Roxithroxyl Uses

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How old is patient?

What is Roxithroxyl?

Erythromycin belongs to the family of medicines called antibiotics. Erythromycin ophthalmic preparations are used to treat infections of the eye. They also may be used to prevent certain eye infections of newborn babies, such as neonatal conjunctivitis and ophthalmia neonatorum. They may be used with other medicines for some eye infections.

Erythromycin is available only with your doctor's prescription.

Roxithroxyl indications

infoAn indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Roxithroxyl is indicated for the treatment of the following types of mild to

moderately severe infections caused by or likely to be caused by susceptible

micro-organisms: • upper respiratory tract infection - acute pharyngitis, tonsillitis and

sinusitis

• dental infections

• lower respiratory tract infection - acute bronchitis; acute exacerbations

of chronic bronchitis and community acquired pneumonia

• skin and skin structure infections

• non-gonococcal urethritis.

How should I use Roxithroxyl?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Do not use erythromycin topical to treat any skin condition that has not been checked by your doctor.

Wash your hands before and after using this medicine.

Clean and dry the skin area before you apply erythromycin topical. Spread the medicine on lightly, without rubbing it in.

Erythromycin topical is usually applied once or twice daily. Follow your doctor's instructions.

It may take up to 12 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 6 weeks of treatment.

Store at room temperature away from moisture and heat. Keep the tube or bottle tightly closed when not in use.

The gel form of this medicine is flammable. Do not use near high heat or open flame.

Uses of Roxithroxyl in details

infoThere are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Roxithroxyl is used to treat ear, nose and throat infections, pneumonia (lung infection), skin infections and infections of the genitalia.

Roxithroxyl description

Roxithroxyl is a semi-synthetic macrolide antibiotic. It is very similar in composition, chemical structure and mechanism of action to erythromycin, azithromycin, or clarithromycin. Roxithroxyl prevents bacteria from growing, by interfering with their protein synthesis. Roxithroxyl binds to the subunit 50S of the bacterial ribosome, and thus inhibits the translocation of peptides. Roxithroxyl has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila. It can treat respiratory tract, urinary and soft tissue infections. It is in the United States, but is available in Australia.

Roxithroxyl dosage

Adults: Recommended Dose: Mild to Moderate Acute Bacterial Exacerbations of COPD, Pneumonia of Mild Severity, Pharyngitis, Tonsillitis and Uncomplicated Skin and Skin Structure Infections: 500 mg as a single dose on the 1st day followed by 250 mg once daily on days 2 through 5.

Genital Ulcer Disease: 1000 mg as single dose.

Urethritis and Cervicitis: 2000 mg as single dose. Capsule should be given at least 1 hr before or 2 hrs after a meal. Azithromycin tablets can be taken with or without food.

Children: Use of azithromycin in children <6 months is not recommended.

Roxithroxyl interactions

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What other drugs will affect Roxithroxyl?

