What is Recort Plus cream, ointment, suppository?
Reducing swelling, itching, and discomfort associated with certain rectal conditions, including hemorrhoids.
Recort Plus cream, ointment, suppository is a topical corticosteroid. It works by depressing the formation, release, and activity of different cells and chemicals that cause swelling, redness, and itching.
Recort Plus cream, ointment, suppository indications
(Systemic use):Endocrine disordes ( primary or secondary adrenocortical insufficiency ).
shock unresponsive to conVentional therapy if adrenocortical insufficiency exists or is suspected, Rheumati
c disorders ( post – traumatic osteoarthritis, synovitis of osteoarthritis, Rheumatoid arthritis, Acute and subacute bursitis.
Epicondylitis, Acute nonspecific tenosynovitis, Acute gouty arthritis, Psoriatic arthritis
Collagen diseases ( systemic lupus erythematosus, Acute rheumatic Carditis, systemic dermatomysitis ), Dermatologic disease ( Pemphigus, Severe erythma multiforme, Exfoliative dermatitis, Severe psoriasis ) ophthalmic diseases, ( in allergic and inflammatory processes involving the eye, such as : Herpes Zoster ophthalmicus, Iritis, iridocy clitis, chorioretinitis, Keratitis ), Gastrointestinal diseases ( ulcerative colitis systemic theropy ) Respiratory diseases ( symptomatic sarcoidosis, Berylliosis ) Hematologic disorders ( Acquired [ autoimmune ] hemolytic anemia ) Neoplastic disease. (Topical use):variety of skin conditions (e.g., insect bites, poison oak/ivy, eczema, dermatitis, allergies, rash, itching of the outer female genitals, anal itching). Hydrocortisone reduces the swelling, itching, and redness that can occur in these types of conditions. This medication is a mild corticosteroid.
How should I use Recort Plus cream, ointment, suppository?
Use Recort Plus cream, ointment, suppository as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Avoid excessive handling of the suppository. It is designed to melt at body temperature.
- Wash your hands before and after using Recort Plus cream, ointment, suppository. If the suppository is too soft to use, put it in the refrigerator for about 15 minutes. You may also run cold water over it. Remove the wrapper. Moisten the suppository with cool water. Lie down on your side. Insert the pointed end of the suppository into the rectum. Use your finger to push it in completely.
- If you miss a dose of Recort Plus cream, ointment, suppository and you are using it regularly, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
Ask your health care provider any questions you may have about how to use Recort Plus cream, ointment, suppository.
Uses of Recort Plus cream, ointment, suppository in details
This medication is used to treat minor pain, itching, swelling, and discomfort caused by hemorrhoids and other problems of the anal area (e.g., anal fissures, itching). Hydrocortisone is a corticosteroid that reduces redness, itching, and swelling.
How to use Recort Plus cream, ointment, suppository rectal
Before use, clean the affected area with mild soap and water, rinse well, and pat dry.
To apply this product inside the anus, use the applicator tip/cap/nozzle, following all instructions in the product package, or use as directed by your doctor. Fill the applicator with medication from the container as directed. Gently insert the applicator tip just 1/2 to 1 inch (1.5 to 2.5 centimeters) inside the anus and apply in and around the anal opening as directed. Do not insert your finger or any part of the container into the anus, and do not insert the applicator tip/nozzle more than 1/2 to 1 inch (1.5 to 2.5 centimeters) inside the anus. Do not use your finger to apply this medication inside the anus. If you are using a single-use tube and applicator, discard after one use.
To apply the product to the outside of the anus only, use your finger to apply a small amount of cream or ointment to the affected area and rub in gently.
Do not cover the area with plastic or waterproof bandages unless directed to do so by your doctor. Covering the treated area may increase the absorption of the medication through the skin. This may improve how well the drug works, but it may also increase the risk of side effects.
Wash hands immediately after use. Avoid getting the product in your eyes, nose, ears or mouth. If the medication gets in these areas, rinse the area immediately with clean water.
