Progan is in a group of drugs called phenothiazines (FEEN-oh-THYE-a-zeens). It works by changing the actions of chemicals in your brain. Progan also acts as an antihistamine. It blocks the effects of the naturally occurring chemical histamine in your body.
Progan is used to treat allergy symptoms such as itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes.
Progan also prevents motion sickness, and treats nausea and vomiting or pain after surgery. It is also used as a sedative or sleep aid.
Progan is not for use in treating symptoms of asthma, pneumonia, or other lower respiratory tract infections.
Progan may also be used for other purposes not listed in this medication guide.
Progan indications
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Oral
Allergic conditions
Adult: As Progan HCl: 25 mg at night, increase to 25 mg bid if necessary. Alternatively, 10-20 mg 2-3 times daily.
Child: As Progan HCl: 2-5 yr 5-15 mg daily in 1 or 2 divided doses; >5-10 yr 10-25 mg daily in 1 or 2 divided doses.
Oral
Short-term management of insomnia
Adult: As Progan HCl: 20-50 mg at night.
Child: As Progan HCl: 2-5 yr 15-20 mg; >5-10 yr 20-25 mg.
Oral
Nausea and vomiting
Adult: As Progan teoclate: 25 mg at night, may increase to 50-75 mg at night or to 25 mg 2-3 times daily if necessary. Max: 100 mg daily.
Child: As Progan teoclate: 5-10 yr 12.5-37.5 mg daily.
Oral
Prophylaxis of motion sickness
Adult: As Progan HCl: 20 mg or 25 mg the night before travelling, followed by a similar dose the following morning if necessary. As Progan teoclate: 25 mg given on the night or 1-2 hr before travelling.
Child: As Progan HCl: 2-5 yr 5 mg; >5-10 yr 10 mg. Doses are given the night before the journey and repeated on the following morning (6-8 hr later) if necessary. As Progan teoclate: 5-10 yr 12.5 mg given either on the night or 1-2 hr before travelling.
Oral
Motion sickness
Adult: As Progan teoclate: 25 mg given as soon as possible and repeated in the evening, followed by a 3rd dose the next evening.
Child: As Progan teoclate: 5-10 yr 12.5 mg given as soon as possible and repeated in the evening, followed by a 3rd dose the next evening.
Parenteral
Allergic conditions, Sedation
Adult: As Progan HCl: 25-50 mg, by deep IM, IV inj or IV infusion at a rate of not more than 25 mg/min. Max: 100 mg.
Child: As Progan HCl: 5-10 yr 6.25-12.5 mg by deep IM.
Parenteral
Nausea and vomiting
Adult: As Progan HCl: 12.5-25 mg, repeated at intervals of not less than 4 hr. Max: 100 mg daily.
Rectal
Short-term management of insomnia
Adult: As Progan HCl: 20-50 mg at night.
Child: As Progan HCl: 2-5 yr 15-20 mg; >5-10 yr 20-25 mg.
Rectal
Allergic conditions
Adult: As Progan HCl: 25 mg at night, increase to 25 mg bid if necessary. Alternatively, 10-20 mg 2-3 times daily.
Child: As Progan HCl: 2-5 yr 5-15 mg daily in 1 or 2 divided doses; >5-10 yr 10-25 mg daily in 1 or 2 divided doses.
Rectal
Prophylaxis of motion sickness
Adult: As Progan HCl: 20 or 25 mg the night before travelling, followed by a similar dose the following morning if necessary.
Child: As Progan HCl: 2-5 yr 5 mg; >5-10 yr 10 mg. Doses are given the night before the journey and repeated on the following morning (6-8 hr later) if necessary.
How should I use Progan?
Use Progan as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Progan is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Progan at home, a health care provider will teach you how to use it. Be sure you understand how to use Progan. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
Progan should be given as an injection into a muscle or a vein. Do not inject Progan into an artery or under the skin.
Do not use Progan if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
If you are using Progan for motion sickness, take a dose at least 30 to 60 minutes before you begin traveling.
If you miss a dose of Progan and you are using it regularly, use it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Progan.
Uses of Progan in details
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Progan is used to prevent and treat nausea and vomiting related to certain conditions (such as before/after surgery, motion sickness). It is also used with other medication to treat severe allergic reactions (anaphylaxis) and reactions to blood products. It may also be used to treat milder allergic reactions when you cannot take Progan by mouth. It may also be used to help you feel sleepy/relaxed before and after surgery, during other procedures, or during labor and delivery. It may also be used to help certain narcotic pain relievers (such as meperidine) work better.
Progan is an antihistamine and works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Its other effects (such as anti-nausea, calming, pain relief) may work by affecting other natural substances (such as acetylcholine) and by acting directly on certain parts of the brain.
