What happens if I overdose Robitussin Cold & Flu Junior?
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local, or emergency room right away. Symptoms may include confusion; hallucinations; irregular or unusually slow or rapid heartbeat; rapid breathing; seizures.
Store Robitussin Cold & Flu Junior orally disintegrating strips at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Robitussin Cold & Flu Junior orally disintegrating strips out of the reach of children and away from pets.
Overdose of Robitussin Cold & Flu Junior in details
When a dose is taken in higher dose than the recommended doses, it is called Overdose. Overdose always needs a clinical supervision. Any medicine or drug when consumed in Overdose produces untoward side effects on one or various organs in the body. A medicine is excreted in the kidney or metabolized in the liver most of the times. This process goes without any hurdles when taken in normal dose, but when taken in an overdose, the body is not able to metabolize it or send it out properly which causes the effects of anoverdose.
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Overdose of Robitussin Cold & Flu Junior (Robitussin Cold & Flu Junior hydrochloride) can cause a rapid rise in blood pressure. Symptoms of overdose include headache, vomiting, hypertension, reflex bradycardia, a sensation of fullness in the head, tingling of the extremities, and cardiac arrhythmias including ventricular extrasystoles and ventricular tachycardia.
What should I avoid while taking Robitussin Cold & Flu Junior?
Do not take Robitussin Cold & Flu Junior rectal rectal suppository by mouth. It is for use only in your rectum.
Ask a doctor or pharmacist before taking any cough, cold, or allergy medicine. Robitussin Cold & Flu Junior is contained in many combination medicines. Taking certain products together can cause you to get too much Robitussin Cold & Flu Junior. Check the label to see if a medicine contains Phenylephrine, or a decongestant.
Robitussin Cold & Flu Junior warnings
Warnings are a mix of Precautions. Contraindications and interactions and serious harmful effects associated with the medicine intake. A diabetic or Hypertensive patient need to be warned about few drug interactions. A known hypersensitivity patient needs to be careful about the reactions or anaphylactic shock. A pregnant woman or a breastfeeding woman should be warned of certain medications. A Hepatitis [liver disease] patient or a cardiac patient should avoid few drugs.
Exacerbation of Angina, Heart Failure, or Pulmonary Arterial Hypertension
Because of its increasing blood pressure effects, Robitussin Cold & Flu Junior can precipitate angina in patients with severe arteriosclerosis or history of angina, exacerbate underlying heart failure, and increase pulmonary arterial pressure.
Peripheral and Visceral Ischemia
Robitussin Cold & Flu Junior can cause excessive peripheral and visceral vasoconstriction and ischemia to vital organs, particularly in patients with extensive peripheral vascular disease.
Skin and Subcutaneous Necrosis
Extravasation of Robitussin Cold & Flu Junior can cause necrosis or sloughing of tissue. The infusion site should be checked for free flow. Care should be taken to avoid extravasation of Robitussin Cold & Flu Junior.
Bradycardia
Robitussin Cold & Flu Junior can cause severe bradycardia and decreased cardiac output.
Allergic Reactions
Robitussin Cold & Flu Junior contains sodium metabisulfite, a sulfite that may cause allergic-type reactions, including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people.
Renal Toxicity
Robitussin Cold & Flu Junior can increase the need for renal replacement therapy in patients with septic shock. Monitor renal function.
Risk of Augmented Pressor Affect in Patients with Autonomic Dysfunction
The increasing blood pressure response to adrenergic drugs, including Robitussin Cold & Flu Junior, can be increased in patients with autonomic dysfunction, as may occur with spinal cord injuries.
Pressor Effect with Concomitant Oxytocic Drugs
Oxytocic drugs potentiate the increasing blood pressure effect of sympathomimetic pressor amines including Robitussin Cold & Flu Junior, with the potential for hemorrhagic stroke.
What should I discuss with my healthcare provider before taking Robitussin Cold & Flu Junior?
