Roxcef Uses

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What is Roxcef?

Roxcef is used to treat bacterial infections in many different parts of the body. Roxcef is also given before certain types of surgery to prevent infections.

Roxcef belongs to the class of medicines known as cephalosporin antibiotics. It works by killing bacteria or preventing their growth. However, Roxcef will not work for colds, flu, or other virus infections.

Roxcef is available only with your doctor's prescription.

Roxcef indications

infoAn indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Before instituting treatment with Roxcef, appropriate specimens should be obtained for isolation of the causative organism and for determination of its susceptibility to the drug. Therapy may be instituted prior to obtaining results of susceptibility testing.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Roxcef for injection USP and other antibacterial drugs, Roxcef for injection USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Roxcef for injection USP is indicated for the treatment of the following infections when caused by susceptible organisms:

Lower Respiratory Tract Infections

caused by Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Escherichia coli, Enterobacter aerogenes, Proteus mirabilis or Serratia marcescens.

Acute Bacterial Otitis Media

caused by Streptococcus pneumoniae, Haemophilus influenzae (including beta-lactamase producing strains) or Moraxella catarrhalis (including beta-lactamase producing strains).

NOTE: In one study lower clinical cure rates were observed with a single dose of Roxcef for injection USP compared to 10 days of oral therapy. In a second study comparable cure rates were observed between single dose Roxcef for injection USP and the comparator. The potentially lower clinical cure rate of Roxcef for injection USP should be balanced against the potential advantages of parenteral therapy.

Skin and Skin Structure Infections

caused by Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Viridans group streptococci, Escherichia coli, Enterobacter cloacae, Klebsiella oxytoca, Klebsiella pneumoniae, Proteus mirabilis, Morganella morganii*, Pseudomonas aeruginosa, Serratia marcescens, Acinetobacter calcoaceticus, Bacteroides fragilis* or Peptostreptococcus species.

Urinary Tract Infections (complicated and uncomplicated)

caused by Escherichia coli, Proteus mirabilis, Proteus vulgaris, Morganella morganii or Klebsiella pneumoniae.

Uncomplicated Gonorrhea (cervical/urethral and rectal)

caused by Neisseria gonorrhoeae, including both penicillinase- and nonpenicillinase-producing strains, and pharyngeal gonorrhea caused by nonpenicillinase-producing strains of Neisseria gonorrhoeae.

Pelvic Inflammatory Disease

caused by Neisseria gonorrhoeae. Roxcef sodium, like other cephalosporins, has no activity against Chlamydia trachomatis. Therefore, when cephalosporins are used in the treatment of patients with pelvic inflammatory disease and Chlamydia trachomatis is one of the suspected pathogens, appropriate antichlamydial coverage should be added.

Bacterial Septicemia

caused by Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, Haemophilus influenzae or Klebsiella pneumoniae.

Bone and Joint Infections

caused by Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae or Enterobacter species.

Intra-Abdominal Infections

caused by Escherichia coli, Klebsiella pneumoniae, Bacteroides fragilis, Clostridium species (Note: most strains of Clostridium difficile are resistant) or Peptostreptococcus species.


caused by Haemophilus influenzae, Neisseria meningitidis or Streptococcus pneumoniae. Roxcef for injection USP has also been used successfully in a limited number of cases of meningitis and shunt infection caused by Staphylococcus epidermidis* and Escherichia coli.*

*Efficacy for this organism in this organ system was studied in fewer than ten infections.

Surgical Prophylaxis

The preoperative administration of a single 1 g dose of Roxcef for injection USP may reduce the incidence of postoperative infections in patients undergoing surgical procedures classified as contaminated or potentially contaminated (e.g., vaginal or abdominal hysterectomy or cholecystectomy for chronic calculous cholecystitis in high-risk patients, such as those over 70 years of age, with acute cholecystitis not requiring therapeutic antimicrobials, obstructive jaundice or common duct bile stones) and in surgical patients for whom infection at the operative site would present serious risk (e.g., during coronary artery bypass surgery). Although Roxcef for injection USP has been shown to have been as effective as cefazolin in the prevention of infection following coronary artery bypass surgery, no placebo-controlled trials have been conducted to evaluate any cephalosporin antibiotic in the prevention of infection following coronary artery bypass surgery.

