Pipolphen Uses

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How do you administer this medicine?

What is Pipolphen?

Pipolphen is in a group of drugs called phenothiazines (FEEN-oh-THYE-a-zeens). It works by changing the actions of chemicals in your brain. Pipolphen also acts as an antihistamine. It blocks the effects of the naturally occurring chemical histamine in your body.

Pipolphen is used to treat allergy symptoms such as itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes.

Pipolphen also prevents motion sickness, and treats nausea and vomiting or pain after surgery. It is also used as a sedative or sleep aid.

Pipolphen is not for use in treating symptoms of asthma, pneumonia, or other lower respiratory tract infections.

Pipolphen may also be used for other purposes not listed in this medication guide.

Pipolphen indications

infoAn indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Oral

Allergic conditions

Adult: As Pipolphen HCl: 25 mg at night, increase to 25 mg bid if necessary. Alternatively, 10-20 mg 2-3 times daily.

Child: As Pipolphen HCl: 2-5 yr 5-15 mg daily in 1 or 2 divided doses; >5-10 yr 10-25 mg daily in 1 or 2 divided doses.

Oral

Short-term management of insomnia

Adult: As Pipolphen HCl: 20-50 mg at night.

Child: As Pipolphen HCl: 2-5 yr 15-20 mg; >5-10 yr 20-25 mg.

Oral

Nausea and vomiting

Adult: As Pipolphen teoclate: 25 mg at night, may increase to 50-75 mg at night or to 25 mg 2-3 times daily if necessary. Max: 100 mg daily.

Child: As Pipolphen teoclate: 5-10 yr 12.5-37.5 mg daily.

Oral

Prophylaxis of motion sickness

Adult: As Pipolphen HCl: 20 mg or 25 mg the night before travelling, followed by a similar dose the following morning if necessary. As Pipolphen teoclate: 25 mg given on the night or 1-2 hr before travelling.

Child: As Pipolphen HCl: 2-5 yr 5 mg; >5-10 yr 10 mg. Doses are given the night before the journey and repeated on the following morning (6-8 hr later) if necessary. As Pipolphen teoclate: 5-10 yr 12.5 mg given either on the night or 1-2 hr before travelling.

Oral

Motion sickness

Adult: As Pipolphen teoclate: 25 mg given as soon as possible and repeated in the evening, followed by a 3rd dose the next evening.

Child: As Pipolphen teoclate: 5-10 yr 12.5 mg given as soon as possible and repeated in the evening, followed by a 3rd dose the next evening.

Parenteral

Allergic conditions, Sedation

Adult: As Pipolphen HCl: 25-50 mg, by deep IM, IV inj or IV infusion at a rate of not more than 25 mg/min. Max: 100 mg.

Child: As Pipolphen HCl: 5-10 yr 6.25-12.5 mg by deep IM.

Parenteral

Nausea and vomiting

Adult: As Pipolphen HCl: 12.5-25 mg, repeated at intervals of not less than 4 hr. Max: 100 mg daily.

Rectal

Short-term management of insomnia

Adult: As Pipolphen HCl: 20-50 mg at night.

Child: As Pipolphen HCl: 2-5 yr 15-20 mg; >5-10 yr 20-25 mg.

Rectal

Allergic conditions

Adult: As Pipolphen HCl: 25 mg at night, increase to 25 mg bid if necessary. Alternatively, 10-20 mg 2-3 times daily.

Child: As Pipolphen HCl: 2-5 yr 5-15 mg daily in 1 or 2 divided doses; >5-10 yr 10-25 mg daily in 1 or 2 divided doses.

Rectal

Prophylaxis of motion sickness

Adult: As Pipolphen HCl: 20 or 25 mg the night before travelling, followed by a similar dose the following morning if necessary.

Child: As Pipolphen HCl: 2-5 yr 5 mg; >5-10 yr 10 mg. Doses are given the night before the journey and repeated on the following morning (6-8 hr later) if necessary.

How should I use Pipolphen?

