The action of the drug on the human body is called Pharmacodynamics in Medical terminology. To produce its effect and to change the pathological process that is happening the body and to reduce the symptom or cure the disease, the medicine has to function in a specific way. The changes it does to the body at cellular level gives the desired result of treating a disease. Drugs act by stimulating or inhibiting a receptor or an enzyme or a protein most of the times. Medications are produced in such a way that the ingredients target the specific site and bring about chemical changes in the body that can stop or reverse the chemical reaction which is causing the disease.
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Pharmacology:Escitalopram (Placida PLUS) is a selective serotonin (5HT) re-uptake inhibitor used for the treatment of depression and panic disorder.
Mechanism of Action: The pharmacological and clinical effects of Escitalopram (Placida PLUS) are attributed to 5HT reuptake inhibition. It has low affinity for a number of receptors including 5HT1A, 5HT2, D1 and D2 receptors, α1, α2, β-adrenoreceptors, histamine, muscarinic, benzodiazepine and opioid receptors.
Pharmacokinetics:The absorption of Escitalopram (Placida PLUS) is almost completely independent of food intake. As with racemic citalopram, the absolute bioavailability of Escitalopram (Placida PLUS) is expected to be 80%. Following a single dose of Escitalopram (Placida PLUS) 20 mg, the mean Tmax was reported to be 5±1.5 hrs. Steady-state plasma levels are reached in about 1 week.
Escitalopram (Placida PLUS) is metabolised in the liver to the demethylated and didemethylated metabolites, both of these are pharmacologically active. Biotransformation of Escitalopram (Placida PLUS) to the demethylated metabolite is mediated primarily by CYP2C19 with some possible contribution by the enzymes CYP3A4 and CYP2D6. The plasma protein-binding is <80% for Escitalopram (Placida PLUS) and its main metabolites.
The elimination t½ after multiple dosing is about 30 hrs and the oral plasma clearance is about 0.6 L/min. Elimination of Escitalopram (Placida PLUS) and the major metabolites are assumed to occur both by the hepatic and the renal routes, with the major part of the dose excreted as metabolites in the urine.
The elimination of Escitalopram (Placida PLUS) is more slow in elderly patients as compared to younger patients. Systemic exposure (AUC) is about 50% higher in elderly compared to young healthy volunteers.
How should I take Escitalopram (Placida PLUS)?
Take Escitalopram (Placida PLUS) only as directed by your doctor to benefit your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.
Escitalopram (Placida PLUS) should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.
Escitalopram (Placida PLUS) may be taken with or without food. If your doctor tells you to take it at a specific time, follow your doctor's instructions.
If you are using the oral liquid, shake the bottle well before measuring each dose. Use a marked measuring spoon, oral syringe, or medicine cup to measure each dose. The average household teaspoon may not hold the right amount of liquid.
You may have to take Escitalopram (Placida PLUS) for a month or longer before you begin to feel better.
Dosing
The dose of Escitalopram (Placida PLUS) will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Escitalopram (Placida PLUS). If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
For oral dosage forms (solution or tablets):
For depression:
Adults and children 12 years of age and older—10 milligrams (mg) once a day, taken either in the morning or evening. Your doctor may adjust your dose as needed. However, the dose is usually not more than 20 mg per day.
Older adults—10 mg once a day, taken either in the morning or evening.
Children younger than 12 years of age—Use and dose must be determined by your doctor.
For generalized anxiety disorder:
Adults—At first, 10 milligrams (mg) once a day, taken either in the morning or evening. Your doctor may adjust your dose as needed. However, the dose is usually not more than 20 mg per day.
Older adults—10 mg once a day, taken either in the morning or evening.
Children—Use and dose must be determined by your doctor.
Missed Dose
If you miss a dose of Escitalopram (Placida PLUS), take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Escitalopram (Placida PLUS) administration
Administration of drug is important to know because the drug absorption and action varies depending on the route and time of administration of the drug. A medicine is prescribed before meals or after meals or along with meals. The specific timing of the drug intake about food is to increase its absorption and thus its efficacy. Few work well when taken in empty stomach and few medications need to be taken 1 or 2 hrs after the meal. A drug can be in the form of a tablet, a capsule which is the oral route of administration and the same can be in IV form which is used in specific cases. Other forms of drug administration can be a suppository in anal route or an inhalation route.
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Oral: Administer once daily (morning or evening), with or without food.
Escitalopram (Placida PLUS) pharmacology
Pharmacokinetics of a drug can be defined as what body does to the drug after it is taken. The therapeutic result of the medicine depends upon the Pharmacokinetics of the drug. It deals with the time taken for the drug to be absorbed, metabolized, the process and chemical reactions involved in metabolism and about the excretion of the drug. All these factors are essential to deciding on the efficacy of the drug. Based on these pharmacokinetic principles, the ingredients, the Pharmaceutical company decides dose and route of administration. The concentration of the drug at the site of action which is proportional to therapeutic result inside the body depends on various pharmacokinetic reactions that occur in the body.
Escitalopram (Placida PLUS) is one of a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs). It is used to treat the depression associated with mood disorders. It is also used on occassion in the treatment of body dysmorphic disorder and anxiety. The antidepressant, antiobsessive-compulsive, and antibulimic actions of Escitalopram (Placida PLUS) are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin. In vitro studies show that Escitalopram (Placida PLUS) is a potent and selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptake. Escitalopram (Placida PLUS) has no significant affinity for adrenergic (alpha1, alpha2, beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors; antagonism of such receptors has been hypothesized to be associated with various anticholinergic, sedative, and cardiovascular effects for other psychotropic drugs. The chronic administration of Escitalopram (Placida PLUS) was found to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. Escitalopram (Placida PLUS) does not inhibit monoamine oxidase.
Actions of Etizolam (Placida PLUS) in details
The action of the drug on the human body is called Pharmacodynamics in Medical terminology. To produce its effect and to change the pathological process that is happening the body and to reduce the symptom or cure the disease, the medicine has to function in a specific way. The changes it does to the body at cellular level gives the desired result of treating a disease. Drugs act by stimulating or inhibiting a receptor or an enzyme or a protein most of the times. Medications are produced in such a way that the ingredients target the specific site and bring about chemical changes in the body that can stop or reverse the chemical reaction which is causing the disease.
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Etizolam (Placida PLUS) belongs to a class of medication called benzodiazepines. It works by enhancing the action of a signaling chemical called gamma amino butyric acid (GABA), which helps to calm the brain. This, in turn, induces sleep and causes relaxation of muscles in the body.
References
NCIt. "Escitalopram: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
EPA DSStox. "Escitalopram: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).
EPA DSStox. "Etizolam: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Placida PLUS are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Placida PLUS. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.
User reports
3 consumers reported administration
When best can I take Placida PLUS, on an empty stomach, before or after food? ndrugs.com website users have also released a report stating that Placida PLUS should be taken After food. In any case, this may not be the right description on how you ought to take this Placida PLUS. Kindly visit your doctor for more medical advice in this regard. Click here to see other users view on when best the Placida PLUS can be taken.
Users
%
After food
2
66.7%
Empty stomach
1
33.3%
Consumer reviews
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