Hepatic impairment. Monitor liver function. Prolonged treatment increases risk of hepatotoxicity. History of arrhythmias. Use in pregnancy (Category B1) Use in lactation
Small amounts of roxithromycin are excreted in the breast milk. Breastfeeding
or treatment of the mother should be discontinued as necessary. No dosage adjustment is required in elderly patients.
Antibiotic-associated pseudomembranous colitis; impaired renal/hepatic function. Patients w/ congenital QT interval prolongation w/ ongoing proarrhythmic conditions (ie, uncorrected hypokalemia or hypomagnesaemia, bradycardia) & receiving antiarrhythmics IA & III. May aggravate myasthenia gravis. Prolonged or repeated use. Not to be used w/ drugs which delay peristalsis eg, opiates & diphenoxylate w/ atropine. Pregnancy. Avoid use in lactation.
- DrugBank. "roxithromycin". http://www.drugbank.ca/drugs/DB00778 (accessed September 17, 2018).
- MeSH. "Anti-Bacterial Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology