Pospargin Uses

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Pospargin indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Pospargin is a blood vessel constrictor and smooth muscle agonist most commonly used to prevent or control excessive bleeding following childbirth and spontaneous or elective abortion. It also causes uterine contractions to aid in expulsion of retained products of conception after a missed abortion (miscarriage in which all or part of the fetus remains in the uterus) and to help deliver the placenta after childbirth

Uses of Pospargin in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

It is used to control the bleeding after the delivery.

Pospargin description

A homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed)

Pospargin dosage

Oral

Prophylaxis of postpartum haemorrhage

Adult: 200 mcg 3-4 times daily in the puerperium for 2-7 days.

Intramuscular

Treatment and prophylaxis of postpartum and postabortal haemorrhage

Adult: 200 mcg. May repeat every 2-4 hr. Max: 5 doses.

Intravenous

Treatment and prophylaxis of postpartum and postabortal haemorrhage

Adult: As an emergency measure: 200 mcg by slow inj over at least 1 minute, may repeat every 2-4 hr, up to a max of 5 doses.

Pospargin interactions

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CYP 3A4 Inhibitors (e.g. Macrolide Antibiotics and Protease Inhibitors)

There have been rare reports of serious adverse events in connection with the coadministration of certain ergot alkaloid drugs (e.g. dihydroergotamine and ergotamine) and potent CYP 3A4 inhibitors, resulting in vasospasm leading to cerebral ischemia and/or ischemia of the extremities. Although there have been no reports of such interactions with methylergonovine alone, potent CYP 3A4 inhibitors should not be coadministered with methylergonovine. Examples of some of the more potent CYP 3A4 inhibitors include macrolide antibiotics (e.g., erythromycin, troleandomycin, clarithromycin), HIV protease or reverse transcriptase inhibitors (e.g., ritonavir, indinavir, nelfinavir, delavirdine) or azole antifungals (e.g., ketoconazole, itraconazole, voriconazole). Less potent CYP 3A4 inhibitors should be administered with caution. Less potent inhibitors include saquinavir, nefazodone, fluconazole, grapefruit juice, fluoxetine, fluvoxamine, zileuton, and clotrimazole. These lists are not exhaustive, and the prescriber should consider the effects on CYP 3A4 of other agents being considered for concomitant use with methylergonovine.

No pharmacokinetic interactions involving other cytochrome P450 isoenzymes are known.

Caution should be exercised when Methergine® (methylergonovine maleate) is used concurrently with other vasoconstrictors or ergot alkaloids.

Pospargin side effects

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HTN, nausea, vomiting, headache, hypotension, hallucination, diarrhea, chest pain/transient chest pain; tinnitus, diaphoresis, palpitation, dyspnea, thrombophlebitis, hematuria, leg cramp, nasal congestion, taste disturbance, allergic reaction, severe arrhythmia, cerebrovascular attack & disturbance, skin eruption, CV reactions.

Pospargin contraindications

Hypersensitivity to Pospargin, other ergot alkaloids. Pregnancy; 1st & 2nd stage of labor & before delivery of the anterior shoulder; severe HTN, preeclampsia, eclampsia, occlusive vascular disease; sepsis.

Active ingredient matches for Pospargin:

Methylergometrine in Indonesia, Myanmar.

Methylergometrine maleate in Indonesia.


Unit description / dosage (Manufacturer)Price, USD
Pospargin 0.125 mg x 10 x 10's$ 5.46
Pospargin 0.2 mg/1 mL x 1 mL x 10's$ 5.83
Pospargin 0.125 mg x 10 Blister x 10 Tablet
Pospargin 0.2 mg/1 mL x 5 tube

List of Pospargin substitutes (brand and generic names):

