Phenylephrine Amdipharm Overdose

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Did you have any side effects with this medicine?

What happens if I overdose Phenylephrine Amdipharm?

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local, or emergency room right away. Symptoms may include confusion; hallucinations; irregular or unusually slow or rapid heartbeat; rapid breathing; seizures.

Proper storage of Phenylephrine Amdipharm orally disintegrating strips:

Store Phenylephrine Amdipharm orally disintegrating strips at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Phenylephrine Amdipharm orally disintegrating strips out of the reach of children and away from pets.

Overdose of Phenylephrine Amdipharm in details

infoWhen a dose is taken in higher dose than the recommended doses, it is called Overdose. Overdose always needs a clinical supervision. Any medicine or drug when consumed in Overdose produces untoward side effects on one or various organs in the body. A medicine is excreted in the kidney or metabolized in the liver most of the times. This process goes without any hurdles when taken in normal dose, but when taken in an overdose, the body is not able to metabolize it or send it out properly which causes the effects of anoverdose.
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Overdose of Phenylephrine Amdipharm hydrochloride can cause a rapid rise in blood pressure. Symptoms of overdose include headache, vomiting, hypertension, reflex bradycardia, and cardiac arrhythmias including ventricular extrasystoles and ventricular tachycardia, and may cause a sensation of fullness in the head and tingling of the extremities.

Consider using an a-adrenergic antagonist.

What should I avoid while taking Phenylephrine Amdipharm?

Use caution when driving, operating machinery, or performing other hazardous activities. Phenylephrine Amdipharm ophthalmic may cause blurred vision. If you experience blurred vision, avoid these activities.

Do not touch the dropper to any surface, including the eyes or hands. The dropper is sterile. If it becomes contaminated, it could cause an infection in the eye.

If you wear contact lenses, remove them before applying Phenylephrine Amdipharm ophthalmic. Ask your doctor if contact lenses can be reinserted after application of the medication. Phenylephrine Amdipharm ophthalmic may contain a preservative (benzalkonium chloride), which may cause discoloration of contact lenses.

Do not use Phenylephrine Amdipharm ophthalmic more often or continuously for longer than 48 to 72 hours without consulting a doctor. Chronic use of this medication may damage the blood vessels (veins and arteries) in the eyes. Consult a doctor if your symptoms do not improve or appear to worsen.

Phenylephrine Amdipharm warnings

infoWarnings are a mix of Precautions. Contraindications and interactions and serious harmful effects associated with the medicine intake. A diabetic or Hypertensive patient need to be warned about few drug interactions. A known hypersensitivity patient needs to be careful about the reactions or anaphylactic shock. A pregnant woman or a breastfeeding woman should be warned of certain medications. A Hepatitis [liver disease] patient or a cardiac patient should avoid few drugs.
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Exacerbation of Angina, Heart Failure, or Pulmonary Arterial Hypertension

Because of its increasing blood pressure effects, Phenylephrine Amdipharm can precipitate angina in patients with severe arteriosclerosis or history of angina, exacerbate underlying heart failure, and increase pulmonary arterial pressure.

Peripheral and Visceral Ischemia

Phenylephrine Amdipharm can cause excessive peripheral and visceral vasoconstriction and ischemia to vital organs, particularly in patients with extensive peripheral vascular disease.

Skin and Subcutaneous Necrosis

Extravasation of Phenylephrine Amdipharm can cause necrosis or sloughing of tissue. The infusion site should be checked for free flow. Care should be taken to avoid extravasation of Phenylephrine Amdipharm.

Bradycardia

Phenylephrine Amdipharm can cause severe bradycardia and decreased cardiac output.

Allergic Reactions

Phenylephrine Amdipharm contains sodium metabisulfite, a sulfite that may cause allergic-type reactions, including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people.

Renal Toxicity

Phenylephrine Amdipharm can increase the need for renal replacement therapy in patients with septic shock. Monitor renal function.

Risk of Augmented Pressor Affect in Patients with Autonomic Dysfunction

The increasing blood pressure response to adrenergic drugs, including Phenylephrine Amdipharm, can be increased in patients with autonomic dysfunction, as may occur with spinal cord injuries.

Pressor Effect with Concomitant Oxytocic Drugs

Oxytocic drugs potentiate the increasing blood pressure effect of sympathomimetic pressor amines including Phenylephrine Amdipharm, with the potential for hemorrhagic stroke.

What should I discuss with my healthcare provider before taking Phenylephrine Amdipharm?

Some medical conditions may interact with Phenylephrine Amdipharm dissolving tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of glaucoma or increased pressure in the eye, enlarged prostate gland or other prostate problems, heart problems, diabetes, high blood pressure, blood vessel problems, adrenal gland problems, overactive thyroid, seizures, or stroke

Some MEDICINES MAY INTERACT with Phenylephrine Amdipharm dissolving tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, entacapone), furazolidone, indomethacin, methyldopa, or MAOIs (eg, phenelzine) because they may increase the risk of Phenylephrine Amdipharm dissolving tablets's side effects
  • Tricyclic antidepressants (eg, amitriptyline) because they may decrease Phenylephrine Amdipharm dissolving tablets's effectiveness
  • Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased
  • Bromocriptine because the risk of its side effects, such as phenylketonuria, may be increased by Phenylephrine Amdipharm dissolving tablets
  • Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Phenylephrine Amdipharm dissolving tablets

This may not be a complete list of all interactions that may occur. Ask your health care provider if Phenylephrine Amdipharm dissolving tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Phenylephrine Amdipharm precautions

infoCertain people who are very sick or very old or who are sensitive show an exacerbation of side effect of the drug which can turn dangerous at times. So, it is very important to remember the precautions while taking the medicine. Pregnancy and Breastfeeding are also special categories wherein extra care or precaution is needed when taking a drug. Few patients may have a hypersensitivity reaction to few medications, and that can be life-threatening rarely. Penicillin hypersensitivity is one example. Diarrhea, rashes are few other symptoms which need a watch. A patient with other co-existing diseases like liver disease, heart disease, kidney disease should take special precautions.
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Exceeding recommended dosages or applying Phenylephrine Amdipharm (Phenylephrine Amdipharm hydrochloride ophthalmic solution) hydrochloride ophthalmic solutions to the instrumented, traumatized, diseased or postsurgical eye or adnexa, or to patients with suppressed lacrimation, as during anesthesia, may result in the absorption of sufficient quantities of Phenylephrine Amdipharm to produce a systemic vasopressor response.

