Roxithromycin Coral Uses

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Roxithromycin Coral indications

infoAn indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Roxithromycin Coral is indicated for the treatment of the following types of mild to

moderately severe infections caused by or likely to be caused by susceptible

micro-organisms: • upper respiratory tract infection - acute pharyngitis, tonsillitis and

sinusitis

• dental infections

• lower respiratory tract infection - acute bronchitis; acute exacerbations

of chronic bronchitis and community acquired pneumonia

• skin and skin structure infections

• non-gonococcal urethritis.

Uses of Roxithromycin Coral in details

infoThere are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Roxithromycin Coral is used to treat ear, nose and throat infections, pneumonia (lung infection), skin infections and infections of the genitalia.

Roxithromycin Coral description

Roxithromycin Coral is a semi-synthetic macrolide antibiotic. It is very similar in composition, chemical structure and mechanism of action to erythromycin, azithromycin, or clarithromycin. Roxithromycin Coral prevents bacteria from growing, by interfering with their protein synthesis. Roxithromycin Coral binds to the subunit 50S of the bacterial ribosome, and thus inhibits the translocation of peptides. Roxithromycin Coral has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila. It can treat respiratory tract, urinary and soft tissue infections. It is in the United States, but is available in Australia.

Roxithromycin Coral dosage

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Oral

Susceptible infections

Adult: 150 mg bid or 300 mg once daily for 5-10 days in susceptible infections.

Child: 6-40 kg: 5-8 mg/kg daily.

Renal impairment: Dosage adjustment may be required.

Hepatic impairment: Usual daily doses should be halved in hepatic impairment.

Roxithromycin Coral interactions

Roxithromycin Coral has a much lower affinity for cytochrome P450 than

erythromycin, and consequently has fewer interactions. Interactions may be

observed, however, with drugs that bind to alpha-1-acid glycoprotein, e.g.

disopyramide.

Roxithromycin Coral does not appear to interact with oral contraceptives,

prednisolone, carbamazepine, ranitidine or antacids.

Theophylline. A study in normal subjects concurrently administered

Roxithromycin Coral and theophylline has shown some increase in the plasma

concentration of the latter. While a change in dosage is usually not required,

patients with high levels of theophylline at commencement of treatment

should have levels monitored.

Ergot alkaloids. Reactions of ergotism with possible peripheral necrosis have

been reported after concomitant therapy of macrolides with vasoconstrictive ergot alkaloids, particularly ergotamine and dihydroergotamine. Because a

clinical interaction with Roxithromycin Coral cannot be excluded, administration of

Roxithromycin Coral to patients taking ergot alkaloids is contraindicated.

Disopyramide. An in vitro study has shown that Roxithromycin Coral can displace

protein bound disopyramide; such an effect in vivo could result in increased

serum levels of disopyramide. Consequently, ECG and, if possible,

disopyramide serum levels should be monitored.

Terfenadine. Some macrolide antibiotics (e.g. erythromycin) may increase

serum levels of terfenadine. This can result in severe cardiovascular adverse

events, including QT prolongation, torsades de pointes and other ventricular

arrhythmias. Such a reaction has not been documented with Roxithromycin Coral,

which has a much lower affinity for cytochrome P450 than erythromycin.

However, in the absence of a systematic interaction study, concomitant

administration of Roxithromycin Coral and terfenadine is not recommended.

Astemizole, cisapride, pimozide. Other drugs, such as astemizole, cisapride

or pimozide, which are metabolised by the hepatic isozyme CYP3A4, have

been associated with QT interval prolongation and/or cardiac arrhythmias

(typically torsades de pointes) as a result of an increase in their serum level

subsequent to interaction with significant inhibitors of this isozyme, including

some macrolide antibacterials. Although Roxithromycin Coral has no or limited ability

to complex CYP3A4 and hence to inhibit the metabolism of other drugs

processed by this isozyme, a potential for clinical interaction of Roxithromycin Coral

with the above mentioned drugs cannot be either ascertained or ruled out in

confidence. Thus, concomitant administration of Roxithromycin Coral and such drugs

is not recommended.

Warfarin. While no interaction was observed in volunteer studies,

Roxithromycin Coral appears to interact with warfarin. Increases in prothrombin time

(international normalised ratio (INR)) have been reported in patients treated

concomitantly with Roxithromycin Coral and warfarin or the related vitamin K

antagonist phenprocoumon, and severe bleeding episodes have occurred as

a consequence.

Digoxin and other cardiac glycosides. A study in healthy volunteers has

shown that Roxithromycin Coral may increase the absorption of digoxin. This effect,

common to other macrolides, may very rarely result in cardiac glycoside

toxicity. This may be manifested by symptoms such as nausea, vomiting,

diarrhoea, headache or dizziness. Cardiac glycoside toxicity may also elicit

heart conduction and/or rhythm disorders. Consequently, in patients treated

with Roxithromycin Coral and digoxin or another cardiac glycoside, ECG and, if

possible, the serum level of the cardiac glycoside should be monitored. This is

mandatory if symptoms suggesting cardiac glycoside overdosage have

occurred.

