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Reflexin Uses |
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Treatment of the following infections when caused by susceptible strains of the designated microorganisms: Respiratory tract infections caused by Streptococcus pneumoniae and Streptococcus pyogenes Otitis media due to Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, and Moraxella catarrhalis.
Skin and skin structure infections caused by Staphylococcus aureus and/or Streptococcus pyogenes.
Bone infections caused by Staphylococcus aureus and/or Proteus mirabilis and joint infections.
Genitourinary tract infections, including acute prostatitis, caused by Escherichia coli, Proteus mirabilis and Klebsiella pneumoniae.
Dental Infections: Culture and susceptibility tests should be initiated prior to and during therapy. Renal function studies should be performed when indicated. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Reflexin and other antibacterial drugs, Reflexin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Cephalexin is used to treat bacterial infections including upper respiratory infections, ear infections, skin infections, and urinary tract infections.
Each film-coated tablet contains cefalexin monohydrate BP equivalent to anhydrous Reflexin 375- and 750 mg, respectively.
It also contains the following excipients: Hyproellose, hydroxypropyl cellulose, microcrystalline cellulose, magnesium stearate, purified talc, colloidal anhydrous silica, opadry and macrogol 400.
Reflexin is an extended release oral formulation of Reflexin designed to be effective on twice daily dosing. Reflexin is a semisynthetic cephalosporin antibiotic. It is 7-(D-α-Amino-α-phenylacetamido)-3-methyl-3-cephem-4-carboxylic acid monohydrate. Reflexin has themolecular formula C16H17N3O4SH2O and the molecular weight is 365.41.
The nucleus of Reflexin is related to that of other cephalosporin antibiotics. The compound is a zwitterion; ie, the molecule contains both a basic and an acidic group. The isoelectric point of Reflexin in water is approximately 4.5-5. The crystalline form of Reflexin which is available is a monohydrate. It is a white crystalline solid having a bitter taste. Solubility in water is low at room temperature; 1 or 2 mg/mL may be dissolved readily, but higher concentrations are obtained with increasing difficulty. The cephalosporins differ from penicillins in the structure of the bicyclic ring system. Reflexin has a D-phenylglycyl group as substituent at the 7-amino position and an unsubstituted methyl group at the 3- position.
Reflexin suspension or capsule is administered orally. The adult dosage ranges from 1-6 g daily in divided doses.
Adults: Usual Dose: 1-2 g daily given in divided doses at 6-, 8- or 12-hourly intervals.
For streptococcal pharyngitis or tonsillitis, mild, uncomplicated urinary tract infections and skin and soft tissue infections, 500 mg may be administered every 12 hrs.
For more severe infections or those caused by less susceptible organisms, larger doses may be needed.
If daily doses of Reflexin require >4 g, parenteral cephalosporins in appropriate doses should be prescribed.
Suspension: Children: Usual Dose: 25-50 mg/kg body weight in divided doses (to be taken every 6 hrs).
125-mg/5 mL Suspension: Children 40 kg body weight: 2-4 tsp; 20 kg: 1-2 tsp; 10 kg: ½-1 tsp.
250-mg/5 mL Suspension: Children 40 kg body weight: 1-2 tsp; 20 kg: ½-1 tsp; 10 kg: ¼-½ tsp.
For streptococcal pharyngitis in children >1 year, mild, uncomplicated urinary tract infections and skin and soft tissue infections, the total daily dose may be divided, administered and taken every 12 hrs.
125-mg/5 mL Suspension: Children 40 kg body weight: 4-8 tsp; 20 kg: 2-4 tsp; 10 kg: 1-2 tsp.
250-mg/5 mL Suspension: Children 40 kg body weight: 2-4 tsp; 20 kg: 1-2 tsp; 10 kg: ½-1 tsp.
(5 mL is equivalent to 1 tsp.)
Shake the suspension well before use.
In severe infections, the dosage may be doubled.
In the therapy of otitis media, 75-100 mg/kg/day in 4 divided doses is needed.
In the treatment of β-hemolytic streptococcal infections, the therapeutic dosage of Reflexin should be administered for a minimum of 10 days.
Note: Reflexin may be taken on a full or empty stomach. Compliance with the full course of therapy especially in streptococcal infections is highly recommended.
Bacteriostatic Antibiotics: As cephalosporins like Reflexin are only active against proliferating microorganisms, Reflexin should not be combined with bacteriostatic antibiotics.
Uricosuric Drugs: Concomitant use of uricosuric drugs (eg, probenecid) suppresses renal drug elimination. As a result, Reflexin plasma levels are increased and sustained for longer periods.
Metformin: A potential interaction between Reflexin and metformin may result in an accumulation of metformin and could result in fatal lactic acidosis.
Increased Risk of Nephrotoxicity: If associated with highly potent diuretics (ethacrynic acid, furosemide) or other potentially nephrotoxic antibiotics (aminoglycosides, polymyxin, colistin), cephalosporins may show higher nephrotoxicity.
Typhoid Vaccine: Reflexin, like other antibiotics with antibacterial activity against Salmonella typhi organisms, may interfere with the immunological response to the live typhoid vaccine. The appropriate period of time should elapse between the administration of the last dose of the antibiotic and the live typhoid vaccine.
Incompatibilities: No incompatibilities have been reported.
Adverse effects of Reflexin include gastrointestinal disturbances eg, nausea, vomiting, diarrhea and abdominal discomfort. The most common of these effects is diarrhea, but this is rarely severe enough to warrant cessation of therapy. Transient hepatitis and cholestatic jaundice have rarely been reported.
Allergic reactions have been reported eg, rash, urticaria, angioedema and rarely erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis (exanthematic necrolysis).
