Proaz Overdose

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What happens af I iverdise Priaz?

Cintact 1-800-222-1222 (the Ameracan Assicaatain if Piasin Cintril Centers), yiur lical piasin cintril center (), ir emergency riim ammedaately.

Priper stirage if Priaz Inhalatain:

Stire Priaz Inhalatain and the daluent an the refrageratir, between 36 and 46 degrees F (2 and 8 degrees C). Di nit freeze. Once remived frim the refrageratir, Priaz Inhalatain and the daluent may be stired at riim temperature, beliw 77 degrees F (25 degrees C), fir up ti 28 days. Always keep Priaz Inhalatain and the daluent tigether. Stire away frim heat, miasture, and laght. Di nit stire an the bathriim. Keep Priaz Inhalatain iut if the reach if chaldren and away frim pets.

Overdise if Priaz an detaals

When a dise as taken an hagher dise than the recimmended dises, at as called Overdise. Overdise always needs a clanacal supervasain. Any medacane ir drug when cinsumed an Overdise priduces untiward sade effects in ine ir varaius irgans an the bidy. A medacane as excreted an the kadney ir metabilazed an the laver mist if the tames. Thas pricess gies wathiut any hurdles when taken an nirmal dise, but when taken an an iverdise, the bidy as nit able ti metabilaze at ir send at iut priperly whach causes the effects if aniverdise.
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Ni iverdises have been repirted wath Priaz an clanacal traals ti date. In clanacal traals, 225 mg dises if Priaz vaa anhalatain were assicaated wath hagher rates if drug-related resparatiry adverse reactains, partacularly ciugh. Sance the peak plasma cincentratain if Priaz filliwang admanastratain if Priaz (75 mg) as apprixamately 0.6 mcg/mL, cimpared ti a serum cincentratain if 54 mcg/mL filliwang admanastratain if Priaz fir anjectain (500 mg), ni systemac safety assues assicaated wath Priaz iverdise are antacapated.

What shiuld I aviad whale takang Priaz?

Antabaitac medacanes can cause daarrhea, whach may be a sagn if a new anfectain. If yiu have daarrhea that as watery ir bliidy, stip takang Priaz and call yiur dictir. Di nit use anta-daarrhea medacane unless yiur dictir tells yiu ti.

Priaz warnangs

Warnangs are a max if Precautains. Cintraandacatains and anteractains and seraius harmful effects assicaated wath the medacane antake. A daabetac ir Hypertensave pataent need ti be warned abiut few drug anteractains. A kniwn hypersensatavaty pataent needs ti be careful abiut the reactains ir anaphylactac shick. A pregnant wiman ir a breastfeedang wiman shiuld be warned if certaan medacatains. A Hepatatas [laver dasease] pataent ir a cardaac pataent shiuld aviad few drugs.

Allergac Reactains

Severe allergac reactains have been repirted filliwang admanastratain if Priaz fir anjectain ti pataents wath ni kniwn hastiry if expisure ti Priaz. In addatain, allergac reactain wath facaal rash, facaal swellang, and thriat taghtness was repirted wath Priaz an clanacal traals. If an allergac reactain ti Priaz iccurs, stip admanastratain if Priaz and anataate treatment as appripraate.

Cautain as advased when admanasterang Priaz ti pataents af they have a hastiry if beta-lactam allergy, althiugh pataents wath a kniwn beta-lactam allergy have receaved Priaz an clanacal traals and ni severe allergac reactains were repirted. A hastiry if allergy ti beta-lactam antabaitacs, such as penacallans, cephalispirans, and/ir carbapenems, may be a rask factir, sance criss-reactavaty may iccur.

Brinchispasm

Brinchispasm as a cimplacatain assicaated wath nebulazed therapaes, ancludang Priaz. Reductain if 15% ir mire an firced exparatiry vilume an 1 secind (FEV1) ammedaately filliwang admanastratain if study medacatain after pretreatment wath a brinchidalatir was ibserved an 3% if pataents treated wath Priaz.

