Quinimax Overdose

Rating: 5 - 1 review(s)
How times a day do you take this medicine?
sponsored

What happens if I overdose Quinimax?

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local, or emergency room immediately. Symptoms may include confusion; dilated pupils; loss of consciousness; nausea and vomiting; rash; ringing in the ears; seizures; severe dizziness; slow or irregular heartbeat; stomach cramping or pain; urine discoloration; vision loss.

Proper storage of Quinimax capsules:

Store Quinimax capsules at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Quinimax capsules out of the reach of children and away from pets.

Overdose of Quinimax in details

When a dose is taken in higher dose than the recommended doses, it is called Overdose. Overdose always needs a clinical supervision. Any medicine or drug when consumed in Overdose produces untoward side effects on one or various organs in the body. A medicine is excreted in the kidney or metabolized in the liver most of the times. This process goes without any hurdles when taken in normal dose, but when taken in an overdose, the body is not able to metabolize it or send it out properly which causes the effects of anoverdose.
sponsored

Quinimax overdose can be associated with serious complications, including visual impairment, hypoglycemia, cardiac arrhythmias, and death. Visual impairment can range from blurred vision and defective color perception, to visual field constriction and permanent blindness. Cinchonism occurs in virtually all patients with Quinimax overdose. Symptoms range from headache, nausea, vomiting, abdominal pain, diarrhea, tinnitus, vertigo, hearing impairment, sweating, flushing, and blurred vision, to deafness, blindness, serious cardiac arrhythmias, hypotension, and circulatory collapse. Central nervous system toxicity (drowsiness, disturbances of consciousness, ataxia, convulsions, respiratory depression and coma) has also been reported with Quinimax overdose, as well as pulmonary edema and adult respiratory distress syndrome.

Most toxic reactions are dose-related; however, some reactions may be idiosyncratic because of the variable sensitivity of patients to the toxic effects of Quinimax. A lethal dose of Quinimax has not been clearly defined, but fatalities have been reported after the ingestion of 2 to 8 grams in adults.

Quinimax, like quinidine, has Class I antiarrhythmic properties. The cardiotoxicity of Quinimax is due to its negative inotropic action, and to its effect on cardiac conduction, resulting in decreased rates of depolarization and conduction, and increased action potential and effective refractory period. ECG changes observed with Quinimax overdose include sinus tachycardia, PR prolongation, T wave inversion, bundle branch block, an increased QT interval, and a widening of the QRS complex. Quinimax's alpha-blocking properties may result in hypotension and further exacerbate myocardial depression by decreasing coronary perfusion. Quinimax overdose has been also associated with hypotension, cardiogenic shock, and circulatory collapse, ventricular arrhythmias, including ventricular tachycardia, ventricular fibrillation, idioventricular rhythm, and torsades de pointes, as well as bradycardia, and atrioventricular block.

Quinimax is rapidly absorbed, and attempts to remove residual Quinimax sulfate from the stomach by gastric lavage may not be effective. Multiple-dose activated charcoal has been shown to decrease plasma Quinimax concentrations.

Forced acid diuresis, hemodialysis, charcoal column hemoperfusion, and plasma exchange were not found to be effective in significantly increasing Quinimax elimination in a series of 16 patients.

What should I avoid while taking Quinimax?

Avoid taking other anti-malaria medications without your doctor's advice. This includes chloroquine (Arelan), halofantrine (Halfan), and mefloquine (Lariam).

Avoid using antacids without your doctor's advice. Use only the type of antacid your doctor recommends. Some antacids can make it harder for your body to absorb Quinimax.

Quinimax may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Do not use Quinimax to treat any medical condition if your doctor did not prescribe Quinimax for that condition. Do not purchase Quinimax on the Internet or from vendors outside of the United States.

Quinimax warnings

Warnings are a mix of Precautions. Contraindications and interactions and serious harmful effects associated with the medicine intake. A diabetic or Hypertensive patient need to be warned about few drug interactions. A known hypersensitivity patient needs to be careful about the reactions or anaphylactic shock. A pregnant woman or a breastfeeding woman should be warned of certain medications. A Hepatitis [liver disease] patient or a cardiac patient should avoid few drugs.
sponsored

Quinimax Dab Sulfate

324 mg Capsules

This leaflet contains a summary of the most important information about Quinimax Dab Sulfate capsules and should be read completely before starting your treatment. This leaflet does not replace talking to your doctor or health care provider about your treatment or medical condition. If you have any questions about your treatment or medical condition, ask your doctor. Only your doctor or other health care provider can prescribe Quinimax Dab Sulfate and determine if it is right for you.

