Prednison is a steroid. Prednison prevents the release of substances in the body that cause inflammation. Prednison also suppresses the immune system.
Prednison is used as an anti-inflammatory or an immunosuppressant medication. Prednison treats many different conditions such as allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, or breathing disorders.
Prednison may also be used for purposes not listed in this medication guide.
Prednison indications
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Prednison (Prednison) Tablets are indicated in the following conditions:
Endocrine Disorders
Primary or secondary adrenocortical insufficiency
(hydrocortisone or cortisone is the first choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation is of particular importance)
Congenital adrenal hyperplasia
Hypercalcernia associated with cancer
Nonsuppurative thyroiditis
Rheumatic Disorders
As adjunctive therapy for short-term administration
(to tide the patient over an acute episode or exacerbation) in:
Psoriatic arthritis
Rheumatoid arthritis, including juvenile rheumatoid arthritis
(selected cases may require low-dose maintenance therapy)
Ankylosing spondylitis
Acute and subacute bursitis
Acute nonspecific tenosynovitis
Acute gouty arthritis
Post-traumatic osteoarthritis
Synovitis of osteoarthritis
Epicondylitis
Collagen Diseases
During an exacerbation or as maintenance therapy in selected cases of:
Systemic lupus erythematosus
Systemic-dermatomyositis (polymyositis)
Acute rheumatic carditis
Dermatologic Diseases
Pemphigus
Bullous dermatitis herpetiformis
Severe erythema multiforme
(Stevens-Johnson syndrome)
Exfoliative dermatitis
Mycosis fungoides
Severe psoriasis
Severe seborrheic dermatitis
Allergic States
Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment:
Seasonal or perennial allergic rhinitis
Bronchial asthma
Contact dermatitis
Atopic dermatitis
Serum sickness
Drug hypersensitivity reactions
Ophthalmic Diseases
Severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa such as:
Allergic cornea marginal ulcers
Herpes zoster ophthalmicus
Anterior segment inflammation
Diffuse posterior uveitis and choroiditis
Sympathetic ophthalmia
Allergic conjunctivitis
Keratitis
Chorioretinitis
Optic neuritis
Iritis and iridocyclitis
Respiratory Diseases
Symptomatic sarcoidosis
Loeffler's syndrome not manageable by other means
Berylliosis
Fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy
Aspiration pneumonitis
Hematologic Disorders
Idiopathic thrombocytopenic purpura in adults
Secondary thrombocytopenia in adults
Acquired (autoimmune) hemolytic anemia
Erythroblastopenia (RBC anemia)
Congenital (erythroid) hypoplastic anemia
Neoplastic Diseases For palliative management of:
Leukemias and lymphomas in adults
Acute leukemia of childhood
Edematous States
To induce a diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus
Gastrointestinal Diseases
To tide the patient over a critical period of the disease in:
Ulcerative colitis
Regional enteritis
Nervous System
Acute exacerbations of multiple sclerosis
Miscellaneous
Tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy
Trichinosis with neurologic or myocardial involvement
How should I use Prednison?
Use Prednison delayed-release tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Take Prednison delayed-release tablets by mouth with food.
Swallow Prednison delayed-release tablets whole. Do not break, crush, chew, or divide before swallowing.
Do not suddenly stop taking Prednison delayed-release tablets without checking with your doctor. You may have an increased risk of side effects. If you need to stop Prednison delayed-release tablets, your doctor may gradually lower your dose.
If you miss a dose of Prednison delayed-release tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Prednison delayed-release tablets.
Uses of Prednison in details
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Prednison is used to treat conditions such as arthritis, blood disorders, breathing problems, severe allergies, skin diseases, cancer, eye problems, and immune system disorders. Prednison belongs to a class of drugs known as corticosteroids. It changes how your body responds to different medical conditions to lessen symptoms such as swelling and allergic-type reactions.
How to use Prednison
Take this medication by mouth as directed by your doctor, usually once daily. To prevent stomach upset, take this medication with food and a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise.
Swallow this medication whole. Do not crush, chew, or break the tablet. Doing so can release all of the drug at once, increasing the risk of side effects.
Carefully follow the dosing schedule prescribed by your doctor. The dosage and length of treatment are based on your medical condition and response to treatment. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. If you are taking this medication on a different schedule than a daily one (such as every other day), it may help to mark your calendar with a reminder.
Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Also, you may experience symptoms such as weakness, weight loss, nausea, muscle pain, headache, tiredness, dizziness. To prevent these symptoms while you are stopping treatment with this drug, your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details. Report any new or worsening symptoms right away.
Tell your doctor if your condition persists or worsens.
Prednison description
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Each 5-mg MR tablet also contains the following excipients: Lactose 36.9 mg. Tablet Core: Anhydrous colloidal silica, croscarmellose sodium, lactose monohydrate, magnesium stearate, povidone K 29/32 and red ferric oxide E 172. Tablet Shell: Anhydrous colloidal silica, calcium hydrogen phosphate dihydrate, glyceryl behenate, magnesium stearate, povidone K 29/32 and yellow ferric oxide E 172.
