Rofenac Uses

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What is Rofenac?

Rofenac is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and other symptoms of arthritis of the joints (eg, osteoarthritis), such as inflammation, swelling, stiffness, and joint pain. However, Rofenac does not cure osteoarthritis and will help you only as long as you continue to use it.

Rofenac topical 3% gel is also used to treat actinic keratosis, a skin problem that may become cancerous if not treated. The exact way that topical Rofenac helps this condition is unknown.

Rofenac topical solution is used to treat pain and swelling caused by osteoarthritis of the knees.

Rofenac topical patch is used to treat acute pain caused by minor strains, sprains, and contusions (bruises).

Rofenac is available only with your doctor's prescription.

Rofenac indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Intramuscular

Renal colic

Adult: As Rofenac Na: 75 mg, may repeat once after 30 min if needed. Max: 150 mg/day. Max period: 2 days.

Intramuscular

Bursitis, Pain and inflammation associated with musculoskeletal and joint disorders, Rheumatoid arthritis, Sprains, Strains, Tendinitis, Acute gout, Dysmenorrhoea

Adult: As Rofenac Na: 75 mg once daily, injected into the gluteal muscle, may increase to 75 mg bid in severe conditions. Max period: 2 days.

Intravenous

Postoperative pain

Adult: As Rofenac Na: 75 mg infusion in glucose 5% or NaCl 0.9% (previously buffered w/ Na bicarbonate) given over 30-120 min or as bolus inj, may repeat after 4-6 hr if necessary. Max period: 2 days.

Intravenous

Prophylaxis of postoperative pain

Adult: As Rofenac Na: Initially, 25-50 mg infusion given after surgery over 15-60 min followed by 5 mg/hr. Alternatively, initial dose may be given as bolus inj over 5-60 sec followed by additional inj, may repeat after 4-6 hr if necessary. Max: 150 mg/day. Max period: 2 days.

Ophthalmic

Postoperative ocular inflammation

Adult: As Rofenac Na (0.1% soln): Instill into the appropriate eye 4 times daily starting 24 hr after surgery for up to 28 days.

Ophthalmic

Inflammation and discomfort after strabismus surgery

Adult: As Rofenac Na (0.1% soln): Instill 1 drop 4 times daily for the 1st wk; then tid in the 2nd wk, bid in the 3rd wk, and as required for the 4th wk.

Ophthalmic

Pain and discomfort after radial keratotomy

Adult: As Rofenac Na (0.1% soln): Instill 1 drop before surgery followed by 1 drop immediately after surgery, and then 1 drop 4 times daily for up to 2 days.

Ophthalmic

Pain after accidental trauma

Adult: As Rofenac Na (0.1% soln): Instill 1 drop 4 times daily for up to 2 days.

Ophthalmic

Control of inflammation after argon laser trabeculoplasty

Adult: As Rofenac Na (0.1% soln): Instill 1 drop 4 times during the 2 hr before procedure followed by 1 drop 4 times daily, up to 7 days after procedure.

Ophthalmic

Prophylaxis of intra-operative miosis

Adult: As Rofenac Na (0.1% soln): Instill into appropriate eye 4 times w/in 2 hr before surgery.

Ophthalmic

Post-photorefractive keratectomy pain

Adult: As Rofenac Na (0.1% soln): Instill into the affected eye twice, an hr before surgery, then 1 drop twice at 5-min intervals immediately after surgery, then every 2-5 hr while awake for up to 24 hr.

Ophthalmic

Seasonal allergic conjunctivitis

Adult: As Rofenac Na (0.1% soln): Instill 1 drop before surgery followed by 1 drop immediately after surgery, and then 1 drop 4 times daily for up to 2 days.

Oral

Bursitis, Pain and inflammation associated with musculoskeletal and joint disorders, Rheumatoid arthritis, Sprains, Strains, Tendinitis, Acute gout, Dysmenorrhoea

Adult: As Rofenac Na: 75-150 mg/day in divided doses. Max: 150 mg/day.

Oral

Migraine

Adult: As Rofenac K: Initially, 50 mg taken at the 1st sign of an attack, an additional dose of 50 mg may be taken after 2 hr if symptoms persist. If needed, further doses of 50 mg may be taken 4-6 hrly. Max: 200 mg/day.

