Rolisporin Dosage

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Dosage of Rolisporin in details

infoThe dose of a drug and dosage of the drug are two different terminologies. Dose is defined as the quantity or amount of medicine given by the doctor or taken by the patient at a given period. Dosage is the regimen prescribed by the doctor about how many days and how many times per day the drug is to be taken in specified dose by the patient. The dose is expressed in mg for tablets or gm, micro gm sometimes, ml for syrups or drops for kids syrups. The dose is not fixed for a drug for all conditions, and it changes according to the condition or a disease. It also changes on the age of the patient. Let us see what a dose of Rolisporin drug for various conditions is.

Usual Adult Dose for Bacterial Infection:

Usual daily dose: 1 to 2 g/day IV or IM in 1 to 2 divided doses, depending on the nature and severity of the infection

For infections caused by Staphylococcus aureus (methicillin-susceptible, MSSA), the recommended dose is 2 to 4 g/day, in order to achieve greater than 90% target attainment.

The total daily dose should not exceed 4 g.

Usual Adult Dose for Bacteremia:

2 g IV every 24 hours for 14 days, depending on the nature and severity of the infection

Usual Adult Dose for Chancroid:

250 mg IM as a single dose

The causative organism is Haemophilus ducreyi.

HIV-infected patients may require longer treatment. Rolisporin should only be given if patient follow-up can be guaranteed.

Patients should be retested for syphilis and HIV in 3 months, if initial tests were negative. The patient's sexual partner(s) should also be evaluated/treated.

Usual Adult Dose for Conjunctivitis:

Gonococcal Conjunctivitis: 1 g IM once

Doxycycline therapy for 7 days (if not pregnant) or single dose azithromycin is also recommended to treat possible concurrent chlamydial infection.

The patient's sexual partner(s) should also be evaluated/treated.

Usual Adult Dose for Endocarditis:

Patients with normal renal function:

Native valve infections due to highly penicillin-susceptible viridans Group Streptococci and S bovis (MIC 0.12 mcg/mL or less): Rolisporin 2 g IV or IM every 24 hours for 4 weeks plus gentamicin 3 mg/kg IV or IM every 24 hours for 2 weeks

Native valve infections due to relatively resistant S viridans and S bovis (MIC greater than 0.12 mcg/mL and 0.5 mcg/mL or less): Rolisporin 2 g IV or IM every 24 hours for 4 weeks plus gentamicin 3 mg/kg IV or IM every 24 hours for 2 weeks

Prosthetic valve infections due to penicillin-susceptible S viridans and S bovis (MIC 0.12 mcg/mL or less): Rolisporin 2 g IV or IM every 24 hours for 6 weeks plus gentamicin 3 mg/kg IV or IM every 24 hours for 2 weeks

Prosthetic valve infections due to relatively or fully penicillin-resistant S viridans and S bovis (MIC greater than 0.12 mcg/mL): Rolisporin 2 g IV or IM every 24 hours for 6 weeks plus gentamicin 3 mg/kg IV or IM every 24 hours for 6 weeks

Native or prosthetic valve infections due to enterococcal strains resistant to penicillin, aminoglycosides, and vancomycin: Rolisporin 2 g IV or IM every 24 hours plus ampicillin 2 g IV every 4 hours for 8 weeks or more

Gonococcal endocarditis: 1 to 2 g IV every 12 hours for at least 4 weeks

Refer to current published guidelines for detailed recommendations.

Usual Adult Dose for Bacterial Endocarditis Prophylaxis:

As an alternative in patients unable to take oral medication, with or without penicillin allergy (non-anaphylactoid type): 1 g IV or IM once 30 to 60 minutes before procedure

Usual Adult Dose for Endometritis:

2 g IV every 24 hours plus clindamycin

Duration:

Parenteral therapy should be continued for at least 24 hours after the patient has remained afebrile, pain free, and the leukocyte count has normalized. Doxycycline therapy for 14 days is recommended if concurrent chlamydial infection is present in late postpartum patients (breast-feeding should be discontinued).

Usual Adult Dose for Epididymitis -- Sexually Transmitted:

Gonococcal epididymitis: 250 mg IM as a single dose

Doxycycline 100 mg twice daily orally for 10 days should be given to treat a concurrent chlamydial infection.

The patient's sexual partner(s) should also be evaluated/treated.

