Pralexin Uses

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Pralexin indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Treatment of the following infections when caused by susceptible strains of the designated microorganisms: Respiratory tract infections caused by Streptococcus pneumoniae and Streptococcus pyogenes Otitis media due to Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, and Moraxella catarrhalis.

Skin and skin structure infections caused by Staphylococcus aureus and/or Streptococcus pyogenes.

Bone infections caused by Staphylococcus aureus and/or Proteus mirabilis and joint infections.

Genitourinary tract infections, including acute prostatitis, caused by Escherichia coli, Proteus mirabilis and Klebsiella pneumoniae.

Dental Infections: Culture and susceptibility tests should be initiated prior to and during therapy. Renal function studies should be performed when indicated. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Pralexin and other antibacterial drugs, Pralexin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Uses of Pralexin in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Cephalexin is used to treat bacterial infections including upper respiratory infections, ear infections, skin infections, and urinary tract infections.

Pralexin description

Each film-coated tablet contains Cefalexin monohydrate BP equivalent to anhydrous Pralexin 375- and 750 mg, respectively.

It also contains the following excipients: Hyproellose, hydroxypropyl cellulose, microcrystalline cellulose, magnesium stearate, purified talc, colloidal anhydrous silica, opadry and macrogol 400.

Pralexin is an extended release oral formulation of Pralexin designed to be effective on twice daily dosing. Pralexin is a semisynthetic cephalosporin antibiotic. It is 7-(D-α-Amino-α-phenylacetamido)-3-methyl-3-cephem-4-carboxylic acid monohydrate. Pralexin has themolecular formula C16H17N3O4SH2O and the molecular weight is 365.41.

The nucleus of Pralexin is related to that of other cephalosporin antibiotics. The compound is a zwitterion; ie, the molecule contains both a basic and an acidic group. The isoelectric point of Pralexin in water is approximately 4.5-5. The crystalline form of Pralexin which is available is a monohydrate. It is a white crystalline solid having a bitter taste. Solubility in water is low at room temperature; 1 or 2 mg/mL may be dissolved readily, but higher concentrations are obtained with increasing difficulty. The cephalosporins differ from penicillins in the structure of the bicyclic ring system. Pralexin has a D-phenylglycyl group as substituent at the 7-amino position and an unsubstituted methyl group at the 3- position.

Pralexin dosage


Pralexin suspension or capsule is administered orally. The adult dosage ranges from 1-6 g daily in divided doses.

Adults: Usual Dose: 1-2 g daily given in divided doses at 6-, 8- or 12-hourly intervals.

For streptococcal pharyngitis or tonsillitis, mild, uncomplicated urinary tract infections and skin and soft tissue infections, 500 mg may be administered every 12 hrs.

For more severe infections or those caused by less susceptible organisms, larger doses may be needed.

If daily doses of Pralexin require >4 g, parenteral cephalosporins in appropriate doses should be prescribed.

Suspension: Children: Usual Dose: 25-50 mg/kg body weight in divided doses (to be taken every 6 hrs).

125-mg/5 mL Suspension: Children 40 kg body weight: 2-4 tsp; 20 kg: 1-2 tsp; 10 kg: ½-1 tsp.

250-mg/5 mL Suspension: Children 40 kg body weight: 1-2 tsp; 20 kg: ½-1 tsp; 10 kg: ¼-½ tsp.

For streptococcal pharyngitis in children >1 year, mild, uncomplicated urinary tract infections and skin and soft tissue infections, the total daily dose may be divided, administered and taken every 12 hrs.

125-mg/5 mL Suspension: Children 40 kg body weight: 4-8 tsp; 20 kg: 2-4 tsp; 10 kg: 1-2 tsp.

250-mg/5 mL Suspension: Children 40 kg body weight: 2-4 tsp; 20 kg: 1-2 tsp; 10 kg: ½-1 tsp.

(5 mL is equivalent to 1 tsp.)

Shake the suspension well before use.

In severe infections, the dosage may be doubled.

In the therapy of otitis media, 75-100 mg/kg/day in 4 divided doses is needed.

In the treatment of β-hemolytic streptococcal infections, the therapeutic dosage of Pralexin should be administered for a minimum of 10 days.

Note: Pralexin may be taken on a full or empty stomach. Compliance with the full course of therapy especially in streptococcal infections is highly recommended.

Pralexin interactions


Bacteriostatic Antibiotics: As cephalosporins like Pralexin are only active against proliferating microorganisms, Pralexin should not be combined with bacteriostatic antibiotics.

Uricosuric Drugs: Concomitant use of uricosuric drugs (eg, probenecid) suppresses renal drug elimination. As a result, Pralexin plasma levels are increased and sustained for longer periods.

Metformin: A potential interaction between Pralexin and metformin may result in an accumulation of metformin and could result in fatal lactic acidosis.

Increased Risk of Nephrotoxicity: If associated with highly potent diuretics (ethacrynic acid, furosemide) or other potentially nephrotoxic antibiotics (aminoglycosides, polymyxin, colistin), cephalosporins may show higher nephrotoxicity.

Oral Anticoagulants:

Combined use of cephalosporins and oral anticoagulants may prolong prothrombin time.

