Potassium Chloride Dosage

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Dosage of Potassium Chloride in details

The dose of a drug and dosage of the drug are two different terminologies. Dose is defined as the quantity or amount of medicine given by the doctor or taken by the patient at a given period. Dosage is the regimen prescribed by the doctor about how many days and how many times per day the drug is to be taken in specified dose by the patient. The dose is expressed in mg for tablets or gm, micro gm sometimes, ml for syrups or drops for kids syrups. The dose is not fixed for a drug for all conditions, and it changes according to the condition or a disease. It also changes on the age of the patient.
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Potassium Chloride Dosage

Applies to the following strength(s): 8 mEq; 10 mEq; 20 mEq; 40 mEq/15 mL; 20 mEq/15 mL; 2 mEq/mL; 1.5 mEq/mL; 10 mEq/100 mL; 10 mEq/50 mL; 20 mEq/100 mL; 30 mEq/100 mL; 20 mEq/50 mL; 40 mEq/100 mL; 500 mg; 25 mEq; 15 mEq; 30 mEq/15 mL; 6.7 mEq; 3 mEq/mL; 99 mg; 40 mEq/250 mL-NaCl 0.9%; 40 mEq/500 mL-NaCl 0.9%; 50 mEq/500 mL-LR; 20 mEq/250 mL-NaCl 0.9%; 4 mEq/10 mL-NaCl 0.9%; 2 mEq/5 mL-NaCl 0.9%; 3 mEq/7.5 mL-NaCl 0.9%; 595 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Hypokalemia

Parenteral

:

40 to 100 mEq Potassium Chloride for injection diluted in an appropriate amount and type of solution to be intravenously infused once at a rate not to exceed 10 to 40 mEq/hour.

Oral

:

40 to 100 mEq orally once a day given in equally divided doses using formulations which include normal-release tablets or capsules, extended-release tablets or capsules, dissolvable tablets, oral solution or powder for dissolution mixed with an appropriate volume of water or juice.

Usual Adult Dose for Prevention of Hypokalemia

Parenteral

:

10 to 40 mEq Potassium Chloride for injection diluted in an appropriate amount and type of solution to be intravenously infused once at a rate not to exceed 40 mEq/hour.

Oral

:

10 to 20 mEq orally once a day given in equally divided doses using formulations which include normal-release tablets or capsules, extended-release tablets or capsules, dissolvable tablets, oral solution or powder for dissolution mixed with an appropriate volume of water or juice.

Usual Pediatric Dose for Hypokalemia

Treatment of hypokalemia: Note: High variability exists in dosing/infusion rate recommendations; therapy should be guided by patient condition and specific institutional guidelines.

Infants and Children:

Oral: 2 to 5 mEq/kg/day in divided doses; not to exceed 1 to 2 mEq/kg as a single dose; if deficits are severe or ongoing losses are great, IV route should be considered preferred route of administration.

Intermittent IV infusion (must be diluted prior to administration): 0.5 to 1 mEq/kg/dose (maximum dose: 40 mEq) to infuse at 0.3 to 0.5 mEq/kg/hour (maximum dose/rate: 1 mEq/kg/hour); then repeated as needed based on frequently obtained lab values; severe depletion or ongoing losses may require more than 200% of normal daily limit needs.

Usual Pediatric Dose for Prevention of Hypokalemia

IV doses in children should be incorporated into the maintenance IV fluids. Intermittent IV potassium administration should be reserved for severe depletion situations. Continuous ECG monitoring should be used for intermittent doses greater than 0.5 mEq/kg/hour.

Normal daily requirements:

Oral or IV:

Infants: 2 to 6 mEq/kg/day

Children: 2 to 3 mEq/kg/day

Prevention of hypokalemia during diuretic therapy:

Infants and Children: 1 to 2 mEq/kg/day orally in 1 to 2 divided doses

Renal Dose Adjustments

CrCl less than 25 mL/min: Extreme caution is recommended because of the high risk of hyperkalemia. Chronic Potassium Chloride therapy is generally not required nor recommended for patients with renal dysfunction.

Liver Dose Adjustments

Data not available

Dose Adjustments

Initial dosages may be adjusted to specific patient needs based on steady state serum potassium concentrations.

Precautions

Potassium Chloride (KCl) is contraindicated in the presence of hyperkalemia; renal failure and conditions in which potassium retention is present, including the concomitant use of potassium-sparing diuretics (such as triamterene, amiloride, or spironolactone); oliguria or azotemia; anuria; crush syndrome; severe hemolytic reactions; adrenocortical insufficiency (untreated Addison's disease); adynamical episodica hereditaria; acute dehydration; heat cramps; and early postoperative oliguria except during gastrointestinal drainage.

Solid dosage forms of potassium supplements are contraindicated in any patient in whom there is cause for arrest or delay in tablet passage throughout the GI tract (including patients who are also taking drugs with anticholinergic properties). Wax matrix KCl preparations have produced esophageal ulceration in cardiac patients with esophageal compression due to an enlarged left atrium. If KCl is necessary for these patients, potassium supplementation as a liquid preparation is recommended.

Some KCl products contain tartrazine, and are contraindicated in patients with tartrazine sensitivity.

Patients should not use potassium-rich salt substitutes without the advice of their healthcare professional during KCl therapy.

In patients with renal insufficiency, use of Potassium Chloride may cause potassium intoxication and life-threatening hyperkalemia.

The administration of intravenous solutions can cause fluid and/or solute overload resulting in dilution of serum electrolyte concentrations, overhydration, pulmonary edema or congested states. The risk of dilutional states is inversely proportional to the electrolyte concentration. The risk of solute overload causing congested states with peripheral and pulmonary edema is directly proportional to the electrolyte concentration.

Serum potassium levels are not necessarily indicative of tissue potassium levels. Solutions containing potassium should be administered with caution in the presence of cardiac or renal disease.

Solid oral dosage forms of Potassium Chloride can produce ulcerative and/or stenotic lesions of the gastrointestinal tract. Potassium Chloride should be discontinued immediately and the possibility of ulceration, obstruction, or perforation should be considered if severe vomiting, abdominal pain, distention, or gastrointestinal bleeding occurs.

Clinical evaluation and periodic laboratory evaluations are necessary to monitor changes in fluid balance, electrolyte concentrations, and acid-base balance during prolonged parenteral therapy or whenever the condition of the patient warrants such evaluation. Significant deviations from normal concentrations may require the administration of additional electrolyte supplements, or the administration of electrolyte-free dextrose solutions to which individualized electrolyte supplements may be added.

Certain Potassium Chloride extended-release tablets contain a wax matrix. This matrix is not absorbed and is excreted in the feces. In some instances the empty matrices may be noticeable in the stool.

Dose selection in the elderly should be cautious and should start at the lower end of the dosing range.

Dialysis

Potassium is rarely, if ever, given to a patient who is on dialysis. Hypokalemia in this case may indicate an inappropriately low predialysis potassium concentration or resolution of an acidotic state which has resulted in a rapid shift of extracellular potassium to the intracellular compartment. Adjustment of the dialysate potassium concentration that will result in a postdialysis serum potassium concentration of 4 mEq/L (4.5 to 5 mEq/L if this patient also has a high digoxin concentration) based on the fractional dialyzer urea clearance (Kt/V) required is recommended.

Hypokalemia may be present during the early stages of dialysis-dependent renal failure because of excessive potassium losses during the early stages in the pathogenesis of renal failure and/or the continued use of a low dialysate potassium in the presence of potassium depletion during this period.

Chronic Potassium Chloride therapy is not recommended for this patient with dialysis-dependent renal insufficiency because of the high risk of hyperkalemia.

Other Comments

Patients who are extremely potassium-depleted may require higher total daily doses of Potassium Chloride to replenish body stores. If large doses are required, administer potassium in equally divided doses 2 to 3 times a day.

Oral Potassium Chloride formulations

:

Because of the high incidence of gastrointestinal irritation, administering Potassium Chloride with food and/or a full glass of water or similar beverage is recommended.

Potassium Chloride tablets or capsules should not be crushed or chewed.

Dissolvable Potassium Chloride tablets, powder or concentrated solutions may be mixed with 3 to 8 ounces of a suitable beverage.

