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Pyreflam Uses |
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Allergic States
Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment in asthma, atopic dermatitis, contact dermatitis, drug hypersensitivity reactions, perennial or seasonal allergic rhinitis, serum sickness, transfusion reactions.
Dermatologic Diseases
Bullous dermatitis herpetiformis, exfoliative erythroderma, mycosis fungoides, pemphigus, severe erythema multiforme (Stevens-Johnson syndrome).
Endocrine Disorders
Congenital adrenal hyperplasia, hypercalcemia associated with cancer, nonsuppurative thyroiditis.
Hydrocortisone or cortisone is the drug of choice in primary or secondary adrenocortical insufficiency. Synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation is of particular importance.
Gastrointestinal Diseases
To tide the patient over a critical period of the disease in regional enteritis and ulcerative colitis.
Hematologic Disorders
Acquired (autoimmune) hemolytic anemia, Diamond-Blackfan anemia, pure red cell aplasia, selected cases of secondary thrombocytopenia.
Miscellaneous
Trichinosis with neurologic or myocardial involvement, tuberculous meningitis with subarachnoid block or impending block when used with appropriate antituberculous chemotherapy.
Neoplastic Diseases
For palliative management of leukemias and lymphomas.
Nervous System
Acute exacerbations of multiple sclerosis; cerebral edema associated with primary or metastatic brain tumor or craniotomy.
Ophthalmic Diseases
Sympathetic ophthalmia, temporal arteritis, uveitis and ocular inflammatory conditions unresponsive to topical corticosteroids.
Renal Diseases
To induce diuresis or remission of proteinuria in idiopathic nephrotic syndrome or that due to lupus erythematosus.
Respiratory Diseases
Berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy, idiopathic eosinophilic pneumonias, symptomatic sarcoidosis.
Rheumatic Disorders
As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in acute gouty arthritis; acute rheumatic carditis; ankylosing spondylitis; psoriatic arthritis; rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy). For the treatment of dermatomyositis, polymyositis, and systemic lupus erythematosus.
The intra-articular or soft tissue administration of Injectable Suspension is indicated as adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in acute gouty arthritis, acute and subacute bursitis, acute nonspecific tenosynovitis, epicondylitis, rheumatoid arthritis, synovitis of osteoarthritis.
The intralesional administration of Injectable Suspension is indicated for alopecia areata; discoid lupus erythematosus; keloids; localized hypertrophic, infiltrated, inflammatory lesions of granuloma annulare, lichen planus, lichen simplex chronicus (neurodermatitis), and psoriatic plaques; necrobiosis lipoidica diabeticorum.
Injectable Suspension may also be useful in cystic tumors of an aponeurosis or tendon (ganglia
Pyreflam: Each tablet contains Ibuprofen (Pyreflam) 300 mg and Paracetamol (Pyreflam) 325 mg.
Pyreflam Kid: Each dispersible tablet contains Ibuprofen (Pyreflam) 100 mg and Paracetamol (Pyreflam) 125 mg. Colour: Tartrazine.
Pyreflam Forte: Each tablet contains Ibuprofen (Pyreflam) 400 mg and Paracetamol (Pyreflam) 500 mg.
For oral use for adult single dose is 25-50 mg 2-3 times / 24 h. Frequency of admission depends on the dosage form employed, the severity of the disease and is 1-3 times / 24 h, rectally - 1 times / 24 h, for the treatment of acute conditions or the exacerbation of chronic edema use intramuscular in dose of 75 mg.
For children older than 6 years and adolescents daily dose is 2 mg / kg.
Topical applied at a dose of 2-4 g (depending on the size of painful area) on the affected area 3-4 times / 24 h.
When used in ophthalmology frequency and duration of administration are determined individually.
The maximum oral daily dose for adults is 150 mg.
At simultaneous application with diclofenac antihypertensive drugs may be weakening their actions.
There are few reports on the occurrence of seizures in patients taking both NSAIDs and antibacterial drugs quinolic series.
At simultaneous application with GCS and increased risk of side effects from the digestive system.
With simultaneous use of diuretics may decrease diuretic effect. With the simultaneous use of potassium-sparing diuretics may increase the concentration of potassium in the blood.
With simultaneous use with other NSAIDs may increase the risk of side effects.
