Proglicem Uses

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What is Proglicem?

Proglicem given orally raises blood sugar by slowing the release of insulin from the pancreas.

Proglicem is used to treat low blood sugar (hypoglycemia) related to certain cancers that affect the pancreas and cause it to release too much insulin.

Proglicem may also be used for purposes other than those listed in this medication guide.

Proglicem indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Proglicem® (ORAL Proglicem) is useful in the management of hypoglycemia due to hyperinsulinism associated with the following conditions:

Adults: Inoperable islet cell adenoma or carcinoma, or extrapancreatic malignancy.
Infants and Children: Leucine sensitivity, islet cell hyperplasia, nesidioblastosis, extrapancreatic malignancy, islet cell adenoma, or adenomatosis. Proglicem® may be used preoperatively as a temporary measure, and postoperatively, if hypoglycemia persists.

Proglicem® should be used only after a diagnosis of hypoglycemia due to one of the above conditions has been definitely established. When other specific medical therapy or surgical management either has been unsuccessful or is not feasible, treatment with Proglicem® should be considered.

How should I use Proglicem?

Use Proglicem suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Proglicem suspension.

Uses of Proglicem in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Use: Labeled Indications

Hyperinsulinemic hypoglycemia: Management of hypoglycemia due to hyperinsulinism due to the following conditions in adults (ie, inoperable islet cell adenoma or carcinoma, or extrapancreatic malignancy) and infants and children (ie, leucine sensitivity, islet cell hyperplasia, nesidioblastosis, extrapancreatic malignancy, islet cell adenoma, or adenomatosis; may be used preoperatively as a temporary measure, and postoperatively, if hypoglycemia persists).

Note: Consider treatment with Proglicem when other specific medical therapy or surgical management for hypoglycemia due to the above conditions either has been unsuccessful or is not feasible.

Proglicem description

A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group. [PubChem]

Proglicem dosage

Proglicem Dosage

Generic name: Proglicem

Dosage form: Injection

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Proglicem I.V. Injection was originally recommended for use by bolus administration of 300 mg. Recent studies have shown that minibolus administration of Proglicem I.V. Injection, ie, doses of 1 to 3 mg/kg repeated at intervals of 5 to 15 minutes is as effective in reducing blood pressure. Minibolus administration usually provides a more gradual reduction in blood pressure and thus may be expected to reduce the circulatory and neurological risks associated with acute hypotension.

Proglicem I.V. Injection is administered undiluted and rapidly by intravenous injections of 1 to 3 mg/kg up to a maximum of 150 mg in a single injection. This dose may be repeated at intervals of 5 to 15 minutes until a satisfactory reduction in blood pressure (diastolic pressure below 100 mmHg) has been achieved.

With the patient recumbent, the calculated dose of Proglicem I.V. Injection is administered intravenously in 30 seconds or less.

Proglicem I.V. Injection should only be given into a peripheral vein. Do not administer it intramuscularly, subcutaneously, or into body cavities. Avoid extravasation of the drug into subcutaneous tissues.

Following the use of Proglicem I.V. Injection, the blood pressure should be monitored closely until it has stabilized. Thereafter, measurements taken hourly during the balance of the effect should indicate any unusual response. A further decrease in blood pressure 30 minutes or more after injection should be investigated for causes other than the action of Proglicem I.V. Injection. It is preferable that the patient remain supine for at least 1 hour after injection. In ambulatory patients, the blood pressure should also be measured with the patient standing before surveillance is ended.

Repeated administration of Proglicem I.V. Injection at intervals of 4 to 24 hours usually will maintain the blood pressure below pretreatment levels until a regimen of oral antihypertensive medication can be instituted. The interval between injections may be adjusted by the duration of the response to each injection. It is usually unnecessary to continue treatment with Proglicem I.V. Injection for more than 4 to 5 days.

Since repeated administration of Proglicem I.V. Injection can lead to sodium and water retention, administration of a diuretic may be necessary both for maximal blood pressure reduction and to avoid congestive heart failure.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

More about Proglicem (Proglicem)

Consumer resources

Professional resources

Related treatment guides

Proglicem interactions

See also:
What other drugs will affect Proglicem?

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Since Proglicem is highly bound to serum proteins, it may displace other substances which are also bound to protein, such as bilirubin or coumarin and its derivatives, resulting in higher blood levels of these substances. Concomitant administration of oral Proglicem and diphenylhydantoin may result in a loss of seizure control. These potential interactions must be considered when administering Proglicem® Capsules or Suspension.

