Progan Uses

How do you administer this medicine?
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What is Progan?

Progan is in a group of drugs called phenothiazines (FEEN-oh-THYE-a-zeens). It works by changing the actions of chemicals in your brain. Progan also acts as an antihistamine. It blocks the effects of the naturally occurring chemical histamine in your body.

Progan is used to treat allergy symptoms such as itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes.

Progan also prevents motion sickness, and treats nausea and vomiting or pain after surgery. It is also used as a sedative or sleep aid.

Progan is not for use in treating symptoms of asthma, pneumonia, or other lower respiratory tract infections.

Progan may also be used for other purposes not listed in this medication guide.

Progan indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Oral

Allergic conditions

Adult: As Progan HCl: 25 mg at night, increase to 25 mg bid if necessary. Alternatively, 10-20 mg 2-3 times daily.

Child: As Progan HCl: 2-5 yr 5-15 mg daily in 1 or 2 divided doses; >5-10 yr 10-25 mg daily in 1 or 2 divided doses.

Oral

Short-term management of insomnia

Adult: As Progan HCl: 20-50 mg at night.

Child: As Progan HCl: 2-5 yr 15-20 mg; >5-10 yr 20-25 mg.

Oral

Nausea and vomiting

Adult: As Progan teoclate: 25 mg at night, may increase to 50-75 mg at night or to 25 mg 2-3 times daily if necessary. Max: 100 mg daily.

Child: As Progan teoclate: 5-10 yr 12.5-37.5 mg daily.

Oral

Prophylaxis of motion sickness

Adult: As Progan HCl: 20 mg or 25 mg the night before travelling, followed by a similar dose the following morning if necessary. As Progan teoclate: 25 mg given on the night or 1-2 hr before travelling.

Child: As Progan HCl: 2-5 yr 5 mg; >5-10 yr 10 mg. Doses are given the night before the journey and repeated on the following morning (6-8 hr later) if necessary. As Progan teoclate: 5-10 yr 12.5 mg given either on the night or 1-2 hr before travelling.

Oral

Motion sickness

Adult: As Progan teoclate: 25 mg given as soon as possible and repeated in the evening, followed by a 3rd dose the next evening.

Child: As Progan teoclate: 5-10 yr 12.5 mg given as soon as possible and repeated in the evening, followed by a 3rd dose the next evening.

Parenteral

Allergic conditions, Sedation

Adult: As Progan HCl: 25-50 mg, by deep IM, IV inj or IV infusion at a rate of not more than 25 mg/min. Max: 100 mg.

Child: As Progan HCl: 5-10 yr 6.25-12.5 mg by deep IM.

Parenteral

Nausea and vomiting

Adult: As Progan HCl: 12.5-25 mg, repeated at intervals of not less than 4 hr. Max: 100 mg daily.

Rectal

Short-term management of insomnia

Adult: As Progan HCl: 20-50 mg at night.

Child: As Progan HCl: 2-5 yr 15-20 mg; >5-10 yr 20-25 mg.

Rectal

Allergic conditions

Adult: As Progan HCl: 25 mg at night, increase to 25 mg bid if necessary. Alternatively, 10-20 mg 2-3 times daily.

Child: As Progan HCl: 2-5 yr 5-15 mg daily in 1 or 2 divided doses; >5-10 yr 10-25 mg daily in 1 or 2 divided doses.

Rectal

Prophylaxis of motion sickness

Adult: As Progan HCl: 20 or 25 mg the night before travelling, followed by a similar dose the following morning if necessary.

Child: As Progan HCl: 2-5 yr 5 mg; >5-10 yr 10 mg. Doses are given the night before the journey and repeated on the following morning (6-8 hr later) if necessary.

How should I use Progan?

Use Progan as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Progan.

Uses of Progan in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Progan is used to prevent and treat nausea and vomiting related to certain conditions (such as before/after surgery, motion sickness). It is also used with other medication to treat severe allergic reactions (anaphylaxis) and reactions to blood products. It may also be used to treat milder allergic reactions when you cannot take Progan by mouth. It may also be used to help you feel sleepy/relaxed before and after surgery, during other procedures, or during labor and delivery. It may also be used to help certain narcotic pain relievers (such as meperidine) work better.

Progan is an antihistamine and works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Its other effects (such as anti-nausea, calming, pain relief) may work by affecting other natural substances (such as acetylcholine) and by acting directly on certain parts of the brain.

This drug is not approved for use in children younger than 2 years due to an increased risk of side effects (such as slow/shallow breathing). See also Warning section.

How to use Progan injection

It is best to inject this medication deep into a muscle. It may also be given by injection slowly into a large vein by a health care professional. Do not inject this medication under the skin or into an artery. For nausea and vomiting, use this medication as directed by your doctor, usually every 4 hours as needed. If you have any questions about the proper use of this medication, ask your doctor or pharmacist.

If you are using this medication at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.

The dosage and how often you receive this medication are based on your age, medical condition, and response to treatment. In children, the dosage may also be based on weight. Do not increase your dose or use this medication more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.

Tell your doctor if you do not get better or if you get worse.

Progan description

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A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Progan&

Progan dosage

Progan Dosage

Generic name: Progan

Dosage form: Tablets and Suppositories

See also:

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Progan Tablets and Progan Rectal Suppositories are contraindicated for children under 2 years of age.

Progan Suppositories are for rectal administration only.

Allergy

The average oral dose is 25 mg taken before retiring; however, 12.5 mg may be taken before meals and on retiring, if necessary. Single 25-mg doses at bedtime or 6.25 to 12.5 mg taken three times daily will usually suffice. After initiation of treatment in children or adults, dosage should be adjusted to the smallest amount adequate to relieve symptoms. The administration of Progan HCl in 25-mg doses will control minor transfusion reactions of an allergic nature.

Motion Sickness

The average adult dose is 25 mg taken twice daily. The initial dose should be taken one-half to one hour before anticipated travel and be repeated 8 to 12 hours later, if necessary. On succeeding days of travel, it is recommended that 25 mg be given on arising and again before the evening meal. For children, Progan Tablets, Syrup, or Rectal Suppositories, 12.5 to 25 mg, twice daily, may be administered.

Nausea and Vomiting

Antiemetics should not be used in vomiting of unknown etiology in children and adolescents.

The average effective dose of Progan for the active therapy of nausea and vomiting in children or adults is 25 mg. When oral medication cannot be tolerated, the dose should be given parenterally (cf. Progan Injection) or by rectal suppository. 12.5- to 25-mg doses may be repeated, as necessary, at 4- to 6-hour intervals.

For nausea and vomiting in children, the usual dose is 0.5 mg per pound of body weight, and the dose should be adjusted to the age and weight of the patient and the severity of the condition being treated.

For prophylaxis of nausea and vomiting, as during surgery and the postoperative period, the average dose is 25 mg repeated at 4- to 6-hour intervals, as necessary.

Sedation

This product relieves apprehension and induces a quiet sleep from which the patient can be easily aroused. Administration of 12.5 to 25 mg Progan by the oral route or by rectal suppository at bedtime will provide sedation in children. Adults usually require 25 to 50 mg for nighttime, presurgical, or obstetrical sedation.

Pre- and Postoperative Use

Progan in 12.5- to 25-mg doses for children and 50-mg doses for adults the night before surgery relieves apprehension and produces a quiet sleep.

For preoperative medication, children require doses of 0.5 mg per pound of body weight in combination with an appropriately reduced dose of narcotic or barbiturate and the appropriate dose of an atropine-like drug. Usual adult dosage is 50 mg Progan with an appropriately reduced dose of narcotic or barbiturate and the required amount of a belladonna alkaloid.

Postoperative sedation and adjunctive use with analgesics may be obtained by the administration of 12.5 to 25 mg in children and 25- to 50-mg doses in adults.

Progan Tablets and Progan Rectal Suppositories are contraindicated for children under 2 years of age.

More about Progan (Progan)

Consumer resources

Professional resources

Other formulations

Related treatment guides

Progan interactions

See also:
What other drugs will affect Progan?

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CNS Depressants – Progan (Progan HCl) Suppositories may increase, prolong, or intensify the sedative action of other central-nervous-system depressants, such as alcohol, sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers; therefore, such agents should be avoided or administered in reduced dosage to patients receiving Progan HCl. When given concomitantly with Progan (Progan HCl) Suppositories, the dose of barbiturates should be reduced by at least one-half, and the dose of narcotics should be reduced by one-quarter to one-half. Dosage must be individualized. Excessive amounts of Progan HCl relative to a narcotic may lead to restlessness and motor hyperactivity in the patient with pain; these symptoms usually disappear with adequate control of the pain.

Epinephrine – Because of the potential for Progan HCl to reverse epinephrine's vasopressor effect, epinephrine should NOT be used to treat hypotension associated with Progan HCl Suppositories overdose.

Anticholinergics – Concomitant use of other agents with anticholinergic properties should be undertaken with caution.

