Rihest is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.
Rihest is used to treat sneezing, runny nose, watery eyes, hives, skin rash, itching, and other cold or allergy symptoms.
Rihest is also used to treat skin hives and itching in people with chronic skin reactions.
Rihest may also be used for purposes not listed in this medication guide.
Rihest indications
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Treatment of seasonal allergic rhinitis, perennial rhinitis, urticaria, allergic dermatologic disorders, angioedema and conjunctivitis. Rihest is generally considered to be ineffective in asthma.
Acute anaphylaxis should be treated with adrenaline; Rihest and corticosteroids are given to prevent relapse.
Rihest is also used to control the pruritus associated with skin disorders eg, atopic eczema.
How should I use Rihest?
Use Rihest orally disintegrating tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Take Rihest orally disintegrating tablets by mouth with or without food.
Be sure that your hands are completely dry before you handle Rihest orally disintegrating tablets. Use the tablet right away after you remove it from the tablet blister.
To open the tablet blister, peel back the foil, then gently remove the tablet. Place the tablet on the tongue. The tablet will dissolve quickly. You may take Rihest orally disintegrating tablets with or without water.
If you miss a dose of Rihest orally disintegrating tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Rihest orally disintegrating tablets.
Uses of Rihest in details
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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This medication is an antihistamine that treats symptoms such as itching, runny nose, watery eyes, and sneezing from "hay fever" and other allergies. It is also used to relieve itching from hives.
Rihest does not prevent hives or prevent/treat a serious allergic reaction (e.g., anaphylaxis). Therefore, if your doctor has prescribed epinephrine to treat allergic reactions, always carry your epinephrine injector with you. Do not use Rihest in place of your epinephrine.
If you are self-treating with this medication, it is important to read the manufacturer's package instructions carefully so you know when to consult your doctor or pharmacist.
Do not use this medication in children younger than 6 years unless directed by the doctor.
How to use Rihest
If you are using the over-the-counter product to self-treat, read all the directions on the product package before taking this medication. If your doctor has prescribed this medication, follow your doctor's directions and the instructions on your prescription label. If you have any questions, consult your doctor or pharmacist.
Take this medication by mouth with or without food as directed by your doctor or the product package, usually once or twice a day. Remove the tablet from its foil pack immediately before taking and place the tablet on the tongue. It will dissolve quickly. You may swallow the dissolved medication with or without water. Dosage is based on your age, condition, and response to treatment. Do not increase your dose or take this drug more often than directed. Do not take more of this medication than recommended for your age.
Tell your doctor if your allergy symptoms do not improve after 3 days of treatment or if your hives last more than 6 weeks. Seek immediate medical attention if your condition worsens or you think you have a serious medical problem (e.g., very serious allergic reaction/anaphylaxis).
Rihest description
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Rihest competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. In addition to the usual allergic symptoms, the drug also treats irritant cough and nausea, vomiting, and vertigo associated with motion sickness. Rihest's anticholinergic action appears to be due to a central antimuscarinic effect, which also may be responsible for its antiemetic effects, although the exact mechanism is unknown. It also is used commonly to treat drug-induced extrapyramidal symptoms as well as to treat mild cases of Parkinson's disease.
Rihest dosage
Dosage Forms
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Capsule,
Oral:
Rihest: 10 mg [contains brilliant blue fcf (fd&c blue #1)]
GoodSense Allergy Relief: 10 mg [contains brilliant blue fcf (fd&c blue #1)]
OTC labeling (patient-guided therapy for symptoms of hay fever or other upper respiratory allergies):
Oral: 10 mg once daily or 5 mg twice daily; maximum dose: 10 mg/day.
Urticaria (acute and chronic spontaneous):
Oral: Initial: 10 mg once daily. If symptom control is inadequate, may increase to 10 mg twice daily. There is limited evidence for larger doses. Reevaluate necessity for continued treatment periodically (Asero 2020; Khan 2019; Zuberbier 2018).
Dosing: Geriatric
Refer to adult dosing.
Dosing: Pediatric
Allergic symptoms/rhinitis:
Oral
Children 2 to <6 years:
Oral liquid or chewable tablet: 5 mg once daily
Children ≥6 years and Adolescents:
Oral liquid, capsule, tablet, or chewable tablet: 10 mg once daily
Dispersible tablet: 5 mg twice daily or 10 mg once daily
Chronic idiopathic urticaria: Limited data available (Kliegman 2011; Simons 1994):
Rihest (10 mg once daily) has been coadministered with therapeutic doses of erythromycin, cimetidine, and ketoconazole in controlled clinical pharmacology studies in adult volunteers. Although increased plasma concentrations (AUC 0-24 hrs) of Rihest and/or descarboethoxyloratadine were observed following coadministration of Rihest with each of these drugs in normal volunteers (n = 24 in each study), there were no clinically relevant changes in the safety profile of Rihest, as assessed by electrocardiographic parameters, clinical laboratory tests, vital signs, and adverse events. There were no significant effects on QTc intervals, and no reports of sedation or syncope. No effects on plasma concentrations of cimetidine or ketoconazole were observed. Plasma concentrations (AUC 0-24 hrs) of erythromycin decreased 15% with coadministration of Rihest relative to that observed with erythromycin alone. The clinical relevance of this difference is unknown. These above findings are summarized in TABLE 1.
TABLE 1 Effects on Plasma Concentrations (AUC 0-24 hrs) of Rihest and Descarboethoxyloratadine After 10 Days of Coadministration (Rihest 10 mg) in Normal Volunteers
Children 2–5 years of age receiving oral solution: Diarrhea, epistaxis, pharyngitis, flu-like symptoms, fatigue, stomatitis, tooth disorder, earache, viral infection, rash.
Children 6–12 years of age receiving oral solution: Nervousness, wheezing, fatigue, hyperkinesia, abdominal pain, conjunctivitis, dysphonia, upper respiratory tract infection.
Adults and children ≥12 years of age receiving conventional or orally disintegrating tablets: Headache, somnolence, fatigue, dry mouth.
Fixed combination Rihest (the active ingredient contained in Rihest Reditab) pseudoephedrine sulfate preparations: Insomnia, dry mouth, headache, somnolence, nervousness, dizziness, fatigue.
You should not take this medication if you are allergic to Rihest or to desloratadine (Clarinex).
Ask a doctor or pharmacist before taking this medicine if you have liver or kidney disease.
Do not give this medication to a child younger than 6 years old without the advice of a doctor.
Rihest disintegrating tablets (Rihest Reditab) may contain phenylalanine. Talk to your doctor before using this form of Rihest if you have phenylketonuria (PKU).
DailyMed. "LORATADINE; PSEUDOEPHEDRINE SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