Malaria is a serious infection, and if not treated, can be life-threatening. Quinimax Dab Sulfate has been used for many years as an effective treatment for uncomplicated malaria caused by the parasite Plasmodium falciparum.

What is Quinimax Dab Sulfate?

Quinimax Dab Sulfate is a prescription medication used in the treatment of uncomplicated malaria caused by the parasite Plasmodium falciparum. Quinimax Dab Sulfate is NOT approved for the prevention of malaria or for the prevention or treatment of night-time leg cramps.

Who should not take Quinimax Dab Sulfate?

Do not take Quinimax Dab Sulfate if you:

·Had previous allergic reactions to Quinimax, quinidine, or mefloquine (LariamÒ).

· Had previous serious side effects to Quinimax, such as decreased platelets, which are components of blood necessary for clotting.

·Have low levels of an enzyme called Glucose-6-phosphate dehydrogenase (G-6-PD).

·Have myasthenia gravis.

·Have optic neuritis, which is an inflammation of the nerve important for vision.

·Have certain heart rhythm problems or certain inherited abnormalities on your electrocardiogram (ECG). Your doctor will tell you whether your ECG has these abnormalities.

What should I tell my doctor or health care provider before taking Quinimax Dab Sulfate?

Tell your doctor or health care provider:

·About all your medical conditions, including any heart, kidney, or liver problems.

·About all the prescription and non-prescription medications you are taking, including vitamins and herbal medications.

·If you are pregnant or could be pregnant. Treatment of malaria is important because it can be a serious disease for a pregnant woman and her unborn baby. Your doctor can tell you more about the benefits and risks of taking this medication during pregnancy for uncomplicated malaria. You and your doctor can decide if Quinimax Dab Sulfate is right for you.

·If you are breast-feeding. Small amounts of Quinimax Dab Sulfate can pass into the breast milk, but no problems with this medicine have been reported in nursing babies. Discuss with your doctor whether you should breastfeed while taking Quinimax Dab Sulfate.

How should I take Quinimax Dab Sulfate?

·Take Quinimax Dab Sulfate exactly as prescribed.

·Quinimax Dab is a clear capsule that is taken by mouth.

·Unless directed otherwise by your doctor, the usual dose is 648 mg (two 324 mg capsules) of Quinimax Dab Sulfate every 8 hours by mouth at the same time every day for 7 days.

·To lower the chance of stomach upset, take this medication WITH FOOD.

·Finish all the Quinimax Dab Sulfate that is prescribed even if you feel better. Do not stop taking the medication without talking to your doctor.

·Do not take more than the amount prescribed. Do not take more than 2 capsules at one time or more than 3 doses in one day. If you take more than the prescribed dose, call your doctor right away.

What should I do if I miss a dose?

If you forget to take Quinimax Dab Sulfate, do NOT double the next dose. If it has been more than 4 hours since the missed dose, WAIT and take the regular dose at the next scheduled time. Call your doctor if you are not sure what to do.

What are the possible side effects of Quinimax Dab Sulfate?

The most common side effects that you may have when taking Quinimax Dab Sulfate are not usually serious, and will usually get better when Quinimax Dab Sulfate is stopped. Common side effects with Quinimax Dab Sulfate include:

·Headache ·Nausea

·Sweating ·Flushing

·Ringing in your ears ·Mild hearing loss

·Dizziness · Blurred vision

·Change in color vision

Occasionally, more severe symptoms such as vomiting, diarrhea, and abdominal pain may occur. Rarely, rapid or irregular heart beat, severe hearing loss, or blindness, may occur. If you experience any severe side effects, call your doctor.

Some patients may experience low blood sugar (hypoglycemia) while taking Quinimax Dab Sulfate. Symptoms of low blood sugar include lightheadedness, dizziness, sweating, confusion, shakiness, anxiety, and weakness. If you experience symptoms of low blood sugar, drink some fruit juice or eat a snack, and call your doctor.

Elderly patients may be more sensitive to the side effects of Quinimax than younger patients, and should quickly report any side effects to their doctor.

Quinimax Dab Sulfate has other less common side effects that are not listed here. For a complete list of side effects, ask your doctor. If you notice any side effects not mentioned in this leaflet, or if you have any concerns about a side effect you are having, talk to your doctor.

Quinimax Dab Sulfate is NOT approved for the treatment of leg cramps because Quinimax has not been proven to work for this condition, and may cause serious or life-threatening side effects. Some of the more serious side effects of Quinimax are blindness, deafness, and abnormal heart rhythm. Your doctor can tell you additional information about serious side effects reported with Quinimax Dab Sulfate.

Call your doctor or health care provider right away if:

·You feel worse; or if you do not start feeling better within a day or two of taking Quinimax Dab Sulfate.