This product is usually used 2 to 4 times daily, or after each bowel movement, or as directed by your doctor. Dosage is based on your medical condition and response to therapy. Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same times each day.
Do not use more of this product, use it more often, or keep using it longer than prescribed by your doctor. If you have been using this medication for a long time or in high doses, do not suddenly stop using it without your doctor's approval. Some conditions may become worse when this drug is suddenly stopped. Your dose may need to be gradually decreased.
Inform your doctor if your condition does not improve or if it worsens after 1 to 2 weeks.
Recort Plus cream, ointment, suppository description
The main glucocorticoid secreted by the adrenal cortex. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
Recort Plus cream, ointment, suppository dosage
DOSAGE AND ADMINISTRATION:
Topical corticosteroids are generally applied to the affected area as a thin film two to four times daily depending on the severity of the condition. Occlusive dressings may be used for the management of psoriasis or recalcitrant conditions. If an infection develops, the use of occlusive dressings should be discontinued and appropriate antimicrobial therapy instituted.
Recort Plus cream, ointment, suppository interactions
(Systemic use):Combinations containing any of the following medications, depending on the amount present, also may interact with this medication:
Acetaminophen-Alcohol-Anti-inflammatory drugs, nonsteroidal (NSAIDs)- Aminoglutethimide
Amphotericin B,Carbonic anhydrase inhibitors,Anabolic steroids,Androgens,Antacids,Anticholinergics, especially atropine and related compounds
Anticoagulants, coumarin- or indanedione-
Heparin orStreptokinase orUrokinase
Antidiabetic agents, oral - Insulin -Antithyroid agents-Thyroid hormones-Contraceptives, oral, estrogen-containing.(Topical use): No specific interactions
Recort Plus cream, ointment, suppository side effects
Applies to hydrocortisone topical: topical application cream, topical application foam, topical application gel/jelly, topical application kit, topical application liquid, topical application lotion, topical application ointment, topical application pad, topical application paste, topical application solution, topical application spray, topical application stick
In addition to its needed effects, some unwanted effects may be caused by hydrocortisone topical (the active ingredient contained in Recort Plus cream, ointment, suppository). In the event that any of these side effects do occur, they may require medical attention.
Major Side Effects
You should check with your doctor immediately if any of these side effects occur when taking hydrocortisone topical:
Incidence not known:
- Blistering, burning, crusting, dryness, or flaking of the skin
- itching, scaling, severe redness, soreness, or swelling of the skin
- redness and scaling around the mouth
- thinning of the skin with easy bruising, especially when used on the face or where the skin folds together (e.g. between the fingers)
- thinning, weakness, or wasting away of the skin
Minor Side Effects
Some of the side effects that can occur with hydrocortisone topical may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
Incidence not known:
- Acne or pimples
- burning and itching of the skin with pinhead-sized red blisters
- burning, itching, and pain in hairy areas, or pus at the root of the hair
- increased hair growth on the forehead, back, arms, and legs
- lightening of normal skin color
- lightening of treated areas of dark skin
- reddish purple lines on the arms, face, legs, trunk, or groin
- softening of the skin
Recort Plus cream, ointment, suppository contraindications
(Systemic use) Prior Arthroplasty of joint, Blood Clotting disorders, intra – articular fracture, infection ( periaticular, current or history of ), osteoporosis, unstable joint.(Topical use): variety of skin conditions (e.g., insect bites, poison oak/ivy, eczema, dermatitis, allergies, rash, itching of the outer female genitals, anal itching). Hydrocortisone reduces the swelling, itching, and redness that can occur in these types of conditions. This medication is a mild corticosteroid.
Recort Plus cream, ointment, suppository pregnancy
Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Recort Plus cream, ointment, suppository overdose
Topically applied corticosteroids can be absorbed in sufficient amounts to produce systemic effects.
Recort Plus cream, ointment, suppository precautions
Systemic absorption of topical corticosteroids has produced reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing's syndrome, hyperglycemia, and glucosuria in some patients.