Satergin 0.2mg/mL INJ / 1ml (Tablets (India) Limited)
0.2 mg x 1 mL x 1ml (Tablets (India) Limited)$ 0.25
Satergin 0.2 mg Injection (Tablets (India) Limited)$ 0.25
SATERGIN inj 0.2 mg x 1 mL x 1ml (Tablets (India) Limited)$ 0.25
Syntharmin 0.125 mcg Tablet (Iscon Lifesciences)$ 0.06
Syntharmin 0.125mg TAB / 10 (Iscon Lifesciences)$ 0.84
Syntharmin 0.25mg INJ / 1ml (Iscon Lifesciences)$ 0.27
SYNTHARMIN tab 0.125 mcg x 10's (Iscon Lifesciences)$ 0.84
SYNTHARMIN inj 0.25 mg x 1ml (Iscon Lifesciences)$ 0.27
Usamema 125 mcg x 100's (Icon)$ 39.89
Utergin 125 mcg x 100's (Ace (Svizera Healthcare) (Maneesh Pharmaceuticals Ltd))
0.2 mg x 1 mL x 1's (Ace (Svizera Healthcare) (Maneesh Pharmaceuticals Ltd))$ 0.28
0.125 mg x 10's (Ace (Svizera Healthcare) (Maneesh Pharmaceuticals Ltd))$ 1.27
Utergin 0.125mg TAB / 10 (Ace (Svizera Healthcare) (Maneesh Pharmaceuticals Ltd))$ 1.27
Utergin 0.2mg/mL INJ / 1 (Ace (Svizera Healthcare) (Maneesh Pharmaceuticals Ltd))$ 0.28
Utergin / amp 0.2 mg/1 mL x 1 mL x 10's (Ace (Svizera Healthcare) (Maneesh Pharmaceuticals Ltd))$ 4.96
Utergin 0.125 mg Tablet (Ace (Svizera Healthcare) (Maneesh Pharmaceuticals Ltd))$ 0.06
Utergin 0.2 mg Injection (Ace (Svizera Healthcare) (Maneesh Pharmaceuticals Ltd))$ 0.28
UTERGIN 0.125 MG TABLET 1 strip / 10 tablets each (Ace (Svizera Healthcare) (Maneesh Pharmaceuticals Ltd))$ 1.35
UTERGIN 0.2 MG INJECTION 1 vial / 2 ML injection each (Ace (Svizera Healthcare) (Maneesh Pharmaceuticals Ltd))$ 0.44
UTERGIN 0.20 MG INJECTION 1 vial / 1 ML injection each (Ace (Svizera Healthcare) (Maneesh Pharmaceuticals Ltd))$ 0.25
UTERGIN inj 0.2 mg x 1 mL x 1ml (Ace (Svizera Healthcare) (Maneesh Pharmaceuticals Ltd))$ 0.28
UTERGIN tab 0.125 mg x 10's (Ace (Svizera Healthcare) (Maneesh Pharmaceuticals Ltd))$ 1.27
Utergin 0.125mg Tablet (Ace (Svizera Healthcare) (Maneesh Pharmaceuticals Ltd))$ 0.14
Utergin 0.20mg Injection (Ace (Svizera Healthcare) (Maneesh Pharmaceuticals Ltd))$ 0.25
Utergin 0.2mg Injection (Ace (Svizera Healthcare) (Maneesh Pharmaceuticals Ltd))$ 0.22
Uterowin 0.125mg TAB / 10 (Bestochem Formulations (India) Ltd.)$ 0.32
Uterowin 0.2mg/mL INJ / 1ml (Bestochem Formulations (India) Ltd.)$ 0.08
0.2 mg x 1 mL x 1ml (Bestochem Formulations (India) Ltd.)$ 0.08
0.125 mg x 10's (Bestochem Formulations (India) Ltd.)$ 0.32
Uterowin 0.2 mg Injection (Bestochem Formulations (India) Ltd.)$ 0.08
Uterowin 0.125 mg Tablet (Bestochem Formulations (India) Ltd.)$ 0.03
UTEROWIN inj 0.2 mg x 1 mL x 1ml (Bestochem Formulations (India) Ltd.)$ 0.08
UTEROWIN tab 0.125 mg x 10's (Bestochem Formulations (India) Ltd.)$ 0.32
UTERYL TABLET 1 strip / 10 tablets each (Votary Laboratories I Ltd)$ 0.91
UTERYL TABLET 1 strip / 15 tablets each (Votary Laboratories I Ltd)$ 0.91
WERGOMET 0.125MG TABLET 1 strip / 10 tablets each (Wockhardt Ltd)$ 0.86

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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