Warnings are a mix of Precautions. Contraindications and interactions and serious harmful effects associated with the medicine intake. A diabetic or Hypertensive patient need to be warned about few drug interactions. A known hypersensitivity patient needs to be careful about the reactions or anaphylactic shock. A pregnant woman or a breastfeeding woman should be warned of certain medications. A Hepatitis [liver disease] patient or a cardiac patient should avoid few drugs.
Hepatic impairment. Monitor liver function. Prolonged treatment increases risk of hepatotoxicity. History of arrhythmias. Use in pregnancy (Category B1) Use in lactation
Small amounts of roxithromycin are excreted in the breast milk. Breastfeeding
or treatment of the mother should be discontinued as necessary. No dosage adjustment is required in elderly patients.
Certain people who are very sick or very old or who are sensitive show an exacerbation of side effect of the drug which can turn dangerous at times. So, it is very important to remember the precautions while taking the medicine. Pregnancy and Breastfeeding are also special categories wherein extra care or precaution is needed when taking a drug. Few patients may have a hypersensitivity reaction to few medications, and that can be life-threatening rarely. Penicillin hypersensitivity is one example. Diarrhea, rashes are few other symptoms which need a watch. A patient with other co-existing diseases like liver disease, heart disease, kidney disease should take special precautions.
Antibiotic-associated pseudomembranous colitis; impaired renal/hepatic function. Patients w/ congenital QT interval prolongation w/ ongoing proarrhythmic conditions (ie, uncorrected hypokalemia or hypomagnesaemia, bradycardia) & receiving antiarrhythmics IA & III. May aggravate myasthenia gravis. Prolonged or repeated use. Not to be used w/ drugs which delay peristalsis eg, opiates & diphenoxylate w/ atropine. Pregnancy. Avoid use in lactation.
- DrugBank. "roxithromycin". http://www.drugbank.ca/drugs/DB00778 (accessed September 18, 2017).
- MeSH. "Anti-Bacterial Agents". https://www.ncbi.nlm.nih.gov/mesh/680009... (accessed September 18, 2017).
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Information checked by Dr. Sachin Kumar, MD Pharmacology