Usual Adult Dose for Epiglottitis:

2 g IV every 24 hours for 7 to 10 days, depending on the nature and severity of the infection

Usual Adult Dose for Gastroenteritis:

2 g IV every 24 hours

Duration: 7 to 10 days in immunocompromised patients

Usual Adult Dose for Gonococcal Infection -- Disseminated:

1 g IV or IM every 24 hours

Duration:

Parenteral therapy should be continued for 24 to 48 hours after clinical improvement is demonstrated.

Oral therapy with cefixime should then be continued to complete a total course of at least 1 week.

Doxycycline therapy for 7 days (if not pregnant) or single dose azithromycin is also recommended to treat possible concurrent chlamydial infection.

The patient's sexual partner(s) should also be evaluated/treated.

Usual Adult Dose for Gonococcal Infection -- Uncomplicated:

Uncomplicated infections of the cervix, urethra, rectum, or pharynx: 250 mg IM once

Doxycycline therapy for 7 days (if not pregnant) or single dose azithromycin is also recommended to treat possible concurrent chlamydial infection.

The patient's sexual partner(s) should also be evaluated/treated.

Usual Adult Dose for Intraabdominal Infection:

2 g IV every 24 hours for 7 to 14 days, depending on the nature and severity of the infection

Usual Adult Dose for Joint Infection:

1 to 2 g IV or IM every 24 hours

Duration: 3 to 4 weeks, depending on the nature and severity of the infection; longer therapy, 6 weeks or more, may be required for prosthetic joint infections

Usual Adult Dose for Lyme Disease -- Arthritis:

2 g IV or IM every 24 hours

Febrile patients should also be evaluated/treated for human granulocytic ehrlichiosis (HGE) and babesiosis.

Duration: 14 days for arthritis, up to 21 days for carditis, and up to 30 days for neurologic Lyme disease

Usual Adult Dose for Lyme Disease -- Carditis:

2 g IV or IM every 24 hours

Febrile patients should also be evaluated/treated for human granulocytic ehrlichiosis (HGE) and babesiosis.

Duration: 14 days for arthritis, up to 21 days for carditis, and up to 30 days for neurologic Lyme disease

Usual Adult Dose for Lyme Disease -- Neurologic:

2 g IV or IM every 24 hours

Febrile patients should also be evaluated/treated for human granulocytic ehrlichiosis (HGE) and babesiosis.

Duration: 14 days for arthritis, up to 21 days for carditis, and up to 30 days for neurologic Lyme disease

Usual Adult Dose for Meningitis:

2 g IV every 12 hours for 14 days, depending on the nature and severity of the infection

Gonococcal meningitis: 1 to 2 g IV every 12 hours for 10 to 14 days

Usual Adult Dose for Meningococcal Meningitis Prophylaxis:

250 mg IM once

Usual Adult Dose for Neurosyphilis:

2 g IV or IM every 24 hours for 10 to 14 days

Aqueous crystalline penicillin G is considered the drug of choice by the CDC.

The patient's sexual partner(s) should also be evaluated/treated.

Usual Adult Dose for Osteomyelitis:

1 to 2 g IV or IM every 24 hours

Duration: 4 to 6 weeks, depending on the nature and severity of the infection; additional oral antibiotic therapy may be required for up to 6 months for chronic osteomyelitis

Usual Adult Dose for Pelvic Inflammatory Disease:

Outpatient treatment of mild PID: 250 mg IM once plus oral doxycycline with or without metronidazole

Severe: 1 to 2 g IV or IM every 24 hours for 14 days, depending on the nature and severity of the infection

Doxycycline therapy for 14 days (if not pregnant) is also recommended to treat possible concurrent chlamydial infection.

The patient's sexual partner(s) should also be evaluated/treated.

Usual Adult Dose for Peritonitis:

2 g IV every 24 hours

Peritoneal dialysis-related peritonitis:

Continuous: 1 g/2 L dialysate intraperitoneally, followed by 250 to 500 mg/2 L dialysate

Intermittent: 1 g/2 L dialysate intraperitoneally every 24 hours

Duration: 10 to 14 days, depending on the nature and severity of the infection

Usual Adult Dose for Pneumonia:

1 to 2 g IV or IM every 24 hours for 7 to 21 days, depending on the nature and severity of the infection

Usual Adult Dose for Prostatitis:

Gonococcal prostatitis: 250 mg IM once

Doxycycline 100 mg twice daily orally for 10 days should be given to treat a concurrent chlamydial infection.

The patient's sexual partner(s) should also be evaluated/treated.

Usual Adult Dose for Pyelonephritis:

1 to 2 g IV or IM every 24 hours

Duration: 14 days, depending on the nature and severity of the infection

Usual Adult Dose for Salmonella Gastroenteritis:

2 g IV every 24 hours

Duration: Up to 14 days in immunocompromised patients, or longer if a relapse occurs

Usual Adult Dose for Sepsis:

Severe: 2 g IV every 24 hours for 14 days, depending on the nature and severity of the infection

Usual Adult Dose for Skin or Soft Tissue Infection:

Severe: 1 to 2 g IV or IM every 24 hours

Duration: 7 to 10 days, depending on the nature and severity of the infection; diabetic soft tissue infections may require treatment for 14 to 21 days

Usual Adult Dose for STD Prophylaxis:

STD prophylaxis, sexual assault: 250 mg IM once, in combination with metronidazole and azithromycin or doxycycline

Sexual partner(s) of patients with chancroid: 250 mg IM once

Usual Adult Dose for Surgical Prophylaxis:

1 g IV once 30 to 120 minutes before surgery

Third generation cephalosporins are generally not recommended for routine surgical prophylaxis.

Usual Adult Dose for Syphilis -- Early:

1 g IV or IM every 24 hours for 10 to 14 days

Benzathine penicillin G is considered the drug of choice by the CDC.

The patient's sexual partner(s) should also be evaluated/treated.

Usual Adult Dose for Typhoid Fever:

2 g IV every 24 hours

Duration: 7 to 10 days; if the patient is immunocompromised or a relapse occurs, 14 days or more of treatment may be required

Usual Adult Dose for Urinary Tract Infection:

Severe: 1 to 2 g IV or IM every 24 hours

Duration: 2 to 3 weeks for complicated infections

Usual Pediatric Dose for Bacterial Infection:

Less than 1 week: 50 mg/kg IV or IM every 24 hours

1 to 4 weeks, 2000 g or less: 50 mg/kg IV or IM every 24 hours

1 to 4 weeks, greater than 2000 g: 50 to 75 mg/kg IV or IM every 24 hours

Rolisporin should be avoided in neonates with hyperbilirubinemia.

1 month or older:

Severe: 50 to 75 mg/kg IV in divided doses every 12 to 24 hours (maximum dose: 2 g/24 hours)

Life-threatening: 80 to 100 mg/kg IV in 1 or 2 divided doses (maximum dose: 4 g/24 hours)

Usual Pediatric Dose for Gonococcal Infection -- Uncomplicated:

Infants of mothers with gonococcal infection (gonococcal prophylaxis): 25 to 50 mg/kg (maximum dose: 125 mg) IV or IM once

Rolisporin should be avoided in neonates with hyperbilirubinemia.

Infant and mother should be evaluated/treated for possible concurrent chlamydial infection. The mother's sexual partner(s) should also be evaluated/treated.

Children with uncomplicated infections of the vulva and vagina, cervix, urethra, rectum, or pharynx:

45 kg or less: 125 mg IM once

Greater than 45 kg: 250 mg IM once

Patients should be evaluated/treated for possible concurrent syphilis and/or chlamydial infections.

Usual Pediatric Dose for Gonococcal Infection -- Disseminated:

0 to 4 weeks: 25 to 50 mg/kg (maximum dose: 125 mg) IV or IM every 24 hours for 7 days, up to 10 to 14 days if meningitis is documented

Rolisporin should be avoided in neonates with hyperbilirubinemia.

1 month or older:

45 kg or less:

Arthritis or bacteremia: 50 mg/kg (maximum dose: 1 g) IV or IM every 24 hours for 7 days

Greater than 45 kg: 1 g IV or IM once a day for 7 days

Patients should be evaluated/treated for possible concurrent syphilis and/or chlamydial infections.

Usual Pediatric Dose for Meningitis:

0 to 4 weeks: 50 to 75 mg/kg every 24 hours

Rolisporin should be avoided in neonates with hyperbilirubinemia.

