An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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this medicine PreFilled Syringe (choriogonadotropin alfa injection) is indicated for the induction of final follicular maturation and early luteinization in infertile women who have undergone pituitary desensitization and who have been appropriately pretreated with follicle stimulating hormones as part of an Assisted Reproductive Technology (ART) program such as in vitro fertilization and embryo transfer. this medicine PreFilled Syringe is also indicated for the induction of ovulation (OI) and pregnancy in anovulatory infertile patients in whom the cause of infertility is functional and not due to primary ovarian failure.
Selection of Patients
1.
Before treatment with gonadotropins is instituted, a thorough gynecologic and endocrinologic evaluation must be performed. This should include an assessment of pelvic anatomy. Patients with tubal obstruction should receive this medicine PreFilled Syringe only if enrolled in an in vitro fertilization program.
2.
Primary ovarian failure should be excluded by the determination of gonadotropin levels.
3.
Appropriate evaluation should be performed to exclude pregnancy.
4.
Patients in later reproductive life have a greater predisposition to endometrial carcinoma as well as a higher incidence of anovulatory disorders. A thorough diagnostic evaluation should always be performed in patients who demonstrate abnormal uterine bleeding or other signs of endometrial abnormalities before starting FSH and this medicine PreFilled Syringe therapy.
5.
Evaluation of the partner
Uses of Pubergen in details
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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This medication is a hormone used in boys (before puberty) to cause the normal dropping of the testicles into the scrotum. It is also used in certain boys to help with normal sexual development. It works by causing the testes to release male sex hormones (e.g., testosterone).
This medication is also used in women to treat fertility problems. It is given after finishing another medication (menotropins) to cause the release of an egg (ovulation). It should not be used in women whose ovaries no longer make eggs properly (primary ovarian failure).
This medication has not been shown to be effective for weight loss and should not be used for this purpose.
How to use A.P.L. intramuscular
This medication is given by injection into a muscle by a health care professional. If you are giving this medication at home, learn all preparation and usage instructions for this product. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. If you have any questions about the use of this medication, ask your doctor or pharmacist.
The dosage is based on your age, weight, medical condition, and response to treatment.
For boys, use this medication usually 3 times a week or as directed by your doctor. For women, use this medication usually for 1 dose after finishing your menotropins treatment.
Use this medication regularly to get the most benefit from it. To help you remember, mark the day(s) on the calendar when you need to receive the medication.
Learn how to store and discard needles and medical supplies safely. Consult your pharmacist for more details.
Pubergen description
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Each vial with powder of Pubergen contains Chorionic Gonadotrophin (HCG) 5,000 IU as the active ingredient and lactose as further ingredient.
Each ampoule with 1 mL solvent of Pubergen contains isotonic sodium chloride solution and dilute hydrochloric acid for pH adjustment.
Pubergen dosage
Female:To Induce Ovulation: 5,000 or 10,000 IU injected once IM.
To Maintain Corpus Luteum Function: 1,500-5,000 IU to be injected IM on the 3rd, 6th and 9th day following ovulation. If desired, Pubergen 1500 can be used.
Male:To Induce Puberty in Boys with Pubertas Tarda: 3,000-5,000 IU IM once a week over a period of 3 months. If desired, Pubergen 1500 can be used.
Hypogonadotrophic Hypogonadism (together with HMG): 1,500-6,000 IU IM per week. If desired, Pubergen 1500 can be used.
As a Diagnostic Agent:For Differential Diagnosis in Boys with Undescended Testicle and to Assess the Function of the Testes in Patients with Hypogonadotrophic Hypogonadism: One (1) time injection of 5,000 IU IM.
Administration: Pubergen is to be injected IM.
Pubergen interactions
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Drug/Laboratory Test Interactions
The following laboratory results may be altered by the use of estrogen-progestin combination drugs:
Increased sulfobromophthalein retention and other hepatic function tests.
Coagulation tests: increase in prothrombin factors VII, VIII, IX and X.
Metyrapone test.
Pregnanediol determination.
Thyroid function: increase in PBI, and butanol extractable protein bound iodine and decrease in T3 uptake values.
Fasting and 2-hour plasma insulin and glucose levels following an oral glucose tolerance test (OGTT) and figrinogen levels were measured in patients receiving PROMETRIUM® Capsules at a dose of 200 mg/day for 12 days per 28 day cycle in combination with conjugated estrogens 0.625 mg/day (n-120). Table 6 summarizes this data. Plasma insulin levels 2 hours post-OGTT were decreased from baseline. The fasting plasma glucose and fasting plasma insulin levels were also decreased from baseline. Glucose levels 2 hours post-OGTT were increased slightly. There was no effect on fibrinogen levels.
For information on changes in lipid profile, see the CLINICAL PHARMACOLOGY, Clinical Studies subsection, Table 5.
Table 6
Pubergen side effects
The following adverse reactions have been previously reported during menotropin therapy:
1.Pulmonary and vascular complications
2.Adnexal torsion (as a complication of ovarian enlargement)
3. Mild to moderate ovarian enlargement
4.Hemoperitoneum
The following medical events have been reported subsequent to pregnancies resulting from hCG therapy in controlled clinical studies:
1.Spontaneous Abortion
2.Ectopic Pregnancy
3.Premature Labor
4.Postpartum Fever
5.Congenital abnormalities
Preferred Term : At Least One Adverse Event
Incidence Rate % (n): 33.1% (78)
Preferred Term : APPLICATION SITE DISORDERS
Incidence Rate % (n): 14.0% (33)
Preferred Term : INJECTION SITE PAIN
Incidence Rate % (n): 7.6% (18)
Preferred Term : INJECTION SITE BRUISING
Incidence Rate % (n): 4.7% (11)
Preferred Term : GASTRO-INTESTINAL SYSTEM DISORDERS
Incidence Rate % (n): 8.5% (20)
Preferred Term : ABDOMINAL PAIN
Incidence Rate % (n): 4.2% (10)
Preferred Term : NAUSEA
Incidence Rate % (n): 3.4% (8)
Preferred Term : VOMITING
Incidence Rate % (n): 2.5% (6)
Preferred Term : SECONDARY TERMS (POST-OPERATIVE PAIN)
Incidence Rate % (n): 4.7% (11)
Preferred Term : POST-OPERATIVE PAIN
Incidence Rate % (n): 4.7% (11)
Pubergen contraindications
PROMETRIUM Capsules should not be used in women with any of the following conditions:
1. PROMETRIUM Capsules should not be used in patients with known hypersensitivity to its ingredients. PROMETRIUM Capsules contain peanut oil and should never be used by patients allergic to peanuts.
The results of a survey conducted on ndrugs.com for Pubergen are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Pubergen. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.
User reports
Consumer reported useful
No survey data has been collected yet
Consumer reported price estimates
No survey data has been collected yet
Consumer reported time for results
No survey data has been collected yet
2 consumers reported age
Users
%
16-29
2
100.0%
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