When administered prior to surgical procedures for which it is indicated, a single 1 g dose of Roxcef for injection USP provides protection from most infections due to susceptible organisms throughout the course of the procedure.

How should I use Roxcef?

Use Roxcef exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Roxcef is injected into a muscle, or into a vein through an IV. You may be shown how to use an IV at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used.

You may need to mix Roxcef with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medication. Use only the diluent your doctor has recommended.

Do not mix Roxcef in the same injection with other antibiotics, or with any diluent that contains calcium, including a TPN (total parenteral nutrition) solution.

After mixing your medicine, you will need to use it within a certain number of hours or days. This will depend on the diluent and how you store the mixture (at room temperature, in a refrigerator, or frozen). Carefully follow the mixing and storage instructions provided with your medicine. Ask your pharmacist if you have questions.

If you use other injectable medications, be sure to flush your intravenous catheter between injections of each medication.

Use Roxcef for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Roxcef will not treat a viral infection such as the common cold or flu.

Roxcef can cause unusual results with certain lab tests for glucose (sugar) in the urine. Tell any doctor who treats you that you are using this medicine.

Store unmixed Roxcef powder at room temperature, away from moisture, heat, and light.

If your medicine was provided in a frozen form or was frozen after mixing, thaw it in a refrigerator or at room temperature. Do not warm in a microwave or boiling water. Use the medicine as soon as possible after thawing it. Do not refreeze.

Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.

Uses of Roxcef in details

infoThere are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Roxcef is used to treat bacterial infections of the brain respiratory tract ear abdomen abdominal wall, urinary tract and kidney, bones, joints, and skin or soft tissues. It is also used in the management of fever with low white blood cells (neutropenia), surgical site infections, joint pain caused by parasite ticks (Lyme disease), typhoid, paratyphoid and sexually transmitted infections (gonorrhea, syphilis).

Roxcef description

Roxcef is a sterile, nonpyrogenic, single use, packaged combination of Roxcef sodium and dextrose injection (diluent) in the Duplex sterile container. The Duplex container is a flexible dual chamber container.

The drug chamber is filled with Roxcef sodium, a sterile, semisynthetic, broad-spectrum cephalosporin antibiotic for IV administration. Roxcef sodium is (6R,7R)-7-[2-(2-Amino-4-thiazolyl)glyoxylamido]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-as-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 72-(Z)-(O-methyloxime), disodium salt, sesquaterhydrate.

Its chemical formula is C18H16N8Na2O7S3·3.5H2O. It has a calculated molecular weight of 661.6.

Roxcef sodium is supplied as a dry powder form equivalent to either 1 or 2 g of Roxcef. It is a white to yellowish-orange crystalline powder which is readily soluble in water, sparingly soluble in methanol and very slightly soluble in ethanol. The pH of a 1% aqueous solution is approximately 6.7. The color of Roxcef sodium solutions ranges from light yellow to amber, depending on the length of storage and concentration.

Roxcef sodium contains approximately 83 mg (3.6 mEq) of sodium per gram of Roxcef activity.

The diluent chamber contains dextrose injection. The concentration of hydrous dextrose in water for injection USP has been adjusted to render the reconstituted drug product iso-osmotic. Dextrose USP has been added to adjust osmolality (approximately 1.87 g and 1.11 g to 1 g and 2 g dosages, respectively). Dextrose injection is sterile, nonpyrogenic, and contains no bacteriostatic or antimicrobial agents.

The molecular weight of hydrous dextrose USP is 198.17.

After removing the peelable foil strip, activating the seals, and thoroughly mixing, the reconstituted drug product is intended for single IV use. When reconstituted, the approximate osmolality for the reconstituted solution for Roxcef is 290 mOsmol/kg.

The Duplex container is latex-free, PVC-free, and DEHP-free.