The concomitant administration of thiazides or other commonly used diuretics may potentiate the hyperglycemic and hyperuricemic effects of Proglicem.

Drug/Laboratory Test Interactions

The hyperglycemic and hyperuricemic effects of Proglicem preclude proper assessment of these metabolic states. Increased renin secretion, IgG concentrations and decreased cortisol secretions have also been noted. Proglicem inhibits glucagon-stimulated insulin release and causes a false-negative insulin response to glucagon.

Proglicem side effects

See also:
What are the possible side effects of Proglicem?

Applies to Proglicem: oral capsule, oral suspension

In addition to its needed effects, some unwanted effects may be caused by Proglicem (the active ingredient contained in Proglicem). In the event that any of these side effects do occur, they may require medical attention.

Stop taking Proglicem and get emergency help immediately if any of the following effects occur:

Rare

Severity: Moderate

If any of the following side effects occur while taking Proglicem, check with your doctor or nurse as soon as possible:

More common:

Less common: Rare

Minor Side Effects

Some of the side effects that can occur with Proglicem may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:

This medicine may cause a temporary increase in hair growth in some people when it is used for a long time. After treatment with Proglicem has ended, normal hair growth should return.

Proglicem contraindications

See also:
What is the most important information I should know about Proglicem?

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You should not take this medication if you are allergic to Proglicem or diuretics (water pills).

Oral Proglicem should not be used to treat occasional hypoglycemia related to diet.

Before taking Proglicem, tell your doctor if you have congestive heart failure, kidney disease, gout, high cholesterol, or low potassium.

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Your doctor may occasionally change your dose to make sure you get the best results from this medication.

If your blood sugar gets too high (hyperglycemia), you may have symptoms such as increased thirst, loss of appetite, fruity breath odor, increased urination, drowsiness, dry skin, nausea, and vomiting. Tell your doctor right away if you have any of these symptoms.

To be sure this medication is helping your condition and not causing harmful effects, your urine will need to be tested often for the presence of glucose (sugar) or ketones. You may be able to do this testing at home. Call your doctor if you have any abnormal test result.

Your doctor may also want you to have blood or urine tests at regular intervals. Do not miss any scheduled appointments.

Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are taking Proglicem.

If your condition does not improve after taking Proglicem for 2 to 3 weeks, stop taking the medication and talk to your doctor.



Active ingredient matches for Proglicem:

Diazoxide in Argentina, France, Germany, Italy, Netherlands, Switzerland.


Unit description / dosage (Manufacturer)Price, USD
Capsule; Oral; Diazoxide 25 mg
Capsule; Oral; Diazoxide 100 mg
Proglicem 25 mg x 100's
Proglicem 100 mg x 100's

List of Proglicem substitutes (brand and generic names):

Injectable; Injection; Diazoxide 300 mg
Injectable; Injection; Diazoxide 15 mg / ml
Proglycem 50 mg/ml Suspension 30ml Bottle$ 197.05
Diazoxide powder$ 85.07
Proglycem 100 mg Capsule$ 1.65
Diazoxide DBL 300 mg/20 mL x 1's
Tablet, Sugar-Coated; Oral; Diazoxide 50 mg (Mercury)
Injectable; Injection; Diazoxide 15 mg / ml (Schering)
20 milliliter in 1 ampule (Schering)
Capsule; Oral; Diazoxide 50 mg (Ifet)
Capsule; Oral; Diazoxide 100 mg (Ifet)
Suspension; Oral; Diazoxide 50 mg / ml (Ifet)
Proglycem 50 mg/1 mL x 30 mL (Ifet)
Proglycem suspension 50 mg/mL (Ifet)
Proglycem capsule 100 mg (Ifet)

References

  1. DailyMed. "DIAZOXIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "diazoxide". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "diazoxide". http://www.drugbank.ca/drugs/DB01119 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Proglicem are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Proglicem. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported useful

No survey data has been collected yet


Consumer reported price estimates

No survey data has been collected yet


1 consumer reported time for results

To what extent do I have to use Proglicem before I begin to see changes in my health conditions?
As part of the reports released by ndrugs.com website users, it takes 3 days and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Proglicem. To get the time effectiveness of using Proglicem drug by other patients, please click here.
Users%
3 days1
100.0%


4 consumers reported age

Users%
< 12
50.0%
46-601
25.0%
30-451
25.0%


Consumer reviews


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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