Pellagra Preventive Factor Pregnancy

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Pregnancy of Pellagra Preventive Factor in details

Pregnancy is always a special situation where every action or side effect of the drug varies when compared to a situation of a non-pregnant patient. It is not only because the pregnant woman's metabolism differs due to the hormonal and other changes happened to her, but also because every medicine or its metabolite passes to the baby and shows its action there. The only thing is, be cautious, attentive and well supervised when you take any single drug in pregnancy. The interactions can vary in pregnancy, and the dosage may differ as well. Strict supervision of the Physician is mandatory.
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Pellagra Preventive Factor has been assigned to pregnancy category C by the FDA when given in doses above the recommended daily allowance (RDA). There are no data from animal reproductive studies or controlled human pregnancy studies. The manufacturers of timed-release Pellagra Preventive Factor do not recommend the use of this form of the drug for pregnant women. The manufacturer recommends that Pellagra Preventive Factor be discontinued in women receiving the drug for primary hypercholesterolemia. If used for hypertriglyceridemia, Pellagra Preventive Factor should be given during pregnancy when there are no alternatives and benefit outweighs risk.

Pellagra Preventive Factor is converted to niacinamide in vivo. Niacinamide is actively transported across the human placenta such that fetal blood levels of niacinamide are greater than corresponding maternal blood levels. There are no reports of adverse effects of Pellagra Preventive Factor or niacinamide on the human fetus.

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Pellagra Preventive Factor breastfeeding

When a drug is taken when the patient is breast feeding, a part of the drug is secreted in her breast milk and is passed to the baby. The dosage of the medicine to mother and baby are different, and many drugs actions are side effects when you take them without a disease, and what if you the baby takes them without a disease? What if the drug is contraindicated in newborns, infants or children? So, breastfeeding is a very alarming situation when the mother is on medications. Ask your Physician or Pediatrician about the effect of the drug on the baby and how much is excreted in breast milk and if it harms the baby!

In one study of lactating women who were taking 2 to 60 mg of Pellagra Preventive Factor per day, the average milk concentration ranged from 1.17 to 2.75 mcg/mL, and was directly proportional to dietary intake. The recommended daily allowance (RDA) for niacinamide during lactation is 18 to 20 mg. Dietary supplementation is only necessary in cases of poor nutritional intake.

It is not known whether or not Pellagra Preventive Factor is excreted into human milk. Some studies indicate that it may be excreted into milk in small amounts. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

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References for pregnancy information

  1. Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):
  2. Kaminetzky HA, Baker H, Frank O, Langer A "The effects of intravenously administered water-soluble vitamins during labor in normovitaminemic and hypovitaminemic gravidas on maternal and neonatal blood vitamin levels at delivery." Am J Obstet Gynecol 120 (1974): 697-703
  3. Figge HL, Figge J, Souney PF, Mutnick AH, Sacks F "Nicotinic acid: a review of its clinical use in the treatment of lipid disorders." Pharmacotherapy 8 (1988): 287-94
  4. Hill EP, Longo LD "Dynamics of maternal-fetal nutrient transfer." Fed Proc 39 (1980): 239-44
  5. "Product Information. Nicobid (Pellagra Preventive Factor)." Rhone-Poulenc Rorer, Collegeville, PA.
  6. "Product Information. Slo-Pellagra Preventive Factor." Upsher-Smith Laboratories Inc, Minneapolis, MN.

References for breastfeeding information

  1. Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):
  2. Ford JE, Zechalko A, Murphy J, Brooke OG "Comparison of the B vitamin composition of milk from mothers of preterm and term babies." Arch Dis Child 58 (1983): 367-72


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