There are reports of hypoglycemia or hyperglycemia in patients with diabetes who engaged in diclofenac together with hypoglycemic drugs.
When applied simultaneously with acetylsalicylic acid may decrease the concentration of diclofenac in plasma.
Although clinical studies have not found the influence of diclofenac on the action of anticoagulants, describes the individual cases of bleeding when used with diclofenac and warfarin.
With simultaneous use may increase digoxin, lithium, and phenytoin in blood plasma.
The absorption of diclofenac from the gastrointestinal tract is reduced by simultaneous application with kolestiraminom, to a lesser extent - with colestipol.
With simultaneous use may increase the concentration of methotrexate in plasma and increased its toxicity.
With simultaneous application of diclofenac could not affect the bioavailability of morphine, but the concentration of the active metabolite of morphine may be enhanced in the presence of diclofenac, which increases the risk of side effects metabolites of morphine, including respiratory depression.
When applied simultaneously with pentazocine described a case of great convulsions, and rifampicin - may decrease the concentration of diclofenac in plasma, with ceftriaxone - increases excretion of ceftriaxone in bile; with cyclosporine - may increase cyclosporine nephrotoxicity.
Ibuprofen (Pyreflam): Cardiovascular System: Tachycardia, flushing, increase in blood pressure.
Central Nervous System: Confusion, hallucinations, mental depression, peripheral neuropathy, tinnitus, drowsiness, insomnia.
Gastrointestinal System: Epigastric pain or discomfort, gastritis, hematemesis, GI perforation, GI ulceration.
Dermatological: Allergic dermatitis, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis.
Renal: Hematuria, cystitis, renal impairment or failure, polyuria, fluid retention/oedema, acute renal failure, interstitial nephritis, nephrotic syndrome.
Hematological: Agranulocytosis, anaemia, aplastic anaemia, eosinophilia, hemolytic anaemia, leukopenia, thrombocytopenia.
Hypersensitivity Reactions: Anginitis, angioedema, bronchospastic allergic reactions, allergic rhinitis, serum sickness-like reaction, systemic lupus erythematosus, aseptic meningitis.
Ear, Nose and Throat: Decreased hearing or any change in hearing, epistaxis.
Hepatic Effect: Hepatitis.
Pancreatic Effect: Pancreatitis.
Paracetamol (Pyreflam): Gastrointestinal System: Nausea, vomiting, stomach pain or cramps, diarrhoea, loss of appetite, hepatotoxicity, hepatic failure, hepatic encephalopathy, GIT bleeding, pancreatitis.
Central Nervous System: Convulsions, respiratory depression, cerebral oedema, coma.
Haematological: Leucopenia, thrombocytopenia, neutropenia, pancytopenia, agranulocytosis, disseminated intravascular coagulation.
Metabolic: Hypoglycaemia, metabolic acidosis.
Cardiovascular System: Cardiac arrhythmias, cardiovascular collapse.
Renal System: Renal tubular necrosis, renal failure.
Dermatological: Skin rashes and other allergic reactions. The rash is usually erythematous or urticarial but sometimes more serious and may be accompanied by fever and mucosal lesions.
Pyreflam is contraindicated in patients with the following conditions: History of severe allergic reaction eg, anaphylaxis or angioedema induced by aspirin or other NSAIDs. Because of the possibility of cross-sensitivity due to structural relationships which exist among non-steroidal anti-inflammatory medicines, acute allergic reactions are likely to occur in patients who have exhibited allergic reactions to these compounds.
Patients sensitive to any of the ingredients.
Aspirin-induced nasal polyps associated with bronchospasm (high risk of severe allergic reactions because of cross-sensitivity).
Active peptic ulceration.
Severe renal function impairment.