Typhoid Vaccine: Pralexin, like other antibiotics with antibacterial activity against Salmonella typhi organisms, may interfere with the immunological response to the live typhoid vaccine. The appropriate period of time should elapse between the administration of the last dose of the antibiotic and the live typhoid vaccine.

Oral Contraceptives:

Pralexin may reduce the effects of oral contraceptives.

Incompatibilities: No incompatibilities have been reported.

Pralexin side effects

Adverse effects of Pralexin include gastrointestinal disturbances eg, nausea, vomiting, diarrhea and abdominal discomfort. The most common of these effects is diarrhea, but this is rarely severe enough to warrant cessation of therapy. Transient hepatitis and cholestatic jaundice have rarely been reported.

Allergic reactions have been reported eg, rash, urticaria, angioedema and rarely erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis (exanthematic necrolysis).

Other adverse effects eg, genital and anal pruritus, genital candidiasis, vaginitis and vaginal discharge, dizziness, fatigue, headache, agitation, confusion, hallucinations, arthralgia, arthritis and joint disorders have been reported.

As with other cephalosporins, interstitial nephritis has rarely been reported.

Eosinophilia, neutropenia, thrombocytopenia and slight elevations in aspartate aminotransferase and alanine aminotransferase have been reported.

As with other broad-spectrum antibiotics prolonged use may result in the overgrowth of non-susceptible organisms eg, candida. This may present a vulvo-vaginitis.

There is a possibility of development of pseudomembranous colitis and it is therefore important to consider its diagnosis in patients who develop diarrhea while taking Pralexin. It may range in severity from mild to life-threatening with mild case usually responding to cessation of therapy. Appropriate measures should be taken with moderate to severe cases.

Pralexin contraindications

Pralexin is contraindicated in patients with a known history of hypersensitivity to local anesthetics of the amide type.

Active ingredient matches for Pralexin:

Cefalexin in Indonesia.

List of Pralexin substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
pms-Opxil 500 mg x 1 Bottle 200 Tablet
Pranceph 250mg TAB / 10 (Pranshu)
Pranceph 500mg CAP / 10 (Pranshu)
Pranceph 125mg DRY-SYR / 30ml (Pranshu)
PRANCEPH tab 250 mg x 10's (Pranshu)
PRANCEPH cap 500 mg x 10's (Pranshu)
PRANCEPH dry syr 125 mg x 30ml (Pranshu)
Pranceph Kid 125mg TAB / 10 (Pranshu)
PRANCEPH KID tab 125 mg x 10's (Pranshu)
Premspor 250mg CAP / 4 (Wockhardt (Merind))$ 0.28
Premspor 125mg x 5mL DRY-SYR / 40ml (Wockhardt (Merind))$ 0.36
250 mg x 4's (Wockhardt (Merind))$ 0.28
125 mg x 5 mL x 40ml (Wockhardt (Merind))$ 0.36
PREMSPOR cap 250 mg x 4's (Wockhardt (Merind))$ 0.28
PREMSPOR dry syr 125 mg x 5 mL x 40ml (Wockhardt (Merind))$ 0.36
Q Cef 500 mg x 5 x 6's (Que Pharma Pvt.Ltd)$ 29.76
Q Cef 125 mg/5 mL x 60 mL x 1's (Que Pharma Pvt.Ltd)$ 4.22
Q Cef 250 mg Tablet (Que Pharma Pvt.Ltd)$ 0.07
Q CEF 250MG CAPSULE 1 strip / 10 capsules each (Que Pharma Pvt.Ltd)$ 0.76
Q CEF 250MG TABLET 1 strip / 10 tablets each (Que Pharma Pvt.Ltd)$ 0.88
Q CEF 500MG CAPSULE 1 strip / 10 capsules each (Que Pharma Pvt.Ltd)$ 1.89
Q Cef 250mg Tablet (Que Pharma Pvt.Ltd)$ 0.09
Q Cef 500mg Capsule (Que Pharma Pvt.Ltd)$ 0.19
QUICEF 125MG SYRUP 1 bottle / 60 ML syrup each (Hind Pharma)$ 1.09
QUICEF 250MG CAPSULE 1 strip / 10 capsules each (Hind Pharma)$ 1.22
QUICEF 500MG CAPSULE 1 strip / 10 capsules each (Hind Pharma)$ 2.31
Quicef 250mg Capsule (Hind Pharma)$ 0.12
Quicef 500mg Capsule (Hind Pharma)$ 0.23
Capsule; Oral; Cephalexin Monohydrate 500 mg (Quimica y farmacia)
Capsule; Oral; Cephalexin 250 mg (Ranbaxy)
Capsule; Oral; Cephalexin 500 mg (Ranbaxy)
Refexin 500 mg x 120's, 320's, 500's, 1000's
250 mg x 100's (Radicura)$ 10.71
500 mg x 100's (Radicura)$ 19.92
125 mg x 5 mL x 30ml (Radicura)$ 0.49
Reflexin 250mg CAP / 100 (Radicura)$ 10.71
Reflexin 500mg CAP / 100 (Radicura)$ 19.92
Reflexin 125mg/5mL D-SYR / 30ml (Radicura)$ 0.49


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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