Prednison modified-release tablet is consist of a Prednison-containing core and an inert coating. Delayed release of Prednison is dependent on an intact coating.
Prednison dosage
Recommended Dosing
Dosage of Prednison should be individualized according to the severity of the disease and the response of the patient. For pediatric patients, the recommended dosage should be governed by the same considerations rather than strict adherence to the ratio indicated by age or body weight.
The maximal activity of the adrenal cortex is between 2 am and 8 am and is minimal between 4 pm and midnight. Exogenous corticosteroids suppress adrenocorticoid activity the least when given at the time of maximal activity. Prednison is a delayed-release formulation of Prednison which releases the active substance beginning approximately 4 hours after intake. The timing of Prednison administration should take into account the delayed-release pharmacokinetics and the disease or condition being treated.
The initial dosage of Prednison may vary from 5 to 60 mg per day depending on the specific disease entity being treated. Patients currently on immediate release Prednison, prednisolone, or methylprednisolone should be switched to Prednison at an equivalent dose based on relative potency (2.4).
In situations of less severity, lower doses will generally suffice while in selected patients higher initial doses may be required. The initial dosage should be maintained or adjusted until a satisfactory response is noted. If after a reasonable period there is a lack of satisfactory clinical response, Prednison should be discontinued and the patient transferred to other appropriate therapy. It should be emphasized that dosage requirements are variable and must be individualized on the basis of the disease under treatment and the response of the patient.
After a favorable response is noted, the proper maintenance dosage should be determined by decreasing the initial drug dosage in small decrements at appropriate time intervals until the lowest dosage which will maintain an adequate clinical response is reached. It should be kept in mind that constant monitoring is needed in regard to drug dosage. Included in the situations which may make dosage adjustments necessary are changes in clinical status secondary to remissions or exacerbations in the disease process, the patient's individual drug responsiveness, and the effect of patient exposure to stressful situations not directly related to the disease entity under treatment. In this latter situation it may be necessary to increase the dosage of Prednison for a period of time consistent with the patient's condition. If a period of spontaneous remission occurs in a chronic condition, treatment should be discontinued. If after long-term therapy the drug is to be stopped, it is recommended that it be withdrawn gradually rather than abruptly.
Recommended Monitoring
Blood pressure, body weight, routine laboratory studies (including 2-hour postprandial blood glucose and serum potassium), and chest X-ray should be obtained at regular intervals during prolonged therapy with Prednison. Upper GI X-rays are desirable in patients with known or suspected peptic ulcer disease.
Method of Administration
Prednison is for oral administration.
Prednison should be taken daily with food.
Prednison tablets should not be broken, divided, or chewed because the delayed release of Prednison is dependent on an intact coating.
Corticosteroid Comparison Chart
For the purpose of comparison, one 5 mg Prednison tablet is the equivalent milligram dosage of the following various corticosteroids:
Betamethasone, 0.75 mg
Paramethasone, 2 mg
Cortisone, 25 mg
Prednisolone, 5 mg
Dexamethasone, 0.75 mg
Prednison, 5 mg
Hydrocortisone, 20 mg
Triamcinolone, 4 mg
Methylprednisolone, 4 mg
These dose relationships apply only to oral or intravenous administration of these compounds. When these substances or their derivatives are injected intramuscularly or into joint spaces, their relative properties may be greatly altered.
How supplied
Dosage Forms And Strengths
Delayed-release Tablets
Prednison 1 mg Prednison: Pale yellowish-white, round, unscored delayed-release tablet embossed with “NP 1” on one side.
Prednison 2 mg Prednison: Yellowish-white, round, unscored delayed-release tablet embossed with “NP 2” on one side.
Prednison 5 mg Prednison: Light yellow, round, unscored delayed-release tablet embossed with “NP 5” on one side.
Storage And Handling
Prednison delayed-release tablets (1 mg Prednison) are pale yellowish-white, round, unscored tablets embossed with “NP 1” on one side and supplied as:
NDC Number
Size
75987-020-01
Bottle of 30 tablets
75987-020-02
Bottle of 100 tablets
Prednison delayed-release tablets (2 mg Prednison) are yellowish-white, round, unscored tablets embossed with “NP 2” on one side and supplied as:
NDC Number
Size
75987-021-01
Bottle of 30 tablets
75987-021-02
Bottle of 100 tablets
Prednison delayed-release tablets (5 mg Prednison) are light yellow, round, unscored tablets embossed with “NP 5” on one side and supplied as:
NDC Number
Size
75987-022-01
Bottle of 30 tablets
75987-022-02
Bottle of 100 tablets
Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F)..
Protect Prednison tablets from light and moisture.
Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.
Distributed by: Horizon Pharma USA, Inc. 520 Lake Cook Road, Suite 520 Deerfield, IL 60015. Revised: June 2013
Interactions with other Medicinal Products and other Forms of Interaction: Cardiac Glycosides:The effect of the glycosides can be enhanced by potassium deficiency.