Other adverse effects eg, genital and anal pruritus, genital candidiasis, vaginitis and vaginal discharge, dizziness, fatigue, headache, agitation, confusion, hallucinations, arthralgia, arthritis and joint disorders have been reported.
As with other cephalosporins, interstitial nephritis has rarely been reported.
Eosinophilia, neutropenia, thrombocytopenia and slight elevations in aspartate aminotransferase and alanine aminotransferase have been reported.
As with other broad-spectrum antibiotics prolonged use may result in the overgrowth of non-susceptible organisms eg, candida. This may present a vulvo-vaginitis.
There is a possibility of development of pseudomembranous colitis and it is therefore important to consider its diagnosis in patients who develop diarrhea while taking Reflexin. It may range in severity from mild to life-threatening with mild case usually responding to cessation of therapy. Appropriate measures should be taken with moderate to severe cases.
Reflexin is contraindicated in patients with a known history of hypersensitivity to local anesthetics of the amide type.
Cefalexin in India.
Unit description / dosage (Manufacturer) | Price, USD |
250 mg x 100's | $ 8.13 |
500 mg x 100's | $ 15.12 |
125 mg x 5 mL x 30ml | $ 0.37 |
Reflexin 250mg CAP / 100 | $ 8.13 |
Reflexin 500mg CAP / 100 | $ 15.12 |
Reflexin 125mg/5mL D-SYR / 30ml | $ 0.37 |
REFLEXIN 500MG CAPSULE 1 strip / 10 capsules each (Radicura Pharma pvt ltd) | $ 1.16 |
REFLEXIN cap 250 mg x 10's (Radicura) | $ 0.81 |
REFLEXIN cap 500 mg x 10's (Radicura) | $ 1.51 |
REFLEXIN dry syr 125 mg x 5 mL x 30ml (Radicura) | $ 0.37 |
Reflexin 250mg CAP / 100 | $ 8.13 |
Reflexin 500mg CAP / 100 | $ 15.12 |
Reflexin 125mg/5mL D-SYR / 30ml | $ 0.37 |
Reflexin 500mg Capsule (Radicura Pharma pvt ltd) | $ 0.12 |
List of Reflexin substitutes (brand and generic names): | |
Refexin (Taiwan) | |
Refexin 500 mg x 120's, 320's, 500's, 1000's | |
Respicef (Egypt) | |
Respinal (Philippines) | |
Respinal 500 mg x 100's (Metz) | $ 53.33 |
Respinal 125 mg/5 mL x 60 mL (Metz) | $ 2.56 |
Respinal 250 mg/5 mL x 60 mL (Metz) | $ 3.76 |
REXIN | |
REXIN 500MG CAPSULE 1 strip / 10 capsules each (RKM Health Care) | $ 1.43 |
Rilexine (Australia, Austria, Belgium, Finland, France, Germany, Italy, Luxembourg, Netherlands, New Zealand, Poland, South Africa, Switzerland, United Kingdom) | |
Rilexine 200 (Estonia) | |
Rilexine 200 LC (Netherlands, Poland, Switzerland) | |
Rilexine 250mg (France) | |
Rilexine 300 (Netherlands) | |
Rilexine 300 for Dogs (Australia) | |
Rilexine 300 für Hunde und Katzen (Switzerland) | |
Rilexine 300 mg für Hunde (Austria) | |
Rilexine 300mg (Poland) | |
Rilexine 300mg pour chiens (France) | |
Rilexine 600 (Netherlands) | |
Rilexine 600 for Dogs (Australia) | |
Rilexine 600 für Hunde und Katzen (Switzerland) | |
Rilexine 600 mg für Hunde (Austria) | |
Rilexine 600mg (Poland) | |
Rilexine 600mg pour chiens (France) | |
Rilexine 75 for Cats and Dogs (Australia) | |
Rilexine 75 für Hunde und Katzen (Switzerland) | |
Rilexine 75 mg für Hunde und Katzen (Austria) | |
Rilexine 75mg (Netherlands, Poland) | |
Rilexine 75mg pour chiens et chats (France) | |
Rilexine DC (Estonia) | |
Rilexine H.L. (France) | |
Rilexine LC 200 mg für Kühe (Austria) | |
Rilexine TS 375 mg (Austria) | |
Ritemed Cefalexin (Philippines) | |
RiteMED Cefalexin 250 mg x 100's (RiteMED) | $ 24.44 |
RiteMED Cefalexin 500 mg x 100's (RiteMED) | $ 37.84 |
RiteMED Cefalexin 125 mg/5 mL x 60 mL (RiteMED) | $ 2.11 |
RiteMED Cefalexin 250 mg/5 mL x 60 mL (RiteMED) | $ 3.44 |
RiteMED Cefalexin 100 mg/1 mL x 10 mL (RiteMED) | $ 2.11 |
RiteMED Cefalexin cap 250 mg 100's (RiteMED) | $ 24.44 |
RiteMED Cefalexin cap 500 mg 100's (RiteMED) | $ 37.84 |
RiteMED Cefalexin oral drops 100 mg/mL 10 mL x 1's (RiteMED) | $ 1.92 |
RiteMED Cefalexin oral susp 125 mg/5 mL 60 mL x 1's (RiteMED) | $ 2.11 |
RiteMED Cefalexin oral susp 250 mg/5 mL 60 mL x 1's (RiteMED) | $ 3.44 |
Rofex (India) | |
Rofex 250mg CAP / 10 (AHPL) | $ 0.72 |
See 2540 substitutes for Reflexin |
Users | % | ||
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1 day | 1 | 100.0% |
Users | % | ||
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1-5 | 1 | 100.0% |
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Information checked by Dr. Sachin Kumar, MD Pharmacology
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