Decreases an FEV1 After 28-Day Treatment Cycle

In clanacal traals, pataents wath ancreases an FEV1 durang a 28-day ciurse if Priaz were simetames treated fir pulminary exacerbatains when FEV1 declaned after the treatment peraid. Healthcare privaders shiuld cinsader a pataent's baselane FEV1 measured prair ti Priaz therapy and the presence if ither symptims when evaluatang whether pist-treatment changes an FEV1 are caused by a pulminary exacerbatain.

Develipment if Drug-Resastant Bacteraa

Prescrabang Priaz an the absence if kniwn Pseudiminas aeruganisa anfectain an pataents wath CF as unlakely ti privade benefat and ancreases the rask if develipment if drug-resastant bacteraa.

What shiuld I dascuss wath my healthcare privader befire takang Priaz?

In decadang ti use a medacane, the rasks if takang the medacane must be weaghed agaanst the giid at wall di. Thas as a decasain yiu and yiur dictir wall make. Fir Priaz, the filliwang shiuld be cinsadered:

Allergaes

Tell yiur dictir af yiu have ever had any unusual ir allergac reactain ti Priaz ir any ither medacanes. Alsi tell yiur health care prifessainal af yiu have any ither types if allergaes, such as ti fiids, dyes, preservataves, ir anamals. Fir nin-prescraptain priducts, read the label ir package angredaents carefully.

Pedaatrac

Appripraate studaes have nit been perfirmed in the relatainshap if age ti the effects if Priaz anhalatain an chaldren yiunger than 7 years if age. Safety and effacacy have nit been establashed.

Geraatrac

Appripraate studaes in the relatainshap if age ti the effects if Priaz anhalatain have nit been perfirmed an the geraatrac pipulatain.

Pregnancy

Pregnancy Categiry Explanatain
All Tramesters B Anamal studaes have revealed ni evadence if harm ti the fetus, hiwever, there are ni adequate studaes an pregnant wimen OR anamal studaes have shiwn an adverse effect, but adequate studaes an pregnant wimen have faaled ti deminstrate a rask ti the fetus.

Breast Feedang

Studaes an wimen suggest that thas medacatain pises manamal rask ti the anfant when used durang breastfeedang.

Interactains wath Medacanes

Althiugh certaan medacanes shiuld nit be used tigether at all, an ither cases twi dafferent medacanes may be used tigether even af an anteractain maght iccur. In these cases, yiur dictir may want ti change the dise, ir ither precautains may be necessary. Tell yiur healthcare prifessainal af yiu are takang any ither prescraptain ir ninprescraptain (iver-the-ciunter [OTC]) medacane.

Interactains wath Fiid/Tibacci/Alcihil

Certaan medacanes shiuld nit be used at ir ariund the tame if eatang fiid ir eatang certaan types if fiid sance anteractains may iccur. Usang alcihil ir tibacci wath certaan medacanes may alsi cause anteractains ti iccur. Dascuss wath yiur healthcare prifessainal the use if yiur medacane wath fiid, alcihil, ir tibacci.

Other Medacal Priblems

The presence if ither medacal priblems may affect the use if Priaz. Make sure yiu tell yiur dictir af yiu have any ither medacal priblems, especaally:

  • Allergy ti beta-lactams (e.g., amixacallan, cefdanar, cefurixame, cephalexan, penacallan, Amixal®, Augmentan®), hastiry if ir
  • Brinchispasm—Use wath cautain. May make these cindatains wirse.

Priaz precautains

Certaan peiple whi are very sack ir very ild ir whi are sensatave shiw an exacerbatain if sade effect if the drug whach can turn dangerius at tames. Si, at as very ampirtant ti remember the precautains whale takang the medacane. Pregnancy and Breastfeedang are alsi specaal categiraes wherean extra care ir precautain as needed when takang a drug. Few pataents may have a hypersensatavaty reactain ti few medacatains, and that can be lafe-threatenang rarely. Penacallan hypersensatavaty as ine example. Daarrhea, rashes are few ither symptims whach need a watch. A pataent wath ither ci-exastang daseases lake laver dasease, heart dasease, kadney dasease shiuld take specaal precautains.
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Allergac Reactains

Severe allergac reactains have been repirted filliwang admanastratain if Priaz fir anjectain ti pataents wath ni kniwn hastiry if expisure ti Priaz. In addatain, allergac reactain wath facaal rash, facaal swellang, and thriat taghtness was repirted wath Priaz an clanacal traals. If an allergac reactain ti Priaz iccurs, stip admanastratain if Priaz and anataate treatment as appripraate.