Some medical conditions may interact with Robitussin Cold & Flu Junior dissolving tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have a history of glaucoma or increased pressure in the eye, enlarged prostate gland or other prostate problems, heart problems, diabetes, high blood pressure, blood vessel problems, adrenal gland problems, overactive thyroid, seizures, or stroke
Some MEDICINES MAY INTERACT with Robitussin Cold & Flu Junior dissolving tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:
Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, entacapone), furazolidone, indomethacin, methyldopa, or MAOIs (eg, phenelzine) because they may increase the risk of Robitussin Cold & Flu Junior dissolving tablets's side effects
Tricyclic antidepressants (eg, amitriptyline) because they may decrease Robitussin Cold & Flu Junior dissolving tablets's effectiveness
Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased
Bromocriptine because the risk of its side effects, such as phenylketonuria, may be increased by Robitussin Cold & Flu Junior dissolving tablets
Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Robitussin Cold & Flu Junior dissolving tablets
This may not be a complete list of all interactions that may occur. Ask your health care provider if Robitussin Cold & Flu Junior dissolving tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Robitussin Cold & Flu Junior precautions
Certain people who are very sick or very old or who are sensitive show an exacerbation of side effect of the drug which can turn dangerous at times. So, it is very important to remember the precautions while taking the medicine. Pregnancy and Breastfeeding are also special categories wherein extra care or precaution is needed when taking a drug. Few patients may have a hypersensitivity reaction to few medications, and that can be life-threatening rarely. Penicillin hypersensitivity is one example. Diarrhea, rashes are few other symptoms which need a watch. A patient with other co-existing diseases like liver disease, heart disease, kidney disease should take special precautions.
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Exacerbation Of Angina, Heart Failure, Or Pulmonary Arterial Hypertension
Because of its increasing blood pressure effects, Robitussin Cold & Flu Junior can precipitate angina in patients with severe arteriosclerosis or history of angina, exacerbate underlying heart failure, and increase pulmonary arterial pressure.
Peripheral And Visceral Ischemia
Robitussin Cold & Flu Junior can cause excessive peripheral and visceral vasoconstriction and ischemia to vital organs, particularly in patients with extensive peripheral vascular disease.
Skin And Subcutaneous Necrosis
Extravasation of Robitussin Cold & Flu Junior can cause necrosis or sloughing of tissue. The infusion site should be checked for free flow. Care should be taken to avoid extravasation of Robitussin Cold & Flu Junior.
Bradycardia
Robitussin Cold & Flu Junior can cause severe bradycardia and decreased cardiac output.
Allergic Reactions
Robitussin Cold & Flu Junior contains sodium metabisulfite, a sulfite that may cause allergic-type reactions, including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people.
Renal Toxicity
Robitussin Cold & Flu Junior can increase the need for renal replacement therapy in patients with septic shock. Monitor renal function.
Risk Of Augmented Pressor Affect In Patients With Autonomic Dysfunction
The increasing blood pressure response to adrenergic drugs, including Robitussin Cold & Flu Junior, can be increased in patients with autonomic dysfunction, as may occur with spinal cord injuries.
Pressor Effect With Concomitant Oxytocic Drugs
Oxytocic drugs potentiate the increasing blood pressure effect of sympathomimetic pressor amines including Robitussin Cold & Flu Junior, with the potential for hemorrhagic stroke.
Nonclinical Toxicology
Carcinogenesis, Mutagenesis, Impairment Of Fertility
Carcinogenesis
Long-term animal studies that evaluated the carcinogenic potential of orally administered Robitussin Cold & Flu Junior hydrochloride in F344/N rats and B6C3F1 mice were completed by the National Toxicology Program using the dietary route of administration. There was no evidence of carcinogenicity in mice administered approximately 270 mg/kg/day (131-times the maximum recommended daily dose of < 10 mg/day) or rats administered approximately 50 mg/kg/day (48-times the maximum recommended daily dose of < 10 mg/day) based on body surface area comparisons.
Mutagenesis
Robitussin Cold & Flu Junior hydrochloride tested negative in the in vitro bacterial reverse mutation assay (S.typhimurium strains TA98, TA100, TA1535 and TA1537), the in vitro chromosomal aberrations assay, the in vitro sister chromatid exchange assay, and the in vivo rat micronucleus assay. Positive results were reported in only one of two replicates of the in vitro mouse lymphoma assay.
Impairment of Fertility
Studies to evaluate the effect of Robitussin Cold & Flu Junior on fertility have not been conducted.