This drug is not approved for use in children younger than 2 years due to an increased risk of side effects (such as slow/shallow breathing). See also Warning section.
How to use Progan injection
It is best to inject this medication deep into a muscle. It may also be given by injection slowly into a large vein by a health care professional. Do not inject this medication under the skin or into an artery. For nausea and vomiting, use this medication as directed by your doctor, usually every 4 hours as needed. If you have any questions about the proper use of this medication, ask your doctor or pharmacist.
If you are using this medication at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.
The dosage and how often you receive this medication are based on your age, medical condition, and response to treatment. In children, the dosage may also be based on weight. Do not increase your dose or use this medication more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.
Tell your doctor if you do not get better or if you get worse.
Progan description
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A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Progan&
Progan dosage
Progan Dosage
Generic name: Progan
Dosage form: Tablets and Suppositories
See also:
Progan Injection injection
Progan Suppositories rectal suppository
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Progan Tablets and Progan Rectal Suppositories are contraindicated for children under 2 years of age.
Progan Suppositories are for rectal administration only.
Allergy
The average oral dose is 25 mg taken before retiring; however, 12.5 mg may be taken before meals and on retiring, if necessary. Single 25-mg doses at bedtime or 6.25 to 12.5 mg taken three times daily will usually suffice. After initiation of treatment in children or adults, dosage should be adjusted to the smallest amount adequate to relieve symptoms. The administration of Progan HCl in 25-mg doses will control minor transfusion reactions of an allergic nature.
Motion Sickness
The average adult dose is 25 mg taken twice daily. The initial dose should be taken one-half to one hour before anticipated travel and be repeated 8 to 12 hours later, if necessary. On succeeding days of travel, it is recommended that 25 mg be given on arising and again before the evening meal. For children, Progan Tablets, Syrup, or Rectal Suppositories, 12.5 to 25 mg, twice daily, may be administered.
Nausea and Vomiting
Antiemetics should not be used in vomiting of unknown etiology in children and adolescents.
The average effective dose of Progan for the active therapy of nausea and vomiting in children or adults is 25 mg. When oral medication cannot be tolerated, the dose should be given parenterally (cf. Progan Injection) or by rectal suppository. 12.5- to 25-mg doses may be repeated, as necessary, at 4- to 6-hour intervals.
For nausea and vomiting in children, the usual dose is 0.5 mg per pound of body weight, and the dose should be adjusted to the age and weight of the patient and the severity of the condition being treated.
For prophylaxis of nausea and vomiting, as during surgery and the postoperative period, the average dose is 25 mg repeated at 4- to 6-hour intervals, as necessary.
Sedation
This product relieves apprehension and induces a quiet sleep from which the patient can be easily aroused. Administration of 12.5 to 25 mg Progan by the oral route or by rectal suppository at bedtime will provide sedation in children. Adults usually require 25 to 50 mg for nighttime, presurgical, or obstetrical sedation.
Pre- and Postoperative Use
Progan in 12.5- to 25-mg doses for children and 50-mg doses for adults the night before surgery relieves apprehension and produces a quiet sleep.
For preoperative medication, children require doses of 0.5 mg per pound of body weight in combination with an appropriately reduced dose of narcotic or barbiturate and the appropriate dose of an atropine-like drug. Usual adult dosage is 50 mg Progan with an appropriately reduced dose of narcotic or barbiturate and the required amount of a belladonna alkaloid.
Postoperative sedation and adjunctive use with analgesics may be obtained by the administration of 12.5 to 25 mg in children and 25- to 50-mg doses in adults.
Progan Tablets and Progan Rectal Suppositories are contraindicated for children under 2 years of age.
CNS Depressants – Progan (Progan HCl) Suppositories may increase, prolong, or intensify the sedative action of other central-nervous-system depressants, such as alcohol, sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers; therefore, such agents should be avoided or administered in reduced dosage to patients receiving Progan HCl. When given concomitantly with Progan (Progan HCl) Suppositories, the dose of barbiturates should be reduced by at least one-half, and the dose of narcotics should be reduced by one-quarter to one-half. Dosage must be individualized. Excessive amounts of Progan HCl relative to a narcotic may lead to restlessness and motor hyperactivity in the patient with pain; these symptoms usually disappear with adequate control of the pain.
Epinephrine – Because of the potential for Progan HCl to reverse epinephrine's vasopressor effect, epinephrine should NOT be used to treat hypotension associated with Progan HCl Suppositories overdose.
Anticholinergics – Concomitant use of other agents with anticholinergic properties should be undertaken with caution.
Monoamine Oxidase Inhibitors (MAOI) – Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly. This possibility should be considered with Progan (Progan HCl) Suppositories.