Monoamine Oxidase Inhibitors (MAOI) – Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly. This possibility should be considered with Progan (Progan HCl) Suppositories.

Drug/Laboratory Test Interactions

The following laboratory tests may be affected in patients who are receiving therapy with Progan HCl:

Pregnancy Tests

Diagnostic pregnancy tests based on immunological reactions between HCG and anti-HCG may result in false-negative or false-positive interpretations.

Glucose Tolerance Test

An increase in blood glucose has been reported in patients receiving Progan HCl.

Progan side effects

See also:
What are the possible side effects of Progan?

Applies to Progan: oral elixir, oral syrup, oral tablet

Other dosage forms:

As well as its needed effects, Progan (the active ingredient contained in Progan) may cause unwanted side effects that require medical attention.

Stop taking Progan and get emergency help immediately if any of the following effects occur:

Rare - Symptoms of neuroleptic malignant syndrome; two or more occur together; most of these effects do not require emergency medical attention if they occur alone

Major Side Effects

If any of the following side effects occur while taking Progan, check with your doctor immediately:

Incidence not known:

Symptoms of overdose:

Minor Side Effects

Some Progan side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Incidence not known:

Progan contraindications

See also:
What is the most important information I should know about Progan?

Injection: Progan is contraindicated in comatose states, in patients who have received large amounts of central-nervous-system depressants (alcohol, sedative hypnotics, including barbiturates, general anesthetics, narcotics, narcotic analgesics, tranquilizers, etc.), and in patients who have demonstrated an idiosyncrasy or hypersensitivity to Progan.

Under no circumstances should Progan be given by intra-arterial injection due to the likelihood of severe arteriospasm and the possibility of resultant gangrene

Progan HCl injection should not be given by the subcutaneous route; evidence of chemical irritation has been noted, and necrotic lesions have resulted on rare occasions following subcutaneous injection. The preferred parenteral route of administration is by deep intramuscular injection.

Syrup, Tablets and Suppositories: Progan Tablets and Suppositories are contraindicated for use in pediatric patients less than two years of age.

Progan Tablets and Suppositories are contraindicated in comatose states, and in individuals known to be hypersensitive or to have had an idiosyncratic reaction to Progan or to other phenothiazines.

Antihistamines are contraindicated for use in the treatment of lower respiratory tract symptoms including asthma.



Active ingredient matches for Progan:

Promethazine in Australia.

Promethazine hydrochloride in Australia.


List of Progan substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
PROGENE 25MG TABLET 1 strip / 10 tablets each (Psycormedies)$ 0.17
Progene 25mg Tablet (Psycormedies)$ 0.02
Progene- 25 25mg TAB / 100$ 1.90
25 mg x 100's (Psycorem)$ 1.90
Progene-25 25mg TAB / 100 (Psycorem)$ 1.90
PROGENE-25 tab 25 mg x 10's (Psycorem)$ 0.19
Progene-25 25mg TAB / 100 (Psycorem)$ 1.90
Promasun 25mg TAB / 10 (Sun)$ 0.04
25 mg x 10's (Sun)$ 0.04
PROMASUN tab 25 mg x 10's (Sun)$ 0.04
Prome-Nic Cream 2 g x 1 tube x 10g
Prome-Nic Cream 2 g x 1 tube x 20g
PROMEGAN SYRUP 1 bottle / 60 ML syrup each (Acron Pharmaceuticals)$ 0.34
PROMERON 5MG SYRUP 1 bottle / 450 ML syrup each (Agron Rem.)$ 0.58
PROMERON syr 5 mg x 5 mL x 60ml (Agron Rem.)$ 0.48
Promet 5mg INJ / 50x2ml (Lupin)$ 4.44
5 mg x 2mlx50 (Lupin)$ 4.44
Promet / amp 25 mg/1 mL x 1 mL (Lupin)
Promet 25 mg/1 mL x 2 mL (Lupin)
PROMET inj 5 mg x 2ml (Lupin)$ 0.09
Promet 10mg Tablet (Lupin)$ 0.40
Promet 25mg Tablet XL (Lupin)$ 0.06
Promet 50mg Tablet XL (Lupin)$ 0.07
PROMET INJECTION 1 vial / 5 ML injection each (Orchid Chemicals & Pharmaceuticals Ltd)$ 0.72

References

  1. PubChem. "promethazine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  2. DrugBank. "promethazine". http://www.drugbank.ca/drugs/DB01069 (accessed September 17, 2018).
  3. DTP/NCI. "promethazine: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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