Roxithromycin JG Uses

• Roxithromycin JG indications
• Uses of Roxithromycin JG in details
• Roxithromycin JG description
• Roxithromycin JG dosage
• Roxithromycin JG interactions
• Roxithromycin JG side effects
• Roxithromycin JG contraindications
• List of Roxithromycin JG substitutes
• Roxithromycin JG reviews

Roxithromycin JG indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Roxithromycin JG is indicated for the treatment of the following types of mild to

moderately severe infections caused by or likely to be caused by susceptible

micro-organisms: • upper respiratory tract infection - acute pharyngitis, tonsillitis and

sinusitis

• dental infections

• lower respiratory tract infection - acute bronchitis; acute exacerbations

of chronic bronchitis and community acquired pneumonia

• skin and skin structure infections

• non-gonococcal urethritis.

Uses of Roxithromycin JG in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Roxithromycin JG is used to treat ear, nose and throat infections, pneumonia (lung infection), skin infections and infections of the genitalia.

Roxithromycin JG description

Roxithromycin JG is a semi-synthetic macrolide antibiotic. It is very similar in composition, chemical structure and mechanism of action to erythromycin, azithromycin, or clarithromycin. Roxithromycin JG prevents bacteria from growing, by interfering with their protein synthesis. Roxithromycin JG binds to the subunit 50S of the bacterial ribosome, and thus inhibits the translocation of peptides. Roxithromycin JG has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila. It can treat respiratory tract, urinary and soft tissue infections. It is in the United States, but is available in Australia.

Roxithromycin JG dosage

Oral

Susceptible infections

Adult: 150 mg bid or 300 mg once daily for 5-10 days in susceptible infections.

Child: 6-40 kg: 5-8 mg/kg daily.

Renal impairment: Dosage adjustment may be required.

Hepatic impairment: Usual daily doses should be halved in hepatic impairment.

Roxithromycin JG interactions

Roxithromycin JG has a much lower affinity for cytochrome P450 than

erythromycin, and consequently has fewer interactions. Interactions may be

observed, however, with drugs that bind to alpha-1-acid glycoprotein, e.g.

disopyramide.

Roxithromycin JG does not appear to interact with oral contraceptives,

prednisolone, carbamazepine, ranitidine or antacids.

Theophylline. A study in normal subjects concurrently administered

Roxithromycin JG and theophylline has shown some increase in the plasma

concentration of the latter. While a change in dosage is usually not required,

patients with high levels of theophylline at commencement of treatment

should have levels monitored.

Ergot alkaloids. Reactions of ergotism with possible peripheral necrosis have

been reported after concomitant therapy of macrolides with vasoconstrictive ergot alkaloids, particularly ergotamine and dihydroergotamine. Because a

clinical interaction with Roxithromycin JG cannot be excluded, administration of

Roxithromycin JG to patients taking ergot alkaloids is contraindicated.

Disopyramide. An in vitro study has shown that Roxithromycin JG can displace

protein bound disopyramide; such an effect in vivo could result in increased

serum levels of disopyramide. Consequently, ECG and, if possible,

disopyramide serum levels should be monitored.

Terfenadine. Some macrolide antibiotics (e.g. erythromycin) may increase

serum levels of terfenadine. This can result in severe cardiovascular adverse

events, including QT prolongation, torsades de pointes and other ventricular

arrhythmias. Such a reaction has not been documented with Roxithromycin JG,

which has a much lower affinity for cytochrome P450 than erythromycin.

However, in the absence of a systematic interaction study, concomitant

administration of Roxithromycin JG and terfenadine is not recommended.

Astemizole, cisapride, pimozide. Other drugs, such as astemizole, cisapride

or pimozide, which are metabolised by the hepatic isozyme CYP3A4, have

been associated with QT interval prolongation and/or cardiac arrhythmias

(typically torsades de pointes) as a result of an increase in their serum level

subsequent to interaction with significant inhibitors of this isozyme, including

some macrolide antibacterials. Although Roxithromycin JG has no or limited ability

to complex CYP3A4 and hence to inhibit the metabolism of other drugs

processed by this isozyme, a potential for clinical interaction of Roxithromycin JG

with the above mentioned drugs cannot be either ascertained or ruled out in

confidence. Thus, concomitant administration of Roxithromycin JG and such drugs

is not recommended.

Warfarin. While no interaction was observed in volunteer studies,

Roxithromycin JG appears to interact with warfarin. Increases in prothrombin time

(international normalised ratio (INR)) have been reported in patients treated

concomitantly with Roxithromycin JG and warfarin or the related vitamin K

antagonist phenprocoumon, and severe bleeding episodes have occurred as

a consequence.

Digoxin and other cardiac glycosides. A study in healthy volunteers has

shown that Roxithromycin JG may increase the absorption of digoxin. This effect,

common to other macrolides, may very rarely result in cardiac glycoside

toxicity. This may be manifested by symptoms such as nausea, vomiting,

diarrhoea, headache or dizziness. Cardiac glycoside toxicity may also elicit

heart conduction and/or rhythm disorders. Consequently, in patients treated

with Roxithromycin JG and digoxin or another cardiac glycoside, ECG and, if

possible, the serum level of the cardiac glycoside should be monitored. This is

mandatory if symptoms suggesting cardiac glycoside overdosage have

occurred.

Midazolam. Roxithromycin JG, like other macrolides, may increase the area

under the midazolam concentration-time curve and the midazolam half-life.

Thus, the effects of midazolam may be enhanced and prolonged in patients treated with Roxithromycin JG. There is no conclusive evidence for an interaction

between Roxithromycin JG and triazolam.

Cyclosporin. A slight increase in plasma concentrations of cyclosporin A has

been observed. This does not generally necessitate altering the usual dosage.

Roxithromycin JG side effects

Applies to benzoyl peroxide topical: topical bar, topical cream, topical foam, topical gel/jelly, topical liquid, topical lotion, topical pad, topical soap, topical solution

In addition to its needed effects, some unwanted effects may be caused by benzoyl peroxide topical (the active ingredient contained in Roxithromycin JG). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking benzoyl peroxide topical:

Less common or rare:

• Painful irritation of skin, including burning, blistering, crusting, itching, severe redness, or swelling
• skin rash

• Difficult breathing
• fainting
• hives
• itching
• swelling of the eyes, face, lips, or tongue
• tightness in the throat

If any of the following symptoms of overdose occur while taking benzoyl peroxide topical, get emergency help immediately:

Symptoms of overdose:

• Burning, itching, scaling, redness, or swelling of skin (severe)

Minor Side Effects

Some of the side effects that can occur with benzoyl peroxide topical may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:

• Dryness or peeling of the skin (may occur after a few days)
• feeling of warmth, mild stinging, and redness of the skin

Roxithromycin JG contraindications

Known allergy to macrolides.

Concomitant administration of Roxithromycin JG with vasoconstrictive ergot (alkaloid) derivatives is contra-indicated since symptoms of ergotism have been described with other macrolides.

Active ingredient matches for Roxithromycin JG:

Roxithromycin in Japan.

References

1. PubChem. "roxithromycin". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
2. DrugBank. "roxithromycin". http://www.drugbank.ca/drugs/DB00778 (accessed September 17, 2018).
3. DTP/NCI. "roxithromycin: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).
4. Wikipedia. "roxithromycin: Link to the compound information in Wikipedia.". https://en.wikipedia.org/wiki/Roxith... (accessed September 17, 2018).
5. MeSH. "Anti-Bacterial Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology