Platof Uses

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What is Platof?

Platof causes changes in your blood that help improve blood flow. This also helps your blood carry oxygen to your tissues and organs.

Platof is used to improve blood flow and reduce certain symptoms of a condition called intermittent claudication (IN-ter-MIT-ent KLOD-ih-KAY-tion). Platof is not a cure for this condition.

Platof may also be used for purposes not listed in this medication guide.

Platof indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Platof® (Platof Extended-release Tablets, USP) is indicated for the treatment of patients with intermittent claudication on the basis of chronic occlusive arterial disease of the limbs. Platof® can improve function and symptoms but is not intended to replace more definitive therapy, such as surgical bypass, or removal of arterial obstructions when treating peripheral vascular disease.

How should I use Platof?

Use Platof as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Platof.

Uses of Platof in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Use: Labeled Indications

Intermittent claudication: Treatment of intermittent claudication on the basis of chronic occlusive arterial disease of the limbs.

Limitations of use: May improve function and symptoms, but not intended to replace more definitive therapy. Note: The American College of Chest Physicians (ACCP) discourages the use of Platof for the treatment of intermittent claudication refractory to exercise therapy (and smoking cessation) (Guyatt, 2012).

Off Label Uses

Alcoholic hepatitis (severe)

Based on the American College of Gastroenterology for Alcoholic Liver Disease guideline, existing evidence does not support the use of Platof in the management of severe alcoholic hepatitis; however, certain patient subgroups, such as those with concomitant renal failure, may benefit. The American Association for the Study for Liver Disease Practice Guideline recommends that Platof be considered in patients with severe alcoholic hepatitis, especially if there are contraindications to steroid therapy.

Venous leg ulcers (with compression therapy)

Based on a meta-analysis of trials evaluating the treatment of venous leg ulcers with compression therapy, the use of Platof was shown to be safe and effective.

Platof description

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A methylxanthine derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing erythrocyte and leukocyte flexibility. It also inhibits platelet aggregation. Platof modulates immunologic activity by stimulating cytokine production.

Platof dosage

Platof Dosage

Generic name: Platof

Dosage form: extended release tablets

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

The usual dosage of Platof® (Platof Extended-release Tablets, USP) in extended-release tablet form is one tablet (400 mg) three times a day with meals.

While the effect of Platof® (Platof Extended-release Tablets, USP) may be seen within 2 to 4 weeks, it is recommended that treatment be continued for at least 8 weeks. Efficacy has been demonstrated in double-blind clinical studies of 6 months duration.

Digestive and central nervous system side effects are dose related. If patients develop these effects it is recommended that the dosage be lowered to one tablet twice a day (800 mg/day). If side effects persist at this lower dosage, the administration of Platof® (Platof Extended-release Tablets, USP) should be discontinued.

More about Platof (Platof)

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Platof interactions

See also:
What other drugs will affect Platof?

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Drug-Drug Interactions

Antacids: In patients with digestive side effects, antacids may be administered with Platof. In comparative bioavailability study, no interference with absorption of Platof by antacids was observed.

Antihypertensive agents: Platof (Platof) may potentiate the action of antihypertensive agents. Patients receiving these agents require blood pressure monitoring and possibly a dose reduction of the antihypertensive agents.

Anticoagulants: There have been reports of bleeding and/or prolonged prothrombin time in patients treated with Platof with and without anticoagulants, including vitamin K antagonists, or platelet aggregation inhibitors. Monitoring of anti-coagulant activity in these patients is recommended when Platof is introduced or the dose is changed.

Patients on warfarin should have more frequent monitoring of prothrombin time, while patients with other risk factors complicated by hemorrhage (e.g. recent surgery) should have periodic examinations for signs of bleeding, including hematocrit and haemoglobin.

Cimetidine: During concurrent use of cimetidine and Platof, cimetidine has been shown to significantly increase the steady-state plasma concentration of Platof, which may enhance the possibility of adverse effects.