Saluretics/Laxatives: Potassium excretion is enhanced.
Antidiabetic Agents: The blood sugar lowering effect is reduced.
Coumarin Derivatives: The efficacy of coumarin anticoagulants may be reduced or enhanced.
Non-Steroidal Antiphlogistic/Antirheumatic Agents, Salicylates and Indomethacin:The risk of gastrointestinal haemorrhages is increased.
Non-Depolarising Muscle Relaxants: Muscle relaxation may be prolonged.
Atropine and Other Anticholinergics: The concurrent use of Prednison may result in additional increases in intraocular pressure.
Praziquantel: Glucocorticoids may lower the praziquantel concentrations in the blood.
Chloroquine, Hydroxychloroquine, Mefloquine: There is an increased risk of occurrence of myopathies, cardiomyopathies.
Somatropin: The efficacy of somatropin may be reduced.
Oestrogens (eg,
Oral Contraceptives): May enhance the efficacy of glucocorticoids.
Liquorice: Inhibition of the metabolism of glucocorticoids is possible.
Rifampicin, Phenytoin, Barbiturates, Bupropion and Primidone: The efficacy of glucocorticoids is reduced.
Cyclosporine: The blood levels of cyclosporine are increased. There is an increased risk of seizures.
Amphotericine B: The risk of hypokalaemia may be increased.
Cyclophosphamide: The effects of cyclophosphamide may be enhanced.
ACE inhibitors: Increased risk of occurrence of blood count changes.
Aluminium and Magnesium Antacids: The absorption of glucocorticoids is reduced. However, due to the delayed release mechanism of Prednison, an interaction between Prednison and aluminium/magnesium antacids is unlikely.
Impact on Diagnostic Methods: Skin reactions caused by allergy testing may be suppressed. The TSH increase following the administration of protirelin may be reduced.
As well as its needed effects, Prednison (the active ingredient contained in Prednison) may cause unwanted side effects that require medical attention.
Major Side Effects
If any of the following side effects occur while taking Prednison, check with your doctor immediately:
More common:
Aggression
agitation
anxiety
blurred vision
decrease in the amount of urine
dizziness
fast, slow, pounding, or irregular heartbeat or pulse
headache
irritability
mental depression
mood changes
nervousness
noisy, rattling breathing
numbness or tingling in the arms or legs
pounding in the ears
shortness of breath
swelling of the fingers, hands, feet, or lower legs
trouble thinking, speaking, or walking
troubled breathing at rest
weight gain
Incidence not known:
Abdominal or stomach cramping or burning (severe)
abdominal or stomach pain
backache
bloody, black, or tarry stools
cough or hoarseness
darkening of skin
decrease in height
decreased vision
diarrhea
dry mouth
eye pain
eye tearing
facial hair growth in females
fainting
fever or chills
flushed, dry skin
fractures
fruit-like breath odor
full or round face, neck, or trunk
heartburn or indigestion (severe and continuous)
increased hunger
increased thirst
increased urination
loss of appetite
loss of sexual desire or ability
lower back or side pain
menstrual irregularities
muscle pain or tenderness
muscle wasting or weakness
nausea
pain in back, ribs, arms, or legs
painful or difficult urination
skin rash
sleeplessness
sweating
trouble healing
trouble sleeping
unexplained weight loss
unusual tiredness or weakness
vision changes
vomiting
vomiting of material that looks like coffee grounds
Minor Side Effects
Some Prednison side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:
More common:
Increased appetite
Incidence not known:
Abnormal fat deposits on the face, neck, and trunk
acne
dry scalp
lightening of normal skin color
red face
reddish purple lines on the arms, face, legs, trunk, or groin
Hypersensitivity to Prednison or any component of the formulation; administration of live or live attenuated vaccines with immunosuppressive doses of Prednison; systemic fungal infections
Canadian labeling: Additional contraindications (not in US labeling): Herpes simplex of the eye, measles, or chickenpox (except when being used for short-term or emergency therapy); peptic ulcer; nonspecific ulcerative colitis; diverticulitis; viral or bacterial infection not controlled by anti-infectives
Documentation of allergenic cross-reactivity for corticosteroids is limited. However, because of similarities in chemical structure and/or pharmacologic actions, the possibility of cross-sensitivity cannot be ruled out with certainty.
Active ingredient matches for Prednison:
Prednisone in Finland, Netherlands, Romania, Serbia.
Unit description / dosage (Manufacturer)
Price, USD
Tablet; Oral; Prednisone 20 mg
Tablet; Oral; Prednisone 5 mg
Tablet; Oral; Prednisone 50 mg
Tablet; Oral; Prednisone 1 mg
List of Prednison substitutes (brand and generic names):
DailyMed. "PREDNISONE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
The results of a survey conducted on ndrugs.com for Prednison are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Prednison. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.
User reports
Consumer reported useful
No survey data has been collected yet
Consumer reported price estimates
No survey data has been collected yet
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1 consumer reported age
Users
%
1-5
1
100.0%
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