An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Treatment of the following infections when caused by susceptible strains of the designated microorganisms: Respiratory tract infections caused by Streptococcus pneumoniae and Streptococcus pyogenes Otitis media due to Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, and Moraxella catarrhalis.
Skin and skin structure infections caused by Staphylococcus aureus and/or Streptococcus pyogenes.
Bone infections caused by Staphylococcus aureus and/or Proteus mirabilis and joint infections.
Genitourinary tract infections, including acute prostatitis, caused by Escherichia coli, Proteus mirabilis and Klebsiella pneumoniae.
Dental Infections: Culture and susceptibility tests should be initiated prior to and during therapy. Renal function studies should be performed when indicated. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Ranceph and other antibacterial drugs, Ranceph should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Uses of Ranceph in details
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Cephalexin is used to treat bacterial infections including upper respiratory infections, ear infections, skin infections, and urinary tract infections.
Ranceph description
Each film-coated tablet contains Cefalexin monohydrate BP equivalent to anhydrous Ranceph 375- and 750 mg, respectively.
It also contains the following excipients: Hyproellose, hydroxypropyl cellulose, microcrystalline cellulose, magnesium stearate, purified talc, colloidal anhydrous silica, opadry and macrogol 400.
Ranceph is an extended release oral formulation of Ranceph designed to be effective on twice daily dosing. Ranceph is a semisynthetic cephalosporin antibiotic. It is 7-(D-α-Amino-α-phenylacetamido)-3-methyl-3-cephem-4-carboxylic acid monohydrate. Ranceph has themolecular formula C16H17N3O4SH2O and the molecular weight is 365.41.
The nucleus of Ranceph is related to that of other cephalosporin antibiotics. The compound is a zwitterion; ie, the molecule contains both a basic and an acidic group. The isoelectric point of Ranceph in water is approximately 4.5-5. The crystalline form of Ranceph which is available is a monohydrate. It is a white crystalline solid having a bitter taste. Solubility in water is low at room temperature; 1 or 2 mg/mL may be dissolved readily, but higher concentrations are obtained with increasing difficulty. The cephalosporins differ from penicillins in the structure of the bicyclic ring system. Ranceph has a D-phenylglycyl group as substituent at the 7-amino position and an unsubstituted methyl group at the 3- position.
Ranceph dosage
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Ranceph suspension or capsule is administered orally. The adult dosage ranges from 1-6 g daily in divided doses.
Adults: Usual Dose: 1-2 g daily given in divided doses at 6-, 8- or 12-hourly intervals.
For streptococcal pharyngitis or tonsillitis, mild, uncomplicated urinary tract infections and skin and soft tissue infections, 500 mg may be administered every 12 hrs.
For more severe infections or those caused by less susceptible organisms, larger doses may be needed.
If daily doses of Ranceph require >4 g, parenteral cephalosporins in appropriate doses should be prescribed.
Suspension:Children: Usual Dose: 25-50 mg/kg body weight in divided doses (to be taken every 6 hrs).
125-mg/5 mL Suspension:Children 40 kg body weight: 2-4 tsp; 20 kg: 1-2 tsp; 10 kg: ½-1 tsp.
250-mg/5 mL Suspension:Children 40 kg body weight: 1-2 tsp; 20 kg: ½-1 tsp; 10 kg: ¼-½ tsp.
For streptococcal pharyngitis in children >1 year, mild, uncomplicated urinary tract infections and skin and soft tissue infections, the total daily dose may be divided, administered and taken every 12 hrs.
125-mg/5 mL Suspension:Children 40 kg body weight: 4-8 tsp; 20 kg: 2-4 tsp; 10 kg: 1-2 tsp.
250-mg/5 mL Suspension:Children 40 kg body weight: 2-4 tsp; 20 kg: 1-2 tsp; 10 kg: ½-1 tsp.
(5 mL is equivalent to 1 tsp.)
Shake the suspension well before use.
In severe infections, the dosage may be doubled.