1 month or older:

Initial dose: 100 mg/kg IV at the start of therapy (maximum dose: 4 g)

Maintenance dose: 100 mg/kg/day IV once a day or in divided doses every 12 hours for 7 to 14 days (maximum dose: 4 g/24 hours)

Gonococcal infection:

45 kg or less: 50 mg/kg/day IV or IM divided every 12 hours for 10 to 14 days (maximum dose: 2 g/day)

Greater than 45 kg: 1 to 2 g IV or IM every 12 hours for 10 to 14 days

Usual Pediatric Dose for Meningococcal Meningitis Prophylaxis:

Less than 15 years: 125 mg IM once

15 years or older: 250 mg IM once

Usual Pediatric Dose for Endocarditis:

Gonococcal infection:

45 kg or less: 50 mg/kg/day IV or IM divided every 12 hours for at least 28 days (maximum dose: 2 g/day)

Greater than 45 kg: 1 to 2 g IV or IM every 12 hours for at least 28 days

Usual Pediatric Dose for Bacterial Endocarditis Prophylaxis:

As an alternative in patients unable to take oral medication, with or without penicillin allergy (non-anaphylactoid type): 50 mg/kg (maximum dose: 1 g) IV or IM once 30 to 60 minutes before procedure

Usual Pediatric Dose for Otitis Media:

Acute bacterial otitis media: 50 mg/kg IM once (maximum dose: 1 g)

Persistent or relapsing acute otitis media: 50 mg/kg IV or IM once a day for 3 days (maximum dose: 1 g/day)

Rolisporin should be avoided in neonates with hyperbilirubinemia.

Usual Pediatric Dose for Epiglottitis:

1 month or older: 50 to 100 mg/kg IV or IM once a day

Duration: Has been reported to range from 2 to 14 days

Usual Pediatric Dose for Skin and Structure Infection:

1 month or older: 50 to 75 mg/kg/day IV or IM in 1 to 2 divided doses (maximum dose: 2 g/day)

Usual Pediatric Dose for Typhoid Fever:

1 month or older: 75 to 80 mg/kg IV once a day for 5 to 14 days

Usual Pediatric Dose for Lyme Disease:

Persistent arthritis, meningitis, encephalitis: 75 to 100 mg/kg/day (maximum dose: 2 g) IV or IM for 2 to 4 weeks

Usual Pediatric Dose for Salmonella Gastroenteritis:

50 to 75 mg/kg/day IV for 2 to 5 days

Treat immunocompromised patients for up to 10 days.

Rolisporin should be avoided in neonates with hyperbilirubinemia.

Usual Pediatric Dose for Shigellosis:

50 to 75 mg/kg/day IV for 2 to 5 days

Treat immunocompromised patients for up to 10 days.

Rolisporin should be avoided in neonates with hyperbilirubinemia.

Usual Pediatric Dose for STD Prophylaxis:

STD prophylaxis, sexual assault:

13 years or older: 250 mg IM once, in combination with metronidazole and azithromycin or doxycycline

Usual Pediatric Dose for Conjunctivitis:

Gonococcal infection:

Neonates: 25 to 50 mg/kg (maximum dose: 125 mg) IV or IM once

1 month or older:

45 kg or less: 50 mg/kg (maximum dose: 1 g) IV or IM once

Greater than 45 kg: 1 g IM once

Usual Pediatric Dose for Chancroid:

1 month or older: 50 mg/kg (maximum dose: 250 mg) IM as a single dose

Usual Pediatric Dose for Epididymitis -- Non-Specific:

250 mg IM as a single dose

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What other drugs will affect Rolisporin?

There may be other drugs that can interact with Rolisporin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Rolisporin interactions

infoInteractions are the effects that happen when the drug is taken along with the food or when taken with other medications. Suppose if you are taking a drug Rolisporin, it may have interactions with specific foods and specific medications. It will not interact with all foods and medications. The interactions vary from drug to drug. You need to be aware of interactions of the medicine you take. Most medications may interact with alcohol, tobacco, so be cautious. The below-mentioned interactions of Rolisporin drug are worth giving a glance!

May increase nephrotoxicity of aminoglycosides. May diminish therapeutic effect of BCG, typhoid vaccine, Na picosulfate. May increase anticoagulant effect of vit K antagonists (e.g. warfarin). May increase serum level w/ probenecid.

Potentially Fatal: Admin w/ Ca-containing IV soln may cause precipitation of a crystalline material in the lungs and kidneys.

References

  1. PubMed Health. "Rocephin: This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhealth... (accessed September 18, 2017).
  2. FDA/SPL Indexing Data. "75J73V1629: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/DataStan... (accessed September 18, 2017).

Reviews

The results of a survey conducted on ndrugs.com for Rolisporin are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Rolisporin. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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