Pregnancy of Potassium Chloride in details
Potassium Chloride is a naturally-occurring molecule. If potassium replacement is necessary in a pregnant patient, close attention to the maternal serum potassium concentration is recommended due to the risk of maternal and fetal cardiac arrhythmias associated with abnormal serum potassium concentrations. Data from the Michigan Medicaid Birth Defects Study, in which 104,339 deliveries between 1980 and 1983 and 229,101 deliveries between 1985 to 1992 were retrospectively studied, reveal inconsistencies with respect to the association of Potassium Chloride and birth defects (written communication, Frank Rosa, MD, Food and Drug Administration, 1994). In these two studies, 116 and 166 women were exposed to Potassium Chloride during gestation, respectively. Of the 116 women from the 1980 to 1983 period, 14 defects were observed (7 were expected), 4 of which were cardiovascular abnormalities (1 was expected). Of the 166 women from the 1985 to 1992 period, 8 defects were observed (7 were expected), none of which were cardiovascular abnormalities. There were no cases of cleft palate from either period studied. While the older data seem to support an association between Potassium Chloride and birth defects, the latter data do not provide evidence of a statistically significant association. There are no data regarding the effects of Potassium Chloride on duration of labor, type of necessary delivery procedure, maternal and neonate responses, and consequent child development when administered intravenously during labor and delivery. Close monitoring of both maternal and neonatal fluid balance, glucose and electrolyte concentrations, and acid-base balance is recommended when administering Potassium Chloride intravenously during labor and delivery.
Potassium Chloride has been assigned to pregnancy category C by the FDA. Animal studies have failed to reveal evidence of teratogenicity. There are no controlled data in human pregnancy. Some experts consider potassium replacement to be relatively safe for pregnant women when indicated. Potassium Chloride should only be given during pregnancy when benefit outweighs risk.
See references
Potassium Chloride breastfeeding
Human milk is naturally low in potassium, averaging approximately 13 mEq/L. There are no reports of adverse effects associated with potassium salts in the nursing infant, and they are considered unlikely as long as the maternal serum potassium level is not excessive. One manufacturer recommends caution when administering intravenous Potassium Chloride solutions to a nursing female.
See references
References for pregnancy information
- Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):
- "Product Information. K-Dur (Potassium Chloride)." Schering Laboratories, Kenilworth, NJ.
References for breastfeeding information
- Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):
- "Product Information. K-Dur (Potassium Chloride)." Schering Laboratories, Kenilworth, NJ.
References
- DailyMed. "AMINO ACIDS; CALCIUM ACETATE; GLYCERIN; MAGNESIUM ACETATE; PHOSPHORIC ACID; POTASSIUM CHLORIDE; SODIUM ACETATE; SODIUM CHLORIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubMed Health. "Potassium Chloride (By mouth): This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
- FAO/WHO Food Additive Evaluation. "POTASSIUM CHLORIDE". http://apps.who.int/food-additives-c... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
