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Dosage of Pralexin in details
The dose of a drug and dosage of the drug are two different terminologies. Dose is defined as the quantity or amount of medicine given by the doctor or taken by the patient at a given period. Dosage is the regimen prescribed by the doctor about how many days and how many times per day the drug is to be taken in specified dose by the patient. The dose is expressed in mg for tablets or gm, micro gm sometimes, ml for syrups or drops for kids syrups. The dose is not fixed for a drug for all conditions, and it changes according to the condition or a disease. It also changes on the age of the patient.
Pralexin suspension or capsule is administered orally. The adult dosage ranges from 1-6 g daily in divided doses.
Adults: Usual Dose: 1-2 g daily given in divided doses at 6-, 8- or 12-hourly intervals.
For streptococcal pharyngitis or tonsillitis, mild, uncomplicated urinary tract infections and skin and soft tissue infections, 500 mg may be administered every 12 hrs.
For more severe infections or those caused by less susceptible organisms, larger doses may be needed.
If daily doses of Pralexin require >4 g, parenteral cephalosporins in appropriate doses should be prescribed.
Suspension: Children: Usual Dose: 25-50 mg/kg body weight in divided doses (to be taken every 6 hrs).
125-mg/5 mL Suspension: Children 40 kg body weight: 2-4 tsp; 20 kg: 1-2 tsp; 10 kg: ½-1 tsp.
250-mg/5 mL Suspension: Children 40 kg body weight: 1-2 tsp; 20 kg: ½-1 tsp; 10 kg: ¼-½ tsp.
For streptococcal pharyngitis in children >1 year, mild, uncomplicated urinary tract infections and skin and soft tissue infections, the total daily dose may be divided, administered and taken every 12 hrs.
125-mg/5 mL Suspension: Children 40 kg body weight: 4-8 tsp; 20 kg: 2-4 tsp; 10 kg: 1-2 tsp.
250-mg/5 mL Suspension: Children 40 kg body weight: 2-4 tsp; 20 kg: 1-2 tsp; 10 kg: ½-1 tsp.
(5 mL is equivalent to 1 tsp.)
Shake the suspension well before use.
In severe infections, the dosage may be doubled.
In the therapy of otitis media, 75-100 mg/kg/day in 4 divided doses is needed.
In the treatment of β-hemolytic streptococcal infections, the therapeutic dosage of Pralexin should be administered for a minimum of 10 days.
Note: Pralexin may be taken on a full or empty stomach. Compliance with the full course of therapy especially in streptococcal infections is highly recommended.
Interactions are the effects that happen when the drug is taken along with the food or when taken with other medications. Suppose if you are taking a drug Pralexin, it may have interactions with specific foods and specific medications. It will not interact with all foods and medications. The interactions vary from drug to drug. You need to be aware of interactions of the medicine you take. Most medications may interact with alcohol, tobacco, so be cautious.
Bacteriostatic Antibiotics: As cephalosporins like Pralexin are only active against proliferating microorganisms, Pralexin should not be combined with bacteriostatic antibiotics.
Uricosuric Drugs: Concomitant use of uricosuric drugs (eg, probenecid) suppresses renal drug elimination. As a result, Pralexin plasma levels are increased and sustained for longer periods.
Metformin: A potential interaction between Pralexin and metformin may result in an accumulation of metformin and could result in fatal lactic acidosis.
Increased Risk of Nephrotoxicity: If associated with highly potent diuretics (ethacrynic acid, furosemide) or other potentially nephrotoxic antibiotics (aminoglycosides, polymyxin, colistin), cephalosporins may show higher nephrotoxicity.
Oral Anticoagulants:Combined use of cephalosporins and oral anticoagulants may prolong prothrombin time.
Typhoid Vaccine: Pralexin, like other antibiotics with antibacterial activity against Salmonella typhi organisms, may interfere with the immunological response to the live typhoid vaccine. The appropriate period of time should elapse between the administration of the last dose of the antibiotic and the live typhoid vaccine.
Oral Contraceptives:Pralexin may reduce the effects of oral contraceptives.
Incompatibilities: No incompatibilities have been reported.
ReviewsThe results of a survey conducted on ndrugs.com for Pralexin are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Pralexin. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.
Consumer reported frequency of useNo survey data has been collected yet
1 consumer reported dosesWhat doses of Pralexin drug you have used?
The drug can be in various doses. Most anti-diabetic, anti-hypertensive drugs, pain killers, or antibiotics are in different low and high doses and prescribed by the doctors depending on the severity and demand of the condition suffered by the patient. In our reports, ndrugs.com website users used these doses of Pralexin drug in following percentages. Very few drugs come in a fixed dose or a single dose. Common conditions, like fever, have almost the same doses, e.g., [acetaminophen, 500mg] of drug used by the patient, even though it is available in various doses.
Information checked by Dr. Sachin Kumar, MD Pharmacology