Conditions which augment systemic absorption include the application of the more potent steroids, use over large surface areas, prolonged use, and the addition of occlusive dressings.
Therefore, patients receiving a large dose of potent topical steroid applied to a large surface area or under an occlusive dressing should be evaluated periodically for evidence of HPA axis suppression by using the urinary free cortisol and ACTH stimulation tests. If HPA axis suppression is noted, an attempt should be made to withdraw the drug, to reduce the frequency of application, or to substitute a less potent steroid.
Recovery of HPA axis function is generally prompt and complete upon discontinuation of the drug. Infrequently, signs and symptoms of steroid withdrawal may occur, requiring supplemental systemic corticosteroids.
Children may absorb proportionally larger amounts of topical corticosteroids and thus be more susceptible to systemic toxicity.
If irritation develops, topical corticosteroids should be discontinued and appropriate therapy instituted.
In the presence of dermatological infections, the use of an appropriate antifungal or antibacterial agent should be instituted. If a favorable response does not occur promptly, the corticosteroid should be discontinued until the infection has been adequately controlled.
Information for the Patient
Patients using topical corticosteroids should receive the following information and instructions:
- This medication is to be used as directed by the physician. It is for external use only. Avoid contact with the eyes.
- Patients should be advised not to use this medication for any disorder other than for which it was prescribed.
- The treated skin area should not be bandaged or otherwise covered or wrapped as to be occlusive unless directed by the physician.
- Patients should report any signs of local adverse reactions especially under occlusive dressings.
- Parents of pediatric patients should be advised not to use tight-fitting diapers or plastic pants on a child being treated in the diaper area, as these garments may constitute occlusive dressings.
The following tests may be helpful in evaluating the HPA axis suppression:
Urinary free cortisol test.
ACTH stimulation test.
Carcinogenesis, Mutagenesis, and Impairment of Fertility
Long-term animal studies have not been performed to evaluate the carcinogenic potential or the effect on fertility of topical corticosteroids.
Studies to determine mutagenicity with prednisolone and hydrocortisone have revealed negative results.
Pregnancy: Teratogenic effects: Pregnancy Category C
Corticosteroids are generally teratogenic in laboratory animals when administered systemically at relatively low dosage levels. The more potent corticosteroids have been shown to be teratogenic after dermal application in laboratory animals. There are no adequate and well-controlled studies in pregnant women on teratogenic effects from topically applied corticosteroids. Therefore, topical corticosteroids should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Drugs of this class should not be used extensively on pregnant patients, in large amounts, or for prolonged periods of time.
It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in breast milk. Systemically administered corticosteroids are secreted into breast milk in quantities not likely to have a deleterious effect on the infant. Nevertheless, caution should be exercised when topical corticosteroids are administered to a nursing woman.
Pediatric patients may demonstrate greater susceptibility to topical corticosteroid-induced hypothalamic-pituitary-adrenal (HPA) axis suppression and Cushing's syndrome, than maturepatients, because of a larger skin surface area to body weight ratio.
Hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing's syndrome, and intracranial hypertension have been reported in pediatric patients receiving topical corticosteroids. Manifestations of adrenal suppression in pediatric patients include linear growth retardation, delayed weight gain, low plasma cortisol levels, and absence of response to ACTH stimulation. Manifestations of intracranial hypertension include bulging fontanelles, headaches, and bilateral papilledema.
Administration of topical corticosteroids to pediatric patients should be limited to the least amount compatible with an effective therapeutic regimen. Chronic corticosteroid therapy may interfere with the growth and development of pediatric patients.
Active ingredient matches for Recort Plus cream, ointment, suppository:
- DailyMed. "CIPROFLOXACIN HYDROCHLORIDE; HYDROCORTISONE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "hydrocortisone". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "hydrocortisone". http://www.drugbank.ca/drugs/DB00741 (accessed September 17, 2018).
- DTP/NCI. "hydrocortisone: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).
- Wikipedia. "cortisol: Link to the compound information in Wikipedia.". https://en.wikipedia.org/wiki/Cortis... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology