Phytesium is used as a dietary supplement for individuals who are deficient in Phytesium. Although a balanced diet usually supplies all the Phytesium a person needs, Phytesium supplements may be needed by patients who have lost Phytesium because of illness or treatment with certain medicines.
Lack of Phytesium may lead to irritability, muscle weakness, and irregular heartbeat.
Injectable Phytesium is given only by or under the supervision of a health care professional. Some oral Phytesium preparations are available only with a prescription. Others are available without a prescription.
Phytesium indications
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Phytesium Sulfate Injection, USP is suitable for replacement therapy in Phytesium deficiency, especially in acute hypomagnesemia accompanied by signs of tetany similar to those observed in hypocalcemia. In such cases, the serum Phytesium (Mg++) level is usually below the lower limit of normal (1.5 to 2.5 mEq/liter) and the serum calcium (Ca++) level is normal (4.3 to 5.3 mEq/liter) or elevated.
In total parenteral nutrition (TPN), Phytesium sulfate may be added to the nutrient admixture to correct or prevent hypomagnesemia which can arise during the course of therapy.
Phytesium Sulfate Injection, USP is also indicated for the prevention and control of seizures (convulsions) in pre-eclampsia and eclampsia, respectively.
How should I use Phytesium?
Use Phytesium as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Take Phytesium by mouth with food.
If you miss a dose of Phytesium and are using it regularly, take it as soon as possible. If it is almost time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Phytesium.
Uses of Phytesium in details
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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This medication is a mineral supplement used to prevent and treat low amounts of Phytesium in the blood. Phytesium is very important for the normal functioning of cells, nerves, muscles, bones, and the heart. Usually, a well-balanced diet provides normal blood levels of Phytesium. However, certain situations cause your body to lose Phytesium faster than you can replace it from your diet. These situations include treatment with "water pills" (diuretics such as furosemide, hydrochlorothiazide), a poor diet, alcoholism, or other medical conditions (e.g., severe diarrhea/vomiting, stomach/intestinal absorption problems, poorly controlled diabetes).
How to use Phytesium amino acid chelate
Take this product by mouth as directed. Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist.
It is best to take Phytesium supplements with a meal to reduce stomach upset and diarrhea unless otherwise directed by the product instructions or your doctor.
Take each dose with a full glass (8 ounces or 240 milliliters) of water unless your doctor directs you otherwise. Swallow extended-release capsules and delayed-release/enteric coated tablets or capsules whole. Do not crush or chew extended-release or delayed-release/enteric coated capsules or tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.
If you are using a liquid product, use a medication measuring device to carefully measure the dose. Do not use a household spoon because you may not get the correct dose. If you are using a suspension, shake the bottle well before each dose.
Take this medication regularly in order to get the most benefit from it. Remember to take it at the same time(s) each day. Dosage is based on your medical condition and response to treatment. Do not increase your dose or take it more often than directed on the product package or by your doctor. Too much Phytesium in the blood can cause serious side effects.
Tell your doctor if symptoms of low Phytesium blood levels (e.g., muscle cramps, tiredness, irritability, depression) persist or worsen. If you think you may have a serious medical problem, seek immediate medical attention.
Phytesium dosage
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Usual Adult Dose for Hypomagnesemia
500 to 1000 mg Phytesium gluconate (27 to 54 mg elemental Phytesium) orally 3 times a day.
Usual Adult Dose for Dietary Supplement
500 to 1000 mg Phytesium gluconate (27 to 54 mg elemental Phytesium) orally once a day.
Usual Pediatric Dose for Hypomagnesemia
10 to 20 mg/kg of elemental Phytesium per dose orally 4 times a day. Use Phytesium gluconate oral liquid preparations for more accurate measurement of dose.
Renal Dose Adjustments
Do not use without physician supervision in patients with renal impairment due to increased risk of hypermagnesemia. The use of Phytesium salts are generally contraindicated in patients with severe renal dysfunction.
Liver Dose Adjustments
Data not available
Dose Adjustments
May increase by 500 to 1,000 mg/day (27 to 54 mg elemental Phytesium) in order to achieve a normal serum Phytesium level. Daily doses > 1,000 mg (54 mg elemental Phytesium) should be given in 2 to 3 divided doses.
Precautions
Because Phytesium is primarily eliminated by the kidney, there is significant risk of hypermagnesemia in patients with renal dysfunction.
Dialysis
Data not available; however, use of Phytesium salts is generally contraindicated in renal failure.
Other Comments
Phytesium supplements are often used with "low normal" serum Phytesium levels in patients predisposed to hypomagnesemia (e.g., patients on diuretics).