Unit description / dosage (Manufacturer) | Price, USD |
PYREFLAM 400 MG/325 MG TABLET 1 strip / 10 tablets each (Jawa Pharmaceuticals Pvt Ltd) | $ 0.13 |
List of Pyreflam substitutes (brand and generic names): | |
Protamol (Vietnam) | |
Protamol 5 Blister x 20 Tablet | |
PYREMOL IB | |
PYREMOL IB 100 MG/162.5 MG SUSPENSION 1 bottle / 60 ML suspension each (Alembic Pharmaceuticals Ltd) | $ 0.24 |
PYREMOL IB 400 MG/325 MG TABLET 1 strip / 10 tablets each (Alembic Pharmaceuticals Ltd) | $ 0.13 |
PYREMOL PLUS IB | |
PYREMOL PLUS IB 400 MG/325 MG TABLET 1 strip / 10 tablets each (Alembic Pharmaceuticals Ltd) | $ 0.09 |
Pyrofen (India) | |
Pyrofen Ibuprofen 400mg, Paracetamol325mg, Racemethionine 32.5mg TAB / 10 (Acto) | $ 0.20 |
10's (Acto) | $ 0.20 |
Pyrofen Ibuprofen 400 mg, paracetamol325 mg, racemethionine 32.5mg. TAB / 10 (Acto) | $ 0.20 |
PYROFEN tab 10's (Acto) | $ 0.20 |
REDUC A | |
REDUC-A | |
REDUC-A 400MG/350MG TABLET 1 strip / 10 tablets each (J B Chemicals and Pharmaceuticals Ltd) | $ 0.77 |
Regaflam (India) | |
Regaflam Ibuprofen 400mg, Paracetamol333mg TAB / 10 (Bal Pharma) | $ 0.10 |
10's (Bal Pharma) | $ 0.10 |
Regaflam Ibuprofen 400 mg, paracetamol333 mg. TAB / 10 (Bal Pharma) | $ 0.10 |
REGAFLAM 400MG/333MG TABLET 1 strip / 10 tablets each (Bal Pharma) | $ 0.10 |
REGAFLAM tab 10's (Bal Pharma) | $ 0.10 |
Regaflam 400 mg/333 mg Tablet (Bal Pharma) | $ 0.01 |
Regalam -C | |
Regalam -C Caffeine 65mg, Ibuprofen400mg, Paracetamol 500mg TAB / 10 | $ 0.25 |
Relaxid (Philippines) | |
Relievo (Philippines) | |
Renofen (India) | |
Renofen Ibuprofen 400mg, Paracetamol325mg TAB / 15 | $ 0.18 |
15's | $ 0.17 |
Renofen Ibuprofen 400 mg, paracetamol325 mg. TAB / 15 | $ 0.19 |
RENOFEN 400 MG/325 MG TABLET 1 strip / 15 tablets each (Indoco Remedies Ltd) | $ 0.21 |
Renofen 400 mg/325 mg Tablet (Indoco Remedies Ltd) | $ 0.01 |
Restolax (Philippines) | |
Restolax 100's (Eurohealth) | |
Restolax Forte (Philippines) | |
Restolax Forte 10's | |
Restolax Forte 120's | $ 11.48 |
Restolax/Restolax Forte (Philippines) | |
Restolax Forte tab 10's (Lloyd) | |
Restolax Forte tab 120's (Lloyd) | |
Restolax tab 10's (Lloyd) | |
Restolax tab 100's (Lloyd) | |
Riflam | |
Riflam Paracetamol 250mg, Ibuprofen20mg, Diclofenac Sodium 50mg TAB / 20x10 | $ 6.35 |
Riflam Paracetamol 250mg, Ibuprofen20mg, Diclofenac Sodium 50mg TAB / 20x10 | $ 6.35 |
RUBIGESIC P | |
RUBIGESIC P 400MG/325MG TABLET 1 strip / 10 tablets each (Bevit Pharmaceuticals Ltd) | $ 0.63 |
Rubigesic P 400 mg/325 mg Tablet (Bevit Pharmaceuticals Ltd) | $ 0.06 |
Rumagesic | |
Rumagesic Paracetamol 325mg, Ibuprofen400mg TAB / 20x10 | $ 3.81 |
Rumagesic Paracetamol 325mg, Ibuprofen400mg TAB / 20x10 | $ 3.81 |
RUMAGESIC 400MG/325MG TABLET 1 strip / 10 tablets each (Numed) | $ 0.24 |
RUMAGESIC PLUS 400 MG/325 MG TABLET 1 strip / 10 tablets each (Numed) | $ 0.48 |
Rumagesic 400mg/325mg Tablet (Numed) | $ 0.02 |
Rumagesic Plus 400 mg/325 mg Tablet (Numed) | $ 0.05 |
RUPAR (India) | |
10's (Medispan) | $ 0.10 |
See 1010 substitutes for Pyreflam |
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Information checked by Dr. Sachin Kumar, MD Pharmacology
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