·If your fevers come back after completing treatment with Quinimax Dab Sulfate, call your doctor to make sure that the malaria has not returned.

·You experience serious problems such as:

o Serious allergic reactions : rash, hives, severe itching, severe flushing, trouble breathing.

o Eyesight problems: blurred vision, double vision, blindne ss.

o Heart problems: chest pain, rapid heart beats, abnormal heart rhythm.

o Other reactions: dizziness, confusion, lightheadedness, fainting, seizure.

o Other problems: abnormal bleeding (such as severe nosebleed, and blood in the urine, or stool), severe bruising, or the appearance of unusual purple-brown or red spots on your skin.

What about other medications I am taking?

·Tell your doctor about all other prescription and non-prescription medications

you are taking, including vitamins and herbal supplements.

·Certain medications should be avoided when you are taking Quinimax Dab Sulfate.

·Your doctor has a list of medications that should be avoided or which may require special precautions while taking Quinimax Dab Sulfate.

How do I store Quinimax Dab Sulfate?

Keep Quinimax Dab Sulfate out of reach of children. Keep the capsules in a tightly closed container. Do not refrigerate or freeze. Store at room temperature; 25-30°C (77-86°F).

General advice about Quinimax Dab Sulfate:

Do not use Quinimax Dab Sulfate for a condition for which it was not prescribed. Do NOT give Quinimax Dab Sulfate to other people, even if they have the same symptoms, because it may be harmful.

This leaflet highlights the most important information about Quinimax Dab Sulfate. For more information, you should talk with your doctor or health care provider.

Active Ingredients: Quinimax Dab Sulfate, USP

Inactive Ingredients: Corn starch, magnesium stearate, talc

What should I discuss with my healthcare provider before taking Quinimax?

Some medical conditions may interact with Quinimax capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

Some MEDICINES MAY INTERACT with Quinimax capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:

This may not be a complete list of all interactions that may occur. Ask your health care provider if Quinimax capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Quinimax precautions

Certain people who are very sick or very old or who are sensitive show an exacerbation of side effect of the drug which can turn dangerous at times. So, it is very important to remember the precautions while taking the medicine. Pregnancy and Breastfeeding are also special categories wherein extra care or precaution is needed when taking a drug. Few patients may have a hypersensitivity reaction to few medications, and that can be life-threatening rarely. Penicillin hypersensitivity is one example. Diarrhea, rashes are few other symptoms which need a watch. A patient with other co-existing diseases like liver disease, heart disease, kidney disease should take special precautions.
sponsored

Use of Quinimax for Treatment or Prevention of Nocturnal Leg Cramps

Quinimax may cause unpredictable serious and life-threatening hematologic reactions including thrombocytopenia and hemolytic-uremic syndrome/thrombotic thrombocytopenic purpura (HUS/TTP) in addition to hypersensitivity reactions, QT prolongation, serious cardiac arrhythmias including torsades de pointes, and other serious adverse events requiring medical intervention and hospitalization. Chronic renal impairment associated with the development of TTP, and fatalities have also been reported. The risk associated with the use of Quinimax in the absence of evidence of its effectiveness for treatment or prevention of nocturnal leg cramps, outweighs any potential benefit in treating and/or preventing this benign, self-limiting condition.

Thrombocytopenia

Quinimax-induced thrombocytopenia is an immune-mediated disorder. Severe cases of thrombocytopenia that are fatal or life threatening have been reported, including cases of HUS/TTP. Chronic renal impairment associated with the development of TTP has also been reported. Thrombocytopenia usually resolves within a week upon discontinuation of Quinimax. If Quinimax is not stopped, a patient is at risk for fatal hemorrhage. Upon re-exposure to Quinimax from any source, a patient with Quinimax-dependent antibodies could develop thrombocytopenia that is more rapid in onset and more severe than the original episode.

QT Prolongation and Ventricular Arrhythmias

QT interval prolongation has been a consistent finding in studies which evaluated electrocardiographic changes with oral or parenteral Quinimax administration, regardless of age, clinical status, or severity of disease. The maximum increase in QT interval has been shown to correspond with peak Quinimax plasma concentration. Quinimax sulfate has been rarely associated with potentially fatal cardiac arrhythmias, including torsades de pointes, and ventricular fibrillation.

Quinimax has been shown to cause concentration-dependent prolongation of the PR and QRS interval. At particular risk are patients with underlying structural heart disease and preexisting conduction system abnormalities, elderly patients with sick sinus syndrome, patients with atrial fibrillation with slow ventricular response, patients with myocardial ischemia or patients receiving drugs known to prolong the PR interval (e.g. verapamil) or QRS interval (e.g. flecainide or quinidine).