Drug/Laboratory Test Interactions
The following laboratory tests may be affected in patients who are receiving therapy with Progan HCl:
Pregnancy Tests
Diagnostic pregnancy tests based on immunological reactions between HCG and anti-HCG may result in false-negative or false-positive interpretations.
Glucose Tolerance Test
An increase in blood glucose has been reported in patients receiving Progan HCl.
Applies to Progan: oral elixir, oral syrup, oral tablet
Other dosage forms:
rectal suppository
solution
As well as its needed effects, Progan (the active ingredient contained in Progan) may cause unwanted side effects that require medical attention.
Stop taking Progan and get emergency help immediately if any of the following effects occur:
Rare - Symptoms of neuroleptic malignant syndrome; two or more occur together; most of these effects do not require emergency medical attention if they occur alone
Convulsions (seizures)
difficult or unusually fast breathing
fast heartbeat or irregular pulse
high fever
high or low (irregular) blood pressure
increased sweating
loss of bladder control
severe muscle stiffness
unusually pale skin
unusual tiredness or weakness
Major Side Effects
If any of the following side effects occur while taking Progan, check with your doctor immediately:
Incidence not known:
Abdominal or stomach pain
black, tarry stools
bleeding gums
blood in urine or stools
bloody nose
blurred vision
chest pain or discomfort
chills
clay-colored stools
confusion as to time, place, or person
cough or hoarseness
dark urine
decreased awareness or responsiveness
difficulty or troubled breathing
double vision
fast, pounding, or irregular heartbeat or pulse
fever with or without chills
fixed position of eye
headache
heavier menstrual periods
high fever
holding false beliefs that cannot be changed by fact
hyperexcitability
increased or decreased blood pressure
increased sweating
irregular, fast or slow, or shallow breathing
itching
large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
lightheadedness, dizziness, or fainting
loss of appetite
loss of bladder control
lower back or side pain
mimicry of speech or movements
mutism
nasal stuffiness
nausea
negativism
nightmares
noisy breathing
not breathing
painful or difficult urination
pale or blue lips, fingernails, or skin
peculiar postures or movements, mannerisms or grimacing
pinpoint red spots on skin
seeing double
seeing, hearing, or feeling things that are not there
seizures
severe muscle stiffness
severe sleepiness
shortness of breath
skin rash
slow or irregular heartbeat
sore throat
sores, ulcers, or white spots on lips or in mouth
sticking out of tongue
swollen glands
tightness in chest
tremors
uncontrolled twisting movements of neck
unpleasant breath odor
unusual bleeding or bruising
unusual excitement, nervousness, or restlessness
unusual tiredness or weakness
vomiting of blood
wheezing
yellow eyes or skin
Symptoms of overdose:
Discouragement
dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
dry mouth
excessive muscle tone
feeling of warmth
feeling sad or empty
irritability
lack of appetite
loss of interest or pleasure
muscle tension or tightness
overactive reflexes
pupils of eyes large and not moving or responding to light
redness of the face, neck, arms and occasionally, upper chest
shakiness and unsteady walk
sudden death
trouble concentrating
trouble sleeping
unconsciousness
unsteadiness, trembling, or other problems with muscle control or coordination
unusual paleness
Minor Side Effects
Some Progan side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:
Incidence not known:
blistering, crusting, irritation, itching, or reddening of skin
continuing ringing or buzzing or other unexplained noise in ears
Injection: Progan is contraindicated in comatose states, in patients who have received large amounts of central-nervous-system depressants (alcohol, sedative hypnotics, including barbiturates, general anesthetics, narcotics, narcotic analgesics, tranquilizers, etc.), and in patients who have demonstrated an idiosyncrasy or hypersensitivity to Progan.
Under no circumstances should Progan be given by intra-arterial injection due to the likelihood of severe arteriospasm and the possibility of resultant gangrene
Progan HCl injection should not be given by the subcutaneous route; evidence of chemical irritation has been noted, and necrotic lesions have resulted on rare occasions following subcutaneous injection. The preferred parenteral route of administration is by deep intramuscular injection.
Syrup, Tablets and Suppositories: Progan Tablets and Suppositories are contraindicated for use in pediatric patients less than two years of age.
Progan Tablets and Suppositories are contraindicated in comatose states, and in individuals known to be hypersensitive or to have had an idiosyncratic reaction to Progan or to other phenothiazines.
Antihistamines are contraindicated for use in the treatment of lower respiratory tract symptoms including asthma.
DTP/NCI. "promethazine: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).
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The results of a survey conducted on ndrugs.com for Progan are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Progan. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.
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2 consumers reported age
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> 60
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100.0%
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