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Roxithroxyl has a much lower affinity for cytochrome P450 than erythromycin, and consequently has fewer interactions. Interactions may be observed, however, with drugs that bind to alpha-1-acid glycoprotein, e.g. disopyramide. Roxithroxyl does not appear to interact with oral contraceptives, prednisolone, carbamazepine, ranitidine or antacids. Theophylline. A study in normal subjects concurrently administered Roxithroxyl and theophylline has shown some increase in the plasma concentration of the latter. While a change in dosage is usually not required, patients with high levels of theophylline at commencement of treatment should have levels monitored. Ergot alkaloids. Reactions of ergotism with possible peripheral necrosis have been reported after concomitant therapy of macrolides with vasoconstrictive ergot alkaloids, particularly ergotamine and dihydroergotamine. Because a clinical interaction with Roxithroxyl cannot be excluded, administration of Roxithroxyl to patients taking ergot alkaloids is contraindicated. Disopyramide. An in vitro study has shown that Roxithroxyl can displace protein bound disopyramide; such an effect in vivo could result in increased serum levels of disopyramide. Consequently, ECG and, if possible, disopyramide serum levels should be monitored. Terfenadine. Some macrolide antibiotics (e.g. erythromycin) may increase serum levels of terfenadine. This can result in severe cardiovascular adverse events, including QT prolongation, torsades de pointes and other ventricular arrhythmias. Such a reaction has not been documented with Roxithroxyl, which has a much lower affinity for cytochrome P450 than erythromycin. However, in the absence of a systematic interaction study, concomitant administration of Roxithroxyl and terfenadine is not recommended. Astemizole, cisapride, pimozide. Other drugs, such as astemizole, cisapride or pimozide, which are metabolised by the hepatic isozyme CYP3A4, have been associated with QT interval prolongation and/or cardiac arrhythmias (typically torsades de pointes) as a result of an increase in their serum level subsequent to interaction with significant inhibitors of this isozyme, including some macrolide antibacterials. Although Roxithroxyl has no or limited ability to complex CYP3A4 and hence to inhibit the metabolism of other drugs processed by this isozyme, a potential for clinical interaction of Roxithroxyl with the above mentioned drugs cannot be either ascertained or ruled out in confidence. Thus, concomitant administration of Roxithroxyl and such drugs is not recommended. Warfarin. While no interaction was observed in volunteer studies, Roxithroxyl appears to interact with warfarin. Increases in prothrombin time (international normalised ratio (INR)) have been reported in patients treated concomitantly with Roxithroxyl and warfarin or the related vitamin K antagonist phenprocoumon, and severe bleeding episodes have occurred as a consequence. Digoxin and other cardiac glycosides. A study in healthy volunteers has shown that Roxithroxyl may increase the absorption of digoxin. This effect, common to other macrolides, may very rarely result in cardiac glycoside toxicity. This may be manifested by symptoms such as nausea, vomiting, diarrhoea, headache or dizziness. Cardiac glycoside toxicity may also elicit heart conduction and/or rhythm disorders. Consequently, in patients treated with Roxithroxyl and digoxin or another cardiac glycoside, ECG and, if possible, the serum level of the cardiac glycoside should be monitored. This is mandatory if symptoms suggesting cardiac glycoside overdosage have occurred. Midazolam. Roxithroxyl, like other macrolides, may increase the area under the midazolam concentration-time curve and the midazolam half-life. Thus, the effects of midazolam may be enhanced and prolonged in patients treated with Roxithroxyl. There is no conclusive evidence for an interaction between Roxithroxyl and triazolam. Cyclosporin. A slight increase in plasma concentrations of cyclosporin A has been observed. This does not generally necessitate altering the usual dosage.

Roxithroxyl side effects

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What are the possible side effects of Roxithroxyl?

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Applies to benzoyl peroxide topical: topical bar, topical cream, topical foam, topical gel/jelly, topical liquid, topical lotion, topical pad, topical soap, topical solution

In addition to its needed effects, some unwanted effects may be caused by benzoyl peroxide topical (the active ingredient contained in Roxithroxyl). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking benzoyl peroxide topical:

Less common or rare:

  • Painful irritation of skin, including burning, blistering, crusting, itching, severe redness, or swelling
  • skin rash
Incidence not known:
  • Difficult breathing
  • fainting
  • hives
  • itching
  • swelling of the eyes, face, lips, or tongue
  • tightness in the throat

If any of the following symptoms of overdose occur while taking benzoyl peroxide topical, get emergency help immediately:

Symptoms of overdose:

  • Burning, itching, scaling, redness, or swelling of skin (severe)

Minor Side Effects

Some of the side effects that can occur with benzoyl peroxide topical may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:

  • Dryness or peeling of the skin (may occur after a few days)
  • feeling of warmth, mild stinging, and redness of the skin

Roxithroxyl contraindications

See also:
What is the most important information I should know about Roxithroxyl?