Midazolam. Roxithromycin Coral, like other macrolides, may increase the area

under the midazolam concentration-time curve and the midazolam half-life.

Thus, the effects of midazolam may be enhanced and prolonged in patients treated with Roxithromycin Coral. There is no conclusive evidence for an interaction

between Roxithromycin Coral and triazolam.

Cyclosporin. A slight increase in plasma concentrations of cyclosporin A has

been observed. This does not generally necessitate altering the usual dosage.

Roxithromycin Coral side effects

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Applies to benzoyl peroxide topical: topical bar, topical cream, topical foam, topical gel/jelly, topical liquid, topical lotion, topical pad, topical soap, topical solution

In addition to its needed effects, some unwanted effects may be caused by benzoyl peroxide topical (the active ingredient contained in Roxithromycin Coral). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking benzoyl peroxide topical:

Less common or rare:

  • Painful irritation of skin, including burning, blistering, crusting, itching, severe redness, or swelling
  • skin rash
Incidence not known:
  • Difficult breathing
  • fainting
  • hives
  • itching
  • swelling of the eyes, face, lips, or tongue
  • tightness in the throat

If any of the following symptoms of overdose occur while taking benzoyl peroxide topical, get emergency help immediately:

Symptoms of overdose:

  • Burning, itching, scaling, redness, or swelling of skin (severe)

Minor Side Effects

Some of the side effects that can occur with benzoyl peroxide topical may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:

  • Dryness or peeling of the skin (may occur after a few days)
  • feeling of warmth, mild stinging, and redness of the skin

Roxithromycin Coral contraindications

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Hypersensitivity to Roxithromycin Coral or macrolides including erythromycin. Severely impaired hepatic function. Vasoconstrictive ergot alkaloids.

Roxithromycin Coral pregnancy

Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

Roxithromycin Coral precautions

Antibiotic-associated pseudomembranous colitis; impaired renal/hepatic function. Patients w/ congenital QT interval prolongation w/ ongoing proarrhythmic conditions (ie, uncorrected hypokalemia or hypomagnesaemia, bradycardia) & receiving antiarrhythmics IA & III. May aggravate myasthenia gravis. Prolonged or repeated use. Not to be used w/ drugs which delay peristalsis eg, opiates & diphenoxylate w/ atropine. Pregnancy. Avoid use in lactation.

Active ingredient matches for Roxithromycin Coral:

Roxithromycin in Vietnam.


Unit description / dosage (Manufacturer)Price, USD
Roxithromycin Coral 50 mg/5 mL x 1 Bottle 30 mL

List of Roxithromycin Coral substitutes (brand and generic names):

Tablet, Film-Coated; Oral; Roxithromycin 300 mg
Roxithroxyl 150 mg x 10 Blister x 10 Tablet (Bangkok Lab & Cosmetic)
Roxithroxyl 150 mg x 100's (Bangkok Lab & Cosmetic)
Roxithroxyl 150 mg x 10 x 10's (Bangkok Lab & Cosmetic)
Roxithroxyl 300 mg x 10 x 10's (Bangkok Lab & Cosmetic)
Roxithroxyl film-coated tab 150 mg 10 x 10's (Bangkok Lab & Cosmetic)
Roxithroxyl film-coated tab 150 mg 100's (Bangkok Lab & Cosmetic)
Roxithroxyl film-coated tab 300 mg 10 x 10's (Bangkok Lab & Cosmetic)
ROXITID 150MG TABLET 1 strip / 10 tablets each (Ranbaxy Laboratories Ltd)$ 0.68
Roxitin 150 mg x 50 x 10's (T P Drug)
Roxitin 150 mg x 500's (T P Drug)
ROXITIS Capsule/ Tablet / 150mg / 10 units (Medley)$ 0.87
ROXITIS Dispersible Tablet / 50mg / 10 units (Medley)$ 0.39
Roxitis 50mg TAB / 10 (Medley)$ 0.39
Roxitis 150mg TAB / 10 (Medley)$ 0.87
Roxitis 50mg/5mL SUSP / 30ml (Medley)$ 0.47
50 mg x 10's (Medley)$ 0.39
150 mg x 10's (Medley)$ 0.87
50 mg x 5 mL x 30ml (Medley)$ 0.47
Roxitis 150 mg x 10 Blister x 10 Tablet (Medley)
ROXITIS tab 50 mg x 10's (Medley)$ 0.39
ROXITIS tab 150 mg x 10's (Medley)$ 0.87
ROXITIS oral susp 50 mg x 5 mL x 30ml (Medley)$ 0.47
Roxitis 50mg TAB / 10 (Medley)$ 0.39

References

  1. PubChem. "roxithromycin". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  2. DrugBank. "roxithromycin". http://www.drugbank.ca/drugs/DB00778 (accessed September 17, 2018).
  3. DTP/NCI. "roxithromycin: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).
  4. Wikipedia. "roxithromycin: Link to the compound information in Wikipedia.". https://en.wikipedia.org/wiki/Roxith... (accessed September 17, 2018).
  5. MeSH. "Anti-Bacterial Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Roxithromycin Coral are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Roxithromycin Coral. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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