Erythromycin: No data are available on the possible interaction of Platof and erythromycin. However concurrent administration of erythromycin and theomycin has resulted in significant elevation of serum theophylline levels with toxic reactions.

Hypoglycemic agents: The blood-sugar lowering effect of insulin or oral antidiabetic agents may be potentiated. In patients treated with hypoglycemic agents, a moderate adjustment in the dose of these agents may be required when Platof is prescribed. Therefore it is recommended that patients under medication for diabetes mellitus be carefully monitored

Sympathomimetics: Combined use with other xanthines or with sympathomimetics may cause excessive CNS stimulation.

Theophylline: Although causality has not been established, concurrent use of Platof with theophylline has resulted in elevated theophylline plasma levels, which may enhance the possibility of adverse effects.

Drug-Food Interactions

Interactions with food have not been established.

Drug-Herb Interactions

Interactions with herbal product have not been established.

Drug-Laboratory Interactions

Interactions with laboratory tests have not been established.

Drug-Lifestyle Interactions

Interactions with lifestyles have not been established.

Platof side effects

See also:
What are the possible side effects of Platof?

Clinical trials were conducted using either extended-release Platof tablets for up to 60 weeks or immediate-release Platof capsules for up to 24 weeks. Dosage ranges in the tablet studies were 400 mg bid to tid and in the capsule studies, 200–400 mg tid. The table summarizes the incidence (in percent) of adverse reactions considered drug related, as well as the numbers of patients who received extended-release Platof tablets, immediate-release Platof capsules, or the corresponding placebos. The incidence of adverse reactions was higher in the capsule studies (where dose related increases were seen in digestive and nervous system side effects) than in the tablet studies. Studies with the capsule include domestic experience, whereas studies with the extended-release tablets were conducted outside the U.S.

The table indicates that in the tablet studies few patients discontinued because of adverse effects.

INCIDENCE (%) OF SIDE EFFECTS
Extended-Release Tablets Immediate-Release Capsules
Commercially Available Used only for Controlled Clinical Trials
Platof Placebo Platof Placebo
(Numbers of Patients at Risk) (321) (128) (177) (138)
Discontinued for Side Effect 3.1 0 9.6 7.2
CARDIOVASCULAR SYSTEM
Angina/Chest Pain 0.3 - 1.1 2.2
Arrhythmia/Palpitation - - 1.7 0.7
Flushing - - 2.3 0.7
DIGESTIVE SYSTEM
Abdominal Discomfort - - 4.0 1.4
Belching/Flatus/Bloating 0.6 - 9.0 3.6
Diarrhea - - 3.4 2.9
Dyspepsia 2.8 4.7 9.6 2.9
Nausea 2.2 0.8 28.8 8.7
Vomiting 1.2 - 4.5 0.7
NERVOUS SYSTEM
Agitation/Nervousness - - 1.7 0.7
Dizziness 1.9 3.1 11.9 4.3
Drowsiness - - 1.1 5.8
Headache 1.2 1.6 6.2 5.8
Insomnia - - 2.3 2.2
Tremor 0.3 0.8 - -
Blurred Vision - - 2.3 1.4

Platof has been marketed in Europe and elsewhere since 1972. In addition to the above symptoms, the following have been reported spontaneously since marketing or occurred in other clinical trials with an incidence of less than 1%; the causal relationship was uncertain:

Cardiovascular - dyspnea, edema, hypotension.
Digestive - anorexia, cholecystitis, constipation, dry mouth/thirst.
Nervous - anxiety, confusion, depression, seizures, aseptic meningitis.
Respiratory - epistaxis, flu-like symptoms, laryngitis, nasal congestion.
Skin and Appendages - brittle fingernails, pruritus, rash, urticaria, angioedema.
Special Senses - blurred vision, conjunctivitis, earache, scotoma.
Miscellaneous - bad taste, excessive salivation, leukopenia, malaise, sore throat/swollen neck glands, weight change.

A few rare events have been reported spontaneously worldwide since marketing in 1972. Although they occurred under circumstances in which a causal relationship with Platof could not be established, they are listed to serve as information for physicians. Cardiovascular — angina, arrhythmia, tachycardia. Digestive — hepatitis, jaundice, cholestasis, increased liver enzymes; and Hemic and Lymphatic — decreased serum fibrinogen, pancytopenia, aplastic anemia, leukemia, purpura, thrombocytopenia. Immune system disorders — anaphylactic reaction, anaphylactoid reaction, anaphylactic shock.

Platof contraindications

See also:
What is the most important information I should know about Platof?

You should not use this medication if you are allergic to Platof, or if you are allergic to caffeine or theophylline (Elixophyllin, Theo-24, Theo-Dur, Slo-Bid, Theochron, Theolair, Uniphyl, and others).

You also should not use Platof if you are breast-feeding a baby, or if you have recently had any type of bleeding in your brain or the retina of your eye.

Before you take Platof, tell your doctor if you have angina (chest pain), a heart rhythm disorder, high blood pressure, a stomach or intestinal ulcer, kidney disease, or if you have recently had surgery.

Tell your doctor about all other medicines you use, especially warfarin (Coumadin, Jantoven), theophylline (Elixophyllin, Theo-24, Theo-Dur, Slo-Bid, Theochron, Theolair, Uniphyl, and others), or blood pressure medication.

Take Platof with food.

Stop taking this medication and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.



Active ingredient matches for Platof:

Pentoxifylline in Indonesia.


Unit description / dosage (Manufacturer)Price, USD
Platof 400 mg x 5 x 10's$ 20.21

List of Platof substitutes (brand and generic names):

Polfilin 100 mg/5 mL x 5 tube (Polpharma)
Polfilin retard 400 mg x 20 Tablet
Tablet; Oral; Fluindione 20 mg (Investi)
Previscan 20 mg x 30 Tablet (Investi)
Tablet; Oral; Pentoxifylline 400 mg (Hexal)
Injectable; Injection; Pentoxifylline 100 mg / ml (Temmler)
Tablet; Oral; Pentoxifylline 200 mg (Temmler)
Injectable; Injection; Pentoxifylline 300 mg / ml
Tablet, Retard; Oral; Pentoxifylline 600 mg
Tablet, Extended Release; Oral; Pentoxifylline 400 mg
Ratio-pentoxifylline tablet / extended-release 400 mg (Ratiopharm Inc Division Of Teva Canada Limited (Canada))
Rb Flex 400mg TAB / 10 (Torrent)$ 0.43
Rb Flex 20mg/mL INJ / 15ml (Torrent)$ 0.09
400 mg x 10's (Torrent)$ 0.43
20 mg x 1 mL x 15ml (Torrent)$ 0.09
RB FLEX tab 400 mg x 10's (Torrent)$ 0.43
RB FLEX inj 20 mg x 1 mL x 15ml (Torrent)$ 0.09
RB Flex 20mg/1ml Injection (Torrent)$ 0.01
RB Flex 400mg Tablet (Torrent)$ 0.04
Tablet; Oral; Citalopram Hydrobromide 20 mg (Unipharm)
Tablets; Oral; Citalopram Hydrobromide 20 mg (Unipharm)
Recital SR 400 mg x 100's (Unipharm)
Recital 20 mg/1 mL x 5 mL (Unipharm)
Recital 20 mg/1 mL x 10 mL (Unipharm)
Recital 20 mg/1 mL x 15 mL (Unipharm)
Injectable; Injection; Pentoxifylline (Amdipharm)
Injectable; Subcutaneous; Pentoxifylline (Amdipharm)
Tablet, Retard; Oral; Pentoxifylline 400 mg (Amdipharm)
Tablet, Retard; Oral; Pentoxifylline 600 mg (Amdipharm)
Reotal 300 mg/15 mL x 1 x 5's (Kalbe)$ 20.71
Reotal -SR 400 400 mg x 3 x 10's (Kalbe)$ 21.64

References

  1. DailyMed. "PENTOXIFYLLINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "pentoxifylline". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "pentoxifylline". http://www.drugbank.ca/drugs/DB00806 (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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