Rectal

Acute gout, Bursitis, Dysmenorrhoea, Pain and inflammation associated with musculoskeletal and joint disorders, Rheumatoid arthritis, Sprains, Strains, Tendinitis

Adult: As Rofenac Na: 100 mg once daily.

Topical/Cutaneous

Actinic keratoses

Adult: As Rofenac Na (3% gel): Apply bid for 60-90 days.

Topical/Cutaneous

Osteoarthritis

Adult: As Rofenac Na (1.6% soln): Apply in small amounts (20 or 40 drops) onto affected area 4 times daily. As Na: (1% gel): Apply to the affected area 4 times daily. Max: 32 g/day over the affected area.

Topical/Cutaneous

Local symptomatic relief of pain and inflammation

Adult: As Rofenac Na (1% gel): Apply onto affected area 3 or 4 times daily.

Transdermal

Acute pain

Adult: Sprains, strains, contusions: 1 patch bid.

How should I use Rofenac?

Use Rofenac solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Rofenac solution comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Rofenac solution refilled.
  • Do not apply Rofenac solution to infected skin; open wounds; or red, swollen, or peeling skin.
  • Wash your hands immediately before and after using Rofenac solution.
  • Wash the affected area and dry completely before using Rofenac solution.
  • To apply Rofenac solution, dispense 10 drops at a time onto the knee or into your hand. Spread Rofenac solution evenly around the front, back, and sides of the knee. Repeat until you have used the whole dose.
  • Be sure that you cover your entire knee with your dose of Rofenac solution. Do not use more than the recommended amount.
  • Do not apply sunscreens, cosmetics, insect repellants, other topical medicines, or any other substance to the treated area until it is completely dry.
  • Do not put on clothes over the treated area until it is completely dry.
  • Do not wrap, bandage, or apply heat to the treated area.
  • Let the treated skin dry before touching it or letting it touch anyone else's skin.
  • Do not shower, bathe, or wash the treated area for at least 30 minutes after you use Rofenac solution.
  • If you miss a dose of Rofenac solution, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Rofenac solution.

Uses of Rofenac in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Rofenac is used to relieve pain from various conditions. This form of Rofenac is used to treat migraine headaches. Rofenac is a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your body's production of certain natural substances that cause inflammation. This effect helps to decrease swelling, pain, or fever.

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This medication may also be used to treat gout attacks.

How to use Rofenac

Read the Medication Guide provided by your pharmacist before you start taking Rofenac and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor. Empty the contents of one packet into a cup containing 1 to 2 ounces (30 to 60 milliliters) of water. Mix well and drink all of it right away. Do not mix with any liquid other than water. If stomach upset occurs while taking this medication, take it with food, milk, or an antacid. However, if you take this medication with a meal high in fat, it may not work as well.

There are different brands and forms of this medication available. Because different forms do not have the same effects at equal strengths, do not switch forms of Rofenac unless your doctor tells you to.

To reduce your risk of stomach bleeding and other side effects, take this medication at the lowest effective dose. Do not increase your dose or take it more often than prescribed.

Pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.

Tell your doctor if your condition persists or worsens.

Rofenac description

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Rofenac potassium is potassium-o-[(2,6-dichlorophenyl)-amino]-phenyl-acetate.

Rofenac resinate is [o-[(2, 6-dichlorophenyl)-amino]-phenyl-acetate resinate.

Each mL of oral drops contains Diclofenac resinate equivalent to Rofenac potassium 15 mg (0.5 mg/drop).

Excipients/Inactive Ingredients: Tablet: Core: Magnesium stearate, povidone, anhydrous colloidal silica, sodium starch glycollate, maize starch, calcium phosphate. Sugar-Coat: Microcrystalline cellulose, polyethylene glycol 8000, red iron oxide (E172) and titanium dioxide (E171) (dispersed Anstead), povidone, talc, sucrose. Polish: Polyethylene glycol 8000, sucrose.

Oral Drops:

Hydrogenated castor oil, liquid paraffin, saccharin sodium, tutti-frutti 503314 T flavour (contains vanillin), copolymer of acrylic and methacrylic acid with divinylbenzene and ethylvinylbenzene (Zerolite 236 SRC 48).

Rofenac dosage

General Dosing Instructions

Carefully consider the potential benefits and risks of Rofenac and other treatment options before deciding to use Rofenac. Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals.

The effectiveness of Rofenac when taken with food has not been studied in clinical studies. Taking Rofenac with food may cause a reduction in effectiveness compared to taking Rofenac on an empty stomach.

Acute Pain

For management of mild to moderate acute pain, the dosage is 18 mg or 35 mg orally three times daily.

Osteoarthritis Pain

For management of osteoarthritis pain, the dosage is 35 mg orally three times daily.

Dosage Adjustments In Patients With Hepatic Impairment

Patients with hepatic disease may require reduced doses of Rofenac compared to patients with normal hepatic function. As with other Rofenac products, start treatment at the lowest dose. If efficacy is not achieved with the lowest dose, discontinue use.

Non-Interchangeability With Other Formulations Of Rofenac

Rofenac capsules are not interchangeable with other formulations of oral Rofenac even if the milligram strength is the same. Rofenac capsules contain Rofenac free acid whereas other Rofenac products contain a salt of Rofenac, i.e., Rofenac potassium or sodium. A 35 mg dose of Rofenac is approximately equal to 37.6 mg of sodium Rofenac or 39.5 mg of potassium Rofenac. Therefore, do not substitute similar dosing strengths of other Rofenac products without taking this into consideration.

How supplied

Dosage Forms And Strengths

Rofenac (Rofenac) capsules: 18 mg - blue body and light green cap (imprinted IP-203 on the body and 18 mg on the cap in white ink).

Rofenac (Rofenac) capsules: 35 mg - blue body and green cap (imprinted IP-204 on the body and 35 mg on the cap in white ink).

Storage And Handling

Rofenac (Rofenac) capsules are supplied as:

  • 18 mg - blue body and light green cap (imprinted IP-203 on the body and 18 mg on the cap in white ink)

NDC (42211-203-23), Bottles of 30 capsules

NDC (42211-203-29), Bottles of 90 capsules

  • 35 mg - blue body and green cap (imprinted IP-204 on the body and 35 mg on the cap in white ink)

NDC (42211-204-23), Bottles of 30 capsules

NDC (42211-204-29), Bottles of 90 capsules

Storage

Store at room temperature 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C to 30°C (59°F to 86°F).

Store in the original container and keep the bottle tightly closed to protect from moisture. Dispense in a tight container if package is subdivided.

Manufactured (under license from iCeutica Pty Ltd) for and Distributed by: Iroko Pharmaceuticals, LLC, One Kew Place, 150 Rouse Boulevard, Philadelphia, PA 19112. Revised: May 2016

Rofenac interactions

See also:
What other drugs will affect Rofenac?

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Aspirin: Concomitant administration of Rofenac and aspirin is not recommended because Rofenac is displaced from its binding sites during the concomitant administration of aspirin, resulting in lower plasma concentrations, peak plasma levels and AUC values.

Anticoagulants: While studies have not shown Rofenac to interact with anticoagulants of the warfarin type, caution should be exercised, nonetheless, since interactions have been seen with other NSAIDs. Because prostaglandins play an important role in hemostasis and NSAIDs affect platelet function as well, concurrent therapy with all NSAIDs, including Rofenac and warfarin, requires close monitoring of patients to be certain that no change in their anticoagulant dosage is required.

Digoxin, Methotrexate, Cyclosporine: Rofenac, like other NSAIDs, may affect renal prostaglandins and increase the toxicity of certain drugs. Ingestion of Rofenac may increase serum concentrations of digoxin and methotrexate and increase cyclosporine's nephrotoxicity. Patients who begin taking Rofenac or who increase their Rofenac dose or any other NSAID while taking digoxin, methotrexate or cyclosporine may develop toxicity characteristics for these drugs. They should be observed closely, particularly if renal function is impaired. In the case of digoxin, serum levels should be monitored.