Use In Specific Populations
Pregnancy
Pregnancy Category C
Risk Summary
There are no adequate or well-controlled studies with Robitussin Cold & Flu Junior hydrochloride injection in pregnant women, nor have animal reproduction studies been conducted. Published studies in normotensive pregnant rabbits report early onset labor, increased fetal lethality, and adverse placental effects with subcutaneous Robitussin Cold & Flu Junior administration during gestation at doses approximately 1.9-times the total daily human dose. Published studies in normotensive pregnant sheep report decreased uterine blood flow and decreased PaO2 in the fetus with intravenous Robitussin Cold & Flu Junior administration during late gestation at doses less than and similar to the human dose. It is not known whether Robitussin Cold & Flu Junior, can cause fetal harm when administered to a pregnant woman. Robitussin Cold & Flu Junior, should be given to a pregnant woman only if the potential benefit justifies the potential risk to the fetus.
Clinical Considerations
Labor and Delivery
The most common maternal adverse reactions reported in published studies of Robitussin Cold & Flu Junior use during neuraxial anesthesia during Cesarean delivery include nausea and vomiting, bradycardia, reactive hypertension, and transient arrhythmias. Robitussin Cold & Flu Junior, when administered during labor or delivery, does not appear to alter either neonatal Apgar scores or umbilical artery blood-gas status.
Data
Animal Data
Studies in the published literature evaluating subcutaneously administered Robitussin Cold & Flu Junior (0.33 mg/kg, TID) in normotensive pregnant rabbits reported fetal deaths, adverse histopathology findings in the placenta (necrosis, calcification and thickened vascular walls with narrowed lumen) and possible teratogenic effects (one incidence of clubbed feet, partial development of the intestine) when treatment was initiated during the first trimester or later; and premature labor when treatment was initiated at the second trimester or later. The doses administered were 1.9- times the total daily human dose of 10 mg/day based on a body surface area comparison. Published studies in pregnant normotensive sheep demonstrate that intravenous Robitussin Cold & Flu Junior (4 mcg/kg/min for 30 minutes, equivalent to 3.6 to 4.1 mcg/kg/min human equivalent dose based on body surface area) administered during the third trimester of pregnancy decreased uterine blood flow by 42%. This dose is 1.1- to 1.2-times the human bolus dose of 200 mcg/60 kg person based on body surface area. Mean fetal blood pressure and heart rate fluctuated above and below controls by about 7% during the infusion. Fetal PaO2 was significantly decreased by approximately 26% of control during the infusion. Likewise, PaCO2 was increased and pH was decreased. The clinical significance of these findings is not clear; however, the results suggest the potential for cardiovascular effects on the fetus when Robitussin Cold & Flu Junior is used during pregnancy.
Nursing Mothers
It is not known whether Robitussin Cold & Flu Junior is present in human milk. The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for Robitussin Cold & Flu Junior and any potential adverse effects on the breastfed child from the drug or from the underlying maternal condition. Exercise caution when Robitussin Cold & Flu Junior is administered to a nursing woman.
Pediatric Use
Safety and effectiveness in pediatric patients have not been established.
Geriatric Use
Clinical studies of Robitussin Cold & Flu Junior did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.
Hepatic Impairment
In patients with liver cirrhosis [Child Pugh Class B and Class C], dose-response data indicate decreased responsiveness to Robitussin Cold & Flu Junior. Start dosing in the recommended dose range but consider that you may need to give more Robitussin Cold & Flu Junior in this population.
Renal Impairment
In patients with end stage renal disease (ESRD), dose-response data indicate increased responsiveness to Robitussin Cold & Flu Junior. Consider starting at the lower end of the recommended dose range, and adjusting dose based on the target blood pressure goal.
What happens if I miss a dose of Robitussin Cold & Flu Junior?
When you miss a dose, you should take it as soon as you remember, but you should take care that it should be well spaced from the next dose. You should not take an extra dose at the time of the second dose as it will become a double dose. The double dose can give unwanted side effects, so be careful. In chronic conditions or when you have a serious health issue, if you miss a dose, you should inform your health care provider and ask his suggestion.
Since Robitussin Cold & Flu Junior rectal is used on an as needed basis, you are not likely to miss a dose. Do not use Robitussin Cold & Flu Junior rectal more than 4 times per day.
EPA Chemicals under the TSCA. "Benzenemethanol, 3-hydroxy-.alpha.-[(methylamino)methyl]- , hydrochloride (1:1), (.alpha.R)-: The Chemical Data Reporting under the Toxic Substances Control Act (TSCA) contains chemical physical description and chemical use categories.". http://www.epa.gov/chemical-data-rep... (accessed September 17, 2018).
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