The Duplex dual chamber container is made from a specially formulated material. The product (diluent and drug) contact layer is a mixture of thermoplastic rubber and a polypropylene ethylene copolymer that contains no plasticizers. The safety of the container system is supported by USP biological evaluation procedures.


Active ingredient matches for Roxcef:

Ceftriaxone in Bahrain, Iraq, Jordan, Kuwait, Lebanon, Libya, Nigeria, Oman, Qatar, Saudi Arabia, Sudan, Syria, United Arab Emirates, Yemen.

List of Roxcef substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
Roxifen Forte 20 mg x 500's (To-chemicals)
Roxifen 10 mg x 1,000's (To-chemicals)
Roxifen / vial + amp 10 mL diluent 1 g x 1's (To-chemicals)
Roxifen / vial + amp 2.5 mL diluent 250 mg x 1's (To-chemicals)
Roxifen / vial + amp 5 mL diluent 500 mg x 1 's (To-chemicals)
Roxifen 0.5 % x 25 g x 1's (To-chemicals)
Roxon 150mg TAB / 10 (Meridian)$ 1.08
Roxon 50mg/5mL SUSP / 30ml (Meridian)$ 0.51
150 mg x 10's (Meridian)$ 1.08
50 mg x 5 mL x 30ml (Meridian)$ 0.51
Roxon 1 g x 1's (Meridian)
Roxon / vial + diluent 250 mg x 1's (Meridian)
Roxon 500 mg x 1's (Meridian)
ROXON 150MG TABLET 1 strip / 10 tablets each (Meridian)$ 1.08
ROXON tab 150 mg x 10's (Meridian)$ 1.08
ROXON oral susp 50 mg x 5 mL x 30ml (Meridian)$ 0.51
Roxon 150mg Tablet (Meridian)$ 0.11
Roxon 500mg Injection (Meridian)$ 0.40
ROXON 1GM INJECTION 1 vial / 10 ML injection each (Rhombus Pharma Pvt Ltd)$ 1.19
ROXON 500MG INJECTION 1 vial / 2 ML injection each (Rhombus Pharma Pvt Ltd)$ 0.79
Rxone 1000mg INJ / 1 (R.K Medicare)$ 1.35
1000 mg x 1's (R.K Medicare)$ 1.35
Safecare 1g VIAL / 1 (Medico Health Care)$ 1.14
Safecare 250mg VIAL / 1 (Medico Health Care)$ 0.56
Safecare 500mg VIAL / 1 (Medico Health Care)$ 0.79
1 g x 1's (Medico Health Care)$ 1.14
250 mg x 1's (Medico Health Care)$ 0.56
500 mg x 1's (Medico Health Care)$ 0.79
Safecare 500 mg Injection (Medico Health Care)$ 0.79
Safecare 250 mg Injection (Medico Health Care)$ 0.56
Safecare 1000 mg Injection (Medico Health Care)$ 1.24
Safegard 1g VIAL / 15ml (Kalpataru Formulations Pvt. Ltd.)$ 0.71


  1. DailyMed. "CEFTRIAXONE SODIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". (accessed September 18, 2017).
  2. Wikipedia. "ceftriaxone: Link to the compound information in Wikipedia.". (accessed September 18, 2017).
  3. PubChem. "ceftriaxone". (accessed September 18, 2017).
  4. FDA Orange Book. "CEFTRIAXONE SODIUM; LIDOCAINE: The publication, Approved Drug Products with Therapeutic Equivalence Evaluations (the List, commonly known as the Orange Book), identifies drug products approved on the basis of safety and effectiveness by the Food and Drug Administration (FDA) under the Federal Food, Drug, and Cosmetic Act (the Act).". (accessed September 18, 2017).


The results of a survey conducted on for Roxcef are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Roxcef. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported useful

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Consumer reported price estimates

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1 consumer reported time for results

To what extent do I have to use Roxcef before I begin to see changes in my health conditions?
As part of the reports released by website users, it takes 1 week and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Roxcef. To get the time effectiveness of using Roxcef drug by other patients, please click here.
1 week1

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