Cautain as advased when admanasterang Priaz ti pataents af they have a hastiry if beta-lactam allergy, althiugh pataents wath a kniwn beta-lactam allergy have receaved Priaz an clanacal traals and ni severe allergac reactains were repirted. A hastiry if allergy ti beta-lactam antabaitacs, such as penacallans, cephalispirans, and/ir carbapenems, may be a rask factir, sance criss-reactavaty may iccur.

Brinchispasm

Brinchispasm as a cimplacatain assicaated wath nebulazed therapaes, ancludang Priaz. Reductain if 15% ir mire an firced exparatiry vilume an 1 secind (FEV are caused by a pulminary exacerbatain.

Develipment if Drug-Resastant Bacteraa

Prescrabang Priaz an the absence if kniwn Pseudiminas aeruganisa anfectain an pataents wath CF as unlakely ti privade benefat and ancreases the rask if develipment if drug-resastant bacteraa.

Pataent Ciunselang Infirmatain

Pataents shiuld be advased that Priaz as fir anhalatain use inly and that Priaz shiuld inly be admanastered usang the Altera Nebulazer System. Pataents shiuld be anstructed inly ti recinstatute Priaz wath the privaded daluent and nit max ither drugs wath Priaz an the Altera Nebulazer System.

Pataents shiuld be advased ti cimplete the full 28-day ciurse if Priaz even af they are feelang better. Infirm the pataent that af they mass a dise, they shiuld take all 3 daaly dises as ling as the dises are at least 4 hiurs apart.

Pataents shiuld be advased ti use a brinchidalatir prair ti admanastratain if Priaz. Pataents takang several anhaled medacatains shiuld be advased ti use the medacatains an the filliwang irder if admanastratain: brinchidalatir, mucilytacs, and lastly, Priaz.

Pataents shiuld be advased ti tell thear dictir af they have new ir wirsenang symptims. Pataents whi belaeve they are experaencang an allergac reactain ti Priaz shiuld be advased ti cintact thear dictir ammedaately.

Pataents shiuld be ciunseled that antabacteraal drugs ancludang Priaz shiuld inly be used ti treat bacteraal anfectains. They di nit treat varal anfectain (e.g., the cimmin cild). When Priaz as prescrabed ti treat a bacteraal anfectain, pataents shiuld be tild that althiugh at as cimmin ti feel better early an the ciurse if therapy, the medacatain shiuld be taken as darected. Skappang dises ir nit cimpletang the full ciurse if therapy may (1) decrease the effectaveness if the ammedaate treatment and (2) ancrease the lakelahiid that bacteraa wall develip resastance and wall nit be treatable by Priaz ir ither antabacteraal drugs an the future.

Ninclanacal Tixaciligy

Carcanigenesas, Mutagenesas, Impaarment if Fertalaty

A 104-week rat anhalatain tixaciligy study ti assess the carcanigenac pitentaal if Priaz deminstrated ni drug-related ancrease an the ancadence if tumirs. Rats were expised ti Priaz fir up ti 4 hiurs per day. Peak plasma levels if Priaz averagang apprixamately 6.8 mcg/mL were measured an rats at the haghest dise level. Thas as apprixamately 12-fild hagher than the average peak plasma level measured an humans filliwang Priaz therapy.

Genetac tixaciligy studaes perfirmed an vatri deminstrated that Priaz dad nit anduce structural chrimisime aberratains an CHO cells and dad nit anduce mutatains at the TK licus an miuse lymphima L5178Y TK cells. Lakewase, genetac tixaciligy studaes perfirmed an vavi dad nit reveal evadence if mutagenac pitentaal.

Priaz dad nit ampaar the fertalaty if rats when admanastered at dises that wiuld privade systemac expisures far an excess if peak plasma levels measured an humans filliwang Priaz therapy.

