Pseudoephedrine Overdose

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How old is patient?

What happens if I overdose Pseudoephedrine?

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include confusion; hallucinations; irregular or unusually slow or rapid heartbeat; rapid breathing; seizures.

Proper storage of Pseudoephedrine sustained-release tablets (24 hour):

Store Pseudoephedrine sustained-release tablets (24 hour) at room temperature, between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Pseudoephedrine sustained-release tablets (24 hour) out of the reach of children and away from pets.

Overdose of Pseudoephedrine in details

infoWhen a dose is taken in higher dose than the recommended doses, it is called Overdose. Overdose always needs a clinical supervision. Any medicine or drug when consumed in Overdose produces untoward side effects on one or various organs in the body. A medicine is excreted in the kidney or metabolized in the liver most of the times. This process goes without any hurdles when taken in normal dose, but when taken in an overdose, the body is not able to metabolize it or send it out properly which causes the effects of anoverdose.
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If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: slow/shallow breathing, hallucinations, seizures.

Notes

This medication is for temporary use only. Do not use for more than 7 days without first consulting your doctor.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Different brands of this medication have different storage needs. Check the product package for instructions on how to store your brand, or ask your pharmacist. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

What should I avoid while taking Pseudoephedrine?

Avoid taking Pseudoephedrine if you also take diet pills, caffeine pills, or other stimulants (such as ADHD medications). Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.

Ask a doctor or pharmacist before using any other cough or cold medicine. Pseudoephedrine or other decongestants are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains Pseudoephedrine or a decongestant.

Pseudoephedrine warnings

infoWarnings are a mix of Precautions. Contraindications and interactions and serious harmful effects associated with the medicine intake. A diabetic or Hypertensive patient need to be warned about few drug interactions. A known hypersensitivity patient needs to be careful about the reactions or anaphylactic shock. A pregnant woman or a breastfeeding woman should be warned of certain medications. A Hepatitis [liver disease] patient or a cardiac patient should avoid few drugs.
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Pseudoephedrine - ORAL

IMPORTANT NOTE: The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

Pseudoephedrine - ORA

(sue-doh-eff-ED-rin)

COMMON BRAND NAME(S): Afrin, Afrinol, Chlor-Trimeton, Novafed, Sudafed

USES D-Pseudoephedrine is used to provide relief from the nasal or sinus congestion caused by allergies or the common cold, or ear congestion caused by inflammation or infection.

HOW TO USE It is recommended to drink plenty of fluids while taking this medication, unless your doctor instructs you to do otherwise.

Sustained-release or long acting tablets and capsules must be swallowed whole. Chewing or crushing them will destroy the long action and may increase side effects.

If symptoms do not improve after 7 days or are accompanied by a high fever, notify your doctor. Do not increase the dose or take this more frequently than recommended.

SIDE EFFECTS Mild stomach upset, trouble sleeping, dizziness, headache, nervousness, or loss of appetite may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Tell your doctor immediately if any of these unlikely but serious side effects occur: fast/irregular heartbeat, difficulty urinating, uncontrolled shaking or tremor.

Tell your doctor immediately if any of these rare, but very serious side effects occur: seizures, chest pain, mental/mood changes.

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching, swelling, severe dizziness, trouble breathing.

If you notice other effects not listed above, contact your doctor or pharmacist.

PRECAUTIONS Before taking Pseudoephedrine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: pre-existing heart problems, kidney or liver disease, lung disease, emphysema, high blood pressure, overactive thyroid, diabetes mellitus, glaucoma, difficulty urinating or an enlarged prostate, history of seizures.

This drug should be used only if clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

D-Pseudoephedrine passes into breast milk and may have undesirable effects on a nursing infant. Using this drug while breast-feeding is not recommended.

DRUG INTERACTIONS Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: sleeping pills, sedatives, tranquilizers, muscle relaxants, medication for depression, high blood pressure drugs.

Tell your doctor if you have taken any MAO inhibitors (e.g., furazolidone, phenelzine, selegiline, tranylcypromine) within the last two weeks.