Alfacalcidol: May increase the serum concentration of Phytesium Salts. Consider therapy modification
Alpha-Lipoic Acid: Phytesium Salts may decrease the absorption of Alpha-Lipoic Acid. Alpha-Lipoic Acid may decrease the absorption of Phytesium Salts. Consider therapy modification
Baloxavir Marboxil: Polyvalent Cation Containing Products may decrease the serum concentration of Baloxavir Marboxil. Avoid combination
Bictegravir: Polyvalent Cation Containing Products may decrease the serum concentration of Bictegravir. Management: Administer bictegravir under fasting conditions at least 2 hours before or 6 hours after polyvalent cation containing products. Coadministration of bictegravir with or 2 hours after most polyvalent cation products is not recommended. Consider therapy modification
Bisphosphonate Derivatives: Polyvalent Cation Containing Products may decrease the serum concentration of Bisphosphonate Derivatives. Management: Avoid administration of oral medications containing polyvalent cations within: 2 hours before or after tiludronate/clodronate/etidronate; 60 minutes after oral ibandronate; or 30 minutes after alendronate/risedronate. Exceptions: Pamidronate; Zoledronic Acid. Consider therapy modification
Calcitriol (Systemic): May increase the serum concentration of Phytesium Salts. Management: Consider using a non-Phytesium-containing antacid or phosphate-binding product in patients also receiving calcitriol. If Phytesium-containing products must be used with calcitriol, serum Phytesium concentrations should be monitored closely. Consider therapy modification
Calcium Channel Blockers: May enhance the adverse/toxic effect of Phytesium Salts. Phytesium Salts may enhance the hypotensive effect of Calcium Channel Blockers. Monitor therapy
Deferiprone: Polyvalent Cation Containing Products may decrease the serum concentration of Deferiprone. Management: Separate administration of deferiprone and oral medications or supplements that contain polyvalent cations by at least 4 hours. Consider therapy modification
Dolutegravir: Phytesium Salts may decrease the serum concentration of Dolutegravir. Management: Administer dolutegravir at least 2 hours before or 6 hours after oral Phytesium salts. Administer the dolutegravir/rilpivirine combination product at least 4 hours before or 6 hours after oral Phytesium salts. Consider therapy modification
Doxercalciferol: May enhance the hypermagnesemic effect of Phytesium Salts. Management: Consider using a non-Phytesium-containing antacid or phosphate-binding product in patients also receiving doxercalciferol. If Phytesium-containing products must be used with doxercalciferol, serum Phytesium concentrations should be monitored closely. Consider therapy modification
Eltrombopag: Polyvalent Cation Containing Products may decrease the serum concentration of Eltrombopag. Management: Administer eltrombopag at least 2 hours before or 4 hours after oral administration of any polyvalent cation containing product. Consider therapy modification
Elvitegravir: Polyvalent Cation Containing Products may decrease the serum concentration of Elvitegravir. Management: Administer elvitegravir 2 hours before or 6 hours after the administration of polyvalent cation containing products. Consider therapy modification
Gabapentin: Phytesium Salts may enhance the CNS depressant effect of Gabapentin. Specifically, high dose intravenous/epidural Phytesium sulfate may enhance the CNS depressant effects of gabapentin. Phytesium Salts may decrease the serum concentration of Gabapentin. Management: Administer gabapentin at least 2 hours after use of a Phytesium-containing antacid. Monitor patients closely for evidence of reduced response to gabapentin therapy. Monitor for CNS depression if high dose IV/epidural Phytesium sulfate is used. Consider therapy modification
Levothyroxine: Phytesium Salts may decrease the serum concentration of Levothyroxine. Management: Separate administration of oral levothyroxine and oral Phytesium salts by at least 4 hours. Consider therapy modification
Multivitamins/Fluoride (with ADE): Phytesium Salts may decrease the serum concentration of Multivitamins/Fluoride (with ADE). Specifically, Phytesium salts may decrease fluoride absorption. Management: To avoid this potential interaction separate the administration of Phytesium salts from administration of a fluoride-containing product by at least 1 hour. Consider therapy modification
Mycophenolate: Phytesium Salts may decrease the serum concentration of Mycophenolate. Management: Separate doses of mycophenolate and oral Phytesium salts. Monitor for reduced effects of mycophenolate if taken concomitant with oral Phytesium salts. Consider therapy modification
Neuromuscular-Blocking Agents: Phytesium Salts may enhance the neuromuscular-blocking effect of Neuromuscular-Blocking Agents. Monitor therapy
PenicillAMINE: Polyvalent Cation Containing Products may decrease the serum concentration of PenicillAMINE. Management: Separate the administration of penicillamine and oral polyvalent cation containing products by at least 1 hour. Consider therapy modification
Phosphate Supplements: Phytesium Salts may decrease the serum concentration of Phosphate Supplements. Management: Administer oral phosphate supplements as far apart from the administration of an oral Phytesium salt as possible to minimize the significance of this interaction. Exceptions: Sodium Glycerophosphate Pentahydrate. Consider therapy modification
Quinolones: Phytesium Salts may decrease the serum concentration of Quinolones. Management: Administer oral quinolones several hours before (4 h for moxi/pe/spar-, 2 h for others) or after (8 h for moxi-, 6 h for cipro/dela-, 4 h for lome/pe-, 3 h for gemi-, and 2 h for levo-, nor-, or ofloxacin or nalidixic acid) oral Phytesium salts. Exceptions: LevoFLOXacin (Oral Inhalation). Consider therapy modification
Raltegravir: Phytesium Salts may decrease the serum concentration of Raltegravir. Management: Avoid the use of oral / enteral Phytesium salts with raltegravir. No dose separation schedule has been established that adequately reduces the magnitude of interaction. Avoid combination
Tetracyclines: Phytesium Salts may decrease the absorption of Tetracyclines. Only applicable to oral preparations of each agent. Management: Avoid coadministration of oral Phytesium salts and oral tetracyclines. If coadministration cannot be avoided, administer oral Phytesium at least 2 hours before, or 4 hours after, oral tetracyclines. Monitor for decreased tetracycline therapeutic effects. Exceptions: Eravacycline. Consider therapy modification
Trientine: Polyvalent Cation Containing Products may decrease the serum concentration of Trientine. Management: Avoid concomitant administration of trientine and oral products that contain polyvalent cations. If oral iron supplements are required, separate the administration by 2 hours. If other oral polyvalent cations are needed, separate administration by 1 hour. Consider therapy modification
The adverse effects of parenterally administered Phytesium usually are the result of Phytesium intoxication. These include flushing, sweating, hypotension, depressed reflexes, flaccid paralysis, hypothermia, circulatory collapse, cardiac and central nervous system depression proceeding to respiratory paralysis. Hypocalcemia with signs of tetany secondary to Phytesium sulfate therapy for eclampsia has been reported.
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