical practice: in addition to adverse events reported from clinical trials, the following events have been identified during post-approval use of Palovir.
General: anaphylaxis, angioedema, fever, headache, pain, peripheral edema.
Nervous: aggressive behavior, agitation, ataxia, coma, confusion, decreased consciousness, delirium, dizziness, encephalopathy, hallucinations, paresthesia, psychosis, seizure, somnolence, tremors. These symptoms may be marked, particularly in older adults or in patients with renal impairment.
Digestive: diarrhea, gastrointestinal distress, nausea.
Hematologic and lymphatic: anemia, leukocytoclastic vasculitis, leukopenia, lymphadenopathy, thrombocytopenia.
Hepatobiliary tract and pancreas: elevated liver function tests, hepatitis, hyperbilirubinemia, jaundice.
Musculoskeletal: myalgia.
Skin: alopecia, erythema multiforme, photosensitive rash, pruritus, rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria.
Skin: alopecia, erythema multiforme, photosensitive rash, pruritus, rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria.
Urogenital: renal failure, elevated blood urea nitrogen, elevated creatinine, hematuria.
Palovir Lotion is contraindicated for premature neonates because their skin may be more permeable than full term infants and their liver enzymes may not be sufficiently developed. It is also contraindicated for patients with Norwegian (crusted) scabies due to possible increased absorption. It is also contraindicated for patients with known seizure disorders and for individuals with a known sensitivity to the product or any of its components.
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Information checked by Dr. Sachin Kumar, MD Pharmacology
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