Lithium: Rofenac decreases lithium renal clearance and increases lithium plasma levels. In patients taking Rofenac and lithium concomitantly, lithium toxicity may develop.

Oral Hypoglycemics:

Rofenac does not alter glucose metabolism in normal subjects nor does it alter the effects of oral hypoglycemic agents. There are rare reports, however, from marketing experiences, of changes in effects of insulin or oral hypoglycemic agents in the presence of Rofenac that necessitated changes in the doses of such agents. Both hypo- and hyperglycemic effects have been reported. A direct causal relationship has not been established, but physicians should consider the possibility that Rofenac may alter a diabetic patient's response to insulin or oral hypoglycemic agents.

Diuretics: Rofenac and other NSAIDs can inhibit the activity of diuretics. Concomitant treatment with potassium-sparing diuretics may be associated with increased serum potassium levels.

Other Drugs: In small groups of patients (7-10/interaction study), the concomitant administration of azathioprine, gold, chloroquine, D-penicillamine, prednisolone, doxycycline or digitoxin did not significantly affect the peak levels and AUC values of Rofenac. Phenobarbital toxicity has been reported to have occurred in a patient on chronic phenobarbital treatment following the initiation of Rofenac therapy.

Rofenac side effects

See also:
What are the possible side effects of Rofenac?

Fluid Retention and Edema: Fluid retention and edema have been observed in some patients taking Rofenac. Therefore, as with other NSAIDs, Rofenac should be used with caution in patients with history of cardiac decompensation, hypertension or other conditions predisposing to fluid retention.

Hematological Effects: Anemia is sometimes seen in patients receiving Rofenac or other NSAIDs. This may be due to fluid retention, GI blood loss or an incompletely described effect upon erythropoiesis.

Renal Effects: As a class, NSAIDs have been associated with renal papillary necrosis and other abnormal renal pathology in long-term administration to animals. In patients treated with Rofenac, rare cases of interstitial nephritis and papillary necrosis have been reported. A second form of renal toxicity, generally associated with NSAIDs, is seen in patients with conditions leading to a reduction in renal blood flow or blood volume, where renal prostaglandins have a supported role in the maintenance of renal perfusion. In these patients, administration of an NSAID results in a dose-dependent decrease in prostaglandin synthesis and secondarily, in a reduction of renal blood flow, which may precipitate over the renal failure. Patients at greater risk of this reaction are those with impaired renal function, heart failure, liver dysfunction, those taking diuretics and the elderly.

Porphyria: The use of Rofenac in patients with hepatic porphyria should be avoided.

Aseptic Meningitis: As with other NSAIDs, aseptic meningitis with fever and coma has been observed in rare occasions in patients on Rofenac therapy. Although it is probably more likely to occur in patients with systemic lupus erythematosus and related connective tissue diseases, it has been reported in patients who do not have an underlying chronic disease. If signs or symptoms of meningitis develop in a patient on Rofenac, the possibility of it being related to Rofenac should be considered.

There may be pain and occasionally tissue damage at the site of injection when given IM.

Rofenac contraindications

See also:
What is the most important information I should know about Rofenac?

Hypersensitivity to Rofenac or to any of the excipients of Rofenac.

Active gastric or intestinal ulcer, bleeding or perforation.

Last trimester of pregnancy.

Hepatic, renal and severe cardiac failure.

Patients in whom attacks of asthma, urticaria or acute rhinitis are precipitated by acetylsalicylic acid and/or other drugs with prostaglandin-synthetase inhibitory activity.

Treatment of peri-operative pain in setting of coronary artery bypass graft (CABG) surgery.

The use of high dose Rofenac (150 mg/day) for >4 weeks is contraindicated in patients with established cardiovascular disease (congestive heart failure, established ischemic heart disease, peripheral arterial disease) or uncontrolled hypertension.

Established Cardiovascular Disease or Significant Cardiovascular Risk Factors: The use of high dose Rofenac (150mg/day) for >4 weeks is contraindicated in patients with established cardiovascular disease (congestive heart failure, established ischemic heart disease, peripheral arterial disease) or uncontrolled hypertension. If Rofenac treatment is needed, patients with established cardiovascular disease, uncontrolled hypertension or significant cardiovascular risk factors (eg, hypertension, hyperlipidaemia, diabetes mellitus and smoking) should be treated only after careful consideration and at doses ≤100 mg daily if the treatment is for >4 weeks. As the cardiovascular risks of Rofenac may increase with dose and duration of exposure, Rofenac should always be prescribed at the lowest effective daily dose and for the shortest duration possible.

Renal Impairment: Rofenac is contraindicated in patients with renal failure. No specific studies have been carried out in patients with renal impairment, therefore, no specific dose adjustment recommendations can be made. Caution is advised when administering Rofenac to patients with mild to moderate renal impairment.

Hepatic Impairment: Rofenac is contraindicated in patients with hepatic failure. No specific studies have been carried out in patients with hepatic impairment, therefore, no specific dose adjustment recommendations can be made. Caution is advised when administering Rofenac to patients with mild to moderate hepatic impairment.



Active ingredient matches for Rofenac:

Diclofenac in Oman.

Diclofenac Sodium


List of Rofenac substitutes (brand and generic names)

Sort by popularity
Unit description / dosage (Manufacturer)Price, USD
Roitonin 25 mg x 100's
Roitonin 25 mg x 500's
Roitonin 25 mg x 1000's
ROLOD K 50MG TABLET 1 strip / 10 tablets each (Tidal Laboratories Pvt Ltd)$ 0.31
Ronac INJ 75mg INJ / 3ml (Rouzel)
75 mg x 3ml (Rouzel)
RONAC INJ inj 75 mg x 3ml (Rouzel)
Ronac-S Diclofenac potassium 50 mg, Serratiopeptidase 15 mg. TAB / 10 (Rouzel)
10's (Rouzel)
RONAC-S tab 10's (Rouzel)
Rozadin Diclofenac diethylammonium, Linseed oil, methylsalicylate, menthol 5 %. GEL / 30g (Hi-Tec)$ 0.71
30g (Hi-Tec)$ 0.71
ROZADIN topical gel 30g (Hi-Tec)$ 0.71
Rubex Gel Diclofenac diethylammonium1.16 %, Methyl salicylate 10%, Menthol 2 %, Linseed oil 3%, Benzyl alcohol 1 % w/w. GEL / 30g (Rapross)$ 0.76
30g (Rapross)$ 0.76
RUBEX GEL topical gel 30g (Rapross)$ 0.76
Rubigel Diclofenac diethylammonium1.16 % w/w, Methyl salicylate10 % w/w, Menthol 5 % w/w. GEL / 30g (Galantica)
30g (Galantica)
RUBIGEL topical gel 30g (Galantica)
Rubwel Diclofenac sodium 1 % w/w, Methyl salicylate 10 % w/w, menthol 5 % w/w. GEL / 30g (Acme Pharma (Optima))$ 0.63
30g (Acme Pharma (Optima))$ 0.63
RUBWEL topical gel 30g (Acme Pharma (Optima))$ 0.63

References

  1. DailyMed. "DICLOFENAC EPOLAMINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "diclofenac". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "diclofenac". http://www.drugbank.ca/drugs/DB00586 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Rofenac are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Rofenac. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

2 consumers reported useful

Was the Rofenac drug useful in terms of decreasing the symptom or the disease?
According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
Users%
Not useful1
50.0%
Useful1
50.0%


3 consumers reported price estimates

Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?
The below mentioned numbers have been reported by ndrugs.com website users about whether the Rofenac drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
Users%
Not expensive2
66.7%
Expensive1
33.3%


7 consumers reported time for results

To what extent do I have to use Rofenac before I begin to see changes in my health conditions?
As part of the reports released by ndrugs.com website users, it takes 2 days and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Rofenac. To get the time effectiveness of using Rofenac drug by other patients, please click here.
Users%
2 days2
28.6%
3 month1
14.3%
2 weeks1
14.3%
5 days1
14.3%
1 week1
14.3%
1 month1
14.3%


22 consumers reported age

Users%
16-297
31.8%
46-605
22.7%
30-455
22.7%
1-52
9.1%
> 602
9.1%
6-151
4.5%


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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