Known allergy to macrolides.

Concomitant administration of Roxithroxyl with vasoconstrictive ergot (alkaloid) derivatives is contra-indicated since symptoms of ergotism have been described with other macrolides.

Active ingredient matches for Roxithroxyl:

Roxithromycin in Thailand.


Unit description / dosage (Manufacturer)Price, USD
Roxithroxyl 150 mg x 10 Blister x 10 Tablet
Roxithroxyl 150 mg x 100's
Roxithroxyl 150 mg x 10 x 10's
Roxithroxyl 300 mg x 10 x 10's
Roxithroxyl film-coated tab 150 mg 10 x 10's (Bangkok Lab & Cosmetic)
Roxithroxyl film-coated tab 150 mg 100's (Bangkok Lab & Cosmetic)
Roxithroxyl film-coated tab 300 mg 10 x 10's (Bangkok Lab & Cosmetic)

List of Roxithroxyl substitutes (brand and generic names):

ROXITID 150MG TABLET 1 strip / 10 tablets each (Ranbaxy Laboratories Ltd)$ 0.68
Roxitin 150 mg x 50 x 10's (T P Drug)
Roxitin 150 mg x 500's (T P Drug)
ROXITIS Capsule/ Tablet / 150mg / 10 units (Medley)$ 0.87
ROXITIS Dispersible Tablet / 50mg / 10 units (Medley)$ 0.39
Roxitis 50mg TAB / 10 (Medley)$ 0.39
Roxitis 150mg TAB / 10 (Medley)$ 0.87
Roxitis 50mg/5mL SUSP / 30ml (Medley)$ 0.47
50 mg x 10's (Medley)$ 0.39
150 mg x 10's (Medley)$ 0.87
50 mg x 5 mL x 30ml (Medley)$ 0.47
Roxitis 150 mg x 10 Blister x 10 Tablet (Medley)
ROXITIS tab 50 mg x 10's (Medley)$ 0.39
ROXITIS tab 150 mg x 10's (Medley)$ 0.87
ROXITIS oral susp 50 mg x 5 mL x 30ml (Medley)$ 0.47
Roxitis 50mg TAB / 10 (Medley)$ 0.39
Roxitis 150mg TAB / 10 (Medley)$ 0.87
Roxitis 50mg/5mL SUSP / 30ml (Medley)$ 0.47
ROXITIS - M Capsule/ Tablet / / 10 units (Medley Pharmaceuticals)$ 1.08
Roxitis- M Roxithromycin 150mg, Ambroxol60mg TAB / 10$ 1.08
Roxitop 150 mg x 10 x 10's (Farmaline)
Roxitop 300 mg x 10 x 10's (Farmaline)
Roxitop tab 150 mg 10 x 10's (Farmaline)
Roxitop tab 300 mg 10 x 10's (Farmaline)
150 mg x 10's (Invision)$ 1.03
50 mg x 10's (Invision)$ 0.48
Roxitrac 150mg TAB / 10 (Invision)$ 1.03
Roxitrac 50mg DISPERTAB / 10 (Invision)$ 0.48
ROXITRAC tab 150 mg x 10's (Invision)$ 1.03
ROXITRAC dispertab 50 mg x 10's (Invision)$ 0.48
Roxitrac 150mg TAB / 10 (Invision)$ 1.03
Roxitrac 50mg DISPERTAB / 10 (Invision)$ 0.48
Tablet; Oral; Roxithromycin 150 mg
Tablet; Oral; Roxithromycin 300 mg

References

  1. PubChem. "roxithromycin". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  2. DrugBank. "roxithromycin". http://www.drugbank.ca/drugs/DB00778 (accessed September 17, 2018).
  3. DTP/NCI. "roxithromycin: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).

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The results of a survey conducted on ndrugs.com for Roxithroxyl are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Roxithroxyl. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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