Pregnancy of Progynon Depot in details
Estrogenic agents have been associated with urogenital abnormalities in offspring that manifest later in life. Vaginal adenosis, squamous cell dysplasia of the uterine cervix and vaginal cancer have developed later in life in female offspring. In male offspring, the risks of urogenital abnormalities and testicular cancer later in life are increased.
Progynon Depot has been assigned to pregnancy category X by the FDA. There are no controlled data in human pregnancy. Progynon Depot is contraindicated during pregnancy.
See references
Progynon Depot breastfeeding
Limited data are available on the excretion of Progynon Depot into human milk. The American Academy of Pediatrics considers Progynon Depot to be usually compatible with breast-feeding despite reports of "withdrawal" and "vaginal bleeding". Progynon Depot has been shown to decrease to quantity and quality of the milk. Estrogens are not indicated for the prevention of postpartum breast engorgement. The manufacturer recommends that caution be used when administering Progynon Depot to nursing women.
See references
References for pregnancy information
- Heinonen O, Slone D, Shapiro S; Kaufman DW ed. "Birth Defects and Drugs in Pregnancy." Littleton, MA: Publishing Sciences Group, Inc. (1977): 297
- "Product Information. Estrace (Progynon Depot)." Bristol-Myers Squibb, Princeton, NJ.
References for breastfeeding information
- "Product Information. Estrace (Progynon Depot)." Bristol-Myers Squibb, Princeton, NJ.
- Committee on Drugs, 1992 to 1993 "The transfer of drugs and other chemicals into human milk." Pediatrics 93 (1994): 137-50
References
- DailyMed. "ESTRADIOL HEMIHYDRATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubMed Health. "Vivelle-Dot: This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
- Human Metabolome Database (HMDB). "Estradiol: The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.". http://www.hmdb.ca/metabolites/HMDB0... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