Parenteral Potassium Chloride formulations

:

The maximum recommended concentration is 60 mEq potassium/L of intravenous fluid for infusion, although extreme emergencies may dictate greater concentrations. It is recommended that Potassium Chloride solutions be infused slowly (up to 20 mEq/hour) to avoid venous irritation and local pain. The rate of infusion will depend on the patient's clinical condition, the initial serum potassium concentration, the rate of change in the serum potassium concentration, peripheral or central intravenous port, and the patient's renal function. Monitoring the serum potassium concentration at appropriate intervals is recommended.

More about Potassium Chloride

Consumer resources

Professional resources

Related treatment guides

What other drugs will affect Potassium Chloride?

The following drugs can interact with Potassium Chloride. Tell your doctor about all other medicines you use, especially:

This list is not complete and there may be other drugs that can interact with Potassium Chloride. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Potassium Chloride interactions

Interactions are the effects that happen when the drug is taken along with the food or when taken with other medications. Suppose if you are taking a drug Potassium Chloride, it may have interactions with specific foods and specific medications. It will not interact with all foods and medications. The interactions vary from drug to drug. You need to be aware of interactions of the medicine you take. Most medications may interact with alcohol, tobacco, so be cautious.
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Aliskiren: Potassium Salts may enhance the hyperkalemic effect of Aliskiren. Monitor therapy

Angiotensin II Receptor Blockers: Potassium Salts may enhance the hyperkalemic effect of Angiotensin II Receptor Blockers. Monitor therapy

Angiotensin-Converting Enzyme Inhibitors: Potassium Salts may enhance the hyperkalemic effect of Angiotensin-Converting Enzyme Inhibitors. Monitor therapy

Anticholinergic Agents: May enhance the ulcerogenic effect of Potassium Chloride. Management: Patients on drugs with substantial anticholinergic effects should avoid using any solid oral dosage form of Potassium Chloride. Avoid combination

Drospirenone: Potassium Salts may enhance the hyperkalemic effect of Drospirenone. Monitor therapy

Eplerenone: May enhance the hyperkalemic effect of Potassium Salts. Management: This combination is contraindicated in patients receiving eplerenone for treatment of hypertension. Consider therapy modification

Glycopyrrolate (Systemic): May enhance the adverse/toxic effect of Potassium Chloride. This is specific to solid oral dosage forms of Potassium Chloride. Avoid combination

Heparin: May enhance the hyperkalemic effect of Potassium Salts. Monitor therapy

Heparins (Low Molecular Weight): May enhance the hyperkalemic effect of Potassium Salts. Monitor therapy

Nicorandil: May enhance the hyperkalemic effect of Potassium Salts. Monitor therapy

Potassium-Sparing Diuretics: Potassium Salts may enhance the hyperkalemic effect of Potassium-Sparing Diuretics. Management: Avoid coadministration of a potassium-sparing diuretic and a potassium salt. This combination should only be used in cases of significant hypokalemia, and only if serum potassium can be closely monitored. Consider therapy modification


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References

  1. DailyMed. "AMINO ACIDS; CALCIUM ACETATE; GLYCERIN; MAGNESIUM ACETATE; PHOSPHORIC ACID; POTASSIUM CHLORIDE; SODIUM ACETATE; SODIUM CHLORIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. FDA/SPL Indexing Data. "RWP5GA015D: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Potassium Chloride are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Potassium Chloride. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

7 consumers reported frequency of use

How frequently do I need to take Potassium Chloride?
It was reported by ndrugs.com website users that Potassium Chloride should ideally be taken Once in a day as the most common frequency of the Potassium Chloride. You should you adhere strictly to the instructions and guidelines provided by your doctor on how frequently this Potassium Chloride should be taken. Get another patient's view on how frequent the capsule should be used by clicking here.
Users%
Once in a day6
85.7%
Twice in a day1
14.3%


7 consumers reported doses

What doses of Potassium Chloride drug you have used?
The drug can be in various doses. Most anti-diabetic, anti-hypertensive drugs, pain killers, or antibiotics are in different low and high doses and prescribed by the doctors depending on the severity and demand of the condition suffered by the patient. In our reports, ndrugs.com website users used these doses of Potassium Chloride drug in following percentages. Very few drugs come in a fixed dose or a single dose. Common conditions, like fever, have almost the same doses, e.g., [acetaminophen, 500mg] of drug used by the patient, even though it is available in various doses.
Users%
11-50mg3
42.9%
51-100mg2
28.6%
101-200mg1
14.3%
6-10mg1
14.3%


Consumer reviews


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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