Use Pipolphen as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Pipolphen is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Pipolphen at home, a health care provider will teach you how to use it. Be sure you understand how to use Pipolphen. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Pipolphen should be given as an injection into a muscle or a vein. Do not inject Pipolphen into an artery or under the skin.
  • Do not use Pipolphen if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you are using Pipolphen for motion sickness, take a dose at least 30 to 60 minutes before you begin traveling.
  • If you miss a dose of Pipolphen and you are using it regularly, use it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Pipolphen.

Uses of Pipolphen in details

infoThere are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Pipolphen is used to prevent and treat nausea and vomiting related to certain conditions (such as before/after surgery, motion sickness). It is also used with other medication to treat severe allergic reactions (anaphylaxis) and reactions to blood products. It may also be used to treat milder allergic reactions when you cannot take Pipolphen by mouth. It may also be used to help you feel sleepy/relaxed before and after surgery, during other procedures, or during labor and delivery. It may also be used to help certain narcotic pain relievers (such as meperidine) work better.

Pipolphen is an antihistamine and works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Its other effects (such as anti-nausea, calming, pain relief) may work by affecting other natural substances (such as acetylcholine) and by acting directly on certain parts of the brain.

This drug is not approved for use in children younger than 2 years due to an increased risk of side effects (such as slow/shallow breathing). See also Warning section.

How to use Pipolphen injection

It is best to inject this medication deep into a muscle. It may also be given by injection slowly into a large vein by a health care professional. Do not inject this medication under the skin or into an artery. For nausea and vomiting, use this medication as directed by your doctor, usually every 4 hours as needed. If you have any questions about the proper use of this medication, ask your doctor or pharmacist.

If you are using this medication at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.

The dosage and how often you receive this medication are based on your age, medical condition, and response to treatment. In children, the dosage may also be based on weight. Do not increase your dose or use this medication more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.

Tell your doctor if you do not get better or if you get worse.

Pipolphen description

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A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Pipolphen&

Pipolphen dosage

Oral

Allergic conditions

Adult: As Pipolphen HCl: 25 mg at night, increase to 25 mg bid if necessary. Alternatively, 10-20 mg 2-3 times daily.

Child: As Pipolphen HCl: 2-5 yr 5-15 mg daily in 1 or 2 divided doses; >5-10 yr 10-25 mg daily in 1 or 2 divided doses.

Oral

Nausea and vomiting

Adult: As Pipolphen teoclate: 25 mg at night, may increase to 50-75 mg at night or to 25 mg 2-3 times daily if necessary. Max: 100 mg daily.

Child: 5-10 yr 12.5-37.5 mg daily.

Oral

Prophylaxis of motion sickness

Adult: As Pipolphen HCl: 20 mg or 25 mg the night before travelling, followed by a similar dose the following morning if necessary. As Pipolphen teoclate: 25 mg given on the night or 1-2 hr before travelling.

Child: As Pipolphen HCl: 2-5 yr 5 mg; >5-10 yr 10 mg. Doses are given the night before the journey and repeated on the following morning (6-8 hr later) if necessary. As Pipolphen teoclate: 5-10 yr 12.5 mg given either on the night or 1-2 hr before travelling.

Oral

Short-term management of insomnia

Adult: As Pipolphen HCl: 20-50 mg at night.

Child: As Pipolphen HCl: 2-5 yr 15-20 mg; >5-10 yr 20-25 mg.

Oral

Motion sickness

Adult: As Pipolphen teoclate: 25 mg given as soon as possible and repeated in the evening, followed by a 3rd dose the next evening.

Child: As Pipolphen teoclate: 5-10 yr 12.5 mg given as soon as possible and repeated in the evening, followed by a 3rd dose the next evening.

Incompatibility: Y-site: Aldesleukin, allopurinol, amphotericin B cholesteryl sulfate complex, cefepime, cefotetan, doxorubicin liposome, foscarnet, furosemide, methotrexate, piperacillin/tazobactam. Syringe: Cefotetan, ceftriaxone, dexamethasone Na phosphate, dimenhydrinate, heparin, iodipamide meglumine 52%, iothalamate meglumine 60%, iothalamate Na 80%, ketorolac, pentobarbital, thiopental.

