Protamol Uses

How do you administer this medicine?

Protamol indications

infoAn indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or Paracetamol (Protamol) is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of Paracetamol (Protamol). A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Protamol Ophthalmic Solution is indicated for inhibition of intraoperative miosis.

Protamol description

Protamol: Each tablet contains Ibuprofen (Protamol) 300 mg and Paracetamol (Protamol) 325 mg.

Protamol Kid: Each dispersible tablet contains Ibuprofen (Protamol) 100 mg and Paracetamol (Protamol) 125 mg. Colour: Tartrazine.

Protamol Forte: Each tablet contains Ibuprofen (Protamol) 400 mg and Paracetamol (Protamol) 500 mg.

Protamol dosage

For oral use for adult single dose is 25-50 mg 2-3 times / 24 h. Frequency of admission depends on the dosage form employed, the severity of the disease and is 1-3 times / 24 h, rectally - 1 times / 24 h, for the treatment of acute conditions or the exacerbation of chronic edema use intramuscular in dose of 75 mg.

For children older than 6 years and adolescents daily dose is 2 mg / kg.

Topical applied at a dose of 2-4 g (depending on the size of painful area) on the affected area 3-4 times / 24 h.

When used in ophthalmology frequency and duration of administration are determined individually.

The maximum oral daily dose for adults is 150 mg.

Protamol interactions


Clinical studies with acetylcholine chloride revealed no interference, and there is no known pharmacological basis for such an interaction. However, with other topical nonsteroidal anti-inflammatory products, there have been reports that acetylcholine chloride and carbachol have been ineffective when used in patients treated with these agents.

Interaction of Protamol with other topical ophthalmic medications has not been fully investigated.

Protamol side effects


The most frequent adverse reactions reported are burning and stinging of short duration. Instances of discomfort, itching and redness have been reported. Other reactions occurring in less than 0.5% of patients include allergy, iritis, pain, chemosis, photophobia, irritation, and punctate epithelial staining.


Systemic reactions related to therapy were not reported in the clinical studies. It is known that some systemic absorption does occur with ocularly applied drugs, and that nonsteroidal anti-inflammatory drugs have been shown to increase bleeding time by interference with thrombocyte aggregation. It is recommended that Protamol be used with caution in patients with bleeding tendencies and those taking anticoagulants.

Protamol contraindications


Protamol is contraindicated in patients with the following conditions: History of severe allergic reaction eg, anaphylaxis or angioedema induced by aspirin or other NSAIDs. Because of the possibility of cross-sensitivity due to structural relationships which exist among non-steroidal anti-inflammatory medicines, acute allergic reactions are likely to occur in patients who have exhibited allergic reactions to these compounds.

Patients sensitive to any of the ingredients.

Aspirin-induced nasal polyps associated with bronchospasm (high risk of severe allergic reactions because of cross-sensitivity).

Active peptic ulceration.

Severe renal function impairment.

Active ingredient matches for Protamol:

Ibuprofen/Paracetamol in Vietnam.

Unit description / dosage (Manufacturer)Price, USD
Protamol 5 Blister x 20 Tablet

List of Protamol substitutes (brand and generic names):

Propain Paracetamol 325mg, Ibuprofen400mg TAB / 20x10 (Restan)$ 3.62
PYREFLAM 400 MG/325 MG TABLET 1 strip / 10 tablets each (Jawa Pharmaceuticals Pvt Ltd)$ 0.13
PYREMOL IB 100 MG/162.5 MG SUSPENSION 1 bottle / 60 ML suspension each (Alembic Pharmaceuticals Ltd)$ 0.24
PYREMOL IB 400 MG/325 MG TABLET 1 strip / 10 tablets each (Alembic Pharmaceuticals Ltd)$ 0.13
PYREMOL PLUS IB 400 MG/325 MG TABLET 1 strip / 10 tablets each (Alembic Pharmaceuticals Ltd)$ 0.09
Pyrofen Ibuprofen 400mg, Paracetamol325mg, Racemethionine 32.5mg TAB / 10 (Acto)$ 0.20
10's (Acto)$ 0.20
Pyrofen Ibuprofen 400 mg, paracetamol325 mg, racemethionine 32.5mg. TAB / 10 (Acto)$ 0.20
PYROFEN tab 10's (Acto)$ 0.20
REDUC-A 400MG/350MG TABLET 1 strip / 10 tablets each (J B Chemicals and Pharmaceuticals Ltd)$ 0.77
Regaflam Ibuprofen 400mg, Paracetamol333mg TAB / 10 (Bal Pharma)$ 0.10
10's (Bal Pharma)$ 0.10
Regaflam Ibuprofen 400 mg, paracetamol333 mg. TAB / 10 (Bal Pharma)$ 0.10
REGAFLAM 400MG/333MG TABLET 1 strip / 10 tablets each (Bal Pharma)$ 0.10
REGAFLAM tab 10's (Bal Pharma)$ 0.10
Regaflam 400 mg/333 mg Tablet (Bal Pharma)$ 0.01
Regalam -C Caffeine 65mg, Ibuprofen400mg, Paracetamol 500mg TAB / 10$ 0.25
Renofen Ibuprofen 400mg, Paracetamol325mg TAB / 15$ 0.18
15's$ 0.17
Renofen Ibuprofen 400 mg, paracetamol325 mg. TAB / 15$ 0.19
RENOFEN 400 MG/325 MG TABLET 1 strip / 15 tablets each (Indoco Remedies Ltd)$ 0.21
Renofen 400 mg/325 mg Tablet (Indoco Remedies Ltd)$ 0.01
Restolax 100's (Eurohealth)
Restolax Forte 10's
Restolax Forte 120's$ 11.48
Restolax Forte tab 10's (Lloyd)
Restolax Forte tab 120's (Lloyd)
Restolax tab 10's (Lloyd)
Restolax tab 100's (Lloyd)
Riflam Paracetamol 250mg, Ibuprofen20mg, Diclofenac Sodium 50mg TAB / 20x10$ 6.35
Riflam Paracetamol 250mg, Ibuprofen20mg, Diclofenac Sodium 50mg TAB / 20x10$ 6.35
RUBIGESIC P 400MG/325MG TABLET 1 strip / 10 tablets each (Bevit Pharmaceuticals Ltd)$ 0.63
Rubigesic P 400 mg/325 mg Tablet (Bevit Pharmaceuticals Ltd)$ 0.06
Rumagesic Paracetamol 325mg, Ibuprofen400mg TAB / 20x10$ 3.81
Rumagesic Paracetamol 325mg, Ibuprofen400mg TAB / 20x10$ 3.81
RUMAGESIC 400MG/325MG TABLET 1 strip / 10 tablets each (Numed)$ 0.24
RUMAGESIC PLUS 400 MG/325 MG TABLET 1 strip / 10 tablets each (Numed)$ 0.48
Rumagesic 400mg/325mg Tablet (Numed)$ 0.02
Rumagesic Plus 400 mg/325 mg Tablet (Numed)$ 0.05


  1. DailyMed. "IBUPROFEN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". (accessed September 17, 2018).
  2. PubChem. "ibuprofen". (accessed September 17, 2018).
  3. DrugBank. "ibuprofen". (accessed September 17, 2018).


The results of a survey conducted on for Protamol are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Protamol. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported useful

No survey data has been collected yet

Consumer reported price estimates

No survey data has been collected yet

1 consumer reported time for results

To what extent do I have to use Protamol before I begin to see changes in my health conditions?
As part of the reports released by website users, it takes > 3 month and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Protamol. To get the time effectiveness of using Protamol drug by other patients, please click here.
> 3 month1

1 consumer reported age


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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