In the therapy of otitis media, 75-100 mg/kg/day in 4 divided doses is needed.
In the treatment of β-hemolytic streptococcal infections, the therapeutic dosage of Ranceph should be administered for a minimum of 10 days.
Note: Ranceph may be taken on a full or empty stomach. Compliance with the full course of therapy especially in streptococcal infections is highly recommended.
Ranceph interactions
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Bacteriostatic Antibiotics: As cephalosporins like Ranceph are only active against proliferating microorganisms, Ranceph should not be combined with bacteriostatic antibiotics.
Uricosuric Drugs: Concomitant use of uricosuric drugs (eg, probenecid) suppresses renal drug elimination. As a result, Ranceph plasma levels are increased and sustained for longer periods.
Metformin: A potential interaction between Ranceph and metformin may result in an accumulation of metformin and could result in fatal lactic acidosis.
Increased Risk of Nephrotoxicity: If associated with highly potent diuretics (ethacrynic acid, furosemide) or other potentially nephrotoxic antibiotics (aminoglycosides, polymyxin, colistin), cephalosporins may show higher nephrotoxicity.
Oral Anticoagulants:
Combined use of cephalosporins and oral anticoagulants may prolong prothrombin time.
Typhoid Vaccine: Ranceph, like other antibiotics with antibacterial activity against Salmonella typhi organisms, may interfere with the immunological response to the live typhoid vaccine. The appropriate period of time should elapse between the administration of the last dose of the antibiotic and the live typhoid vaccine.
Oral Contraceptives:
Ranceph may reduce the effects of oral contraceptives.
Incompatibilities: No incompatibilities have been reported.
Ranceph side effects
Adverse effects of Ranceph include gastrointestinal disturbances eg, nausea, vomiting, diarrhea and abdominal discomfort. The most common of these effects is diarrhea, but this is rarely severe enough to warrant cessation of therapy. Transient hepatitis and cholestatic jaundice have rarely been reported.
Allergic reactions have been reported eg, rash, urticaria, angioedema and rarely erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis (exanthematic necrolysis).
Other adverse effects eg, genital and anal pruritus, genital candidiasis, vaginitis and vaginal discharge, dizziness, fatigue, headache, agitation, confusion, hallucinations, arthralgia, arthritis and joint disorders have been reported.
As with other cephalosporins, interstitial nephritis has rarely been reported.
Eosinophilia, neutropenia, thrombocytopenia and slight elevations in aspartate aminotransferase and alanine aminotransferase have been reported.
As with other broad-spectrum antibiotics prolonged use may result in the overgrowth of non-susceptible organisms eg, candida. This may present a vulvo-vaginitis.
There is a possibility of development of pseudomembranous colitis and it is therefore important to consider its diagnosis in patients who develop diarrhea while taking Ranceph. It may range in severity from mild to life-threatening with mild case usually responding to cessation of therapy. Appropriate measures should be taken with moderate to severe cases.
Ranceph contraindications
Ranceph is contraindicated in patients with a known history of hypersensitivity to local anesthetics of the amide type.
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The results of a survey conducted on ndrugs.com for Ranceph are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Ranceph. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.
User reports
1 consumer reported useful
Was the Ranceph drug useful in terms of decreasing the symptom or the disease? According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
Users
%
Useful
1
100.0%
Consumer reported price estimates
No survey data has been collected yet
4 consumers reported time for results
To what extent do I have to use Ranceph before I begin to see changes in my health conditions? As part of the reports released by ndrugs.com website users, it takes 3 days and a few days before you notice an improvement in your health conditions. Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Ranceph. To get the time effectiveness of using Ranceph drug by other patients, please click here.
Users
%
3 days
2
50.0%
1 week
1
25.0%
> 3 month
1
25.0%
25 consumers reported age
Users
%
1-5
8
32.0%
6-15
6
24.0%
< 1
4
16.0%
46-60
3
12.0%
30-45
3
12.0%
> 60
1
4.0%
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