Parenteral

Allergic conditions; Sedation

Adult: As Pipolphen HCl: 25-50 mg, by deep IM, IV inj or IV infusion at a rate of not more than 25 mg/min. Max: 100 mg.

Child: As Pipolphen HCl: 5-10 yr 6.25-12.5 mg by deep IM.

Incompatibility: Y-site: Aldesleukin, allopurinol, amphotericin B cholesteryl sulfate complex, cefepime, cefotetan, doxorubicin liposome, foscarnet, furosemide, methotrexate, piperacillin/tazobactam. Syringe: Cefotetan, ceftriaxone, dexamethasone Na phosphate, dimenhydrinate, heparin, iodipamide meglumine 52%, iothalamate meglumine 60%, iothalamate Na 80%, ketorolac, pentobarbital, thiopental.

Parenteral

Nausea and vomiting

Adult: As Pipolphen HCl: 12.5-25 mg, repeated at intervals of not less than 4 hr. Max: 100 mg daily.

Incompatibility: Y-site: Aldesleukin, allopurinol, amphotericin B cholesteryl sulfate complex, cefepime, cefotetan, doxorubicin liposome, foscarnet, furosemide, methotrexate, piperacillin/tazobactam. Syringe: Cefotetan, ceftriaxone, dexamethasone Na phosphate, dimenhydrinate, heparin, iodipamide meglumine 52%, iothalamate meglumine 60%, iothalamate Na 80%, ketorolac, pentobarbital, thiopental.

Rectal

Allergic conditions

Adult: As Pipolphen HCl: 25 mg at night, increase to 25 mg bid if necessary. Alternatively, 10-20 mg 2-3 times daily.

Child: As Pipolphen HCl: 2-5 yr 5-15 mg daily in 1 or 2 divided doses; >5-10 yr 10-25 mg daily in 1 or 2 divided doses.

Rectal

Short-term management of insomnia

Adult: As Pipolphen HCl: 20-50 mg at night.

Child: As Pipolphen HCl: 2-5 yr 15-20 mg; >5-10 yr 20-25 mg.

Rectal

Prophylaxis of motion sickness

Adult: As Pipolphen HCl: 20 or 25 mg the night before travelling, followed by a similar dose the following morning if necessary.

Child: As Pipolphen HCl: 2-5 yr 5 mg; >5-10 yr 10 mg. Doses are given the night before the journey and repeated on the following morning (6-8 hr later) if necessary.

Pipolphen interactions

See also:
What other drugs will affect Pipolphen?

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CNS Depressants – Pipolphen (Pipolphen HCl) Suppositories may increase, prolong, or intensify the sedative action of other central-nervous-system depressants, such as alcohol, sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers; therefore, such agents should be avoided or administered in reduced dosage to patients receiving Pipolphen HCl. When given concomitantly with Pipolphen (Pipolphen HCl) Suppositories, the dose of barbiturates should be reduced by at least one-half, and the dose of narcotics should be reduced by one-quarter to one-half. Dosage must be individualized. Excessive amounts of Pipolphen HCl relative to a narcotic may lead to restlessness and motor hyperactivity in the patient with pain; these symptoms usually disappear with adequate control of the pain.

Epinephrine – Because of the potential for Pipolphen HCl to reverse epinephrine's vasopressor effect, epinephrine should NOT be used to treat hypotension associated with Pipolphen HCl Suppositories overdose.

Anticholinergics – Concomitant use of other agents with anticholinergic properties should be undertaken with caution.

Monoamine Oxidase Inhibitors (MAOI) – Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly. This possibility should be considered with Pipolphen (Pipolphen HCl) Suppositories.

Drug/Laboratory Test Interactions

The following laboratory tests may be affected in patients who are receiving therapy with Pipolphen HCl:

Pregnancy Tests

Diagnostic pregnancy tests based on immunological reactions between HCG and anti-HCG may result in false-negative or false-positive interpretations.