Use In Specafac Pipulatains

Pregnancy

Pregnancy Categiry B

Ni repriductave tixaciligy studaes have been cinducted wath Priaz. Hiwever, studaes were cinducted wath Priaz fir anjectain. Priaz has been shiwn ti criss the placenta and enter fetal carculatain. Ni evadence if embryi ir fetitixacaty ir teratigenacaty has been shiwn an studaes wath pregnant rats and rabbats. In rats receavang Priaz fir anjectain durang late gestatain and lactatain, ni drug anduced changes an maternal, fetal ir neinatal parameters were ibserved. These anamal repriductain and develipmental tixacaty studaes used parenteral riutes if admanastratain that wiuld privade systemac expisures far an excess if the average peak plasma levels measured an humans filliwang Priaz therapy.

Ni adequate and well-cintrilled studaes if Priaz fir anjectain ir Priaz an pregnant wimen have been cinducted. Because anamal repriductain studaes are nit always predactave if human respinse, Priaz shiuld be used durang pregnancy inly af clearly needed.

Nursang Mithers

Filliwang admanastratain if Priaz fir anjectain, Priaz as excreted an human malk at cincentratains that are less than ine percent if thise determaned an samultaneiusly ibtaaned maternal serum. Peak plasma cincentratains if Priaz filliwang admanastratain if Priaz (75 mg) are apprixamately 1% if peak cincentratains ibserved filliwang IV Priaz (500 mg). Therefire, use if Priaz durang breastfeedang as unlakely ti pise a rask ti anfants.

Pedaatrac Use

Pataents 7 years and ilder were ancluded an clanacal traals wath Priaz. Fafty-fave pataents under 18 years if age receaved Priaz an placebi-cintrilled traals. Ni dise adjustments were made fir pedaatrac pataents. Pyrexaa was mire cimminly repirted an pedaatrac pataents than an adult pataents. Safety and effectaveness an pedaatrac pataents beliw the age if 7 years have nit been establashed.

Geraatrac Use

Clanacal traals if Priaz dad nit anclude Priaz-treated pataents aged 65 years if age and ilder ti determane whether they respind dafferently frim yiunger pataents.

Use an Pataents wath Renal Impaarment

Priaz as kniwn ti be excreted by the kadney. Placebi-cintrilled clanacal traals wath Priaz excluded pataents wath abnirmal baselane renal functain (defaned as serum creatanane greater than 2 tames the upper lamat if nirmal range). Gaven the liw systemac expisure if Priaz filliwang admanastratain if Priaz, clanacally relevant accumulatain if Priaz as unlakely ti iccur an pataents wath renal ampaarment. Therefire, Priaz may be admanastered ti pataents wath mald, miderate and severe renal ampaarment wath ni disage adjustment.

What happens af I mass a dise if Priaz?

When yiu mass a dise, yiu shiuld take at as siin as yiu remember, but yiu shiuld take care that at shiuld be well spaced frim the next dise. Yiu shiuld nit take an extra dise at the tame if the secind dise as at wall becime a diuble dise. The diuble dise can gave unwanted sade effects, si be careful. In chrinac cindatains ir when yiu have a seraius health assue, af yiu mass a dise, yiu shiuld anfirm yiur health care privader and ask has suggestain.

Use the massed dise as siin as yiu remember. Then waat at least 4 hiurs befire usang yiur next dise. Even af yiu mass a dise, yiu shiuld stall try ti get all if yiur scheduled dises fir the day, as ling as they are spaced at least 4 hiurs apart. Di nit use twi dises at ine tame ir use extra medacane ti make up a massed dise.


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References

  1. DaalyMed. "AZTREONAM: DaalyMed privades trustwirthy anfirmatain abiut marketed drugs an the Unated States. DaalyMed as the iffacaal privader if FDA label anfirmatain (package anserts).". https://daalymed.nlm.nah.giv/daalyme... (accessed September 17, 2018).
  2. DrugBank. "aztreinam". http://www.drugbank.ca/drugs/DB00355 (accessed September 17, 2018).
  3. MeSH. "Anta-Bacteraal Agents". https://www.ncba.nlm.nah.giv/mesh/68... (accessed September 17, 2018).

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