Roxithromycin Dosage

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Dosage of Roxithromycin in details

infoThe dose of a drug and dosage of the drug are two different terminologies. Dose is defined as the quantity or amount of medicine given by the doctor or taken by the patient at a given period. Dosage is the regimen prescribed by the doctor about how many days and how many times per day the drug is to be taken in specified dose by the patient. The dose is expressed in mg for tablets or gm, micro gm sometimes, ml for syrups or drops for kids syrups. The dose is not fixed for a drug for all conditions, and it changes according to the condition or a disease. It also changes on the age of the patient.
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Oral

Susceptible infections

Adult: 150 mg bid or 300 mg once daily for 5-10 days in susceptible infections.

Child: 6-40 kg: 5-8 mg/kg daily.

Renal impairment: Dosage adjustment may be required.

Hepatic impairment: Usual daily doses should be halved in hepatic impairment.

Roxithromycin interactions

infoInteractions are the effects that happen when the drug is taken along with the food or when taken with other medications. Suppose if you are taking a drug Roxithromycin, it may have interactions with specific foods and specific medications. It will not interact with all foods and medications. The interactions vary from drug to drug. You need to be aware of interactions of the medicine you take. Most medications may interact with alcohol, tobacco, so be cautious.

Roxithromycin has a much lower affinity for cytochrome P450 than

erythromycin, and consequently has fewer interactions. Interactions may be

observed, however, with drugs that bind to alpha-1-acid glycoprotein, e.g.

disopyramide.

Roxithromycin does not appear to interact with oral contraceptives,

prednisolone, carbamazepine, ranitidine or antacids.

Theophylline. A study in normal subjects concurrently administered

roxithromycin and theophylline has shown some increase in the plasma

concentration of the latter. While a change in dosage is usually not required,

patients with high levels of theophylline at commencement of treatment

should have levels monitored.

Ergot alkaloids. Reactions of ergotism with possible peripheral necrosis have

been reported after concomitant therapy of macrolides with vasoconstrictive ergot alkaloids, particularly ergotamine and dihydroergotamine. Because a

clinical interaction with roxithromycin cannot be excluded, administration of

roxithromycin to patients taking ergot alkaloids is contraindicated.

Disopyramide. An in vitro study has shown that roxithromycin can displace

protein bound disopyramide; such an effect in vivo could result in increased

serum levels of disopyramide. Consequently, ECG and, if possible,

disopyramide serum levels should be monitored.

Terfenadine. Some macrolide antibiotics (e.g. erythromycin) may increase

serum levels of terfenadine. This can result in severe cardiovascular adverse

events, including QT prolongation, torsades de pointes and other ventricular

arrhythmias. Such a reaction has not been documented with roxithromycin,

which has a much lower affinity for cytochrome P450 than erythromycin.

However, in the absence of a systematic interaction study, concomitant

administration of roxithromycin and terfenadine is not recommended.

Astemizole, cisapride, pimozide. Other drugs, such as astemizole, cisapride

or pimozide, which are metabolised by the hepatic isozyme CYP3A4, have

been associated with QT interval prolongation and/or cardiac arrhythmias

(typically torsades de pointes) as a result of an increase in their serum level

subsequent to interaction with significant inhibitors of this isozyme, including

some macrolide antibacterials. Although roxithromycin has no or limited ability

to complex CYP3A4 and hence to inhibit the metabolism of other drugs

processed by this isozyme, a potential for clinical interaction of roxithromycin

with the above mentioned drugs cannot be either ascertained or ruled out in

confidence. Thus, concomitant administration of roxithromycin and such drugs

is not recommended.

Warfarin. While no interaction was observed in volunteer studies,

roxithromycin appears to interact with warfarin. Increases in prothrombin time

(international normalised ratio (INR)) have been reported in patients treated

concomitantly with roxithromycin and warfarin or the related vitamin K

antagonist phenprocoumon, and severe bleeding episodes have occurred as

a consequence.

Digoxin and other cardiac glycosides. A study in healthy volunteers has

shown that roxithromycin may increase the absorption of digoxin. This effect,

common to other macrolides, may very rarely result in cardiac glycoside

toxicity. This may be manifested by symptoms such as nausea, vomiting,

diarrhoea, headache or dizziness. Cardiac glycoside toxicity may also elicit

heart conduction and/or rhythm disorders. Consequently, in patients treated

with roxithromycin and digoxin or another cardiac glycoside, ECG and, if

possible, the serum level of the cardiac glycoside should be monitored. This is

mandatory if symptoms suggesting cardiac glycoside overdosage have

occurred.

Midazolam. Roxithromycin, like other macrolides, may increase the area

under the midazolam concentration-time curve and the midazolam half-life.

Thus, the effects of midazolam may be enhanced and prolonged in patients treated with roxithromycin. There is no conclusive evidence for an interaction

between roxithromycin and triazolam.

Cyclosporin. A slight increase in plasma concentrations of cyclosporin A has

been observed. This does not generally necessitate altering the usual dosage.


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References

  1. FDA/SPL Indexing Data. "21KOF230FA: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/DataStan... (accessed September 18, 2017).

Reviews

The results of a survey conducted on ndrugs.com for Roxithromycin are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Roxithromycin. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

2 consumers reported frequency of use

How frequently do I need to take Roxithromycin?
It was reported by ndrugs.com website users that Roxithromycin should ideally be taken Once in a day as the most common frequency of the Roxithromycin. You should you adhere strictly to the instructions and guidelines provided by your doctor on how frequently this Roxithromycin should be taken. Get another patient's view on how frequent the capsule should be used by clicking here.
Users%
Once in a day1
50.0%
3 times in a day1
50.0%

1 consumer reported doses

What doses of Roxithromycin drug you have used?
The drug can be in various doses. Most anti-diabetic, anti-hypertensive drugs, pain killers, or antibiotics are in different low and high doses and prescribed by the doctors depending on the severity and demand of the condition suffered by the patient. In our reports, ndrugs.com website users used these doses of Roxithromycin drug in following percentages. Very few drugs come in a fixed dose or a single dose. Common conditions, like fever, have almost the same doses, e.g., [acetaminophen, 500mg] of drug used by the patient, even though it is available in various doses.
Users%
501mg-1g1
100.0%

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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