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Pospargin Uses |
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Pospargin is a blood vessel constrictor and smooth muscle agonist most commonly used to prevent or control excessive bleeding following childbirth and spontaneous or elective abortion. It also causes uterine contractions to aid in expulsion of retained products of conception after a missed abortion (miscarriage in which all or part of the fetus remains in the uterus) and to help deliver the placenta after childbirth
It is used to control the bleeding after the delivery.
A homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed)
Prophylaxis of postpartum haemorrhage
Adult: 200 mcg 3-4 times daily in the puerperium for 2-7 days.
Treatment and prophylaxis of postpartum and postabortal haemorrhage
Adult: 200 mcg. May repeat every 2-4 hr. Max: 5 doses.
Treatment and prophylaxis of postpartum and postabortal haemorrhage
Adult: As an emergency measure: 200 mcg by slow inj over at least 1 minute, may repeat every 2-4 hr, up to a max of 5 doses.
CYP 3A4 Inhibitors (e.g. Macrolide Antibiotics and Protease Inhibitors)
There have been rare reports of serious adverse events in connection with the coadministration of certain ergot alkaloid drugs (e.g. dihydroergotamine and ergotamine) and potent CYP 3A4 inhibitors, resulting in vasospasm leading to cerebral ischemia and/or ischemia of the extremities. Although there have been no reports of such interactions with methylergonovine alone, potent CYP 3A4 inhibitors should not be coadministered with methylergonovine. Examples of some of the more potent CYP 3A4 inhibitors include macrolide antibiotics (e.g., erythromycin, troleandomycin, clarithromycin), HIV protease or reverse transcriptase inhibitors (e.g., ritonavir, indinavir, nelfinavir, delavirdine) or azole antifungals (e.g., ketoconazole, itraconazole, voriconazole). Less potent CYP 3A4 inhibitors should be administered with caution. Less potent inhibitors include saquinavir, nefazodone, fluconazole, grapefruit juice, fluoxetine, fluvoxamine, zileuton, and clotrimazole. These lists are not exhaustive, and the prescriber should consider the effects on CYP 3A4 of other agents being considered for concomitant use with methylergonovine.
No pharmacokinetic interactions involving other cytochrome P450 isoenzymes are known.
Caution should be exercised when Methergine® (methylergonovine maleate) is used concurrently with other vasoconstrictors or ergot alkaloids.
HTN, nausea, vomiting, headache, hypotension, hallucination, diarrhea, chest pain/transient chest pain; tinnitus, diaphoresis, palpitation, dyspnea, thrombophlebitis, hematuria, leg cramp, nasal congestion, taste disturbance, allergic reaction, severe arrhythmia, cerebrovascular attack & disturbance, skin eruption, CV reactions.
Hypersensitivity to Pospargin, other ergot alkaloids. Pregnancy; 1st & 2nd stage of labor & before delivery of the anterior shoulder; severe HTN, preeclampsia, eclampsia, occlusive vascular disease; sepsis.
Methylergometrine in Indonesia, Myanmar.
Methylergometrine maleate in Indonesia.
Unit description / dosage (Manufacturer) | Price, USD |
Pospargin 0.125 mg x 10 x 10's | $ 5.46 |
Pospargin 0.2 mg/1 mL x 1 mL x 10's | $ 5.83 |
Pospargin 0.125 mg x 10 Blister x 10 Tablet | |
Pospargin 0.2 mg/1 mL x 5 tube | |
List of Pospargin substitutes (brand and generic names): | |
Partan M (Japan) | |
Satergin (India) | |
Satergin 0.2mg/mL INJ / 1ml (Tablets (India) Limited) | |
0.2 mg x 1 mL x 1ml (Tablets (India) Limited) | $ 0.25 |
Satergin 0.2 mg Injection (Tablets (India) Limited) | $ 0.25 |
SATERGIN inj 0.2 mg x 1 mL x 1ml (Tablets (India) Limited) | $ 0.25 |
Spasut (Indonesia) | |
Syntharmin (India) | |
Syntharmin 0.125 mcg Tablet (Iscon Lifesciences) | $ 0.06 |
Syntharmin 0.125mg TAB / 10 (Iscon Lifesciences) | $ 0.84 |
Syntharmin 0.25mg INJ / 1ml (Iscon Lifesciences) | $ 0.27 |
SYNTHARMIN tab 0.125 mcg x 10's (Iscon Lifesciences) | $ 0.84 |
SYNTHARMIN inj 0.25 mg x 1ml (Iscon Lifesciences) | $ 0.27 |
Urgotin (Bangladesh) | |
Usamema (Philippines) | |
Usamema 125 mcg x 100's (Icon) | $ 39.89 |
Utergin (India, Philippines) | |
Utergin 125 mcg x 100's (Ace (Svizera Healthcare) (Maneesh Pharmaceuticals Ltd)) | |
0.2 mg x 1 mL x 1's (Ace (Svizera Healthcare) (Maneesh Pharmaceuticals Ltd)) | $ 0.28 |
0.125 mg x 10's (Ace (Svizera Healthcare) (Maneesh Pharmaceuticals Ltd)) | $ 1.27 |
Utergin 0.125mg TAB / 10 (Ace (Svizera Healthcare) (Maneesh Pharmaceuticals Ltd)) | $ 1.27 |
Utergin 0.2mg/mL INJ / 1 (Ace (Svizera Healthcare) (Maneesh Pharmaceuticals Ltd)) | $ 0.28 |
Utergin / amp 0.2 mg/1 mL x 1 mL x 10's (Ace (Svizera Healthcare) (Maneesh Pharmaceuticals Ltd)) | $ 4.96 |
Utergin 0.125 mg Tablet (Ace (Svizera Healthcare) (Maneesh Pharmaceuticals Ltd)) | $ 0.06 |
Utergin 0.2 mg Injection (Ace (Svizera Healthcare) (Maneesh Pharmaceuticals Ltd)) | $ 0.28 |
UTERGIN 0.125 MG TABLET 1 strip / 10 tablets each (Ace (Svizera Healthcare) (Maneesh Pharmaceuticals Ltd)) | $ 1.35 |
UTERGIN 0.2 MG INJECTION 1 vial / 2 ML injection each (Ace (Svizera Healthcare) (Maneesh Pharmaceuticals Ltd)) | $ 0.44 |
UTERGIN 0.20 MG INJECTION 1 vial / 1 ML injection each (Ace (Svizera Healthcare) (Maneesh Pharmaceuticals Ltd)) | $ 0.25 |
UTERGIN inj 0.2 mg x 1 mL x 1ml (Ace (Svizera Healthcare) (Maneesh Pharmaceuticals Ltd)) | $ 0.28 |
UTERGIN tab 0.125 mg x 10's (Ace (Svizera Healthcare) (Maneesh Pharmaceuticals Ltd)) | $ 1.27 |
Utergin 0.125mg Tablet (Ace (Svizera Healthcare) (Maneesh Pharmaceuticals Ltd)) | $ 0.14 |
Utergin 0.20mg Injection (Ace (Svizera Healthcare) (Maneesh Pharmaceuticals Ltd)) | $ 0.25 |
Utergin 0.2mg Injection (Ace (Svizera Healthcare) (Maneesh Pharmaceuticals Ltd)) | $ 0.22 |
Uterjin (Turkey) | |
Uterowin (India) | |
Uterowin 0.125mg TAB / 10 (Bestochem Formulations (India) Ltd.) | $ 0.32 |
Uterowin 0.2mg/mL INJ / 1ml (Bestochem Formulations (India) Ltd.) | $ 0.08 |
0.2 mg x 1 mL x 1ml (Bestochem Formulations (India) Ltd.) | $ 0.08 |
0.125 mg x 10's (Bestochem Formulations (India) Ltd.) | $ 0.32 |
Uterowin 0.2 mg Injection (Bestochem Formulations (India) Ltd.) | $ 0.08 |
Uterowin 0.125 mg Tablet (Bestochem Formulations (India) Ltd.) | $ 0.03 |
UTEROWIN inj 0.2 mg x 1 mL x 1ml (Bestochem Formulations (India) Ltd.) | $ 0.08 |
UTEROWIN tab 0.125 mg x 10's (Bestochem Formulations (India) Ltd.) | $ 0.32 |
UTERYL | |
UTERYL TABLET 1 strip / 10 tablets each (Votary Laboratories I Ltd) | $ 0.91 |
UTERYL TABLET 1 strip / 15 tablets each (Votary Laboratories I Ltd) | $ 0.91 |
Utesel (Turkey) | |
WERGOMET | |
WERGOMET 0.125MG TABLET 1 strip / 10 tablets each (Wockhardt Ltd) | $ 0.86 |
See 412 substitutes for Pospargin |
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Information checked by Dr. Sachin Kumar, MD Pharmacology
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