A significant elevation in blood pressure is rare but has been reported following conjunctival instillation of recommended doses of Phenylephrine Amdipharm (Phenylephrine Amdipharm hydrochloride ophthalmic solution) 10 percent ophthalmic solutions. Caution, therefore, should be exercised in administering the 10 percent solutions to children of low body weight, the elderly, and patients with insulin-dependent diabetes, hypertension, hyperthyroidism, generalized arteriosclerosis, or cardiovascular disease. The posttreatment blood pressure of these patients, and any patients who develop symptoms, should be carefully monitored.

Ordinarily, any mydriatic, including Phenylephrine Amdipharm (Phenylephrine Amdipharm hydrochloride ophthalmic solution) hydrochloride, is contraindicated in patients with glaucoma, since it may occasionally raise intraocular pressure. However, when temporary dilatation of the pupil may free adhesions or when vasoconstriction of intrinsic vessels may lower intraocular tension, these advantages may temporarily outweigh the danger from coincident dilatation of the pupil.

Rebound miosis has been reported in older persons one day after receiving Phenylephrine Amdipharm (Phenylephrine Amdipharm hydrochloride ophthalmic solution) hydrochloride ophthalmic solutions, and reinstillation of the drug produced a reduction in mydriasis. This may be of clinical importance in dilating the pupils of older subjects prior to retinal detachment or cataract surgery.

Due to a strong action of the drug on the dilator muscle, older individuals may also develop transient pigment floaters in the aqueous humor 30 to 45 minutes following the administration of Phenylephrine Amdipharm (Phenylephrine Amdipharm hydrochloride ophthalmic solution) hydrochloride ophthalmic solutions. The appearance may be similar to anterior uveitis or to a microscopic hyphema.

To prevent pain, a drop of suitable topical anesthetic may be applied before using the 10 percent ophthalmic solution.

Carcinogenesis, Mutagenesis, Impairment of Fertility: No long-term animal studies have been done to evaluate the potential of Phenylephrine Amdipharm (Phenylephrine Amdipharm hydrochloride ophthalmic solution) in these areas.

Pregnancy Category C: Animal reproduction studies have not been conducted with Phenylephrine Amdipharm (Phenylephrine Amdipharm hydrochloride ophthalmic solution). It is also not known whether Phenylephrine Amdipharm (Phenylephrine Amdipharm hydrochloride ophthalmic solution) can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Phenylephrine Amdipharm (Phenylephrine Amdipharm hydrochloride ophthalmic solution) should be given to a pregnant woman only if clearly needed.

Nursing Mothers: It is not known whether this drug is excreted in milk; many are. Caution should be exercised when Phenylephrine Amdipharm (Phenylephrine Amdipharm hydrochloride ophthalmic solution) hydrochloride ophthalmic solution is administered to a nursing woman.

Pediatric Use: Phenylephrine Amdipharm (Phenylephrine Amdipharm hydrochloride ophthalmic solution) hydrochloride 10 percent ophthalmic solutions are contraindicated in infants. For use in older children see DOSAGE AND ADMINISTRATION.

Exceeding recommended dosages or applying Phenylephrine Amdipharm (Phenylephrine Amdipharm hydrochloride ophthalmic solution) hydrochloride ophthalmic solutions to the instrumented, traumatized, diseased or postsurgical eye or adnexa, or to patients with suppressed lacrimation, as during anesthesia, may result in the absorption of sufficient quantities of Phenylephrine Amdipharm to produce a systemic vasopressor response.

The hypertensive effects of Phenylephrine Amdipharm may be treated with an alpha-adrenergic blocking agent such as phentolamine mesylate, 5 mg to 10 mg intravenously, repeated as necessary.

The oral LD50 of Phenylephrine Amdipharm in the rat: 350 mg/kg, in the mouse: 120 mg/kg.

What happens if I miss a dose of Phenylephrine Amdipharm?

infoWhen you miss a dose, you should take it as soon as you remember, but you should take care that it should be well spaced from the next dose. You should not take an extra dose at the time of the second dose as it will become a double dose. The double dose can give unwanted side effects, so be careful. In chronic conditions or when you have a serious health issue, if you miss a dose, you should inform your health care provider and ask his suggestion.

Since Phenylephrine Amdipharm rectal is used on an as needed basis, you are not likely to miss a dose. Do not use Phenylephrine Amdipharm rectal more than 4 times per day.



References

  1. DrugBank. "phenylephrine". http://www.drugbank.ca/drugs/DB00388 (accessed September 17, 2018).
  2. MeSH. "Cardiotonic Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
  3. EPA Chemicals under the TSCA. "Benzenemethanol, 3-hydroxy-.alpha.-[(methylamino)methyl]- , hydrochloride (1:1), (.alpha.R)-: The Chemical Data Reporting under the Toxic Substances Control Act (TSCA) contains chemical physical description and chemical use categories.". http://www.epa.gov/chemical-data-rep... (accessed September 17, 2018).

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