Quinimax Pregnancy

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Pregnancy of Quinimax in details

Pregnancy is always a special situation where every action or side effect of the drug varies when compared to a situation of a non-pregnant patient. It is not only because the pregnant woman's metabolism differs due to the hormonal and other changes happened to her, but also because every medicine or its metabolite passes to the baby and shows its action there. The only thing is, be cautious, attentive and well supervised when you take any single drug in pregnancy. The interactions can vary in pregnancy, and the dosage may differ as well. Strict supervision of the Physician is mandatory.

Quinimax has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of teratogenicity. There are no controlled data in human pregnancy. Congenital abnormalities (including damage to the auditory and optic nerve) have been reported following the use of large doses of Quinimax for its abortifacient effect. Quinimax is only recommended for use during pregnancy when there are no alternatives and benefit outweighs risk.

Quinimax crosses the placenta and gives measurable blood concentrations in the fetus. In 8 women who delivered live infants 1 to 6 days after starting Quinimax therapy, placental cord plasma Quinimax levels were between 1.0 and 4.6 mg/L and the ratio of cord plasma to maternal plasma Quinimax levels averaged 0.32. During a study of women with Plasmodium falciparum malaria, difference in the rate of stillbirths at greater than 28 weeks of gestation was not significant in pregnant women treated with Quinimax compared to a control group without malaria or exposure to antimalarial agents during pregnancy. The overall rate of congenital malformations was not different for women treated with Quinimax (1.4%) compared with the control group (1.7%). The rate of spontaneous abortion was lower in women treated with Quinimax (3.5%) than in the control group (10.9%). In an epidemiologic survey, risk of structural birth defects was not increased in 104 mother-child pairs exposed to Quinimax during the first 4 months of pregnancy. Two fetal malformations (1.9%) were reported. Teratogenic effects were observed in 21 infants exposed to Quinimax during the first trimester following unsuccessful abortion attempts. These effects included central nervous system, digestive organ, urogenital, and vertebral anomalies; limb, facial, and heart defects; and hernias. Neonatal and maternal thrombocytopenia purpura and hemolysis in glucose-6-phosphate dehydrogenase-deficient newborns have been reported with Quinimax use. The Michigan Medicaid Birth Defects Study included 35 newborns exposed to Quinimax during the first trimester. Two (5.7%) major birth defects were observed; 1 was expected. There were no observations of cardiovascular defects, cleft palate, spina bifida, polydactyly, limb reduction, or hypospadias. Briggs, et al has assigned Risk Factor D to Quinimax. Although increased teratogenic risk has not been proven, avoiding Quinimax use during pregnancy has been recommended. A manufacturer of a formerly available Quinimax product considered it contraindicated in pregnancy. There is no evidence that Quinimax causes uterine contractions at the doses recommended to treat malaria. In doses several times higher than those used to treat malaria, Quinimax may stimulate the pregnant uterus.

See references

Quinimax breastfeeding

When a drug is taken when the patient is breast feeding, a part of the drug is secreted in her breast milk and is passed to the baby. The dosage of the medicine to mother and baby are different, and many drugs actions are side effects when you take them without a disease, and what if you the baby takes them without a disease? What if the drug is contraindicated in newborns, infants or children? So, breastfeeding is a very alarming situation when the mother is on medications. Ask your Physician or Pediatrician about the effect of the drug on the baby and how much is excreted in breast milk and if it harms the baby!

Quinimax is excreted into human milk in small amounts. Adverse effects in the nursing infant are unlikely, but the diagnosis of glucose-6-phosphate dehydrogenase deficiency should be ruled out before breast-feeding. Quinimax is considered compatible with breast-feeding by the American Academy of Pediatrics.

See references

References for pregnancy information

  1. "Multum Information Services, Inc. Expert Review Panel"
  2. Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 7th ed." Philadelphia, PA: Lippincott Williams & Wilkins (2005):
  3. "Product Information. Qualaquin (Quinimax)." AR Scientific Inc, Philadelphia, PA.

References for breastfeeding information

  1. "Product Information. Qualaquin (Quinimax)." AR Scientific Inc, Philadelphia, PA.
  2. "Multum Information Services, Inc. Expert Review Panel"


  1. DailyMed. "QUININE SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubMed Health. "Quinine (By mouth) (Qualaquin): This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
  3. Human Metabolome Database (HMDB). "Quinine: The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.". http://www.hmdb.ca/metabolites/HMDB0... (accessed September 17, 2018).


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