Quinimax is not recommended for use with other drugs known to cause QT prolongation, including Class IA antiarrhythmic agents (e.g., quinidine, procainamide, disopyramide), and Class III antiarrhythmic agents (e.g., amiodarone, sotalol, dofetilide).

The use of macrolide antibiotics such as erythromycin should be avoided in patients receiving Quinimax. Fatal torsades de pointes was reported in an elderly patient who received concomitant Quinimax, erythromycin, and dopamine. Although a causal relationship between a specific drug and the arrhythmia was not established in this case, erythromycin is a CYP3A4 inhibitor and has been shown to increase Quinimax plasma levels when used concomitantly. A related macrolide antibiotic, troleandomycin, has also been shown to increase Quinimax exposure in a pharmacokinetic study.

Quinimax may inhibit the metabolism of certain drugs that are CYP3A4 substrates and are known to cause QT prolongation, e.g., astemizole, cisapride, terfenadine, pimozide, halofantrine and quinidine. Torsades de pointes has been reported in patients who received concomitant Quinimax and astemizole. Therefore, concurrent use of Quinimax with these medications, or drugs with similar properties, should be avoided.

Concomitant administration of Quinimax with the antimalarial drugs, mefloquine or halofantrine, may result in electrocardiographic abnormalities, including QT prolongation, and increase the risk for torsades de pointes or other serious ventricular arrhythmias. Concurrent use of Quinimax and mefloquine may also increase the risk of seizures.

Quinimax should also be avoided in patients with known prolongation of QT interval and in patients with clinical conditions known to prolong the QT interval, such as uncorrected hypokalemia, bradycardia, and certain cardiac conditions.

Concomitant Use of Rifampin

Treatment failures may result from the concurrent use of rifampin with Quinimax, due to decreased plasma concentrations of Quinimax, and concomitant use of these medications should be avoided.

Concomitant Use of Neuromuscular Blocking Agents

The use of neuromuscular blocking agents should be avoided in patients receiving Quinimax. In one patient who received pancuronium during an operative procedure, subsequent administration of Quinimax resulted in respiratory depression and apnea. Although there are no clinical reports with succinylcholine or tubocurarine, Quinimax may also potentiate neuromuscular blockade when used with these drugs.

Hypersensitivity

Serious hypersensitivity reactions reported with Quinimax sulfate include anaphylactic shock, anaphylactoid reactions, urticaria, serious skin rashes, including Stevens-Johnson syndrome and toxic epidermal necrolysis, angioedema, facial edema, bronchospasm, and pruritus.

A number of other serious adverse reactions reported with Quinimax, including thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS), thrombocytopenia, immune thrombocytopenic purpura (ITP), blackwater fever, disseminated intravascular coagulation, leukopenia, neutropenia, granulomatous hepatitis, and acute interstitial nephritis may also be due to hypersensitivity reactions.

Quinimax should be discontinued in case of any signs or symptoms of hypersensitivity.

Atrial Fibrillation and Flutter

Quinimax should be used with caution in patients with atrial fibrillation or atrial flutter. A paradoxical increase in ventricular response rate may occur with Quinimax, similar to that observed with quinidine. If digoxin is used to prevent a rapid ventricular response, serum digoxin levels should be closely monitored, because digoxin levels may be increased with use of Quinimax.

Hypoglycemia

Quinimax stimulates release of insulin from the pancreas, and patients, especially pregnant women, may experience clinically significant hypoglycemia.

What happens if I miss a dose of Quinimax?

When you miss a dose, you should take it as soon as you remember, but you should take care that it should be well spaced from the next dose. You should not take an extra dose at the time of the second dose as it will become a double dose. The double dose can give unwanted side effects, so be careful. In chronic conditions or when you have a serious health issue, if you miss a dose, you should inform your health care provider and ask his suggestion.

Take the missed dose as soon as you remember. If you are more than 4 hours late for your dose, skip the missed dose and take the medicine at your next scheduled dose time. Do not take extra medicine to make up the missed dose.



References

  1. DailyMed. "QUININE SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. DrugBank. "Quinine". http://www.drugbank.ca/drugs/DB00468 (accessed September 17, 2018).
  3. MeSH. "Analgesics, Non-Narcotic". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

Reviews

Consumer reviews


There are no reviews yet. Be the first to write one!


Your name: 
Email: 
Spam protection:  < Type 26 here

Information checked by Dr. Sachin Kumar, MD Pharmacology

| Privacy Policy
This site does not supply any medicines. It contains prices for information purposes only.
© 2003 - 2022 ndrugs.com All Rights Reserved