Glucose Tolerance Test

An increase in blood glucose has been reported in patients receiving Pipolphen HCl.

Pipolphen side effects

See also:
What are the possible side effects of Pipolphen?

Respiratory Depression

Pipolphen is contraindicated in pediatric patients less than 2 years of age, because of the potential for fatal respiratory depression. Pipolphen should be used with caution in pediatric patients 2 years of age and older.

Severe Tissue Injury, Including Gangrene

Pipolphen can cause severe chemical irritation and damage to tissues regardless of the route of administration. Irritation and damage can result from perivascular extravasation, unintentional intra-arterial injection, and intraneuronal or perineuronal infiltration. Adverse reactions include burning, pain, erythema, swelling, sensory loss, palsies, paralysis, severe spasm of distal vessels, thrombophlebitis, venous thrombosis, phlebitis, abscesses, tissue necrosis, and gangrene. In some cases, surgical intervention, including fasciotomy, skin graft, and/or amputation have been required.

Central Nervous System

Drowsiness is the most prominent CNS effect of this drug. Sedation, somnolence, blurred vision, dizziness, confusion, disorientation, and extrapyramidal symptoms such as oculogyric crisis, torticollis, and tongue protrusion; lassitude, tinnitus, incoordination, fatigue, euphoria, nervousness, diplopia, insomnia, tremors, convulsive seizures, excitation, catatonic-like states, hysteria. Hallucinations have also been reported.

Cardiovascular

Increased or decreased blood pressure, tachycardia, bradycardia, faintness.

Dermatologic

Dermatitis, photosensitivity, urticaria.

Hematologic

Leukopenia, thrombocytopenia, thrombocytopenic purpura, agranulocytosis.

Gastrointestinal

Dry mouth, nausea, vomiting, jaundice.

Respiratory

Asthma, nasal stuffiness, respiratory depression (potentially fatal) and apnea (potentially fatal).

Other

Angioneurotic edema. Neuroleptic Malignant Syndrome (potentially fatal) has also been reported.

Paradoxical Reactions

Hyperexcitability and abnormal movements have been reported in patients following a single administration of Pipolphen. Consideration should be given to the discontinuation of Pipolphen and to the use of other drugs if these reactions occur. Respiratory depression, nightmares, delirium, and agitated behavior have also been reported in some of these patients.

Pipolphen contraindications

See also:
What is the most important information I should know about Pipolphen?

Pipolphen (Pipolphen HCl) Suppositories are contraindicated for use in pediatric patients less than two years of age.

Pipolphen (Pipolphen HCl) Suppositories are contraindicated in comatose states, and in individuals known to be hypersensitive or to have had an idiosyncratic reaction to Pipolphen or to other phenothiazines.

Antihistamines are contraindicated for use in the treatment of lower respiratory tract symptoms including asthma.

WARNINGS

WARNING:

Pipolphen (Pipolphen HCL SUPPOSITORIES SHOULD NOT BE USED IN PEDIATRIC PATIENTS LESS THAN 2 YEARS OF AGE BECAUSE OF THE POTENTIAL FOR FATAL RESPIRATORY DEPRESSION.

POSTMARKETING CASES OF RESPIRATORY DEPRESSION, INCLUDING FATALITIES, HAVE BEEN REPORTED WITH USE OF Pipolphen HCL SUPPOSITORIES IN PEDIATRIC PATIENTS LESS THAN 2 YEARS OF AGE. A WIDE RANGE OF WEIGHT- BASED DOSES OF Pipolphen HCL SUPPOSITORIES HAVE RESULTED IN RESPIRATORY DEPRESSION IN THESE PATIENTS.

CAUTION SHOULD BE EXERCISED WHEN ADMINISTERING Pipolphen HCL TO PEDIATRIC PATIENTS 2 YEARS OF AGE AND OLDER. IT IS RECOMMENDED THAT THE LOWEST EFFECTIVE DOSE OF Pipolphen HCL BE USED IN PEDIATRIC PATIENTS 2 YEARS OF AGE AND OLDER AND CONCOMITANT ADMINISTRATION OF OTHER DRUGS WITH RESPIRATORY DEPRESSANT EFFECTS BE AVOIDED.