OVERDOSE If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly. Symptoms of overdose may include irregular or unusually slow or rapid heartbeat, unusual nervousness or excitement, rapid breathing, confusion, hallucinations, and seizures.

NOTES Talk with your doctor, pharmacist or nurse about diseases you have and drugs you are already taking before using any new medication.

MISSED DOSE If you miss a dose, take it as soon as remembered if within an hour. If you do not remember until later, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the doses.

STORAGE Store at room temperature between 59 and 86 degrees F (between 15 and 30 degrees C) away from moisture and sunlight. Do not store in the bathroom. Keep all medicines away from children and pets.

What should I discuss with my healthcare provider before taking Pseudoephedrine?

Some medical conditions may interact with Pseudoephedrine suspension. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of heart problems, diabetes, glaucoma, an enlarged prostate or other prostate problems, adrenal gland problems, high blood pressure, seizures, stroke, blood vessel problems, or an overactive thyroid

Some MEDICINES MAY INTERACT with Pseudoephedrine suspension. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Rauwolfia derivatives (eg, reserpine) because they may decrease Pseudoephedrine suspension's effectiveness
  • Beta-blockers (eg, propranolol), cocaine, furazolidone, indomethacin, MAOIs (eg, phenelzine), methyldopa, oxytocic medicines (eg, oxytocin), rauwolfia derivatives (eg, reserpine), or tricyclic antidepressants (eg, amitriptyline) because the risk of Pseudoephedrine suspension's side effects may be increased
  • Bromocriptine, catechol-O-methyltransferase (COMT) inhibitors (eg, entacapone), digoxin, or droxidopa because the the risk of their side effects may be increased by Pseudoephedrine suspension
  • Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Pseudoephedrine suspension

This may not be a complete list of all interactions that may occur. Ask your health care provider if Pseudoephedrine suspension may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Pseudoephedrine precautions

infoCertain people who are very sick or very old or who are sensitive show an exacerbation of side effect of the drug which can turn dangerous at times. So, it is very important to remember the precautions while taking the medicine. Pregnancy and Breastfeeding are also special categories wherein extra care or precaution is needed when taking a drug. Few patients may have a hypersensitivity reaction to few medications, and that can be life-threatening rarely. Penicillin hypersensitivity is one example. Diarrhea, rashes are few other symptoms which need a watch. A patient with other co-existing diseases like liver disease, heart disease, kidney disease should take special precautions.
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Before taking Pseudoephedrine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Also tell your doctor if you have had negative reactions to other sympathomimetics (such as ephedrine, phenylephrine). This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

If you have any of the following health problems, consult your doctor or pharmacist before using this product: diabetes, a certain eye condition (glaucoma), heart problems (such as heart attack, chest pain, heart failure), fast/irregular heart beat, high blood pressure, kidney disease, overactive thyroid (hyperthyroidism), difficulty urinating (such as due to enlarged prostate).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Liquid products, chewable tablets, or dissolving tablets/strips may contain sugar and/or aspartame. Liquid products may also contain alcohol. Caution is advised if you have diabetes, alcohol dependence, liver disease, phenylketonuria (PKU), or any other condition that requires you to limit/avoid these substances in your diet. Ask your doctor or pharmacist about using this product safely.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially fast/irregular heartbeat, dizziness, problems urinating, trouble sleeping, or confusion.

Children may be more sensitive to the effects of this medication, especially restlessness.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

Pseudoephedrine passes into breast milk. Discuss the risks and benefits with your doctor before breast-feeding.

What happens if I miss a dose of Pseudoephedrine?

infoWhen you miss a dose, you should take it as soon as you remember, but you should take care that it should be well spaced from the next dose. You should not take an extra dose at the time of the second dose as it will become a double dose. The double dose can give unwanted side effects, so be careful. In chronic conditions or when you have a serious health issue, if you miss a dose, you should inform your health care provider and ask his suggestion.

Since Pseudoephedrine is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.



References

  1. DailyMed. "PSEUDOEPHEDRINE SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. DrugBank. "PSEUDOEPHEDRINE". http://www.drugbank.ca/drugs/DB00852 (accessed September 17, 2018).
  3. MeSH. "Nasal Decongestants". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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