Active ingredient matches for Pipolphen:

Promethazine in Georgia, Hungary, Lithuania, Russian Federation.

Promethazine Hcl

Promethazine hydrochloride in Hungary, Russia.


Unit description / dosage (Manufacturer)Price, USD
Dragee; Oral; Promethazine Hydrochloride 25 mg
Injectable; Injection; Promethazine Hydrochloride 25 mg / ml
Pipolphen 50 mg/2 mL x 100 tube

List of Pipolphen substitutes (brand and generic names):

Dragee; Oral; Promethazine Hydrochloride 25 mg
Injectable; Injection; Promethazine Hydrochloride 25 mg / ml
Injectable; Injection; Promethazine Hydrochloride 25 mg / ml
Syrup; Oral; Promethazine Hydrochloride 10 mg / 5 ml
PMZ 25MG INJECTION 1 vial / 2 ML injection each (Mankind Pharma Ltd)$ 0.12
PREMAGAN 10MG TABLET 1 strip / 10 tablets each (Shine Pharmaceuticals Ltd)$ 0.10
PREMAGAN 25MG TABLET 1 strip / 10 tablets each (Shine Pharmaceuticals Ltd)$ 0.33
PREMAGAN 5MG SYRUP 1 bottle / 60 ML syrup each (Shine Pharmaceuticals Ltd)$ 0.20
PREMAGAN INJECTION 1 vial / 2 ML injection each (Shine Pharmaceuticals Ltd)$ 0.08
Premagan 25mg Tablet (Shine Pharmaceuticals Ltd)$ 0.03
Premagan 5mg Syrup (Shine Pharmaceuticals Ltd)$ 0.20
Premagan 25mg Injection (Shine Pharmaceuticals Ltd)$ 0.04
5 mg x 5 mL x 60ml (Mandar)$ 0.27
25 mg x 2 mL x 1's (Mandar)$ 0.07
Primozyn 5mg x 5mL SYR / 60ml (Mandar)$ 0.27
Primozyn 25mg x 2mL AMP / 1 (Mandar)$ 0.07
PRIMOZYN 5MG SYRUP 1 bottle / 60 ML syrup each (Mandar)$ 0.48
PRIMOZYN syr 5 mg x 5 mL x 60ml (Mandar)$ 0.27
PRIMOZYN inj 25 mg x 2 mL x 2ml (Mandar)$ 0.07
Primozyn 5mg x 5mL SYR / 60ml (Mandar)$ 0.27
Primozyn 25mg x 2mL AMP / 1 (Mandar)$ 0.07
Primozyn 5mg Syrup (Mandar)$ 0.48
60ml (Mandar)$ 0.32
Primozyn-P Promethazine hydrochloride 2.5mg, Paracetamol 125 mg/5 mL. SYR / 60ml (Mandar)$ 0.32
PRIMOZYN-P syr 60ml (Mandar)$ 0.32
Primozyn-P Promethazine hydrochloride 2.5mg, paracetamol 125 mg/5 mL. SYR / 60ml (Mandar)$ 0.32
PRO BURN POWDER 1 box / 200 GM powder each (British Biologicals)$ 4.23
Procodyl 5 mg/5 mL x 100 mL
PROGENE 25MG TABLET 1 strip / 10 tablets each (Psycormedies)$ 0.17
Progene 25mg Tablet (Psycormedies)$ 0.02
Progene- 25 25mg TAB / 100$ 1.90

References

  1. PubChem. "promethazine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  2. DrugBank. "promethazine". http://www.drugbank.ca/drugs/DB01069 (accessed September 17, 2018).
  3. DTP/NCI. "promethazine: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Pipolphen are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Pipolphen. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported useful

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3 consumers reported age

Users%
1-51
33.3%
6-151
33.3%
< 11
33.3%


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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